Effect of dopaminergic substances on sleep/wakefulness in saline- and MPTP-treated mice.

Abstract:

:Sleep/wakefulness (S/W) disorders are frequent in Parkinson's disease (PD). The underlying causes have yet to be elucidated but dopaminergic neurodegenerative lesions seem to contribute to appearance of the disorders and anti-Parkinsonian medication is known to accentuate S/W problems. Hence, we reasoned that studying the acute effect of dopaminergic compounds on S/W in an animal model of PD might improve our knowledge of S/W regulation in the context of partial dopaminergic depletion. To this end, we tested the effect of levodopa (l-dopa), pergolide (a mixed D(2)/D(1) agonist) and lisuride (a D(2) agonist) on S/W recordings in MPTP-treated mice, in comparison with controls. Our results showed that dopaminergic compounds modify S/W amounts in both control and MPTP mice. Wakefulness amounts are greater in MPTP mice after l-dopa (50 mg kg(-1)) and lisuride (1 mg kg(-1)) injections compared with control mice. Moreover, the paradoxical sleep latency was significantly longer in MPTP mice after high-dose l-dopa administration. Our observations suggest that the actions of both l-dopa and lisuride on S/W differ slightly in MPTP mice relative to controls. Hence, MPTP-induced partial DA depletion may modulate the effect of dopaminergic compounds on S/W regulation.

journal_name

J Sleep Res

authors

Laloux C,Derambure P,Houdayer E,Jacquesson JM,Bordet R,Destée A,Monaca C

doi

10.1111/j.1365-2869.2008.00625.x

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

101-10

issue

1

eissn

0962-1105

issn

1365-2869

pii

JSR625

journal_volume

17

pub_type

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