C-Terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins.

abstract：:The induction of the granulocytic differentiation of leukemic cells by all-trans retinoic acid (RA) has been a major breakthrough in terms of survival for acute promyelocytic leukemia (APL) patients. Here we highlight the synergism and the underlying novel mechanism between RA and the granulocyte colony-stimulating fa...

journal_title：Molecular and cellular biology

authors： Cassinat B,Zassadowski F,Ferry C,Llopis L,Bruck N,Lainey E,Duong V,Cras A,Despouy G,Chourbagi O,Beinse G,Fenaux P,Rochette Egly C,Chomienne C

更新日期：2011-04-01 00:00:00

abstract：:Tissue culture transfection and in vitro biochemical studies have suggested that heterodimers of thyroid hormone receptors (TRs) and 9-cis retinoic acid receptors (RXRs) are the likely in vivo complexes that mediate the biological effects of thyroid hormone, 3,5,3'-triiodothyronine (T3). However, direct in vivo eviden...

journal_title：Molecular and cellular biology

authors： Puzianowska-Kuznicka M,Damjanovski S,Shi YB

更新日期：1997-08-01 00:00:00

abstract：:Hepatitis C virus (HCV) NS5B protein is a membrane-associated phosphoprotein that possesses an RNA-dependent RNA polymerase activity. We recently reported that NS5A protein interacts with TRAF2 and modulates tumor necrosis factor alpha (TNF-alpha)-induced NF-kappaB and Jun N-terminal protein kinase (JNK). Since NS5A a...

journal_title：Molecular and cellular biology

authors： Choi SH,Park KJ,Ahn BY,Jung G,Lai MM,Hwang SB

更新日期：2006-04-01 00:00:00

abstract：:Very little is known about the mechanisms mediating longevities of mRNAs. As a means of identifying potential cis- and trans-acting elements which stabilize an individual mRNA, naturally occurring mutations that decreased stability of the normally long-lived globin mRNA were analyzed. Our previous studies demonstrated...

journal_title：Molecular and cellular biology

authors： Weiss IM,Liebhaber SA

更新日期：1995-05-01 00:00:00

abstract：:The male-specific-lethal (MSL) proteins in Drosophila melanogaster serve to adjust gene expression levels in male flies containing a single X chromosome to equal those in females with a double dose of X-linked genes. Together with noncoding roX RNA, MSL proteins form the "dosage compensation complex" (DCC), which inte...

journal_title：Molecular and cellular biology

authors： Morales V,Regnard C,Izzo A,Vetter I,Becker PB

更新日期：2005-07-01 00:00:00

abstract：:We assayed phosphatidylinositol (PI) kinase (EC 2.7.1.67) activity in detergent extracts of nontransformed or virus-transformed cells. Nontransformed chicken embryo fibroblasts (CEF) contain PI kinase activity with an apparent specific activity of 20 pmol/min per mg of protein. This activity sedimented as a single pea...

journal_title：Molecular and cellular biology

authors： Sugano S,Hanafusa H

更新日期：1985-09-01 00:00:00

abstract：:Gene targeting is a very powerful tool for studying mammalian development and physiology and for creating models of human diseases. In many instances, however, it is desirable to study different modifications of a target gene, but this is limited by the generally low frequency of homologous recombination in mammalian ...

journal_title：Molecular and cellular biology

authors： Cohen-Tannoudji M,Robine S,Choulika A,Pinto D,El Marjou F,Babinet C,Louvard D,Jaisser F

更新日期：1998-03-01 00:00:00

abstract：:Neutrophils are first responders rapidly mobilized to inflammatory sites by a tightly regulated, nonredundant hierarchy of chemoattractants. These chemoattractants engage neutrophil cell surface receptors triggering heterotrimeric G-protein Gα(i) subunits to exchange GDP for GTP. By limiting the duration that Gα(i) su...

journal_title：Molecular and cellular biology

authors： Cho H,Kamenyeva O,Yung S,Gao JL,Hwang IY,Park C,Murphy PM,Neubig RR,Kehrl JH

更新日期：2012-11-01 00:00:00

abstract：:Maintaining optimal bone integrity, mass, and strength throughout adult life requires ongoing bone remodeling, which involves coordinated activity between actions of bone-resorbing osteoclasts and bone forming-osteoblasts. Osteoporosis is a disorder of remodeling in which bone resorption outstrips deposition, leading ...

journal_title：Molecular and cellular biology

authors： Mukherjee A,Rotwein P

更新日期：2012-01-01 00:00:00

abstract：:We have examined the in vivo sites of action for topoisomerases II in the 87A7 heat shock locus as a function of gene activity. When the hsp70 genes are induced, there is a dramatic redistribution of topoisomerase II in the locus which parallels many of the observed alterations in chromatin structure. In addition to c...

journal_title：Molecular and cellular biology

authors： Udvardy A,Schedl P

更新日期：1993-12-01 00:00:00

abstract：:We have analyzed the effects of transformation by Rous sarcoma virus on expression of types I and II collagen and fibronectin genes in vertebral chondrocytes and compared them with expression of these genes in skin fibroblasts. Transformed chondrocytes display a dramatically decreased amount of type II collagen RNA, w...

journal_title：Molecular and cellular biology

authors： Allebach ES,Boettiger D,Pacifici M,Adams SL

更新日期：1985-05-01 00:00:00

abstract：:The doublesex and mab-3 related transcription factor 1 (Dmrt1) is a putative transcriptional regulator that is expressed exclusively in the gonads and is required for postnatal testis differentiation. Here we describe the transcriptional mechanisms regulating testis-specific expression of the Dmrt1 gene. Transient-tra...

journal_title：Molecular and cellular biology

authors： Lei N,Heckert LL

更新日期：2004-01-01 00:00:00

abstract：:A prominent hallmark of most human cancer is aneuploidy, which is a result of the chromosomal instability of cancer cells and is thought to contribute to the initiation and progression of most carcinomas. The developmentally regulated GATA6 transcription factor is commonly lost in ovarian cancer, and the loss of its e...

journal_title：Molecular and cellular biology

authors： Capo-chichi CD,Cai KQ,Testa JR,Godwin AK,Xu XX

更新日期：2009-09-01 00:00:00

abstract：:Circadian clock genes are regulated through a transcriptional-translational feedback loop. Alterations of the chromatin structure by histone acetyltransferases and histone deacetylases (HDACs) are commonly implicated in the regulation of gene transcription. However, little is known about the transcriptional regulation...

journal_title：Molecular and cellular biology

authors： Naruse Y,Oh-hashi K,Iijima N,Naruse M,Yoshioka H,Tanaka M

更新日期：2004-07-01 00:00:00

abstract：:Ligand activation of Notch receptors leads to release of the intracellular receptor domain (Notch IC), which translocates to the nucleus and interacts with the DNA-binding protein RBP-Jkappa to control expression of specific target genes. A number of proteins have been shown to interact with Notch ICs and to modulate ...

journal_title：Molecular and cellular biology

authors： Wallberg AE,Pedersen K,Lendahl U,Roeder RG

更新日期：2002-11-01 00:00:00

abstract：:Biallelic expression of Igf2 is frequently seen in cancers because Igf2 functions as a survival factor. In many tumors the activation of Igf2 expression has been correlated with de novo methylation of the imprinted region. We have compared the intrinsic susceptibilities of the imprinted region of Igf2 and H19, other i...

journal_title：Molecular and cellular biology

authors： Biniszkiewicz D,Gribnau J,Ramsahoye B,Gaudet F,Eggan K,Humpherys D,Mastrangelo MA,Jun Z,Walter J,Jaenisch R

更新日期：2002-04-01 00:00:00

abstract：:Transcription factor-induced reprogramming of somatic cells to pluripotency is mediated via profound alterations in the epigenetic landscape. The histone variant macroH2A1 (mH2A1) is a barrier to the cellular reprogramming process. We demonstrate here that mH2A1 blocks reprogramming and contributes to the preservation...

journal_title：Molecular and cellular biology

authors： Pliatska M,Kapasa M,Kokkalis A,Polyzos A,Thanos D

更新日期：2018-04-30 00:00:00

abstract：:Unlike other eukaryotes, the protein-coding genes of Trypanosoma cruzi are arranged in large polycistronic gene clusters transcribed by polymerase II (Pol II). Thus, it is thought that trypanosomes rely solely on posttranscriptional processes to regulate gene expression. Here, we show that the glucosylated thymine DNA...

journal_title：Molecular and cellular biology

authors： Ekanayake DK,Minning T,Weatherly B,Gunasekera K,Nilsson D,Tarleton R,Ochsenreiter T,Sabatini R

更新日期：2011-04-01 00:00:00

abstract：:The roles of PDZ domain-containing proteins such as Dlg and Scrib have been well described for Drosophila; however, their requirement for mammalian development is poorly understood. Here we show that Dlg, Scrib, MAGI1, MAGI3, and MPDZ are expressed in the mouse ocular lens. We demonstrate that the increase in prolifer...

journal_title：Molecular and cellular biology

authors： Nguyen MM,Nguyen ML,Caruana G,Bernstein A,Lambert PF,Griep AE

更新日期：2003-12-01 00:00:00

abstract：:Although it is generally believed that the 60- and 81-base-pair (60/81-bp) repeats of the Xenopus laevis ribosomal DNA (rDNA) spacer are position-independent transcriptional enhancers, this has not been shown directly. We have now developed a critical assay which proves that the 60/81-bp repeats do, in fact, stimulate...

journal_title：Molecular and cellular biology

authors： Pape LK,Windle JJ,Mougey EB,Sollner-Webb B

更新日期：1989-11-01 00:00:00

abstract：:The serum response factor (SRF) and myocyte enhancer factor 2A (MEF2A) represent two human members of the MADS-box transcription factor family. Each protein has a distinct biological function which is reflected by the distinct specificities of the proteins for coregulatory protein partners and DNA-binding sites. In th...

journal_title：Molecular and cellular biology

authors： West AG,Shore P,Sharrocks AD

更新日期：1997-05-01 00:00:00

abstract：:The intracellular accumulation of the unspliced RNA of Rous sarcoma virus was decreased when translation was prematurely terminated by the introduction of nonsense codons within its 5' proximal gene, the gag gene. Subcellular fractionation of transfected cells suggested that nonsense codon-mediated instability occurre...

journal_title：Molecular and cellular biology

authors： Barker GF,Beemon K

更新日期：1994-03-01 00:00:00

abstract：:A 249-nucleotide coding region instability determinant (CRD) destabilizes c-myc mRNA. Previous experiments identified a CRD-binding protein (CRD-BP) that appears to protect the CRD from endonuclease cleavage. However, it was unclear why a CRD-BP is required to protect a well-translated mRNA whose coding region is cove...

journal_title：Molecular and cellular biology

authors： Lemm I,Ross J

更新日期：2002-06-01 00:00:00

abstract：:The TIS11 primary response gene is rapidly and transiently induced by both 12-O-tetradecanoylphorbol-13-acetate and growth factors. The predicted TIS11 protein contains a 6-amino-acid repeat, YKTELC. We cloned two additional cDNAs, TIS11b and TIS11d, that contain the YKTELC sequence. TIS11, TIS11b, and TIS11d proteins...

journal_title：Molecular and cellular biology

authors： Varnum BC,Ma QF,Chi TH,Fletcher B,Herschman HR

更新日期：1991-03-01 00:00:00

abstract：:A Dictyostelium discoideum cDNA encoding an alpha-type subunit of casein kinase II was isolated, and its cDNA was used to study developmental expression of casein kinase II during the Dictyostelium life cycle. The 1.3-kb cDNA insert contained an open reading frame of 337 amino acids (M(r) 39,900). The deduced amino ac...

journal_title：Molecular and cellular biology

authors： Kikkawa U,Mann SK,Firtel RA,Hunter T

更新日期：1992-12-01 00:00:00

abstract：:Our current knowledge of recombination hot spot activity in mammalian systems implicates a role for both the primary DNA sequence and the nature of the chromatin domain around it. In mice, the only recombination hot spots mapped to date have been confined to a cluster within the major histocompatibility complex (MHC) ...

journal_title：Molecular and cellular biology

authors： Nishant KT,Ravishankar H,Rao MR

更新日期：2004-06-01 00:00:00

abstract：:A transcriptional enhancer has been mapped to a region 5.5 kilobases 3' of the C beta 2 gene in the human T-cell receptor (TCR) beta-chain locus. Transient transfections allowed localization of enhancer activity to a 480-base-pair HincII-XbaI restriction enzyme fragment. The TCR beta enhancer was active on both the mi...

journal_title：Molecular and cellular biology

authors： Gottschalk LR,Leiden JM

更新日期：1990-10-01 00:00:00

abstract：:The telomeric single-strand DNA binding protein protection of telomeres 1 (POT1) protects telomeres from rapid degradation in Schizosaccharomyces pombe and has been implicated in positive and negative telomere length regulation in humans. Human POT1 appears to interact with telomeres both through direct binding to the...

journal_title：Molecular and cellular biology

authors： Kelleher C,Kurth I,Lingner J

更新日期：2005-01-01 00:00:00

abstract：:We analyzed the impact of a GAGA element on a transgenic promoter in Drosophila melanogaster that was activated by proteins composed of the Tet(on) DNA binding domain and either the heat shock factor (HSF) activation domain or a potent subdomain of VP16. Permanganate footprinting was used to monitor polymerase II (Pol...

journal_title：Molecular and cellular biology

authors： Wang YV,Tang H,Gilmour DS

更新日期：2005-05-01 00:00:00

abstract：:Phosphatidylinositol (PI) 3-kinase plays an important role in various metabolic actions of insulin including glucose uptake and glycogen synthesis. Although PI 3-kinase primarily functions as a lipid kinase which preferentially phosphorylates the D-3 position of phospholipids, the effect of hydrolysis of the key PI 3-...

journal_title：Molecular and cellular biology

authors： Wada T,Sasaoka T,Funaki M,Hori H,Murakami S,Ishiki M,Haruta T,Asano T,Ogawa W,Ishihara H,Kobayashi M

更新日期：2001-03-01 00:00:00