Immune RNA therapy for renal cell carcinoma: survival and immunologic monitoring.

Abstract:

:Twenty patients with metastatic renal cell carcinoma and nine patients with minimal residual disease (MRD) but at high risk for recurrence following nephrectomy received weekly four milligram intradermal injections of purified RNA extracted from lymphoid organs of sheep immunized with human renal cell carcinoma. Eighty-six consecutive UCLA patients with metastatic renal cell carcinoma served as retrospective controls. Survival between subpopulations in each group matched by computer according to extent and location of metastases, age, sex, and interval between nephrectomy and occurrence of metastases were compared by Life Table Analysis. Survival was significantly greater in RNA-treated patients (P < .05) who had multiple metastases limited to the lungs when compared with matched controls. RNA therapy did not influence survival of patients with metastases to other sites (bone, brain, liver, lymph nodes, or skin) or multiple organ involvement. All nine MRD patients treated with RNA remained free of recurrence for a mean observation period of 18 months, range ten to 34 months. No significant toxicity was observed. Changes in skin test responses were related primarily to tumor burden. Increased lymphocyte mediated cytotoxicity in RNA recipients was associated with a somewhat improved survival period. Changes in absolute lymphocyte counts had no correlation with clinical course, and complement fixing antibody generally decreased after excision of tumor, was absent in patients with progression, and was present in low levels in patients with a favorable clinical response. RNA therapy may be of value in selected patients with metastatic renal cell carcinoma, and as an adjunct to definitive surgery.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Ramming KP,deKernion JB

doi

10.1097/00000658-197710000-00007

subject

Has Abstract

pub_date

1977-10-01 00:00:00

pages

459-67

issue

4

eissn

0003-4932

issn

1528-1140

journal_volume

186

pub_type

杂志文章
  • The American Association of Endocrine Surgeons Guidelines for the Definitive Surgical Management of Thyroid Disease in Adults.

    abstract:OBJECTIVE:To develop evidence-based recommendations for safe, effective, and appropriate thyroidectomy. BACKGROUND:Surgical management of thyroid disease has evolved considerably over several decades leading to variability in rendered care. Over 100,000 thyroid operations are performed annually in the US. METHODS:The...

    journal_title:Annals of surgery

    pub_type: 杂志文章,实务指引

    doi:10.1097/SLA.0000000000003580

    authors: Patel KN,Yip L,Lubitz CC,Grubbs EG,Miller BS,Shen W,Angelos P,Chen H,Doherty GM,Fahey TJ 3rd,Kebebew E,Livolsi VA,Perrier ND,Sipos JA,Sosa JA,Steward D,Tufano RP,McHenry CR,Carty SE

    更新日期:2020-03-01 00:00:00

  • Metabolic changes in patients severely affected by tetanus.

    abstract::Metabolic changes in six severely affected tetanus patients suffering from characteristic labile hypertension (maximum systolic blood pressure greater than 200 mmHG, maximum diurnal change in systolic pressure greater than 100 mmHg) were investigated. Daily urinary excretion of urea nitrogen increased gradually from t...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199101000-00011

    authors: Hiraide A,Katayama M,Sugimoto H,Yoshioka T,Sugimoto T

    更新日期:1991-01-01 00:00:00

  • Tailoring the management of nonparasitic liver cysts.

    abstract:OBJECTIVE:To determine the optimal management of symptomatic non-parasitic liver cysts. SUMMARY BACKGROUND DATA:Management options for symptomatic nonparasitic liver cysts lack substantiation through comparative studies with respect to safety and long-term effectiveness. METHODS:A retrospective review of the surgical...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199808000-00004

    authors: Martin IJ,McKinley AJ,Currie EJ,Holmes P,Garden OJ

    更新日期:1998-08-01 00:00:00

  • Prospective analysis of long-term psychosocial outcomes in breast reconstruction: two-year postoperative results from the Michigan Breast Reconstruction Outcomes Study.

    abstract:OBJECTIVE:To prospectively evaluate the psychosocial outcomes and body image of patients 2 years postmastectomy reconstruction using a multicenter, multisurgeon approach. BACKGROUND:Although breast reconstruction has been shown to confer significant psychosocial benefits in breast cancer patients at year 1 postreconst...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0b013e3181728a5c

    authors: Atisha D,Alderman AK,Lowery JC,Kuhn LE,Davis J,Wilkins EG

    更新日期:2008-06-01 00:00:00

  • The comparative survivals of alcoholics versus nonalcoholics after distal splenorenal shunt.

    abstract::Survival after distal splenorenal shunt in appreciably better in nonalcoholic patients than in alcoholics. This increase in survival does not appear to be dependent upon the state of biochemical liver function or the severity of changes in liver histology since these latter were similar for both groups. We suggest tha...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197805000-00008

    authors: Zeppa R,Hensley GT,Levi JU,Bergstresser PR,Hutson DG Sr,Livingstone AS,Schiff ER,Fink P

    更新日期:1978-05-01 00:00:00

  • Intraoperative blood salvage during liver resection: a randomized controlled trial.

    abstract:OBJECTIVE:A randomized controlled trial was conducted to clarify the effectiveness of intraoperative blood salvage in reducing blood loss. BACKGROUND:Although reduction of central venous pressure (CVP) is thought to decrease blood loss during liver resection, no consistently effective and safe method for obtaining the...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.sla.0000255562.60215.3b

    authors: Hashimoto T,Kokudo N,Orii R,Seyama Y,Sano K,Imamura H,Sugawara Y,Hasegawa K,Makuuchi M

    更新日期:2007-05-01 00:00:00

  • Management of external gastrointestinal fistulas.

    abstract::We analyzed the course of 186 patients with external gastrointestinal fistulas treated at the University of California Medical Center, San Francisco from 1968 to 1977. There were 82 patients in the earlier group (1968-1971) and 104 patients in the later group (1972-1977). The groups differed in that 35% of patients in...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197810000-00003

    authors: Reber HA,Roberts C,Way LW,Dunphy JE

    更新日期:1978-10-01 00:00:00

  • Improving the AJCC/TNM staging for adenocarcinomas of the appendix: the prognostic impact of histological grade.

    abstract:PURPOSE:Though histological grade is known to have a major prognostic impact in metastatic mucinous appendiceal adenocarcinomas, the prognostic impact of grade in localized disease, and the validity of the American Joint Committee on Cancer AJCC Staging Manual 7th edition's decision to combine moderately and poorly dif...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e318269d680

    authors: Overman MJ,Fournier K,Hu CY,Eng C,Taggart M,Royal R,Mansfield P,Chang GJ

    更新日期:2013-06-01 00:00:00

  • Evaluation of hepatic venous congestion: proposed indication criteria for hepatic vein reconstruction.

    abstract:OBJECTIVE:To establish criteria for venous reconstruction of middle hepatic vein (MHV) tributaries of the right liver graft in adult-to-adult living donor liver transplantation (LDLT). SUMMARY BACKGROUND DATA:In adult LDLT using the right hemiliver, the MHV is usually separated from the graft, which results in potenti...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000658-200208000-00013

    authors: Sano K,Makuuchi M,Miki K,Maema A,Sugawara Y,Imamura H,Matsunami H,Takayama T

    更新日期:2002-08-01 00:00:00

  • Lack of preoperative enteral nutrition reduces gut-associated lymphoid cell numbers in colon cancer patients: a possible mechanism underlying increased postoperative infectious complications during parenteral nutrition.

    abstract:OBJECTIVE:To examine preoperative dietary influences on gut-associated lymphoid tissue (GALT) cell number in the context of postoperative infectious complications. BACKGROUND:There is little clinical evidence regarding whether nutritional routes affect GALT size and/or phenotype. The influence of GALT atrophy on clini...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31827a0e05

    authors: Okamoto K,Fukatsu K,Hashiguchi Y,Ueno H,Shinto E,Moriya T,Saitoh D,Yamamoto J,Hase K

    更新日期:2013-12-01 00:00:00

  • Effect of a prior portasystemic shunt on subsequent liver transplantation.

    abstract::Fifteen patients who had a prior portasystemic shunt underwent orthotopic liver transplantation. Shunt types were portacaval in six patients, H-graft mesocaval in six, distal splenorenal in two, and proximal splenorenal in one. Mean blood loss and hospital stay were highest in the portacaval group. Retransplants (two ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198901000-00008

    authors: Brems JJ,Hiatt JR,Klein AS,Millis JM,Colonna JO,Quinones-Baldrich WJ,Ramming KP,Busuttil RW

    更新日期:1989-01-01 00:00:00

  • Harvey Cushing and the battle of Boston common: military medical preparedness for world war one.

    abstract:OBJECTIVE:To explore the events and people that shaped Harvey Cushing, one of the nation's leading surgeons, into a political actor as he rallied support for the issue of military medical preparedness for World War One. SUMMARY BACKGROUND DATA:In a little remembered episode of American medical history, for 2 years bef...

    journal_title:Annals of surgery

    pub_type: 传,历史文章,杂志文章

    doi:10.1097/SLA.0b013e3181e77bdc

    authors: Rutkow E,Rutkow I

    更新日期:2010-07-01 00:00:00

  • Subareolar versus peritumoral injection for location of the sentinel lymph node.

    abstract:BACKGROUND:Sentinel lymph node (SLN) biopsy is fast becoming the standard for testing lymph node involvement in many institutions. However, questions remain as to the best method of injection. The authors hypothesized that a subareolar injection of material would drain to the same lymph node as a peritumoral injection,...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000658-199906000-00013

    authors: Klimberg VS,Rubio IT,Henry R,Cowan C,Colvert M,Korourian S

    更新日期:1999-06-01 00:00:00

  • Is Less More? A Microsimulation Model Comparing Cost-effectiveness of the Revised American Thyroid Association's 2015 to 2009 Guidelines for the Management of Patients With Thyroid Nodules and Differentiated Thyroid Cancer.

    abstract:OBJECTIVE:To assess relative clinical and economic performance of the revised American Thyroid Association (ATA) thyroid cancer guidelines compared to current standard of care. BACKGROUND:Diagnosis of thyroid cancer in the United States has tripled whereas mortality has only marginally increased. Most patients present...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003074

    authors: White C,Weinstein MC,Fingeret AL,Randolph GW,Miyauchi A,Ito Y,Zhan T,Ali A,Gazelle GS,Lubitz CC

    更新日期:2020-04-01 00:00:00

  • Clinical behavior and prognostic factors of periampullary adenocarcinoma.

    abstract:OBJECTIVE:The authors evaluated the outcome and potential prognostic factors of 60 patients with surgically resected periampullary tumors. SUMMARY BACKGROUND DATA:Periampullary carcinomas exhibit different clinical behaviors according to their site of origin. There are no prognostic factors for deciding the type of su...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199511000-00005

    authors: Chan C,Herrera MF,de la Garza L,Quintanilla-Martinez L,Vargas-Vorackova F,Richaud-Patín Y,Llorente L,Uscanga L,Robles-Diaz G,Leon E

    更新日期:1995-11-01 00:00:00

  • Strategies in the surgical treatment of malignant ventricular arrhythmias. An 8-year experience.

    abstract::Introduction of the automatic implantable cardioverter defibrillator (AICD) has dramatically affected the surgical treatment of malignant ventricular tachyarrhythmias. The authors continue to perform electrophysiologically directed subendocardial resection (SER) of left ventricular (LV) scars in selected patients, and...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199209000-00010

    authors: Geha AS,Elefteriades JA,Hsu J,Biblo LA,Hoch DH,Batsford WP,Rosenfeld LE,Carlson MD,Johnson NJ,Waldo AL

    更新日期:1992-09-01 00:00:00

  • HuR status is a powerful marker for prognosis and response to gemcitabine-based chemotherapy for resected pancreatic ductal adenocarcinoma patients.

    abstract:BACKGROUND:Pancreatic ductal adenocarcinoma (PDA) is a devastating disease that killed nearly 38,000 people in the United States this past year. OBJECTIVE:Treatment of PDA typically includes surgery and/or chemotherapy with gemcitabine. No reliable biomarker exists for prognosis or response to chemotherapy. Two previo...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181f1fd44

    authors: Richards NG,Rittenhouse DW,Freydin B,Cozzitorto JA,Grenda D,Rui H,Gonye G,Kennedy EP,Yeo CJ,Brody JR,Witkiewicz AK

    更新日期:2010-09-01 00:00:00

  • Preoperative Gemcitabine-based Chemoradiation Therapy for Borderline Resectable Pancreatic Cancer: Impact of Venous and Arterial Involvement Status on Surgical Outcome and Pattern of Recurrence.

    abstract:OBJECTIVE:To evaluate the outcome of preoperative gemcitabine-based chemoradiation therapy (CRT) for borderline resectable pancreatic cancer (BRPC), focusing on the associations among the tumor-vascular relationship, surgical outcomes, and pattern of recurrence. SUMMARY BACKGROUND DATA:Among the various multimodal tre...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001547

    authors: Takahashi H,Akita H,Tomokuni A,Kobayashi S,Ohigashi H,Fijiwara Y,Yano M,Sakon M,Ishikawa O

    更新日期:2016-12-01 00:00:00

  • Muscle protein catabolism after severe burn: effects of IGF-1/IGFBP-3 treatment.

    abstract:OBJECTIVE:To determine the effects of recombinant human insulin-like growth factor-1 (IGF-1) complexed with its principal binding protein, IGFBP-3, on skeletal muscle metabolism in severely burned children. SUMMARY BACKGROUND DATA:Severe burns are associated with a persistent hypermetabolic response characterized by h...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-199905000-00014

    authors: Herndon DN,Ramzy PI,DebRoy MA,Zheng M,Ferrando AA,Chinkes DL,Barret JP,Wolfe RR,Wolf SE

    更新日期:1999-05-01 00:00:00

  • Carotid artery disease following external cervical irradiation.

    abstract::A retrospective study of 910 patients surviving at least five years after cervical irradiation for Hodgkin's disease, non-Hodgkin's lymphoma, or primary head an neck neoplasms showed the incidence of stroke following cervical irradiation was 63 of 910 patients (6.3%) during a mean period of observation of nine years. ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198111000-00009

    authors: Elerding SC,Fernandez RN,Grotta JC,Lindberg RD,Causay LC,McMurtrey MJ

    更新日期:1981-11-01 00:00:00

  • Congenital mixed vascular deformities of the lower limb: the relevance of lymphatic abnormalities to their diagnosis and treatment.

    abstract::Nineteen patients with vascular deformities of the lower extremity were studied and were classified into three groups based on their clinical and angiographic findings. 1) The Klippel or Venous Dysplasia Group (n = 8) demonstrated: cutaneous nevi of metameric distribution, congenital varices (many of which were anomal...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197702000-00005

    authors: O'Donnell TF Jr

    更新日期:1977-02-01 00:00:00

  • Clinical characteristics and current management of medically refractory unstable angina.

    abstract::Of 531 patients admitted to the Duke Coronary Care Unit with unstable angina (UA) from June 1981 to September 1982, 100 had persistent angina despite optimal medical therapy of nitrates, propranolol, and nifedipine. At catheterization, 70% of the refractory patients had left main (LM) or three-vessel disease (TVD), 68...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198410000-00007

    authors: Rankin JS,Newton JR Jr,Califf RM,Jones RH,Wechsler AS,Oldham HN Jr,Wolfe WG,Lowe JE

    更新日期:1984-10-01 00:00:00

  • Sciatic and Femoral Nerve Resection During Extended Radical Surgery for Advanced Pelvic Tumours: Long-term Survival, Functional, and Quality-of-life Outcomes.

    abstract:OBJECTIVE:To report survival, functional, and quality-of-life (QoL) outcomes after extended radical resection for advanced pelvic tumors with en bloc sciatic or femoral nerve resection. BACKGROUND:Advanced pelvic tumors involving the sciatic or femoral nerve have traditionally been considered inoperable. Small studies...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003390

    authors: Brown KGM,Solomon MJ,Lau YC,Steffens D,Austin KKS,Lee PJ

    更新日期:2019-06-07 00:00:00

  • Primary Open Versus Closed Implantation Strategy for Totally Implantable Venous Access Ports: The Multicentre Randomized Controlled PORTAS-3 Trial (DRKS 00004900).

    abstract:OBJECTIVES:PORTAS-3 was designed to compare the frequency of pneumothorax or haemothorax in a primary open versus closed strategy for port implantation. BACKGROUND DATA:The implantation strategy for totally implantable venous access ports with the optimal benefit/risk ratio remains unclear. METHODS:PORTAS-3 was a mul...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003705

    authors: Hüttner FJ,Bruckner T,Hackbusch M,Weitz J,Bork U,Kotschenreuther P,Heupel O,Kümmel S,Schlitt HJ,Mattulat M,Pintér L,Seiler CM,Gutt CN,Nottberg HS,Pohl A,Ghanem F,Meyer T,Imdahl A,Neudecker J,Müller VA,Gehrig T,R

    更新日期:2020-12-01 00:00:00

  • Total thyroidectomy for benign thyroid disease: is it really worthwhile?

    abstract:OBJECTIVE:To compare the outcomes of bilateral subtotal (BST) versus total thyroidectomy (TT) for benign bilateral thyroid disease (BBTD). BACKGROUND:The extent of thyroid resection in benign goiter is controversial. Potential advantages of TT over BST may include: one-stage removal of incidental thyroid cancer, and a...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3182360118

    authors: Barczyński M,Konturek A,Stopa M,Cichoń S,Richter P,Nowak W

    更新日期:2011-11-01 00:00:00

  • Variability in Patterns of Recurrence After Resection of Primary Retroperitoneal Sarcoma (RPS): A Report on 1007 Patients From the Multi-institutional Collaborative RPS Working Group.

    abstract:BACKGROUND:Retroperitoneal sarcomas (RPS) are rare tumors composed of several well defined histologic subtypes. The aim of this study was to analyze patterns of recurrence and treatment variations in a large population of patients, treated at reference centers. METHODS:All consecutive patients with primary RPS treated...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000001447

    authors: Gronchi A,Strauss DC,Miceli R,Bonvalot S,Swallow CJ,Hohenberger P,Van Coevorden F,Rutkowski P,Callegaro D,Hayes AJ,Honoré C,Fairweather M,Cannell A,Jakob J,Haas RL,Szacht M,Fiore M,Casali PG,Pollock RE,Raut CP

    更新日期:2016-05-01 00:00:00

  • Does the subspecialty of the surgeon performing primary colonic resection influence the outcome of patients with hepatic metastases referred for resection?

    abstract:OBJECTIVE:To compare resection rates and outcome of patients subsequently referred with hepatic metastases whose initial colon cancers were resected by surgeons with different specialty interests. SUMMARY BACKGROUND DATA:Variation in practice among noncolorectal specialist surgeons has led to recommendations that colo...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199912000-00004

    authors: Wigmore SJ,Madhavan K,Currie EJ,Bartolo DC,Garden OJ

    更新日期:1999-12-01 00:00:00

  • A single-arm, nonrandomized phase II trial of neoadjuvant gemcitabine and oxaliplatin in patients with resectable pancreas adenocarcinoma.

    abstract:BACKGROUND:The role for neoadjuvant systemic therapy in resectable pancreas adenocarcinoma remains undefined. OBJECTIVE:We evaluated the efficacy of gemcitabine and oxaliplatin administered as preoperative therapy in patients with resectable pancreas adenocarcinoma. METHODS:Eligible patients were screened using compu...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/SLA.0000000000000251

    authors: OʼReilly EM,Perelshteyn A,Jarnagin WR,Schattner M,Gerdes H,Capanu M,Tang LH,LaValle J,Winston C,DeMatteo RP,DʼAngelica M,Kurtz RC,Abou-Alfa GK,Klimstra DS,Lowery MA,Brennan MF,Coit DG,Reidy DL,Kingham TP,Allen PJ

    更新日期:2014-07-01 00:00:00

  • Natural History and Management of Blunt Traumatic Pseudoaneurysms of the Internal Carotid Artery: The Harborview Algorithm Based Off a 10-Year Experience.

    abstract:OBJECTIVE:To define the natural history of, and treatment strategy for, blunt traumatic internal carotid artery (ICA) pseudoaneurysms. BACKGROUND:The natural history and management of traumatic ICA pseudoaneurysms is controversial. METHODS:We retrospectively identified all traumatic ICA pseudoaneurysms diagnosed on h...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001158

    authors: Morton RP,Levitt MR,Emerson S,Ghodke BV,Hallam DK,Sekhar LN,Kim LJ,Chesnut RM

    更新日期:2016-04-01 00:00:00

  • Physiologic role of cholecystokinin in the intestinal phase of pancreatic polypeptide release.

    abstract::Release of pancreatic polypeptide (PP) after a meal is biphasic, with an early transient peak believed to be under cholinergic control, and a secondary, prolonged intestinal phase thought to be mediated by hormones. Endogenous release of PP was stimulated by intraduodenal oleate (6.8 mmol/hr) or by intravenous adminis...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198411000-00008

    authors: Fried GM,Ogden WD,Greeley GH Jr,Thompson JC

    更新日期:1984-11-01 00:00:00