Isolated tumor cells are frequently detectable in the peritoneal cavity of gastric and colorectal cancer patients and serve as a new prognostic marker.

Abstract:

OBJECTIVE:To evaluate the prognostic significance of isolated tumor cells detected by a panel of various monoclonal antibodies. SUMMARY BACKGROUND DATA:Previously, we showed by using immunocytology that cancer cells are frequently found in bone marrow and peritoneal cavity samples of gastrointestinal cancer patients. METHODS:Findings in bone marrow and peritoneal cavity samples were compared and correlated with the 4-year survival rate of 84 gastric and 109 colorectal patients with cancer. RESULTS:Although positive results in the bone marrow showed little prognostic significance, the peritoneal cavity results correlated with the 4-year survival rate (gastric cancer: p = 0.0038; colorectal cancer: p = 0.0079). Additionally, in subgroups of patients with early (gastric cancer: p = 0.02, colorectal cancer: p = 0.48) and advanced (gastric cancer: p = 0.02, colorectal cancer: p < 0.0001) tumor stages, a correlation of immunocytologic findings and the survival rate was seen. CONCLUSIONS:The detection of minimal residual disease in the peritoneal cavity serves as a new prognostic marker.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Schott A,Vogel I,Krueger U,Kalthoff H,Schreiber HW,Schmiegel W,Henne-Bruns D,Kremer B,Juhl H

doi

10.1097/00000658-199803000-00009

subject

Has Abstract

pub_date

1998-03-01 00:00:00

pages

372-9

issue

3

eissn

0003-4932

issn

1528-1140

journal_volume

227

pub_type

杂志文章
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    authors: Silberman AW,McVay C,Cohen JS,Altura JF,Brackert S,Sarna GP,Palmer D,Ko A,Memsic L

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    doi:10.1097/00000658-198107000-00005

    authors: Sudo T,Kawamura M,Umemura H,Shiraha S,Kuyama T

    更新日期:1981-07-01 00:00:00

  • The Importance of Registries in the Postmarketing Surveillance of Surgical Meshes.

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    authors: Köckerling F,Simon T,Hukauf M,Hellinger A,Fortelny R,Reinpold W,Bittner R

    更新日期:2018-12-01 00:00:00

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    doi:10.1097/00000658-199210000-00003

    authors: Goss JA,Nakafusa Y,Flye MW

    更新日期:1992-10-01 00:00:00

  • Impaired nonspecific cellular immunity in experimental cholestasis.

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    doi:10.1097/00000658-198711000-00004

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  • Postoperative Morbidity After Radical Resection of Primary Retroperitoneal Sarcoma: A Report From the Transatlantic RPS Working Group.

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    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000002250

    authors: MacNeill AJ,Gronchi A,Miceli R,Bonvalot S,Swallow CJ,Hohenberger P,Van Coevorden F,Rutkowski P,Callegaro D,Hayes AJ,Honoré C,Fairweather M,Cannell A,Jakob J,Haas RL,Szacht M,Fiore M,Casali PG,Pollock RE,Barretta F,

    更新日期:2018-05-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199910000-00006

    authors: Jimenez RE,Warshaw AL,Z'graggen K,Hartwig W,Taylor DZ,Compton CC,Fernández-del Castillo C

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    pub_type: 杂志文章,多中心研究,随机对照试验

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    更新日期:1981-08-01 00:00:00

  • Molecules, cancer, and the surgeon. A review of molecular biology and its implications for surgical oncology.

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    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/00000658-199007000-00002

    authors: Arbeit JM

    更新日期:1990-07-01 00:00:00

  • When should the third renal transplant rejection episode be treated?

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    pub_type: 杂志文章

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    authors: Matas AJ,Simmons RL,Kjellstrand CM,Fryd DS,Najarian JS

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    doi:10.1097/00000658-199202000-00015

    authors: Davidoff AM,Branum GD,Murray EA,Chong WK,Ware RE,Kinney TR,Pappas TN,Meyers WC

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    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002025

    authors: McAdams-DeMarco MA,King EA,Luo X,Haugen C,DiBrito S,Shaffer A,Kucirka LM,Desai NM,Dagher NN,Lonze BE,Montgomery RA,Walston J,Segev DL

    更新日期:2017-12-01 00:00:00

  • Carotid artery disease following external cervical irradiation.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198111000-00009

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    更新日期:1981-11-01 00:00:00

  • Anterior resection for rectal cancer with mesorectal excision: a prospective evaluation of 622 patients.

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    pub_type: 杂志文章

    doi:10.1097/01.sla.0000133185.23514.32

    authors: Law WL,Chu KW

    更新日期:2004-08-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/00000658-199312000-00014

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    更新日期:1993-12-01 00:00:00

  • Prospective Phase II Trials Validate the Effect of Neoadjuvant Chemotherapy on Pattern of Recurrence in Pancreatic Adenocarcinoma.

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  • Improving the Quality of Ward-based Surgical Care With a Human Factors Intervention Bundle.

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    doi:10.1097/SLA.0000000000002089

    authors: Johnston MJ,Arora S,King D,Darzi A

    更新日期:2018-01-01 00:00:00

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    pub_type: 杂志文章,随机对照试验

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    更新日期:2005-12-01 00:00:00

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    更新日期:1990-02-01 00:00:00

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    pub_type: 临床试验,杂志文章

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    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181568cab

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  • The Safer Delivery of Surgical Services Program (S3): Explaining Its Differential Effectiveness and Exploring Implications for Improving Quality in Complex Systems.

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    pub_type: 杂志文章,多中心研究

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    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002475

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    authors: Fidler JP,Hoefer RW,Polanyi TG,Bredemeier HC,Siler VE,Altemeier WA

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