Clinical behavior and prognostic factors of periampullary adenocarcinoma.

Abstract:

OBJECTIVE:The authors evaluated the outcome and potential prognostic factors of 60 patients with surgically resected periampullary tumors. SUMMARY BACKGROUND DATA:Periampullary carcinomas exhibit different clinical behaviors according to their site of origin. There are no prognostic factors for deciding the type of surgery to be used or for choosing patients with tumors that have a poor prognosis for adjuvant treatment. METHODS:A retrospective review was performed of 15 clinical and pathologic variables encountered among 60 patients with periampullary tumors. Tumors were divided into four groups according to their site of origin. Kaplan-Meier survival curves of the four groups were plotted and differences were evaluated with the log-rank test. Cox's proportional hazards model was used to test for separate and combined independent predictors of disease-free survival. RESULTS:Twenty-nine ampullary carcinomas, 20 ductal pancreatic carcinomas, 7 distal common bile duct carcinomas, and 4 carcinomas of the periampullary duodenum were found. Five-year disease-free survival was 43%, 0%, 0%, and 75%, respectively. According to the Cox analysis, absence of neural invasion and use of adjuvant chemotherapy were significant factors for longer survival of patients with ampullary tumors. Lymphatic invasion was related to a shorter survival in patients with pancreatic carcinoma. CONCLUSIONS:Five-year disease-free survival of patients with periampullary tumors is related to tumor type. Prognosis was better for ampullary tumors if neural invasion was absent and if adjuvant chemotherapy was used. Lymphatic invasion was associated with a shorter recurrence-free survival among patients with pancreatic carcinoma.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Chan C,Herrera MF,de la Garza L,Quintanilla-Martinez L,Vargas-Vorackova F,Richaud-Patín Y,Llorente L,Uscanga L,Robles-Diaz G,Leon E

doi

10.1097/00000658-199511000-00005

subject

Has Abstract,Author List Incomplete

pub_date

1995-11-01 00:00:00

pages

632-7

issue

5

eissn

0003-4932

issn

1528-1140

journal_volume

222

pub_type

杂志文章
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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197612000-00014

    authors: Altman P,Voorhees AB Jr

    更新日期:1976-12-01 00:00:00

  • Pedal vasomotor tone following aortofemoral reconstructions: a randomized study of concomitant lumbar sympathectomy.

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    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

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    authors: Shanik GD,Ford J,Hayes AC,Baker WH,Barnes RW

    更新日期:1976-02-01 00:00:00

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    journal_title:Annals of surgery

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    authors: Thiede A,Engemann R,Korner HH,Deltz E,Muller-Ruchholtz W

    更新日期:1981-03-01 00:00:00

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    journal_title:Annals of surgery

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    authors: Kosuge T,Yamamoto J,Shimada K,Yamasaki S,Makuuchi M

    更新日期:1999-11-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/00000658-200204000-00002

    authors: Prandi M,Lionetto R,Bini A,Francioni G,Accarpio G,Anfossi A,Ballario E,Becchi G,Bonilauri S,Carobbi A,Cavaliere P,Garcea D,Giuliani L,Morziani E,Mosca F,Mussa A,Pasqualini M,Poddie D,Tonetti F,Zardo L,Rosso R

    更新日期:2002-04-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章

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    authors: Krige JE,Kotze UK,Bornman PC,Shaw JM,Klipin M

    更新日期:2006-11-01 00:00:00

  • An Implementation Assessment of the Virtual Acute Care for Elders Program From the Perspective of Key Stakeholders.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004433

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    更新日期:2020-11-16 00:00:00

  • System Factors Affecting Patient Safety in the OR: An Analysis of Safety Threats and Resiliency.

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    journal_title:Annals of surgery

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    更新日期:2019-10-04 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000133185.23514.32

    authors: Law WL,Chu KW

    更新日期:2004-08-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181bce334

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199805000-00009

    authors: Huber TS,Carlton LM,Harward TR,Russin MM,Phillips PT,Nalli BJ,Flynn TC,Seeger JM

    更新日期:1998-05-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章

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    authors: Thomas M,Otis SM,Rush M,Zyroff J,Dilley RB,Bernstein EF

    更新日期:1984-07-01 00:00:00

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    journal_title:Annals of surgery

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199607000-00010

    authors: Heitmiller RF,Redmond M,Hamilton SR

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  • Investigating Adverse Event Free Admissions in Medicare Inpatients as a Patient Safety Indicator.

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    journal_title:Annals of surgery

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    doi:10.1097/SLA.0000000000001792

    authors: King A,Bottle A,Faiz O,Aylin P

    更新日期:2017-05-01 00:00:00

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    pub_type: 杂志文章

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    authors: McCutcheon BA,Talamini MA,Chang DC,Rose JA,Bandyk DF,Wilson SE

    更新日期:2013-09-01 00:00:00

  • Training future surgical scientists: realities and recommendations.

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    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

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    journal_title:Annals of surgery

    pub_type: 杂志文章

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    pub_type: 杂志文章

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  • Proximal splenorenal shunts for extrahepatic portal venous obstruction in children.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199402000-00011

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    更新日期:1994-02-01 00:00:00

  • Carotid endarterectomy: neurologic complications as related to surgical techniques.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197706000-00010

    authors: Prioleau WH Jr,Alken AF,Hairston P

    更新日期:1977-06-01 00:00:00

  • Lymphoma of the breast.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198112000-00015

    authors: Schouten JT,Weese JL,Carbone PP

    更新日期:1981-12-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199802000-00011

    authors: Kashiwagi M,Friess H,Uhl W,Graber H,Duarte R,Zimmermann A,Büchler MW

    更新日期:1998-02-01 00:00:00

  • Lead poisoning from retained missiles. An experimental study.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198611000-00014

    authors: Manton WI,Thal ER

    更新日期:1986-11-01 00:00:00

  • Do safety checklists improve teamwork and communication in the operating room? A systematic review.

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    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

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    更新日期:2013-12-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.sla.0000217555.49001.ca

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    pub_type: 临床试验,杂志文章,meta分析,随机对照试验

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