Surgery in Zollinger-Ellison syndrome alters the natural history of gastrinoma.

Abstract:

OBJECTIVE:The authors assessed the impact of gastrinoma resection on the subsequent development of hepatic metastases in Zollinger-Ellison syndrome. SUMMARY BACKGROUND DATA:The symptoms of acid hypersecretion can be controlled medically in Zollinger-Ellison syndrome with high-dose pharmacologic therapy. The current role of surgery is curative excision of the gastrinoma. Because biochemical cure is obtained only in a portion of the patients and the neoplastic disease may be indolent in this syndrome, the ability of surgical resection of gastrinoma to alter or improve the subsequent development of hepatic metastases and mortality has not been defined. METHODS:One hundred twenty-four patients with the biochemical diagnosis of Zollinger-Ellison syndrome and no hepatic metastases on initial imaging studies were evaluated. Ninety-eight patients underwent surgical exploration for curative gastrinoma resections while 26 patients were managed medically. Long-term follow-up regarding development of hepatic metastases and survival were evaluated. RESULTS:Surgical exploration with gastrinoma excision resulted in a significantly decreased incidence of hepatic metastases 3% (3/98) compared with patients managed medically 23% (6/26) with comparable follow-up (p < 0.003). Two deaths due to metastatic gastrinoma occurred in the nonoperative group compared with no disease-specific deaths in the surgical group (p = 0.085). CONCLUSIONS:For the patient with Zollinger-Ellison syndrome without metastatic disease, surgical exploration with attempted curative gastrinoma resection is recommended because it may alter the natural history of this syndrome.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Fraker DL,Norton JA,Alexander HR,Venzon DJ,Jensen RT

doi

10.1097/00000658-199409000-00008

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

320-8; discussion 328-30

issue

3

eissn

0003-4932

issn

1528-1140

journal_volume

220

pub_type

临床试验,杂志文章
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    abstract:OBJECTIVE:To investigate the correlation between in-hospital surgical delay before appendectomy for suspected appendicitis and the finding of perforated appendicitis in children. METHODS:All children undergoing acute appendectomy for suspected acute appendicitis at Karolinska University Hospital, Stockholm, Sweden fro...

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    authors: Almström M,Svensson JF,Patkova B,Svenningsson A,Wester T

    更新日期:2017-03-01 00:00:00

  • Phospholipase A2 isoforms are altered in chronic pancreatitis.

    abstract:OBJECTIVE:To determine if phospholipase A2 (PLA2) type II and type IV mRNA expression and protein are altered in chronic pancreatitis. SUMMARY BACKGROUND DATA:PLA2s have an important regulatory function in several signaling pathways, especially in inflammation. In this study, we examined the expression of three PLA2 i...

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    doi:10.1097/00000658-199802000-00011

    authors: Kashiwagi M,Friess H,Uhl W,Graber H,Duarte R,Zimmermann A,Büchler MW

    更新日期:1998-02-01 00:00:00

  • Fas and Fas-ligand expression in human pancreatic cancer.

    abstract:OBJECTIVE:To investigate Fas and FasL expression in pancreatic tissues and cultured pancreatic cancer cell lines, and to assess the ability of anti-Fas antibodies to induce apoptosis. SUMMARY BACKGROUND DATA:Activation of the Fas receptor by Fas-ligand (FasL) results in apoptosis, and dysregulation of this pathway may...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200003000-00010

    authors: Kornmann M,Ishiwata T,Kleeff J,Beger HG,Korc M

    更新日期:2000-03-01 00:00:00

  • Cholangitis with acute renal failure: priorities in therapeutics.

    abstract::Obstructive cholangitis with acute renal failure is a dramatic syndrome which merits individual definition. Twenty-one patients with acute suppurative cholangitis complicated by rapidly developing renal insufficiency were studied, and the severity of the renal failure, an acute interstitial tubulopathy, bore no signif...

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    doi:10.1097/00000658-197506000-00022

    authors: Bismuth H,Kuntziger H,Corlette MB

    更新日期:1975-06-01 00:00:00

  • Release of cholecystokinin and gallbladder contraction before and after gastrectomy.

    abstract::The contraction of the gallbladder by ultrasonography and release of cholecystokinin (CCK) by specific radioimmunoassay in response to the ingestion of oral fatty meal before and 1 month after gastrectomy in five patients with early gastric cancer was studied. Before gastrectomy, basal concentrations of CCK (13.4 +/- ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:

    authors: Inoue K,Fuchigami A,Hosotani R,Kogire M,Huang YS,Miyashita T,Suzuki T,Tsuda K,Seino Y,Rayford PL

    更新日期:1987-01-01 00:00:00

  • The effects of metoclopramide on postoperative ileus. A randomized double-blind study.

    abstract::Metoclopramide or placebo was administered postoperatively in a randomized, double-blind fashion to 115 patients undergoing laparotomy. The effect of metoclopramide on postoperative adynamic ileus (PAI) was evaluated. The patients were stratified into two groups: Group A--those with laparotomy without a gastrointestin...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-197907000-00006

    authors: Davidson ED,Hersh T,Brinner RA,Barnett SM,Boyle LP

    更新日期:1979-07-01 00:00:00

  • Proposed Modification of the 8th Edition of the AJCC Staging System for Pancreatic Ductal Adenocarcinoma.

    abstract:OBJECTIVE:The aim of this study was to improve the 8th edition (8th) of the American Joint Committee on Cancer (AJCC) staging system for pancreatic ductal adenocarcinoma (PDAC). BACKGROUND:The new 8th AJCC staging system for PDAC was released in October, 2016, and will be applied in clinical practice in 2018. METHODS...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002668

    authors: Shi S,Hua J,Liang C,Meng Q,Liang D,Xu J,Ni Q,Yu X

    更新日期:2019-05-01 00:00:00

  • Combined preoperative mechanical bowel preparation with oral antibiotics significantly reduces surgical site infection, anastomotic leak, and ileus after colorectal surgery.

    abstract:OBJECTIVES:To clarify whether bowel preparation use or its individual components [mechanical bowel preparation (MBP)/oral antibiotics] impact specific outcomes after colorectal surgery. METHODS:National Surgical Quality Improvement Program-targeted colectomy data initiated in 2012 capture information on the use/type o...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001416

    authors: Kiran RP,Murray AC,Chiuzan C,Estrada D,Forde K

    更新日期:2015-09-01 00:00:00

  • The treatment of venous leg ulcers: a new therapeutic use of iloprost.

    abstract:BACKGROUND:We conducted a study using an intravenous (i.v.) infusion of iloprost in the treatment of venous ulcers to verify whether the association of i.v. iloprost + local therapy + elastic compression has a favorable effect when compared with traditional treatment with local therapy and elastic compression. STUDY D...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0b013e3180caa44c

    authors: Ferrara F,Meli F,Raimondi F,Amato C,Bonura F,Mulè G,Novo G,Novo S S

    更新日期:2007-11-01 00:00:00

  • Impact of statistical approaches for handling missing data on trauma center quality.

    abstract:OBJECTIVE:To determine whether imputed data can be used to produce unbiased hospital quality measures. BACKGROUND:Different methods for handling missing data may influence which hospitals are designated as quality outliers. METHODS:Monte-Carlo simulation study based on 63,020 patients with no missing data in 68 hospi...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31818e544b

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    更新日期:2009-01-01 00:00:00

  • Laparoscopic Lavage Versus Primary Resection for Acute Perforated Diverticulitis: Review and Meta-analysis.

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    journal_title:Annals of surgery

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/SLA.0000000000002236

    authors: Penna M,Markar SR,Mackenzie H,Hompes R,Cunningham C

    更新日期:2018-02-01 00:00:00

  • Axillary-contralateral brachial artery bypass for arm ischemia.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197406000-00001

    authors: Jacobson JH 2nd,Baron MG

    更新日期:1974-06-01 00:00:00

  • Does the subspecialty of the surgeon performing primary colonic resection influence the outcome of patients with hepatic metastases referred for resection?

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    pub_type: 杂志文章

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    authors: Wigmore SJ,Madhavan K,Currie EJ,Bartolo DC,Garden OJ

    更新日期:1999-12-01 00:00:00

  • Impact of graft type on outcome in pediatric liver transplantation: a report From Studies of Pediatric Liver Transplantation (SPLIT).

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    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0b013e3180caa415

    authors: Diamond IR,Fecteau A,Millis JM,Losanoff JE,Ng V,Anand R,Song C,SPLIT Research Group.

    更新日期:2007-08-01 00:00:00

  • Surgery for post-myocardial infarct ventricular septal defect.

    abstract::Forty-three patients (mean age 62 +/- 1 years) were treated for ventricular septal defect (VSD) secondary to myocardial infarction. Whenever possible, operation was postponed until six weeks post-onset chest pain. However, hemodynamic instability, evidenced by cardiogenic shock, refractory pulmonary edema, or a rising...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197709000-00004

    authors: Daggett WM,Guyton RA,Mundth ED,Buckley MJ,McEnany MT,Gold HK,Leinbach RC,Austen WG

    更新日期:1977-09-01 00:00:00

  • Postconditioning, a series of brief interruptions of early reperfusion, prevents neurologic injury after spinal cord ischemia.

    abstract:OBJECTIVE:We sought to test whether postconditioning, a series of brief mechanical interruptions of reperfusion applied during the onset of reperfusion, can prevent neurologic injury of the spinal cord after transient ischemia. SUMMARY BACKGROUND DATA:Ischemia-reperfusion injury of the spinal cord is the principal mec...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000217608.08582.35

    authors: Jiang X,Shi E,Nakajima Y,Sato S

    更新日期:2006-07-01 00:00:00

  • The role of tumor necrosis factor and nitric oxide in the acute cardiovascular response to endotoxin.

    abstract:OBJECTIVE:This study was designed to examine the differential effects of tumor necrosis factor (TNF) and nitric oxide on the acute cardiovascular changes that occur in response to endotoxemia. SUMMARY BACKGROUND DATA:Recent studies have suggested that some, if not all, of the cardiovascular effects of TNF are mediated...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199601000-00009

    authors: Fahey TJ 3rd,Yoshioka T,Shires GT,Fantini GA

    更新日期:1996-01-01 00:00:00

  • Laparoscopic repair of very large hiatus hernia with sutures versus absorbable mesh versus nonabsorbable mesh: a randomized controlled trial.

    abstract:OBJECTIVE:Determine whether absorbable or nonabsorbable mesh in repair of large hiatus hernias reduces the risk of recurrence, compared with suture repair. BACKGROUND:Repair of large hiatus hernia is associated with radiological recurrence rates of up to 30%, and to improve outcomes mesh repair has been recommended. P...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/SLA.0000000000000842

    authors: Watson DI,Thompson SK,Devitt PG,Smith L,Woods SD,Aly A,Gan S,Game PA,Jamieson GG

    更新日期:2015-02-01 00:00:00

  • Impact of hospital volume on in-hospital mortality of infants undergoing repair of congenital diaphragmatic hernia.

    abstract:OBJECTIVES:Congenital diaphragmatic hernia (CDH) remains a significant cause of neonatal morbidity and mortality. SUMMARY OF BACKGROUND DATA:Previous studies have suggested that hospital volume is an independent predictor of in-hospital mortality. We sought to validate this effect using a large national database incor...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181f5b538

    authors: Bucher BT,Guth RM,Saito JM,Najaf T,Warner BW

    更新日期:2010-10-01 00:00:00

  • Intraperitoneal povidone-iodine in experimental peritonitis.

    abstract::Two experimental models were utilized to study the efficacy of intraperitoneal povidone-iodine in an established peritonitis. In both models, there was a 100% mortality in the povidone-iodine treated group. In laboratories which have reported favorable results, the animals were treated before peritonitis was allowed t...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197806000-00005

    authors: Lagarde MC,Bolton JS,Cohn I Jr

    更新日期:1978-06-01 00:00:00

  • Soft tissue sarcomas.

    abstract::One hundred fifty-five adult patients with "operable" soft part sarcomas including rhabdomyosarcoma, liposarcoma, leiomyosarcoma and fibrosarcoma of the trunk and extremities are reviewed. Local recurrences of 93% and 60% occurred after local and wide excisions of the primary tumor. In this series of patients, amputat...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197506000-00007

    authors: Gerner RE,Moore GE,Pickren JW

    更新日期:1975-06-01 00:00:00

  • Group IIA phospholipase A2 mediates lung injury in intestinal ischemia-reperfusion.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200007000-00013

    authors: Koike K,Yamamoto Y,Hori Y,Ono T

    更新日期:2000-07-01 00:00:00

  • Intermittent Pneumatic Compression in Addition to Standard Prophylaxis of Postoperative Venous Thromboembolism in Extremely High-risk Patients (IPC SUPER): A Randomized Controlled Trial.

    abstract:OBJECTIVE:To assess the efficacy of adjunctive IPC to standard prophylaxis of postoperative VTE in patients at extremely high-risk. SUMMARY OF BACKGROUND DATA:The standard prophylaxis for postoperative VTE is insufficient in extremely high-risk patients. It is unclear whether an adjunctive use of IPC would result in a...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004556

    authors: Lobastov K,Sautina E,Alencheva E,Bargandzhiya A,Schastlivtsev I,Barinov V,Laberko L,Rodoman G,Boyarintsev V

    更新日期:2020-11-12 00:00:00

  • Appendectomy by residents is safe and not associated with a higher incidence of complications: a retrospective cohort study.

    abstract:OBJECTIVE:The purpose of this retrospective cohort study was to investigate whether current practice where residents perform appendectomies affects quality of care. Therefore, we investigated whether there was a difference in incidence of complications and mortality in appendectomies performed by surgeons (S), supervis...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e318248bdb5

    authors: Graat LJ,Bosma E,Roukema JA,Heisterkamp J

    更新日期:2012-04-01 00:00:00

  • Single-incision Laparoscopic Appendectomy Versus Conventional Laparoscopic Appendectomy: Experiences From 1208 Cases of Single-incision Laparoscopic Appendectomy. Experiences From 1208 Cases of Single-incision Laparoscopic Appendectomy.

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1097/00000658-198803000-00002

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    更新日期:1988-03-01 00:00:00

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    pub_type: 杂志文章

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    pub_type: 临床试验,杂志文章,随机对照试验

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    authors: Fong Y,Hesse DG,Tracey KJ,Albert JD,Legaspi A,Brennan MF,Lowry SF

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