Abstract:
:The Psychomotor Vigilance Test (PVT) is a widely used assay of behavioural alertness sensitive to the effects of sleep loss and circadian misalignment. However, there is currently no accepted PVT composite outcome metric that captures response slowing, attentional lapses and compensatory premature reactions observed typically in sleep-deprived subjects. We developed a novel likelihood ratio metric (LRM) based on relative frequency distributions in 50 categories of reaction times (RT) and false starts in alert and sleep-deprived subjects (acute total sleep deprivation: n = 31 subjects). The LRM had the largest effect size both in a 33-h total sleep deprivation protocol [1.96; 95% confidence interval (CI): 1.61-2.44; followed by response speed 1/RT, effect size 1.93, 95% CI: 1.55-2.65] and in a chronic partial sleep restriction protocol (1.22; 95% CI: 0.96-1.59; followed by response speed 1/RT, effect size 1.21, 95% CI: 0.94-1.59; 5 nights at 4 h sleep per night; n = 43 subjects). LRM scores correlated highly with response speed (R(2 ) = 0.986), and less well with five other common PVT outcome metrics (R(2 ) = 0.111-0.886). In conclusion, the new LRM is a sensitive PVT outcome metric with high statistical power that takes subtle sleep loss-related changes in the distribution of reaction times (including false starts) into account, is not prone to outliers, does not require baseline data and can be calculated and interpreted easily. Congruence between LRM and PVT response speed and their similar effect size rankings support the use of response speed as the primary, most sensitive and most parsimonious standard PVT outcome metric for determining neurobehavioural deficits from sleep loss.
journal_name
J Sleep Resjournal_title
Journal of sleep researchauthors
Basner M,Mcguire S,Goel N,Rao H,Dinges DFdoi
10.1111/jsr.12322subject
Has Abstractpub_date
2015-12-01 00:00:00pages
702-13issue
6eissn
0962-1105issn
1365-2869journal_volume
24pub_type
杂志文章abstract::Sleep/wakefulness (S/W) disorders are frequent in Parkinson's disease (PD). The underlying causes have yet to be elucidated but dopaminergic neurodegenerative lesions seem to contribute to appearance of the disorders and anti-Parkinsonian medication is known to accentuate S/W problems. Hence, we reasoned that studying...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.2008.00625.x
更新日期:2008-03-01 00:00:00
abstract::The present study sought to investigate whether a single night of partial sleep deprivation (PSD) would alter fasting insulin sensitivity and cephalic phase insulin release (CPIR) in humans. A rise in circulating insulin in response to food-related sensory stimulation may prepare tissues to break down ingested glucose...
journal_title:Journal of sleep research
pub_type: 杂志文章,随机对照试验
doi:10.1111/jsr.12340
更新日期:2016-02-01 00:00:00
abstract::Rapid eye movement (REM) sleep behaviour disorder (RBD) has been suggested to predict the development of neurodegenerative disorders. Patients with RBD are acting out dream behaviour associated with loss of normal muscle atonia of REM sleep. The aim of the present study was to confirm that exogenous melatonin improves...
journal_title:Journal of sleep research
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1365-2869.2010.00848.x
更新日期:2010-12-01 00:00:00
abstract::This laboratory study investigated the impact of restricted sleep during a simulated school week on circadian phase, sleep stages and daytime functioning. Changes were examined across and within days and during a simulated weekend recovery. Participants were 12 healthy secondary school students (six male) aged 15-17 y...
journal_title:Journal of sleep research
pub_type: 临床试验,杂志文章
doi:10.1111/jsr.12473
更新日期:2017-04-01 00:00:00
abstract::This study used data from 2,222 mothers and infants participating in a population-based birth cohort to verify whether maternal depression in the perinatal period was associated with poor infant sleep. Mothers who scored ≥13 points on the Edinburgh Postnatal Depression Scale at 16-24 weeks of gestation and/or 3 months...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.13047
更新日期:2020-04-14 00:00:00
abstract::Genetic factors affect many aspects of sleep, such as sleep length. We investigated the contribution of genetic factors to stability and change of sleep length among adults over a 15-year period. In this representative follow-up study we used the Finnish Twin Cohort as the study population. Questionnaire surveys were ...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12051
更新日期:2013-10-01 00:00:00
abstract::An intermediate phenotype of a disease is a trait in the path of pathogenesis from genetic predisposition to disease manifestation. Identifying intermediate phenotypes with high heritability is helpful in delineating the genetics of a disorder. In this study, we aimed to examine various traits with regards to obesity,...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.13191
更新日期:2020-09-14 00:00:00
abstract::Models of nightmare aetiology postulate an interaction between trait and state factors. However, most of the studies that support these models have been cross-sectional and longitudinal studies are scarce. The present data were obtained from N = 888 participants completing two online dream studies carried out independ...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.13126
更新日期:2020-06-11 00:00:00
abstract::Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent disorder occurring in approximately 3-5% of school-aged children. The core symptoms of ADHD are effectively treated with stimulant medications such as methylphenidate; however, there are also negative side effects, including insomnia. It has been su...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.2010.00845.x
更新日期:2010-12-01 00:00:00
abstract::The relation between subjective and objective (polysomnography) is of obvious interest in understanding sleep. The aim of the present study was to examine the item structure of the Karolinska Sleep Diary (KSD), and the covariation between KSD and sleep-stage variables, with cross-sectional (inter-individual) data obta...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.1997.00217.x
更新日期:1997-12-01 00:00:00
abstract::This cross-sectional study examined the association between objectively measured sleep patterns and body composition in very elderly community-dwelling women. Participants included 191 community-dwelling adults aged ≥ 80 years (mean age: 83.4 ± 2.6 years; age range: 80-92 years). Sleep and physical activity were monit...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12326
更新日期:2015-12-01 00:00:00
abstract::According to Eysenck's theory of Introversion-Extroversion (I-E), introverts demonstrate higher levels of basal activity within the reticular-thalamic-cortical loop, yielding higher tonic cortical arousal than Extraverts, who are described conversely as chronically under-aroused and easily bored. We hypothesized that ...
journal_title:Journal of sleep research
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1365-2869.2007.00611.x
更新日期:2007-12-01 00:00:00
abstract::The relationship between duration of the ultradian sleep cycle and intensity of tonic vasoconstrictor sympathetic outflow to thermoregulatory heat exchangers was studied in cats chronically implanted with EEG and EMG electrodes, and temperature transducers. Vasoconstrictor sympathetic outflow to heat exchangers was in...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.1995.tb00149.x
更新日期:1995-03-01 00:00:00
abstract::Using a nap design, we have recently shown that training at a complex cognitive task at bedtime improves objective sleep quality by reducing sleep fragmentation. In order to extend our findings to nighttime sleep, here we assess the impact of a multi-componential cognitive task at bedtime on the subsequent sleep episo...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12929
更新日期:2020-12-01 00:00:00
abstract::Sleep-related attentional bias is thought to play a role in the maintenance of insomnia. However, this concept has been questioned by several studies that did not show the presence of sleep-related attentional bias in clinical insomnia or poor sleepers. Our goal in the present study was to test whether the mood state ...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12748
更新日期:2019-04-01 00:00:00
abstract::Parents of children with special healthcare needs (CSHCNs) report poorer sleep than parents of typically developing (TD) children, which has been associated with poorer mental health. The relations between sleep disturbances and general health and memory among this population are unknown. The current study aimed to re...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12329
更新日期:2016-02-01 00:00:00
abstract::The aim of the present study was to determine whether the motor process of handwriting is influenced by a circadian rhythm. Nine healthy young male subjects underwent a 40-h sleep deprivation protocol under constant routine conditions. Starting at 09:00 hours, subjects performed every 3 h two handwriting tasks of diff...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.2008.00727.x
更新日期:2009-06-01 00:00:00
abstract::While high levels of activity and exercise training have been associated with improvements in sleep quality, minimum levels of activity likely to improve sleep outcomes have not been explored. A two-armed parallel randomized controlled trial (N=41; 30 females) was designed to assess whether increasing physical activit...
journal_title:Journal of sleep research
pub_type: 杂志文章,随机对照试验
doi:10.1111/jsr.12297
更新日期:2015-10-01 00:00:00
abstract::Slow-wave sleep is one of the most important restorative components of sleep and central for our health and cognitive functioning. Although the amount of slow-wave sleep depends on sleep drive, age and other factors, also the pre-sleep mental state might influence sleep depth. We had shown that a pre-sleep hypnotic su...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.13168
更新日期:2020-08-17 00:00:00
abstract::The aim of this study was to investigate the effects of various forms of TV exposure on the quality of children's sleep. In this randomized population-based survey questionnaires concerning TV viewing, sleep disturbances, and psychiatric symptoms were administered to 321 parents of children aged 5-6 years. Sleep distu...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.2006.00525.x
更新日期:2006-06-01 00:00:00
abstract::The pathophysiological processes of Alzheimer's dementia predate its clinical manifestation. Sleep disturbances can accelerate the aging process and are common features of dementia. This study examined whether quantitative sleep electroencephalogram changes predate the clinical development of mild cognitive impairment...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12666
更新日期:2019-06-01 00:00:00
abstract::Night sleep in sedentary African subjects living in the sahelian zone lasts from 7 h to 8 h, with high amounts of slow-wave sleep (SWS) and paradoxical sleep (PS), SWS being present in each sleep cycle. We report here on sleep patterns in 6 healthy male European expatriates (aged 32-39 years) living in the same tropic...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.1992.tb00037.x
更新日期:1992-09-01 00:00:00
abstract::Epidemiological data indicate a link between sleep-disordered breathing and elevation of arterial pressure. Previous studies suggest increased activity of the sympathetic nervous system in patients with sleep apnoea. The response of muscle sympathetic nerve activity was further investigated in normal, awake subjects f...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.1995.tb00183.x
更新日期:1995-06-01 00:00:00
abstract::Sleep problems have a high prevalence and negative daytime consequences in adolescents. Current sleep measures for this age group have limitations. The Patient-Reported Outcomes Measurement Information System (PROMIS® ) developed sleep item banks for adults. In a previous validation study, these item banks were adapte...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.13029
更新日期:2020-03-16 00:00:00
abstract::The beneficial effect of sleep on motor memory consolidation is well known for motor sequence memory, but remains unsettled for visuomotor adaptation in humans. The aim of this study was to characterize more clearly the influence of sleep on consolidation of visuomotor adaptation using a between-subjects functional ma...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.2012.01059.x
更新日期:2013-04-01 00:00:00
abstract::To determine whether the circadian disruption of the sleep/wake cycle observed in sleeping sickness, human African trypanosomiasis (HAT), can be reversed after trypanosomicide treatment, 10 Congolese patients infected by Trypanosoma brucei gambiense underwent 24-h polysomnographic recordings before treatment with mela...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1046/j.1365-2869.1999.00160.x
更新日期:1999-09-01 00:00:00
abstract::An accurate home sleep study to assess electroencephalography (EEG)-based sleep stages and EEG power would be advantageous for both clinical and research purposes, such as for longitudinal studies measuring changes in sleep stages over time. The purpose of this study was to compare sleep scoring of a single-channel EE...
journal_title:Journal of sleep research
pub_type: 临床试验,杂志文章
doi:10.1111/jsr.12417
更新日期:2016-12-01 00:00:00
abstract::The effect of caffeine on sleep has been well documented. However, most studies examined this relationship in laboratories or used a cross-sectional design analysing between-person differences. This study investigated the within-person relationship between caffeine intake and sleep duration at home. In a national data...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12996
更新日期:2020-12-01 00:00:00
abstract::Previous studies have estimated an overall prevalence for narcolepsy between 15 and 70 cases per 100 000 inhabitants. We aimed to estimate the prevalence of narcolepsy in Catalunya (Catalonia), a north-east region of Spain (7 424 754 inhabitants), on 31 December 2014 by identifying all living subjects diagnosed with n...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12640
更新日期:2018-10-01 00:00:00
abstract::The purpose of this study was to assess the prevalence of sleep disturbance in subjects diagnosed with retinitis pigmentosa (RP), as well as the influence of age and gender. Sleep quality was assessed, by means of the Pittsburgh Sleep Quality Index (PSQI), in people with RP (n=177) and gender-and age-matched normally ...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1046/j.1365-2869.2001.00251.x
更新日期:2001-06-01 00:00:00