Abstract:
:The thalamus, known as the pacemaker for spindle rhythms in sleep, has several enabling features that promote such pacemaking. These include a circuitry that interconnects large groups of excitatory and inhibitory neurons, all of which are essentially capable of firing high-frequency 'bursts' of discharges. Bursts in thalamic reticular neurons produce powerful inhibition in thalamic relay neurons, which leads to rebound excitation. The timing properties of the inhibition regulate the network activity by controlling rebound burst latency. Anatomical features within thalamus such as convergence and divergence determine the spread and synchronization of pacemaking activity. The anatomical basis of divergence, i.e. the degree of axonal arborization of elements within the thalamic circuit, can be functionally modified in a dynamic fashion by biochemical pathways that regulate the properties of synaptic release. These data suggest that it will be possible to therapeutically regulate the thalamus to modify not only the propensity to sleep but also forms of epilepsy that rely on similar thalamic circuitry.
journal_name
J Sleep Resjournal_title
Journal of sleep researchauthors
Huguenard JRdoi
10.1046/j.1365-2869.7.s1.5.xsubject
Has Abstractpub_date
1998-01-01 00:00:00pages
24-9eissn
0962-1105issn
1365-2869journal_volume
7 Suppl 1pub_type
杂志文章abstract::For the first time, the relationship between depressive symptoms and sleep quality was explored prospectively during pregnancy. Participants (n = 273) completed the Pittsburgh Sleep Quality Index and Beck Depression Inventory at three 8-week intervals, starting from 15-23 weeks gestation. In addition to sleep quality ...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.2008.00655.x
更新日期:2008-06-01 00:00:00
abstract::Most cognitive tests administered during sleep loss are well rehearsed to remove practice effects. This can introduce tedium and a loss of novelty, which may be the key to the test's subsequent sensitivity to sleep loss, and why it may need only a few minutes administration before sleep loss effects are apparent. Ther...
journal_title:Journal of sleep research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1365-2869.1998.00104.x
更新日期:1998-06-01 00:00:00
abstract::Actigraphy is a cost-efficient method to estimate sleep-wake patterns over long periods in natural settings. However, the lack of methodological standards in actigraphy research complicates the generalization of outcomes. A rapidly growing methodological diversity is visible in the field, which increasingly necessitat...
journal_title:Journal of sleep research
pub_type: 杂志文章,评审
doi:10.1111/jsr.13134
更新日期:2020-07-08 00:00:00
abstract::We aimed to investigate the effect of increased sleep pressure and shortened sleep duration on subjective sleep perception in relation to electroencephalographic sleep measures. We analyzed the data from a study in which 14 healthy male volunteers had completed a baseline assessment with 8 hr time in bed, a sleep depr...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12706
更新日期:2019-06-01 00:00:00
abstract::This consensus paper provides an overview of the state of the art in research on the aetiology and treatment of nightmare disorder and outlines further perspectives on these issues. It presents a definition of nightmares and nightmare disorder followed by epidemiological findings, and then explains existing models of ...
journal_title:Journal of sleep research
pub_type: 杂志文章,评审
doi:10.1111/jsr.12820
更新日期:2019-08-01 00:00:00
abstract::Sleep paralysis is a relatively common but under-researched phenomenon. In this paper we examine prevalence in a UK sample and associations with candidate risk factors. This is the first study to investigate the heritability of sleep paralysis in a twin sample and to explore genetic associations between sleep paralysi...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12282
更新日期:2015-08-01 00:00:00
abstract::Actigraphy is increasingly used in the assessment and treatment of various clinical conditions, being a convenient and cost-effective method of capturing bodily movements over long periods of time. This study examined the use of actigraphy in the measurement of sleep of patients with depression and insomnia. Fifty-fou...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.2011.00917.x
更新日期:2012-02-01 00:00:00
abstract::The Psychomotor Vigilance Test (PVT) is a widely used assay of behavioural alertness sensitive to the effects of sleep loss and circadian misalignment. However, there is currently no accepted PVT composite outcome metric that captures response slowing, attentional lapses and compensatory premature reactions observed t...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12322
更新日期:2015-12-01 00:00:00
abstract::The objectives of this study were: (i) to compare the sleep quality at home of patients with fibromyalgia with that of healthy controls; and (ii) to examine the factors associated with sleep quality in patients with fibromyalgia. In addition to anthropometric measures, 75 women with fibromyalgia and 48 healthy control...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.2011.00929.x
更新日期:2012-02-01 00:00:00
abstract::This study aimed to compare the critical flicker frequency (CFF) and the mail-in cognitive function screening ınstrument (MCFSI) tests' effectiveness in diagnosing neurocognitive function losses in patients having severe obstructive sleep apnea syndrome (OSAS). A total of 85 subjects (47 patients with a diagnosis of s...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12531
更新日期:2017-10-01 00:00:00
abstract::This study used data from 2,222 mothers and infants participating in a population-based birth cohort to verify whether maternal depression in the perinatal period was associated with poor infant sleep. Mothers who scored ≥13 points on the Edinburgh Postnatal Depression Scale at 16-24 weeks of gestation and/or 3 months...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.13047
更新日期:2020-04-14 00:00:00
abstract::Sleep and memory studies often focus on overnight rather than long-term memory changes, traditionally associating overnight memory change (OMC) with sleep architecture and sleep patterns such as spindles. In addition, (para-)sympathetic innervation has been associated with OMC after a daytime nap using heart rate vari...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12910
更新日期:2020-06-01 00:00:00
abstract::Alertness and performance on a wide variety of tasks are impaired immediately upon waking from sleep due to sleep inertia, which has been found to dissipate in an asymptotic manner following waketime. It has been suggested that behavioural or environmental factors, as well as sleep stage at awakening, may affect the s...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.1999.00128.x
更新日期:1999-03-01 00:00:00
abstract::The aim of this experiment was to study the effects on sleep and temperature rhythms of a 6-hour (h) phase advance of the sleep/wake cycle in healthy elderly subjects. Twenty-five subjects (77-91 y.o.) lived in a time-isolation apartment on an experimenter-controlled routine for 15 days. The experiment started with fi...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1046/j.1365-2869.1996.00015.x
更新日期:1996-06-01 00:00:00
abstract::Self-reported short or long sleep duration has been repeatedly found to be associated with increased mortality and health risks. However, there is still an insufficient amount of detailed knowledge available to characterize the short and long sleep duration groups in general population. Consequently, the underlying me...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.2006.00543.x
更新日期:2006-09-01 00:00:00
abstract::High-altitude exposure is characterized by the appearance of periodic breathing during sleep. Only limited evidence is available, however, on the presence of gender-related differences in this breathing pattern. In 37 healthy subjects, 23 male and 14 female, we performed nocturnal cardio-respiratory monitoring in the ...
journal_title:Journal of sleep research
pub_type: 杂志文章,随机对照试验
doi:10.1111/jsr.12012
更新日期:2013-06-01 00:00:00
abstract::It has been hypothesized that insufficient sleep may compromise neuronal function and contribute to neurodegenerative processes. While sleep loss by itself may not lead to cell death directly, it may affect the sensitivity to a subsequent neurodegenerative insult. Here we examined the effects of chronic sleep restrict...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.2011.00932.x
更新日期:2012-02-01 00:00:00
abstract::The pathophysiological processes of Alzheimer's dementia predate its clinical manifestation. Sleep disturbances can accelerate the aging process and are common features of dementia. This study examined whether quantitative sleep electroencephalogram changes predate the clinical development of mild cognitive impairment...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12666
更新日期:2019-06-01 00:00:00
abstract::Spatiotemporal activity patterns of neurones are organized by different types of coherent network oscillations. Frequency content and cross-frequency coupling of cortical oscillations are strongly state-dependent, indicating that different patterns of wakefulness or sleep, respectively, support different cognitive or ...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.2012.01037.x
更新日期:2012-12-01 00:00:00
abstract::According to Eysenck's theory of Introversion-Extroversion (I-E), introverts demonstrate higher levels of basal activity within the reticular-thalamic-cortical loop, yielding higher tonic cortical arousal than Extraverts, who are described conversely as chronically under-aroused and easily bored. We hypothesized that ...
journal_title:Journal of sleep research
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1365-2869.2007.00611.x
更新日期:2007-12-01 00:00:00
abstract::It is believed that sexual activity increases the need to sleep in many species. However, the relationship between copulatory activity and sleep has been poorly studied. Several studies have observed variations in the sleep of female rats and women as a function of their reproductive state. These effects have been cor...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1046/j.1365-2869.2002.00304.x
更新日期:2002-09-01 00:00:00
abstract::In patients with chronic obstructive pulmonary disease (COPD), sleep is often fragmented while, conversely, the use of sleep medications is of concern in these patients due to potential impairment of nocturnal breathing. This randomised, double-blind, placebo-controlled, two-period crossover study was conducted to eva...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.13248
更新日期:2021-01-08 00:00:00
abstract::The decline in sleep quality that often accompanies aging is thought to be the consequence of alterations in both circadian and homeostatic processes widely assumed to be responsible for sleep/wake regulation. A number of experimental approaches have been used to examine various aspects of age-related sleep changes, b...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.2007.00567.x
更新日期:2007-03-01 00:00:00
abstract::Activity-rest patterns displayed by an animal under various circumstances are suggested to result from the combined influences of two virtually identical circadian pacemaker components. Increased output of each component proportionally increases the probability of activity of the animal. Such a dual circadian pacemake...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.1992.tb00015.x
更新日期:1992-06-01 00:00:00
abstract::Accuracy and limitations of automatic scoring of sleep stages and electroencephalogram arousals from a single derivation (Fp1 -Fp2 ) were studied in 29 healthy adults using a portable wireless polysomnographic recorder. All recordings were scored five times: twice by a referent scorer who viewed the standard polysomno...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12105
更新日期:2014-04-01 00:00:00
abstract::Cetacean sleep phenomenology consists of a combination of unihemispheric slow wave sleep and a massive reduction in the amount of rapid eye movement sleep. Despite various proposals, the selection pressure driving the evolution of this combined sleep phenomenology is unknown. It was recently suggested that the need to...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.2004.00419.x
更新日期:2004-12-01 00:00:00
abstract::The current definition of rapid eye movement (REM) sleep without atonia has no quantitative character, and cut-off values above which the level of electromyographic tone can be considered to be 'excessive' are unclear. The aim of this study was to analyse the characteristics of chin electromyographic amplitude by mean...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.2011.00958.x
更新日期:2012-06-01 00:00:00
abstract::Neurocognitive impairment is a trait marker of schizophrenia, but no effective treatment has yet been identified. Sleep spindle deficits have been associated with diminished sleep-dependent memory learning. We examined whether this link could be extended into various cognitive domains by investigating the association ...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12672
更新日期:2019-02-01 00:00:00
abstract::Sleep-related attentional bias is thought to play a role in the maintenance of insomnia. However, this concept has been questioned by several studies that did not show the presence of sleep-related attentional bias in clinical insomnia or poor sleepers. Our goal in the present study was to test whether the mood state ...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12748
更新日期:2019-04-01 00:00:00
abstract::It is presently unclear whether chronic fatigue syndrome (CFS) patients exhibit daytime sleepiness in addition to fatigue. Both, fatigue, such as that seen in CFS patients, and excessive daytime sleepiness, such as in sleep apnea-hypopnea syndrome (SAHS), remain poorly understood. Both daytime conditions are generally...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.2008.00679.x
更新日期:2008-12-01 00:00:00