Training future surgical scientists: realities and recommendations.

Abstract:

OBJECTIVE:To examine factors influencing surgical research and assess the current state of training future surgical scientists. SUMMARY BACKGROUND DATA:The number of surgeons actively engaged in research seems to be decreasing. Training future surgical scientists to increase these numbers depends on a variety of factors that are constantly changing. Current trends at the National Institutes of Health (NIH) and changes in graduate medical education make the training of the next generation of surgical scientists more challenging than ever. METHODS:Recent literature in surgical education, surgical research, and funding patterns at the NIH were reviewed. RESULTS:Quantitative and qualitative deficiencies exist in surgical research. Although an increasing number of students are becoming interested in surgery, the burden of debt from medical school may preclude them from pursuing research during or after residency. Research training is complicated by the fact that no formal curriculum exists for training in research and oversight is lacking. Junior faculty face increased demands for clinical revenue, which decreases time for research. In addition, surgeons are less successful at obtaining NIH funding when compared with nonsurgeons and seem to be at a disadvantage. CONCLUSIONS:Development of the next generation of surgical scientists begins by attracting the best students into surgery and by providing a structured research curriculum with appropriate oversight. Senior surgical faculty need to become more active at the NIH and provide appropriate financial support and mentorship for residents and junior faculty engaged in research.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Suliburk JW,Kao LS,Kozar RA,Mercer DW

doi

10.1097/SLA.0b013e318163d27d

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

741-9

issue

5

eissn

0003-4932

issn

1528-1140

pii

00000658-200805000-00005

journal_volume

247

pub_type

杂志文章,评审
  • Total pancreatectomy with preservation of the duodenum and pylorus for chronic pancreatitis.

    abstract::In an effort to minimize the nutritional complications that follow resection of the pancreas for severe chronic pancreatitis, the authors have performed a duodenum-preserving total pancreatectomy in eight patients for severe unremitting pain requiring large doses of opiate analgesia. Good relief of pain was obtained i...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199111000-00007

    authors: Easter DW,Cuschieri A

    更新日期:1991-11-01 00:00:00

  • A Novel Method to Improve Perfusion of Ex Vivo Pumped Human Kidneys.

    abstract:OBJECTIVE:To determine if addition of the S-nitrosylating agent ethyl nitrite (ENO) to the preservation solution can improve perfusion parameters in pumped human kidneys. BACKGROUND:A significant percentage of actively stored kidneys experience elevations in resistance and decreases in flow rate during the ex vivo sto...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003702

    authors: Zhu L,Qureshi A,Awad M,Hausladen A,Perez-Protto S,Latifi SQ,Lebovitz DJ,Chavin K,Stamler JS,Reynolds JD

    更新日期:2019-12-05 00:00:00

  • Percutaneous transluminal angioplasty as an adjunct to the surgical management of peripheral vascular disease.

    abstract::Percutaneous transluminal angioplasty (PTA) was performed as an adjunct to an operation in 43 patients with peripheral arterial insufficiency. This represents 26% of patients undergoing PTA over the past 44 months. In 23 patients PTA was done in conjunction with planned vascular reconstruction. It was successful in al...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198206000-00016

    authors: Kadir S,Smith GW,White RI Jr,Kaufman SL,Barth KH,Williams GM,O'Mara CS,Burdick JF

    更新日期:1982-06-01 00:00:00

  • The impact of gastric distension on the lower esophageal sphincter and its exposure to acid gastric juice.

    abstract:BACKGROUND AND AIMS:The lower esophageal sphincter (LES) in patients with gastroesophageal reflux disease often has a low resting pressure and a short abdominal length. The mechanism by which this occurs is unknown. We hypothesize that gastric distension causes progressive effacement of the abdominal portion of the LES...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181e3e411

    authors: Ayazi S,Tamhankar A,DeMeester SR,Zehetner J,Wu C,Lipham JC,Hagen JA,DeMeester TR

    更新日期:2010-07-01 00:00:00

  • A prospective study on fish bone ingestion. Experience of 358 patients.

    abstract::A prospective study was performed on 358 patients to examine the diagnosis, management, and natural history of fish bone ingestion. All patients admitted with the complaint had a thorough oral examination. Flexible endoscopy under local pharyngeal anesthesia would be performed on patients with negative findings. Of 11...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199004000-00012

    authors: Ngan JH,Fok PJ,Lai EC,Branicki FJ,Wong J

    更新日期:1990-04-01 00:00:00

  • Vaccinia virus GLV-1h153 is effective in treating and preventing metastatic triple-negative breast cancer.

    abstract:OBJECTIVE:This study aimed to investigate the therapeutic impact of a new oncolytic vaccinia virus in a triple-negative breast cancer (TNBC) murine model and its potential for treating distant metastatic disease. BACKGROUND:TNBCs are aggressive tumors associated with a high metastatic rate. Their lack of targets for h...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3182654572

    authors: Gholami S,Chen CH,Lou E,De Brot M,Fujisawa S,Chen NG,Szalay AA,Fong Y

    更新日期:2012-09-01 00:00:00

  • Surgery, trauma and immune suppression. Evolving the mechanism.

    abstract::A major surgical procedure can impair the delayed hypersensitivity response. This impairment is associated with suppressor cell activity that can alter either afferent or efferent responses. Using the third party mixed leukocyte culture to define cell types involved, major immune impairment was seen with the combinati...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198304000-00010

    authors: Lundy J,Ford CM

    更新日期:1983-04-01 00:00:00

  • Laparoscopy decreases postoperative complication rates after abdominal colectomy: results from the national surgical quality improvement program.

    abstract:OBJECTIVE:Compare outcomes of non-emergent laparoscopic to open colon surgery. BACKGROUND:Laparoscopy has revolutionized much of gastrointestinal surgery. Colon and rectal surgery has seen drastic changes with many of the abdominal operations being performed laparoscopically. However, data comparing recovery and compl...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31819ec903

    authors: Kennedy GD,Heise C,Rajamanickam V,Harms B,Foley EF

    更新日期:2009-04-01 00:00:00

  • K-ras oncogene mutations indicate malignancy in cystic tumors of the pancreas.

    abstract:OBJECTIVE:To evaluate clinical parameters, presurgical diagnostic tests, histologic findings, and the presence of K-ras oncogene mutations in cystic tumors of the pancreas to determine which best predict malignancy. SUMMARY BACKGROUND DATA:Because presurgical, intraoperative, and final pathologic differentiation is di...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199807000-00012

    authors: Bartsch D,Bastian D,Barth P,Schudy A,Nies C,Kisker O,Wagner HJ,Rothmund M

    更新日期:1998-07-01 00:00:00

  • The role of splenectomy in multimodality treatment of thrombotic thrombocytopenic purpura.

    abstract::Current treatment modalities for thrombotic thrombocytopenic purpura (TTP) include plasmapheresis (PP), splenectomy, steroids, dextran, other antiplatelet agents, and vinca alkaloids. Prior to the development of PP and use of multimodality treatment for TTP, mortality rates exceeded 50%. This report reviews 11 patient...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198509000-00007

    authors: Schneider PA,Rayner AA,Linker CA,Schuman MA,Liu ET,Hohn DC

    更新日期:1985-09-01 00:00:00

  • Enhanced Recovery After Surgery (ERAS) Pathway in Esophagectomy: Is a Reasonable Prediction of Hospital Stay Possible?

    abstract:OBJECTIVE:To assess whether perioperative variables or deviation from enhanced recovery after surgery (ERAS) items could be associated with delayed discharge after esophagectomy, and to convert them into a scoring system to predict it. SUMMARY BACKGROUND DATA:ERAS perioperative pathways have been recently applied to e...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002775

    authors: Parise P,Ferrari C,Cossu A,Puccetti F,Elmore U,De Pascale S,Garutti L,Fumagalli UR,Di Serio MS,Rosati R

    更新日期:2019-07-01 00:00:00

  • Magnetic resonance imaging versus computed tomography in the evaluation of soft tissue tumors of the extremities.

    abstract::Twenty patients with extremity soft tissue tumors were prospectively evaluated with magnetic resonance imaging (MRI) and computed tomography (CT) scans with subsequent anatomic correlation of surgical findings. MRI and CT had a similar percentage of accuracy in assessing tumor relationship with major neurovascular (80...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198704000-00002

    authors: Chang AE,Matory YL,Dwyer AJ,Hill SC,Girton ME,Steinberg SM,Knop RH,Frank JA,Hyams D,Doppman JL

    更新日期:1987-04-01 00:00:00

  • Impact of current management practices on early and late death in more than 500 consecutive cardiac transplant recipients.

    abstract:OBJECTIVE:To study risk factors for early and late death after heart transplantation in the current era. SUMMARY BACKGROUND DATA:The current cardiac transplant population differs from earlier periods in that an increasing number of sicker patients, such as those with ventricular assist device (LVAD) support, prior car...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200009000-00002

    authors: John R,Rajasinghe H,Chen JM,Weinberg AD,Sinha P,Itescu S,Lietz K,Mancini D,Oz MC,Smith CR,Rose EA,Edwards NM

    更新日期:2000-09-01 00:00:00

  • Prophylactic revascularization of the gut.

    abstract::Reconstitution of the mesenteric vascular circulation, in our experience, is advisable when advanced occlusive disease is noted on the preoperative arteriogram of patients selected for aortoiliofemoral, renal artery, or aortic aneurysm surgery. A lateral aortogram is mandatory, and the presence of an anastomotic meand...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197910000-00011

    authors: Connolly JE,Kwaan JH

    更新日期:1979-10-01 00:00:00

  • Management of combined pancreatoduodenal injuries.

    abstract::From 1969 to 1985, 129 patients with combined pancreatoduodenal injuries were treated at one urban trauma center. A total of 104 patients (80.6%) had penetrating wounds, and multiple visceral and vascular injuries were usually associated with the pancreatoduodenal injury. Primary repair or resection of one or both org...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198706000-00009

    authors: Feliciano DV,Martin TD,Cruse PA,Graham JM,Burch JM,Mattox KL,Bitondo CG,Jordan GL Jr

    更新日期:1987-06-01 00:00:00

  • Investigating Adverse Event Free Admissions in Medicare Inpatients as a Patient Safety Indicator.

    abstract:OBJECTIVE:To investigate adverse event free admissions as a potential, patient-centered indicator aligned directly with the goal of patient safety-freedom from harm. BACKGROUND:Preventable adverse event rates in healthcare could be further reduced. These are generally measured separately, one adverse event at a time. ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001792

    authors: King A,Bottle A,Faiz O,Aylin P

    更新日期:2017-05-01 00:00:00

  • Intrathymic injection of donor alloantigens induces donor-specific vascularized allograft tolerance without immunosuppression.

    abstract::The induction of donor-specific tolerance could prevent the side effects of immunosuppression while improving allograft survival. Male adult Buffalo (RT1b) rats underwent an intrathymic (IT), portal venous (PV), intrasplenic (IS), or subcutaneous (SQ) injection of 25 x 10(6) major histocompatibility complex (MHC) mism...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199210000-00003

    authors: Goss JA,Nakafusa Y,Flye MW

    更新日期:1992-10-01 00:00:00

  • Subclassification of Microscopic Vascular Invasion in Hepatocellular Carcinoma.

    abstract:OBJECTIVE:To investigate whether subclassification of microscopic vascular invasion (MiVI) affects the long-term outcome after curative surgical resection or liver transplantation (LT) in patients with hepatocellular carcinoma (HCC). SUMMARY OF BACKGROUND DATA:The most important factor for TNM staging in HCC is MiVI, ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003781

    authors: Kang I,Jang M,Lee JG,Han DH,Joo DJ,Kim KS,Kim MS,Choi JS,Kim SI,Park YN,Choi GH

    更新日期:2020-01-14 00:00:00

  • Acute bleeding varices: a five-year prospective evaluation of tamponade and sclerotherapy.

    abstract::In a five-year study of massive upper gastrointestinal hemorrhage, 143 patients had esophageal varices diagnosed on emergency endoscopic examination. Seventy-one patients had active bleeding from varices and required Sengstaken tube tamponade during at least one hospital admission. The remaining patients included 33 w...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198110000-00015

    authors: Terblanche J,Yakoob HI,Bornman PC,Stiegmann GV,Bane R,Jonker M,Wright J,Kirsch R

    更新日期:1981-10-01 00:00:00

  • Relapse-free survival in patients with nonmetastatic, surgically resected pancreatic neuroendocrine tumors: an analysis of the AJCC and ENETS staging classifications.

    abstract:BACKGROUND:The risk of metastatic spread among patients with early-stage pancreatic neuroendocrine tumors has not been well established. The authors sought to evaluate whether the new TNM staging systems proposed by the American Joint Committee on Cancer (AJCC) and European Neuroendocrine Tumor Society (ENETS) are prog...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31824e6108

    authors: Strosberg JR,Cheema A,Weber JM,Ghayouri M,Han G,Hodul PJ,Kvols LK

    更新日期:2012-08-01 00:00:00

  • Laparoscopy in combination with fast track multimodal management is the best perioperative strategy in patients undergoing colonic surgery: a randomized clinical trial (LAFA-study).

    abstract:OBJECTIVE:To investigate which perioperative treatment, ie, laparoscopic or open surgery combined with fast track (FT) or standard care, is the optimal approach for patients undergoing segmental resection for colon cancer. SUMMARY BACKGROUND DATA:Important developments in elective colorectal surgery are the introducti...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/SLA.0b013e31821fd1ce

    authors: Vlug MS,Wind J,Hollmann MW,Ubbink DT,Cense HA,Engel AF,Gerhards MF,van Wagensveld BA,van der Zaag ES,van Geloven AA,Sprangers MA,Cuesta MA,Bemelman WA,LAFA study group.

    更新日期:2011-12-01 00:00:00

  • Effect of ethanol on pancreatic interstitial pH and blood flow in cats with chronic pancreatitis.

    abstract:OBJECTIVE:The objective of this study was to investigate the effects of ethanol on pancreatic blood flow and interstitial pH in chronic pancreatitis. BACKGROUND:Ethanol is known to contribute to the development of both acute and chronic pancreatitis. However, it is unclear how ethanol precipitates episodes of acute pa...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199702000-00011

    authors: Toyama MT,Patel AG,Nguyen T,Ashley SW,Reber HA

    更新日期:1997-02-01 00:00:00

  • Management and In-hospital Mortality of 2235 Patients With a Traumatic Intimal Tear of the Thoracic Aorta.

    abstract:OBJECTIVE:Our goal was to describe contemporary management and in-hospital mortality associated with blunt thoracic aortic intimal tears (IT) within the American College of Surgeons Trauma Quality Improvement Program. SUMMARY BACKGROUND DATA:The evidence basis for nonoperative expectant management of traumatic IT of t...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004415

    authors: Jacob-Brassard J,Al-Omran M,Nathens AB,Forbes TL,de Mestral C

    更新日期:2020-09-01 00:00:00

  • Survival and function of hepatocytes on a novel three-dimensional synthetic biodegradable polymer scaffold with an intrinsic network of channels.

    abstract:OBJECTIVE:To evaluate the survival and function of hepatocytes (HCs) on a novel three-dimensional (3D) synthetic biodegradable polymer scaffold with an intrinsic network of interconnected channels under continuous flow conditions. SUMMARY BACKGROUND DATA:The authors' laboratory has investigated HC transplantation usin...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199807000-00002

    authors: Kim SS,Utsunomiya H,Koski JA,Wu BM,Cima MJ,Sohn J,Mukai K,Griffith LG,Vacanti JP

    更新日期:1998-07-01 00:00:00

  • The impact of Clostridium difficile on a surgical service: a prospective study of 374 patients.

    abstract:OBJECTIVE:To evaluate the epidemiology of Clostridium difficile colitis (CDC) in a subset of patients admitted specifically to a surgical service. SUMMARY BACKGROUND DATA:CDC is an increasingly prevalent nosocomial infection that can prolong hospitalization and adversely affect patient outcome. Although this disease h...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199802000-00021

    authors: Kent KC,Rubin MS,Wroblewski L,Hanff PA,Silen W

    更新日期:1998-02-01 00:00:00

  • Chronic respiratory symptoms and occult gastroesophageal reflux. A prospective clinical study and results of surgical therapy.

    abstract::Seventy-seven patients with a primary complaint of persistent cough, wheezing, and/or recurrent pneumonia were evaluated for the presence of occult gastroesophageal reflux disease. Fifty-four patients (70%) had increased esophageal acid exposure on 24-hour pH monitoring of the distal esophagus. In 28% of these patient...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199003000-00005

    authors: DeMeester TR,Bonavina L,Iascone C,Courtney JV,Skinner DB

    更新日期:1990-03-01 00:00:00

  • Chemical debridement of burns.

    abstract::The development of effective, non-toxic (local and systemic) methods for the rapid chemical (enzymatic and non-enzymatic) debridement of third degree burns would dramatically reduce the morbidity and mortality of severely burned patients. Sepsis is still the major cause of death of patients with extensive deep burns. ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197410000-00032

    authors: Levenson SM,Kan D,Gruber C,Crowley LV,Lent R,Watford A,Seifter E

    更新日期:1974-10-01 00:00:00

  • The spectrum and natural history of common bile duct stenosis in chronic alcohol-induced pancreatitis.

    abstract::Sixty patients with chronic alcohol-induced pancreatitis with endoscopic retrograde cholangiopancreatography evidence of common bile duct stenosis were studied to determine the clinical spectrum and natural history of this complication, as well as the indications for biliary bypass. In 17% of patients, common bile duc...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198911000-00007

    authors: Kalvaria I,Bornman PC,Marks IN,Girdwood AH,Bank L,Kottler RE

    更新日期:1989-11-01 00:00:00

  • Reperfusion inhibits elevated splanchnic prostanoid production after hemorrhagic shock.

    abstract::The effect of reperfusion following hemorrhagic shock on splanchnic prostanoid release was studied. Anesthetized male rats were bled to a mean arterial blood pressure of 30 mmHg for 30 minutes and either killed or treated with shed blood for 60 minutes and then killed. The superior mesenteric arterial bed was cannulat...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199012000-00006

    authors: Myers SI,Taylor BJ,Stanislawska M

    更新日期:1990-12-01 00:00:00

  • Endocrine tumors of the duodenum. Clinical characteristics and hormone content.

    abstract::Nineteen patients with primary duodenal carcinoid were analysed retrospectively, and eight of the tumors were immunocytochemically examined. One tumor contained somatostatin, two tumors gastrin, two tumors both these peptides, and one tumor contained serotonin. In two tumors no peptide or amine could be demonstrated. ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198304000-00003

    authors: Lasson A,Alwmark A,Nobin A,Sundler F

    更新日期:1983-04-01 00:00:00