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Simultaneous translocation of both TCR Loci (14q11) with rare partner loci (Xq22 and 12p13) in a case of T-lymphoblastic leukemia.

Abstract：

:The most common recurrent cytogenetic abnormalities in T-lymphoblastic leukemia (T-acute lymphoblastic leukemia [T-ALL]) involve T-cell receptor (TCR) loci and a variety of partner genes, including HOX11, HOX11L2, MYC, and TAL1. In this report, we present a rare case involving simultaneous translocation of the TCR α/δ loci with different partner loci (Xq22 and 12p13); this resulted in a poor prognosis. Chromosomal analysis showed 46,Y,t(X;14)(q22;q11.2),t(12;14)(p13;q11.2) and FISH analysis by using a T-cell receptor alpha delta DNA probe, Split Signal (DakoCytomation, Denmark), showed translocations at the same TCR α/δ locus on both chromosomes. FISH with 2 bacterial artificial chromosome clones showed break apart signal, which suggests involvement of the IRS4 gene. To our knowledge, this is the first report of T-ALL in which both TCR α/δ loci were translocated with different partner loci, and 1 of the partner loci, Xq22, was a rare translocation partner locus that included IRS4 gene.

journal_name

Ann Lab Med

journal_title

Annals of laboratory medicine

authors

Kang DH,Kim SH,Jun JW,Lee YW,Shin HB,Ahn JY,Hong DS,Lee YK,Jeon BR

doi

10.3343/alm.2012.32.3.220

keywords:

["IRS4 gene","Simultaneous translocation of TCR loci","T-lymphoblastic leukemia"]

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

220-4

issue

3

eissn

2234-3806

issn

2234-3814

journal_volume

32

pub_type

杂志文章

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