Excision repair functions in Saccharomyces cerevisiae recognize and repair methylation of adenine by the Escherichia coli dam gene.

abstract：:CD8+ T-cell apoptosis is essential for the contraction phase of the immune response, yet the initiating signals and precise pathways involved are unresolved. The ST3Gal-I sialyltransferase is a candidate mechanistic component and catalyzes sialic acid addition to core 1 O-glycans during protein O glycosylation. ST3Gal...

journal_title：Molecular and cellular biology

authors： Van Dyken SJ,Green RS,Marth JD

更新日期：2007-02-01 00:00:00

abstract：:Appropriate cell cycle checkpoint control is essential for the maintenance of cell and organismal homeostasis. Members of the Nek (NIMA-related kinase) family of serine/threonine protein kinases have been implicated in the regulation of various aspects of the cell cycle. We explored the cellular functions of Nek10, a ...

journal_title：Molecular and cellular biology

authors： Moniz LS,Stambolic V

更新日期：2011-01-01 00:00:00

abstract：:The TIS11 primary response gene is rapidly and transiently induced by both 12-O-tetradecanoylphorbol-13-acetate and growth factors. The predicted TIS11 protein contains a 6-amino-acid repeat, YKTELC. We cloned two additional cDNAs, TIS11b and TIS11d, that contain the YKTELC sequence. TIS11, TIS11b, and TIS11d proteins...

journal_title：Molecular and cellular biology

authors： Varnum BC,Ma QF,Chi TH,Fletcher B,Herschman HR

更新日期：1991-03-01 00:00:00

abstract：:Ras GTPases were long thought to function exclusively from the plasma membrane (PM). However, a current model suggests that Ras proteins can compartmentalize to regulate different functions, and an oncogenic H-Ras mutant that is restricted to the endomembrane can still transform cells. In this study, we demonstrated t...

journal_title：Molecular and cellular biology

authors： Cheng CM,Li H,Gasman S,Huang J,Schiff R,Chang EC

更新日期：2011-03-01 00:00:00

abstract：:Human MED26 was originally purified in the cofactor required for the Sp1 activation complex (CRSP) as a 70-kDa component named CRSP70. This polypeptide was specific to metazoans and the “small” form of the Mediator complex. We report here that a Drosophila melanogaster homologue of MED26 similarly interacts with other...

journal_title：Molecular and cellular biology

authors： Marr SK,Lis JT,Treisman JE,Marr MT 2nd

更新日期：2014-07-01 00:00:00

abstract：:Alternative mRNA splicing is an important means of diversifying function in higher eukaryotes. Notably, both NCoR and SMRT corepressors are subject to alternative mRNA splicing, yielding a series of distinct corepressor variants with highly divergent functions. Normal adipogenesis is associated with a switch in corepr...

journal_title：Molecular and cellular biology

authors： Goodson ML,Young BM,Snyder CA,Schroeder AC,Privalsky ML

更新日期：2014-11-15 00:00:00

abstract：:SRC family kinases play essential roles in a variety of cellular functions, including proliferation, survival, differentiation, and apoptosis. The activities of these kinases are regulated by intramolecular interactions and by heterologous binding partners that modulate the transition between active and inactive struc...

journal_title：Molecular and cellular biology

authors： Burnham MR,Bruce-Staskal PJ,Harte MT,Weidow CL,Ma A,Weed SA,Bouton AH

更新日期：2000-08-01 00:00:00

abstract：:CD83 is one of the best-known surface markers for fully mature dendritic cells (mature DCs), and its cell-type- and maturation-specific regulation makes the CD83 promoter an interesting tool for the genetic modulation of DCs. To determine the mechanisms regulating this DC- and maturation-specific CD83 expression, chro...

journal_title：Molecular and cellular biology

authors： Stein MF,Lang S,Winkler TH,Deinzer A,Erber S,Nettelbeck DM,Naschberger E,Jochmann R,Stürzl M,Slany RK,Werner T,Steinkasserer A,Knippertz I

更新日期：2013-04-01 00:00:00

abstract：:The hsp70-interacting protein Hip participates in the assembly pathway for progesterone receptor complexes. During assembly, Hip appears at early assembly stages in a transient manner that parallels hsp70 interactions. In this study, a cDNA for human Hip was used to develop various mutant Hip forms in the initial mapp...

journal_title：Molecular and cellular biology

authors： Prapapanich V,Chen S,Toran EJ,Rimerman RA,Smith DF

更新日期：1996-11-01 00:00:00

abstract：:To interrogate genes essential for cell growth, proliferation and survival in human cells, we carried out a genome-wide clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 screen in a B-cell lymphoma line using a custom extended-knockout (EKO) library of 278,754 single-guide RNAs (sgRNAs) that targe...

journal_title：Molecular and cellular biology

authors： Bertomeu T,Coulombe-Huntington J,Chatr-Aryamontri A,Bourdages KG,Coyaud E,Raught B,Xia Y,Tyers M

更新日期：2017-12-13 00:00:00

abstract：:We report results showing that several gamma gene promoter elements participate in the developmental control of gamma-globin genes. Four gamma gene constructs with 5' truncated at -141, -201, -382, and -730 of the A gamma gene promoter linked to a micro locus control region (microLCR) cassette were used for production...

journal_title：Molecular and cellular biology

authors： Stamatoyannopoulos G,Josephson B,Zhang JW,Li Q

更新日期：1993-12-01 00:00:00

abstract：:The molecular chaperone HSP90 regulates stability and function of multiple protein kinases. The HSP90-binding drug geldanamycin interferes with this activity and promotes proteasome-dependent degradation of most HSP90 client proteins. Geldanamycin also binds to GRP94, the HSP90 paralog located in the endoplasmic retic...

journal_title：Molecular and cellular biology

authors： Marcu MG,Doyle M,Bertolotti A,Ron D,Hendershot L,Neckers L

更新日期：2002-12-01 00:00:00

abstract：:The abundance of the mRNA for human triosephosphate isomerase (TPI) is decreased to approximately 20% of normal by frameshift and nonsense mutations that cause translation to terminate at a nonsense codon within the first three-fourths of the reading frame. Results of previous studies inhibiting RNA synthesis with act...

journal_title：Molecular and cellular biology

authors： Cheng J,Maquat LE

更新日期：1993-03-01 00:00:00

abstract：:CAP, a protein from Saccharomyces cerevisiae that copurifies with adenylyl cyclase, appears to be required for yeast cells to be fully responsive to RAS proteins. CAP also appears to be required for normal cell morphology and responsiveness to nutrient deprivation and excess. We describe here a molecular and phenotypi...

journal_title：Molecular and cellular biology

authors： Gerst JE,Ferguson K,Vojtek A,Wigler M,Field J

更新日期：1991-03-01 00:00:00

abstract：:The retinoblastoma tumor suppressor protein (Rb) plays a vital role in regulating mammalian cell cycle progression and inactivation of Rb is necessary for entry into S phase. Rb is inactivated by phosphorylation upon growth factor stimulation of quiescent cells, facilitating the transition from G(1) phase to S phase. ...

journal_title：Molecular and cellular biology

authors： Dasgupta P,Sun J,Wang S,Fusaro G,Betts V,Padmanabhan J,Sebti SM,Chellappan SP

更新日期：2004-11-01 00:00:00

abstract：:A recent analysis of gene expression in renal cell carcinoma cells led to the identification of mRNAs whose translation was dependent on the presence of the von Hippel-Lindau (VHL) tumor suppressor gene product, pVHL. Here, we investigate the finding that pVHL-expressing RCC cells (VHL(+)) exhibited elevated levels of...

journal_title：Molecular and cellular biology

authors： Galbán S,Martindale JL,Mazan-Mamczarz K,López de Silanes I,Fan J,Wang W,Decker J,Gorospe M

更新日期：2003-10-01 00:00:00

abstract：:The first processing step in the maturation of mouse precursor rRNA involves cleavage at nucleotide ca. +650, at the 5' border of a 200-nucleotide region that is conserved across mammals and contains the sequences that direct the processing. To identify the relevant sequence elements, we used rRNAs with small internal...

journal_title：Molecular and cellular biology

authors： Craig N,Kass S,Sollner-Webb B

更新日期：1991-01-01 00:00:00

abstract：:Glucose-6-phosphate dehydrogenase (G6PD) produces cellular NADPH, which is required for the biosynthesis of fatty acids and cholesterol. Although G6PD is required for lipogenesis, it is poorly understood whether G6PD in adipocytes is involved in energy homeostasis, such as lipid and glucose metabolism. We report here ...

journal_title：Molecular and cellular biology

authors： Park J,Rho HK,Kim KH,Choe SS,Lee YS,Kim JB

更新日期：2005-06-01 00:00:00

abstract：:The cytoplasmic domain of the cloned erythropoietin (EPO) receptor (EPOR) contains no protein kinase motif, yet addition of EPO to EPO-responsive cells causes an increase in protein-tyrosine phosphorylation. Here we show that addition of EPO or interleukin-3 (IL-3) to an IL-3-dependent cell line expressing the wild-ty...

journal_title：Molecular and cellular biology

authors： Yoshimura A,Lodish HF

更新日期：1992-02-01 00:00:00

abstract：:The lactogenic hormones, i.e., prolactin and glucocorticoids, act in concert to stimulate transcription factors responsible for hormone-dependent milk protein gene expression. In the mammary gland, prolactin activates Stat5a and Stat5b and glucocorticoids activate the glucocorticoid receptor (GR). Immunoprecipitation ...

journal_title：Molecular and cellular biology

authors： Cella N,Groner B,Hynes NE

更新日期：1998-04-01 00:00:00

abstract：:Bone-specific transcription of the osteocalcin (OC) gene is regulated principally by the Runx2 transcription factor and is further stimulated in response to 1alpha,25-dihydroxyvitamin D3 via its specific receptor (VDR). The rat OC gene promoter contains three recognition sites for Runx2 (sites A, B, and C). Mutation o...

journal_title：Molecular and cellular biology

authors： Paredes R,Arriagada G,Cruzat F,Villagra A,Olate J,Zaidi K,van Wijnen A,Lian JB,Stein GS,Stein JL,Montecino M

更新日期：2004-10-01 00:00:00

abstract：:Mutations were introduced in 7 kilobases of 5'-flanking rat alpha 1-fetoprotein (AFP) genomic DNA, linked to the chloramphenicol acetyltransferase gene. AFP promoter activity and its repression by a glucocorticoid hormone were assessed by stable and transient expression assays. Stable transfection assays were more sen...

journal_title：Molecular and cellular biology

authors： Guertin M,LaRue H,Bernier D,Wrange O,Chevrette M,Gingras MC,Bélanger L

更新日期：1988-04-01 00:00:00

abstract：:All-trans retinoic acid (RA) induces transforming growth factor beta (TGF-beta)-dependent autocrine growth of mouse embryonic fibroblasts (MEFs). We have used chromatin immunoprecipitation to map 354 RA receptor (RAR) binding loci in MEFs, most of which were similarly occupied by the RAR alpha and RAR gamma receptors....

journal_title：Molecular and cellular biology

authors： Delacroix L,Moutier E,Altobelli G,Legras S,Poch O,Choukrallah MA,Bertin I,Jost B,Davidson I

更新日期：2010-01-01 00:00:00

abstract：:Two-dimensional electrophoretograms of newly synthesized polypeptides from low-metastatic (P29) and high-metastatic (D6) Lewis lung carcinoma cells were compared. The results showed that the synthesis of tropomyosin 2 (TM2) was significantly less in D6 cells than in P29 cells. Furthermore, suppression of TM2 synthesis...

journal_title：Molecular and cellular biology

authors： Takenaga K,Nakamura Y,Sakiyama S

更新日期：1988-09-01 00:00:00

abstract：:The autonomously replicating rRNA genes (rDNA) in the somatic nucleus of Tetrahymena thermophila are maintained at a copy number of approximately 10(4) per nucleus. A mutant in which the replication properties of this molecule were altered was isolated and characterized. This mutation of inbred strain C3, named rmm4, ...

journal_title：Molecular and cellular biology

authors： Yaeger PC,Orias E,Shaiu WL,Larson DD,Blackburn EH

更新日期：1989-02-01 00:00:00

abstract：:Phospholipase C-gamma2 (PLC-gamma2) plays an important role in B-cell signaling. Phosphorylation of various tyrosine residues of PLC-gamma2 has been implicated in regulation of its lipase activity. With the use of antibodies specific for each of the putative phosphorylation sites, we have now shown that PLC-gamma2 is ...

journal_title：Molecular and cellular biology

authors： Kim YJ,Sekiya F,Poulin B,Bae YS,Rhee SG

更新日期：2004-11-01 00:00:00

abstract：:Overexpression of the nuclear receptor 4A1 (NR4A1) in breast cancer patients is a prognostic factor for decreased survival and increased metastasis, and this has been linked to NR4A1-dependent regulation of transforming growth factor β (TGF-β) signaling. Results of RNA interference studies demonstrate that basal migra...

journal_title：Molecular and cellular biology

authors： Hedrick E,Lee SO,Doddapaneni R,Singh M,Safe S

更新日期：2016-04-15 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a potent angiogenic inducer that stimulates the expression of tissue factor (TF), the major cellular initiator of blood coagulation. Here we show that signaling triggered by VEGF induced DNA-binding and transcriptional activities of nuclear factor of activated T cells (NFAT...

journal_title：Molecular and cellular biology

authors： Armesilla AL,Lorenzo E,Gómez del Arco P,Martínez-Martínez S,Alfranca A,Redondo JM

更新日期：1999-03-01 00:00:00

abstract：:Numerous nonribosomal trans-acting factors involved in pre-rRNA processing have been characterized, but few of them are specifically required for the last cytoplasmic steps of 18S rRNA maturation. We have recently demonstrated that Rrp10p/Rio1p is such a factor. By BLAST analysis, we identified the product of a previo...

journal_title：Molecular and cellular biology

authors： Vanrobays E,Gelugne JP,Gleizes PE,Caizergues-Ferrer M

更新日期：2003-03-01 00:00:00

abstract：:Gonadotropin-releasing hormone (GnRH) interacts with a G protein-coupled receptor and increases the transcription of the glycoprotein hormone alpha-subunit gene. We have explored the possibility that mitogen-activated protein kinase (MAPK) plays a role in mediating GnRH effects on transcription. Activation of the MAPK...

journal_title：Molecular and cellular biology

authors： Roberson MS,Misra-Press A,Laurance ME,Stork PJ,Maurer RA

更新日期：1995-07-01 00:00:00