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Evaluation of anxiolysis and pain associated with combined peri- and retrobulbar eye block for cataract surgery.

Abstract：

STUDY OBJECTIVES:To evaluate five different preoperative anxiolytic regimens in cataract surgery performed under regional anesthesia; to quantify the pain associated with combined peri- and retrobulbar injection (PRBI) of local anesthetic drugs; and to describe a technique of painless eye block. DESIGN:Randomized, double blind, placebo-controlled study. SETTING:Private clinic. PATIENTS:376 ASA I and II patients presenting for cataract surgery. INTERVENTIONS:Patients were extensively briefed by the nursing staff on the various procedures. Of the 376 study patients, 136 preferred to have no anxiolytic drug. The remaining 240 patients were randomly allocated to one of six groups to receive either 3 mg of bromazepam, 6 mg of bromazepam, 0.5 mg of alprazolam, 1 mg of alprazolam, 5 mg of diazepam, or a placebo on a double-blind protocol. All patients received a standard combined peri- and retrobulbar eye block (PRBB) before surgery. MEASUREMENTS AND MAIN RESULTS:Anxiety at various stages of the procedure and PRBB were measured on visual analog scale (0-10). PRBB pain was compared with pain of intravenous (i.v.) cannula placement. On admission, anxiety of the 136 patients who preferred no anxiolytic premedication was significantly less than that of the 240 patients assigned to one of the six treatment groups (p < 0.05). There was no difference between the six treatment groups in reported anxiety before surgery (p > 0.05) except for Group 1 (3 mg bromazepam), where anxiety increased before and during PRBB administration (p < 0.05). In all six treatment groups, anxiety decreased significantly 30 minutes after medication was administered (p < 0.05). For the total group, 61.18% of patients reported more or equal pain associated with the placement of the 20-gauge i.v. cannula than by the PRBB. Of the patients who received medication, 94% stated that, should they require another eye operation, they would like the same anxiolytic treatment. No patient requested general anesthesia for their next operation or to be rendered unconscious for PRBB. CONCLUSIONS:1. There was interpersonal variation in the level of preoperative anxiety. 2. In patients who were anxious, the anxiolytic drugs and placebo decreasedanxiety although the level of anxiety did not differ between the anxiolytic drugs or between placebo and the anxiolytic drugs. The only difference was in Group 1 patients (3 mg promazepam), who reported slightly increased anxiety before and during PRBB administration (p < 0.05). 3. Placement of the PRBB is less painful than the insertion of a 20 g i.v. cannula.

journal_name

J Clin Anesth

journal_title

Journal of clinical anesthesia

authors

Boezaart AP,Berry RA,Laubscher JJ,Nell ML

doi

10.1016/s0952-8180(98)00008-7

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

204-10

issue

eissn

0952-8180

issn

1873-4529

pii

S0952818098000087

journal_volume

pub_type

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Evaluation of anxiolysis and pain associated with combined peri- and retrobulbar eye block for cataract surgery.