The treatment of venous leg ulcers: a new therapeutic use of iloprost.

Abstract:

BACKGROUND:We conducted a study using an intravenous (i.v.) infusion of iloprost in the treatment of venous ulcers to verify whether the association of i.v. iloprost + local therapy + elastic compression has a favorable effect when compared with traditional treatment with local therapy and elastic compression. STUDY DESIGN:We evaluated the effects of iloprost in 98 consecutive patients with noncomplicated venous ulcers of lower limbs subdivided into 2 groups: the first group (48 patients) received iloprost in saline solution for 3 weeks and the second group (50 patients) received a venous infusion of a saline solution. The patients were examined at baseline time 0 (first visit) and then after 15, 30, 45, 60, 75, 90, 105, 120, 135, and 150 days. RESULTS:In the first group, after 90 days, all the ulcers had healed, whereas in the second group only 50% of ulcers had healed after 105 days. At the end of the study, in the second group only 84.09% of ulcers had healed. The statistical analysis showed a significant difference between the first (iloprost group) and the second group (placebo group). Besides, in the first group the cicatrization of the ulcer happened in a shorter period (27.90% after 60 days; 41.86% after 75 days; and 100% after 100 days) whereas in the second group, at the end of the study, in 15.91% of patients the ulcers had not recovered. CONCLUSION:Iloprost can significantly reduce healing time for venous leg ulcers through several actions.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Ferrara F,Meli F,Raimondi F,Amato C,Bonura F,Mulè G,Novo G,Novo S S

doi

10.1097/SLA.0b013e3180caa44c

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

860-5

issue

5

eissn

0003-4932

issn

1528-1140

pii

00000658-200711000-00025

journal_volume

246

pub_type

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