Abstract：
STUDY OBJECTIVE AND DESIGN:The mechanism of action of commonly used general anesthetics is largely unknown. One hypothesized mechanism is through modulation of microtubule stability. Taxanes, a subset of chemotherapeutic drugs known to alter microtubule stability and commonly used to treat breast cancer, offer a natural experiment to test our hypothesis that patients exposed to taxanes prior to surgery, as compared to after surgery, would have a partial resistance to general anesthetics. SETTING, PATIENTS, AND MEASUREMENTS:The anesthetic record of adult women with nonmetastatic breast cancer was used to obtain changes in heart rate and blood pressure surrounding incision, and the amount of inhaled anesthetic agent, induction, and rescue drugs administered. MAIN RESULTS:Change in blood pressure in response to incision was significantly higher in the neoadjuvant group (P = .03), whereas change in heart rate was not (P = .53). A greater amount of morphine was administered in the neoadjuvant group (26.3 vs 15.5 mg, P = .02), although not a higher concentration of inhaled anesthetics (P = .15). CONCLUSION:These results suggest that the alteration of microtubule stability is one of a number of mechanisms of inhaled anesthetics.
journal_name
J Clin Anesthjournal_title
Journal of clinical anesthesiaauthors
Linganna RE,Levy WJ,Dmochowski IJ,Eckenhoff RG,Speck RMdoi
10.1016/j.jclinane.2015.05.001subject
Has Abstractpub_date
2015-09-01 00:00:00pages
481-5issue
6eissn
0952-8180issn
1873-4529pii
S0952-8180(15)00148-8journal_volume
27pub_type
杂志文章abstract：:A case of unusual triple knotting of a central venous catheter inserted through the left basilic vein is reported. The catheter with intact triple knots could be withdrawn without an invasive maneuver. A possible cause of triple knotting was discussed in regard to the anatomic configuration of the central veins. This ...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/0952-8180(89)90045-7
更新日期：1989-01-01 00:00:00
abstract：:Lung transplantation has become an accepted option for many patients with end-stage pulmonary diseases. Anesthesia and surgery following lung transplantation may be required for various diseases that may affect both systemic organs and the transplanted graft. When a patient with a lung transplant undergoes surgery, th...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章,评审
doi：10.1016/j.jclinane.2011.05.002
更新日期：2011-09-01 00:00:00
abstract：:Propofol, a phenol compound with a short elimination half-life, was compared with thiopental and isoflurane for induction and maintenance of general anesthesia in 60 consenting ASA I, II, and III patients. The study was randomized and open label in design. Hemodynamically, the propofol patients showed a mean +/- SEM d...
journal_title：Journal of clinical anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0952-8180(89)90026-3
更新日期：1989-01-01 00:00:00
abstract：STUDY OBJECTIVE:To evaluate the accuracy and precision of estimation of partial pressure of carbon dioxide (Pa(CO2)) using end-tidal or transcutaneous CO2 (TcP(CO2)) measurements during mechanical ventilation in the elderly patient. DESIGN:A prospective, observational study was conducted. SETTINGS:The study was done ...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/j.jclinane.2006.02.007
更新日期：2006-09-01 00:00:00
abstract：:The most frequent and acute complications of subclavian vein catheterization are arterial puncture to the subclavian artery and pneumothorax. We report an arterial puncture directly to the pulmonary artery in infant during subclavian vein catheterization. ...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/j.jclinane.2007.10.012
更新日期：2008-05-01 00:00:00
abstract：:Since the first robotic prostatectomy in 2000, the number of prostatectomies performed using robot-assisted laparoscopy has been increasing. As of 2009, 90,000 robotic radical prostatectomies were performed worldwide, and 80% of all radical prostatectomies performed in the United States were performed robotically. Rob...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章,评审
doi：10.1016/j.jclinane.2012.03.003
更新日期：2012-09-01 00:00:00
abstract：STUDY OBJECTIVE:To define the optimal dose of lidocaine to be added to propofol to reduce the incidence of pain during its injection. DESIGN:Double-blind, randomized, placebo-controlled study. SETTING:Medical center operating rooms. PATIENTS:135 ASA I and II female patients undergoing minor outpatient surgery. INTE...
journal_title：Journal of clinical anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0952-8180(96)00133-x
更新日期：1996-11-01 00:00:00
abstract：STUDY OBJECTIVE:To compare the intraoperative effects and recovery characteristics when either midazolam or propofol was used for sedation during local or regional anesthesia. DESIGN:Open-label, randomized study with blinded observer assessing recovery data. SETTING:Outpatients undergoing elective surgical procedures...
journal_title：Journal of clinical anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0952-8180(91)90203-y
更新日期：1991-01-01 00:00:00
abstract：STUDY OBJECTIVE:To determine if intrathecal opioid decreases time to extubation after coronary artery bypass surgery without compromising postoperative analgesia. DESIGN:Prospective randomized trial. SETTING:Veterans Affairs Hospital. PATIENTS:21 ASA physical status III and IV men scheduled for elective coronary byp...
journal_title：Journal of clinical anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0952-8180(97)00081-0
更新日期：1997-08-01 00:00:00
abstract：STUDY OBJECTIVE:To evaluate the reliability of assessments of nasal flow rate for improved nostril selection for nasotracheal intubation. DESIGN:Prospective, randomized, double-blinded study. SETTING:Operating room of a university-affiliated hospital. PATIENTS:118 ASA physical status 1 and 2 patients, aged 18-65 yea...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jclinane.2011.08.006
更新日期：2012-06-01 00:00:00
abstract：STUDY OBJECTIVE:Obesity has detrimental effects on general health and respiratory function. This study aimed to evaluate respiratory muscle strength in the morbidly obese population, before and after bariatric surgery, and to compare these estimates with the predictive values using different mathematical equations avai...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/j.jclinane.2016.03.005
更新日期：2016-08-01 00:00:00
abstract：STUDY OBJECTIVE:To study the development and implementation of a hospital-wide protocol regarding preoperative beta-blocker therapy. DESIGN:Prospective, observational clinical study. SETTING:Preoperative test center at a university hospital. PATIENTS:1,000 consecutive patients presenting for a preoperative visit and...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/j.jclinane.2008.06.007
更新日期：2008-12-01 00:00:00
abstract：STUDY OBJECTIVE:We evaluated a department's long-term (6.5-year) success of achieving an overall and individual incidence of anesthesiologists working late of approximately 20% of days when not on call to work late, if necessary, and providing care in operating rooms. DESIGN:Historical cohort study, January 2014 throu...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/j.jclinane.2020.110151
更新日期：2020-12-02 00:00:00
abstract：STUDY OBJECTIVES:To evaluate changes in cerebral tissue oxygen index (TOI) values under the beach chair position before and during general anesthesia in surgical patients with or without cardiovascular risk factors. DESIGN:Prospective study. SETTING:Operating room in the university hospital. PATIENTS:Ninety-one pati...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/j.jclinane.2015.06.007
更新日期：2015-09-01 00:00:00
abstract：STUDY OBJECTIVE:To compare esophageal, tympanic membrane, and forehead skin temperatures in patients undergoing elective surgeries. DESIGN:Prospective clinical study. SETTING:Operating room and postanesthesia care unit of a tertiary care teaching hospital. PATIENTS:40 adult ASA status I, II and III patients requirin...
journal_title：Journal of clinical anesthesia
pub_type： 临床试验,杂志文章
doi：10.1016/0952-8180(96)00103-1
更新日期：1996-09-01 00:00:00
abstract：:We anesthesized a patient susceptible to malignant hyperthermia (MH) three different times by epidural anesthesia with different types of local anesthetics. His skinned fiber test showed a marked acceleration of calcium (Ca2+)-induced Ca2+ release (CICR). When ester type local anesthetic was used for ankle contracture...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/0952-8180(95)00204-9
更新日期：1996-03-01 00:00:00
abstract：:Neuromuscular blocking agents are used in many surgical procedures and have enabled new surgical advances. The expanded landscape of neuromuscular blockade (NMB) reversal drugs allows for fast and complete NMB reversal and the reduction of postoperative complications from residual block. In the United States, neostigm...
journal_title：Journal of clinical anesthesia
pub_type： 信件
doi：10.1016/j.jclinane.2017.07.004
更新日期：2017-11-01 00:00:00
abstract：STUDY OBJECTIVES:To assess whether the year of residency in anesthesiology is associated with residents' overall perceptions of the learning environment and to evaluate the association between year of residency and each of the five domains of the Dundee Ready Education Environment Measure (DREEM) survey. DESIGN:Cross-...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/j.jclinane.2016.09.017
更新日期：2016-12-01 00:00:00
abstract：:Over a 12-month period, 1,743 patients were retrospectively evaluated for anaphylactic/anaphylactoid reactions during cardiac surgery. Reactions to protamine, vancomycin, blood, and metocurine were observed in eight patients (0.46%). Baseline to reaction mean arterial pressures decreased from 81 +/- 9 mmHg to 50 +/- 7...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/0952-8180(89)90005-6
更新日期：1989-01-01 00:00:00
abstract：:We report an interaction of a transesophageal atrial pacemaker (TAP) with a permanently implanted pacemaker in a cardiac patient who had undergone ablative therapy for atrial tachyarrhythmia 5 years earlier. The patient's permanent A-V pacemaker was completely inhibited by the TAP, and there was loss of ventricular co...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/s0952-8180(99)00107-5
更新日期：1999-12-01 00:00:00
abstract：STUDY OBJECTIVE:To determine the effect-site target concentration (C(et)) of remifentanil that provides optimal conditions for patients and operators during cataract surgery during monitored anesthesia care using a target controlled infusion (TCI) of propofol and remifentanil. DESIGN:Prospective, randomized, double-bl...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jclinane.2010.02.007
更新日期：2010-11-01 00:00:00
abstract：:Hereditary angioedema with normal C1-esterase inhibitor (HAE-nC1INH) perioperative is a rare condition which could have potential disastrous ramifications for the anesthesiologist in the perioperative period. However, there is limited evidence and/or guidelines on the optimal way to manage these patients. We present t...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/j.jclinane.2016.08.042
更新日期：2016-12-01 00:00:00
abstract：STUDY OBJECTIVES:To evaluate the efficacy and safety of granisetron-droperidol combination for the prevention of postoperative nausea and vomiting (PONV) after middle ear surgery. DESIGN:Prospective, randomized, double-blind study. SETTING:University hospital. PATIENTS:150 ASA physical status I patients (108 females...
journal_title：Journal of clinical anesthesia
pub_type： 临床试验,杂志文章,随机对照试验,收录出版
doi：10.1016/s0952-8180(99)00011-2
更新日期：1999-03-01 00:00:00
abstract：:This case describes a postoperative complication after single-lung ventilation in a 10-year-old patient scheduled for scoliosis repair. This patient underwent an anterior thoracoscopic excision of several vertebral discs followed by a posterior double-rod fixation of her spine. The postoperative course was complicated...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/s0952-8180(02)00482-8
更新日期：2003-03-01 00:00:00
abstract：:Oxymetazoline nasal spray is a potent alpha 1-adrenergic agonist commonly used to vasoconstrict blood vessels in the nasal mucosa. In this incident, oxymetazoline nasal spray 0.025% was administered to a 2-year-old patient during general anesthesia for nasal endoscopy. Severe hypertension with reflex bradycardia progr...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/0952-8180(95)00060-u
更新日期：1995-09-01 00:00:00
abstract：:A 37-year-old patient undergoing operative hysteroscopy developed noncardiogenic pulmonary edema after fluid absorption of 6 L of Ringer's lactate distension solution. No electrolyte or neurologic sequelae were associated with this fluid absorption. A subsequent 35-year-old patient having similar surgery in which a de...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/j.jclinane.2003.03.010
更新日期：2004-02-01 00:00:00
abstract：STUDY OBJECTIVES:To identify airway management and tracheal intubation techniques for glossopexy in infants with preexisting airway obstruction under general anesthesia. DESIGN:Retrospective, observational study. SETTINGS:Operating room of a university hospital between January 2003 and March 2015. All operations were...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/j.jclinane.2016.10.019
更新日期：2017-02-01 00:00:00
abstract：:We describe the anesthetic management of a morbidly obese patient with obstructive sleep apnea who underwent awake craniotomy. The patient's personal continuous positive airway pressure (CPAP) machine was used to support ventilation intraoperatively. Dexmedetomidine was used as the primary sedative. During cortical ma...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/j.jclinane.2007.10.015
更新日期：2008-06-01 00:00:00
abstract：BACKGROUND:Childhood and adolescent obesity increased in recent decades, and caregivers face an increasing number of obese pediatric surgical patients. Some clinical and pharmacogenetic data suggest that obese patients have altered pain sensitivity and analgesic requirements. OBJECTIVE:To test the primary hypothesis t...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/j.jclinane.2020.109729
更新日期：2020-06-01 00:00:00
abstract：OBJECTIVE:When dexmedetomidine is used in patients undergoing spinal anesthesia, high incidence of bradycardia in response to parasympathetic activation is reported. Therefore, we aimed to evaluate the effectiveness of atropine premedication for preventing the incidence of bradycardia and the hemodynamic effect on pati...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jclinane.2016.07.012
更新日期：2016-12-01 00:00:00
