Effects of vagotomy and gastrectomy on pancreatic glucagon release.

Abstract:

:The effects of gastrectomy and vagotomy on pancreatic glucagon release were investigated clinically. The study included 20 men and eight women, who ranged in age from 28 to 69 years, and who were divided into the following four groups: 1) patients with gastroduodenal ulcers treated with partial gastrectomy, by the Billroth I method, whose hepatic branch was preserved (n = 7). 2) Patients with gastroduodenal ulcers treated with partial gastrectomy, by the Billroth II method, whose hepatic branch was preserved (n = 7). 3) Patients with gastric carcinoma treated with subtotal gastrectomy, by the Billroth I method. In these cases lymphadenectomy required section of the hepatic branch (n = 7). 4) Patients with gastric carcinoma treated with subtotal gastrectomy, by the Billroth II method. In these cases lymphadenectomy required section of the hepatic branch (n = 7). Oral glucose tolerance tests were performed in 10 patients, before operation, and in 28 gastrectomized and vagotomized patients. In the preoperative patients and in the first group, oral glucose (50g) suppressed pancreatic glucagon release, but in the other groups pancreatic glucagon levels were markedly increased.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Sudo T,Kawamura M,Umemura H,Shiraha S,Kuyama T

doi

10.1097/00000658-198107000-00005

subject

Has Abstract

pub_date

1981-07-01 00:00:00

pages

23-8

issue

1

eissn

0003-4932

issn

1528-1140

journal_volume

194

pub_type

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