Shc and Enigma are both required for mitogenic signaling by Ret/ptc2.

abstract：:Tax corresponds to a 40-kDa transforming protein from the pathogenic retrovirus human T-cell leukemia virus type 1 (HTLV-1) that activates nuclear expression of the NF-kappaB/Rel family of transcription factors by an unknown mechanism. Tax expression promotes N-terminal phosphorylation and degradation of IkappaB alpha...

journal_title：Molecular and cellular biology

authors： Geleziunas R,Ferrell S,Lin X,Mu Y,Cunningham ET Jr,Grant M,Connelly MA,Hambor JE,Marcu KB,Greene WC

更新日期：1998-09-01 00:00:00

abstract：:RAG1 and RAG2 catalyze the first DNA cleavage steps in V(D)J recombination. We demonstrate that the isolated central domain of RAG1 has inherent single-stranded (ss) DNA cleavage activity, which does not require, but is enhanced by, RAG2. The central domain, therefore, contains the active-site residues necessary to pe...

journal_title：Molecular and cellular biology

authors： De P,Peak MM,Rodgers KK

更新日期：2004-08-01 00:00:00

abstract：:Within mineralized bone, osteocytes form dendritic processes that travel through canaliculi to make contact with other osteocytes and cells on the bone surface. This three-dimensional syncytium is thought to be necessary to maintain viability, cell-to-cell communication, and mechanosensation. E11/gp38 is the earliest ...

journal_title：Molecular and cellular biology

authors： Zhang K,Barragan-Adjemian C,Ye L,Kotha S,Dallas M,Lu Y,Zhao S,Harris M,Harris SE,Feng JQ,Bonewald LF

更新日期：2006-06-01 00:00:00

abstract：:With v-yes DNA as the probe, a human cDNA library made from placental RNA was screened under relaxed conditions, and DNA clones derived from a novel genetic locus, termed lyn, were obtained. Nucleotide sequencing revealed that lyn could encode a novel tyrosine kinase that was very similar to mouse T-lymphocyte-specifi...

journal_title：Molecular and cellular biology

authors： Yamanashi Y,Fukushige S,Semba K,Sukegawa J,Miyajima N,Matsubara K,Yamamoto T,Toyoshima K

更新日期：1987-01-01 00:00:00

abstract：:We have recently reported that the yeast chromatin-remodeling factor Swi1 can exist as a prion, [SWI(+)], demonstrating a link between prionogenesis and global transcriptional regulation. To shed light on how the Swi1 conformational switch influences Swi1 function and to define the sequence and structural requirements...

journal_title：Molecular and cellular biology

authors： Du Z,Crow ET,Kang HS,Li L

更新日期：2010-10-01 00:00:00

abstract：:The c-Myc oncoprotein (Myc) controls cell fate by regulating gene transcription in association with a DNA-binding partner, Max. While Max lacks a transcription regulatory domain, the N terminus of Myc contains a transcription activation domain (TAD) that recruits cofactor complexes containing the histone acetyltransfe...

journal_title：Molecular and cellular biology

authors： Faiola F,Liu X,Lo S,Pan S,Zhang K,Lymar E,Farina A,Martinez E

更新日期：2005-12-01 00:00:00

abstract：:Transcription factor-induced reprogramming of somatic cells to pluripotency is mediated via profound alterations in the epigenetic landscape. The histone variant macroH2A1 (mH2A1) is a barrier to the cellular reprogramming process. We demonstrate here that mH2A1 blocks reprogramming and contributes to the preservation...

journal_title：Molecular and cellular biology

authors： Pliatska M,Kapasa M,Kokkalis A,Polyzos A,Thanos D

更新日期：2018-04-30 00:00:00

abstract：:The simian virus 40 core origin of replication consists of nucleotides 5211 through 31. These 64 base pairs contain three functional domains with strict sequence requirements and two spacer regions with relaxed sequence specificity but precise positional constraints. The early domain extends for 10 contiguous base pai...

journal_title：Molecular and cellular biology

authors： Deb S,DeLucia AL,Baur CP,Koff A,Tegtmeyer P

更新日期：1986-05-01 00:00:00

abstract：:Gene targeting is a very powerful tool for studying mammalian development and physiology and for creating models of human diseases. In many instances, however, it is desirable to study different modifications of a target gene, but this is limited by the generally low frequency of homologous recombination in mammalian ...

journal_title：Molecular and cellular biology

authors： Cohen-Tannoudji M,Robine S,Choulika A,Pinto D,El Marjou F,Babinet C,Louvard D,Jaisser F

更新日期：1998-03-01 00:00:00

abstract：:Activation of transforming potential of the cellular raf gene has uniformly been associated with the deletion of amino-terminal coding sequences. In order to determine whether 5' truncation alone could activate cellular raf, we constructed 21 human c-raf-1 cDNAs with variable BAL 31-generated deletions distal to a Mol...

journal_title：Molecular and cellular biology

authors： Stanton VP Jr,Nichols DW,Laudano AP,Cooper GM

更新日期：1989-02-01 00:00:00

abstract：:The activity of p21ras is required for the proliferative response to colony-stimulating factor 1 (CSF-1), and signals transduced by both the CSF-1 receptor (CSF-1R) and p21ras stimulate transcription from promoter elements containing overlapping binding sites for Fos/Jun- and Ets-related proteins. A sequence encoding ...

journal_title：Molecular and cellular biology

authors： Langer SJ,Bortner DM,Roussel MF,Sherr CJ,Ostrowski MC

更新日期：1992-12-01 00:00:00

abstract：:The endoplasmic reticulum (ER) is the major cellular compartment where folding and maturation of secretory and membrane proteins take place. When protein folding needs exceed the capacity of the ER, the unfolded protein response (UPR) pathway modulates gene expression and downregulates protein translation to restore h...

journal_title：Molecular and cellular biology

authors： DuRose JB,Scheuner D,Kaufman RJ,Rothblum LI,Niwa M

更新日期：2009-08-01 00:00:00

abstract：:In the sea urchin embryo, late histone genes are transcribed at low levels during cleavage and blastula formation and at substantially higher levels in later stages of embryogenesis. To investigate the molecular basis of the stage-specific expression of a late H2B histone gene, we injected mutant genes lacking portion...

journal_title：Molecular and cellular biology

authors： Zhao AZ,Colin AM,Bell J,Baker M,Char BR,Maxson R

更新日期：1990-12-01 00:00:00

abstract：:Microtubule-associated serine/threonine kinase like (MASTL), also known as Greatwall (Gwl) kinase, has an important role in the regulation of mitosis. By inhibiting protein phosphatase 2A (PP2A), it plays a crucial role in activating one of the most important mitotic kinases, known as cyclin-dependent kinase 1 (CDK1)....

journal_title：Molecular and cellular biology

authors： Reshi I,Nisa MU,Farooq U,Gillani SQ,Bhat SA,Sarwar Z,Nabi N,Fazili KM,Andrabi S

更新日期：2020-04-28 00:00:00

abstract：:We have studied leucine transport in several Chinese hamster-human hybrid cell lines obtained by fusion of a temperature-sensitive line of Chinese hamster ovary cells, ts025C1, and normal human leukocytes. A hybrid cell line exhibiting a twofold increase in L-leucine uptake over that in the parental cell line was foun...

journal_title：Molecular and cellular biology

authors： Lobaton CD,Moreno A,Oxender DL

更新日期：1984-03-01 00:00:00

abstract：:Unlike the DNA of higher eucaryotes, the DNA of Saccharomyces cerevisiae (bakers' yeast) is not methylated. Introduction of the Escherichia coli dam gene into yeast cells results in methylation of the N-6 position of adenine. The UV excision repair system of yeast cells specifically responds to the methylation, sugges...

journal_title：Molecular and cellular biology

authors： Hoekstra MF,Malone RE

更新日期：1986-10-01 00:00:00

abstract：:Transcription of the c-rel proto-oncogene was induced transiently when resting mouse NIH 3T3 fibroblasts were stimulated with serum or phorbol-12-myristate-13-acetate. Addition of cycloheximide increased the steady-state levels of c-rel mRNA. These results indicate that c-rel is another member of the early-response ge...

journal_title：Molecular and cellular biology

authors： Bull P,Hunter T,Verma IM

更新日期：1989-11-01 00:00:00

abstract：:Cells respond to environmental stimuli by fine-tuned regulation of gene expression. Here we investigated the dose-dependent modulation of gene expression at high temporal resolution in response to nutrient and stress signals in yeast. The GAL1 activity in cell populations is modulated in a well-defined range of galact...

journal_title：Molecular and cellular biology

authors： Rienzo A,Poveda-Huertes D,Aydin S,Buchler NE,Pascual-Ahuir A,Proft M

更新日期：2015-11-01 00:00:00

abstract：:In a gene trap screen for genes expressed in the primitive streak and tail bud during mouse embryogenesis, we isolated a mutation in Jade1, a gene encoding a PHD zinc finger protein previously shown to interact with the tumor suppressor pVHL. Expressed sequence tag analysis indicates that Jade1 is subject to posttrans...

journal_title：Molecular and cellular biology

authors： Tzouanacou E,Tweedie S,Wilson V

更新日期：2003-12-01 00:00:00

abstract：:Fos and Jun transcription factors are induced during the normal course of the proliferative response of quiescent cells to serum or to growth factors. We have shown that delta FosB, an alternatively spliced form of FosB, is formed as rapidly as FosB in serum-stimulated Rat-1A cells. Although delta FosB lacks the C-ter...

journal_title：Molecular and cellular biology

authors： Nakabeppu Y,Oda S,Sekiguchi M

更新日期：1993-07-01 00:00:00

abstract：:Spatial control of cytokinesis is essential for proper cell division. The molecular mechanisms that anchor the dynamic assembly and constriction of the cytokinetic ring at the plasma membrane remain unclear. In the fission yeast Schizosaccharomyces pombe, the cytokinetic ring is assembled in the cell middle from corti...

journal_title：Molecular and cellular biology

authors： Guzman-Vendrell M,Baldissard S,Almonacid M,Mayeux A,Paoletti A,Moseley JB

更新日期：2013-01-01 00:00:00

abstract：:Complete replication of the genome is an essential prerequisite for normal cell division, but a variety of factors can block the replisome, triggering replication stress and potentially causing mutation or cell death. The cellular response to replication stress involves recruitment of proteins to stabilize the replica...

journal_title：Molecular and cellular biology

authors： Her J,Ray C,Altshuler J,Zheng H,Bunting SF

更新日期：2018-03-29 00:00:00

abstract：:Budding yeast Rad53 is an essential protein kinase that is phosphorylated and activated in a MEC1- and TEL1-dependent manner in response to DNA damage. We studied the role of Rad53 phosphorylation through mutation of consensus phosphorylation sites for upstream kinases Mec1 and Tel1. Alanine substitution of the Rad53 ...

journal_title：Molecular and cellular biology

authors： Lee SJ,Schwartz MF,Duong JK,Stern DF

更新日期：2003-09-01 00:00:00

abstract：:Runx1/AML1 is a transcription factor implicated in tissue stem cell regulation and belongs to the small Runx family of cancer genes. In the hair follicle (HF), Runx1 epithelial deletion in morphogenesis impairs normal adult hair homeostasis (cycle) and blocks adult hair follicle stem cells (HFSCs) in quiescence. Here,...

journal_title：Molecular and cellular biology

authors： Hoi CS,Lee SE,Lu SY,McDermitt DJ,Osorio KM,Piskun CM,Peters RM,Paus R,Tumbar T

更新日期：2010-05-01 00:00:00

abstract：:Glucocorticoids are among the most potent and effective agents for treating inflammatory diseases and hematological cancers. However, subpopulations of patients are often resistant to steroid therapy, and determining the molecular mechanisms that contribute to glucocorticoid resistance is thus critical to addressing t...

journal_title：Molecular and cellular biology

authors： Ramamoorthy S,Cidlowski JA

更新日期：2013-05-01 00:00:00

abstract：:The multisubunit yeast transcription factor IIIC (TFIIIC) is a multifunctional protein required for promoter recognition, transcription factor IIIB recruitment, and chromatin antirepression. We report the isolation and characterization of TFC7, an essential gene encoding the 55-kDa polypeptide, tau55, present in affin...

journal_title：Molecular and cellular biology

authors： Manaud N,Arrebola R,Buffin-Meyer B,Lefebvre O,Voss H,Riva M,Conesa C,Sentenac A

更新日期：1998-06-01 00:00:00

abstract：:Previously we demonstrated that the heat shock transcription factor Hsf1 is indispensable for transformation of mammary epithelial cells by the Her2 oncogene. Since Hsf1 affects oncogene-induced senescence (OIS), these findings suggest that Hsf1 affects tumor initiation when OIS plays a role. Indeed, here we report th...

journal_title：Molecular and cellular biology

authors： Gabai VL,Meng L,Kim G,Mills TA,Benjamin IJ,Sherman MY

更新日期：2012-03-01 00:00:00

abstract：:The Polycomb group proteins are involved in maintenance of the silenced state of several developmentally regulated genes. These proteins form large aggregates with different subunit compositions. To explore the nature of these complexes and their function, we used the full-length Eed (embryonic ectoderm development) p...

journal_title：Molecular and cellular biology

authors： Denisenko O,Shnyreva M,Suzuki H,Bomsztyk K

更新日期：1998-10-01 00:00:00

abstract：:We have demonstrated that a highly conserved segment of DNA between positions -288 and -317 (upstream sequence element IV [USE IV]) is largely responsible for the transcriptional activation of the sea urchin H1-beta histone gene during the blastula stage of embryogenesis. This sequence is capable of acting as an embry...

journal_title：Molecular and cellular biology

authors： DeAngelo DJ,DeFalco J,Childs G

更新日期：1993-03-01 00:00:00

abstract：:Inactivation of the tumor suppressor p53 by degradation is a mechanism utilized by cells to adapt to endoplasmic reticulum (ER) stress. However, the mechanisms of p53 destabilization by ER stress are not known. We demonstrate here that the E3 ubiquitin-ligase Hdm2 is essential for the nucleocytoplasmic transport and p...

journal_title：Molecular and cellular biology

authors： Pluquet O,Qu LK,Baltzis D,Koromilas AE

更新日期：2005-11-01 00:00:00