Prognostic evaluation of stage B colon cancer patients is improved by an adequate lymphadenectomy: results of a secondary analysis of a large scale adjuvant trial.

Abstract:

OBJECTIVE:To determine if the extent of lymphadenectomy (number of recovered lymph nodes) was associated with long-term outcome in patients operated on for stage B and C colon cancer. SUMMARY BACKGROUND DATA:Lymphatic spreading is the main prognostic indicator in colon cancer patients, although the optimal extent of lymphadenectomy and its prognostic impact are still unknown. METHODS:In 3,648 patients (median follow-up 3.6 years) enrolled in two consecutive INTACC multicentric trials on adjuvant therapy for colon cancer, we studied the association of the number of recovered nodes with overall survival and relapse free survival by means of univariate and Cox regression analysis. RESULTS:The worst overall survival was related to ages > 65 (risk ratio [RR] = 1.30), higher grading (RR = 1.96). Better overall survival was related to female gender (RR = 0.80) and to higher number of recovered nodes (8-12 nodes, RR = 0.46, 13-17 nodes, RR = 0.76, nodes > or = 18, RR = 0.79). The same pattern was observed for relapse free survival. Longer overall and relapse free survival were related to a higher number of recovered nodes with P =.034 and P =.003 respectively (stratified analysis for absence or presence of positive nodes). Stage B patients with fewer than 7 nodes in the specimen had both shorter overall survival (P =.0000) and relapse free survival (P =.0016) than the other B patients. Outcome of stage C patients was not related to the number of recovered nodes (P =.28 and 0.12 respectively). The interaction test between stage of disease and number of recovered nodes was statistically significant (P =.017). CONCLUSIONS:Stage B patients with a small number of examined nodes may be understaged. Thus, these patients might be considered for adjuvant therapy because of their poorer life expectancy than other stage B patients. For stage C patients, the number of recovered nodes does not seem to affect long-term outcome.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Prandi M,Lionetto R,Bini A,Francioni G,Accarpio G,Anfossi A,Ballario E,Becchi G,Bonilauri S,Carobbi A,Cavaliere P,Garcea D,Giuliani L,Morziani E,Mosca F,Mussa A,Pasqualini M,Poddie D,Tonetti F,Zardo L,Rosso R

doi

10.1097/00000658-200204000-00002

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

458-63

issue

4

eissn

0003-4932

issn

1528-1140

journal_volume

235

pub_type

杂志文章,多中心研究
  • Autologous blood in the treatment of intraoperative hemorrhage.

    abstract::Severe hemorrhage associated with major trauma and vascular procedures is seen frequently in our operating rooms. Immediate autotransfusion has enabled us to safely and adquately correct blood losses without placing overwhelming demands on our blood bank. Since October 1973, a device capable of retrieving, filtering a...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197703000-00013

    authors: Bonfils-Roberts EA,Stutman L,Nealon TF Jr

    更新日期:1977-03-01 00:00:00

  • Optimization of staging of the neck with prophylactic central and lateral neck dissection for papillary thyroid carcinoma.

    abstract:OBJECTIVE:To analyze the yield and rate of node metastases (pN1) for prophylactic central (CND) and lateral neck dissection (LND) for papillary thyroid carcinoma, the risk factors for pN1, and outcomes. BACKGROUND:Prophylactic CND and LND are not routinely employed. Adjuvant radioiodine treatment may be modulated, how...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31824b7b68

    authors: Hartl DM,Leboulleux S,Al Ghuzlan A,Baudin E,Chami L,Schlumberger M,Travagli JP

    更新日期:2012-04-01 00:00:00

  • Biostatistical basis of elective node dissection for malignant melanoma.

    abstract::During the years 1954 through 1964, 259 individuals with primary malignant melanoma had an elective node dissection. Microscopic metastases were found in 15% of these patients. The presence of only a microscopic focus of involvement gave a 10-year cure rate of 67%; metastasis larger than a microscopic focus in a singl...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197707000-00014

    authors: Fortner JG,Woodruff J,Schottenfeld D,Maclean B

    更新日期:1977-07-01 00:00:00

  • Effect of lymphatic mapping on diagnosis and treatment of patients with T1a, T1b favorable breast cancer.

    abstract:OBJECTIVE:To investigate the incidence of nodal metastasis in a consecutive series of patients treated at the authors' institution with highly selective criteria, and to determine the impact that lymphatic mapping and sentinel node biopsy have on the detection of nodal metastases in this carefully selected patient popu...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.SLA.0000071564.27229.A9

    authors: Jakub JW,Ebert MD,Diaz NM,Cantor A,Reintgen DS,Dupont EL,Shons AR,Cox CE

    更新日期:2003-06-01 00:00:00

  • Results of omental flap transposition for deep sternal wound infection after cardiovascular surgery.

    abstract:OBJECTIVE:Our experience with omental flap transposition in the treatment of deep sternal wound infections is reviewed here with an emphasis on efficacy, risk factors for in-hospital mortality rates, and long-term results. SUMMARY BACKGROUND DATA:Even with improvements in muscle and omental flap transposition, the tim...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199803000-00019

    authors: Yasuura K,Okamoto H,Morita S,Ogawa Y,Sawazaki M,Seki A,Masumoto H,Matsuura A,Maseki T,Torii S

    更新日期:1998-03-01 00:00:00

  • Brochial stump closure techniques following pneumonectomy: A serial comparative study.

    abstract::Three methods of closing bronchial stumps were evaluated in 90 dogs undergoing left pneumonectomy:interrupted 3-0 silk sutures, interrupted 3-0 nylon sutures, and stapling with an automatic device. The dogs were sacrificed at 24 hours, 3, 5, 7, 10, and 14 days after pneumonectomy. Brochial stump leakage pressures and ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197608000-00012

    authors: Scott RN,Faraci RP,Hough A,Chretien PB

    更新日期:1976-08-01 00:00:00

  • Effect of proximal gastric vagotomy on feeding stimulated Heidenhain pouch acid secretion and gastrin release.

    abstract::Truncal vagotomy (TV) is known to increase the feeding stimulated acid output of Heidenhain pouches. A series of experiments were performed in dogs to see if proximal gastric vagotomy (PGV) also had this effect. Dogs were prepared with gastric fistulas (GF) and Heidenhain pouches (HP). Gastric function testing include...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197811000-00011

    authors: Harmon JW,Trout HH 3rd

    更新日期:1978-11-01 00:00:00

  • Abdominal aneurysm and horseshoe kidney: a review.

    abstract::Two patients with aortic abdominal aneurysms in association with horseshoe kidney are presented, making a total of 34 cases recorded in the literature. In 29 patients, the aneurysm was resected and five patients were non-resectable. Because of the abnormalities in vascular supply to the abnormal kidney, it is importan...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197503000-00015

    authors: Bietz DS,Merendino KA

    更新日期:1975-03-01 00:00:00

  • Primary hepatocytes outperform Hep G2 cells as the source of biotransformation functions in a bioartificial liver.

    abstract:OBJECTIVE:Metabolic activity of transformed human liver (Hep G2) cells and primary rat hepatocytes were compared during in vitro application of a gel entrapment bioartificial liver. BACKGROUND:Clinical trials of bioartificial liver devices containing either transformed liver cells or primary hepatocytes have been init...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:

    authors: Nyberg SL,Remmel RP,Mann HJ,Peshwa MV,Hu WS,Cerra FB

    更新日期:1994-07-01 00:00:00

  • Lung vascular injury with protease infusion. Relationship to plasma fibronectin.

    abstract::Fibronectin exists in a soluble form in plasma and in an insoluble form in tissues. Plasma fibronectin can modulate phagocytic function as well as incorporate into the tissue matrix where it is believed to influence microvascular integrity and tissue repair. The temporal alterations in plasma and lung lymph fibronecti...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198508000-00016

    authors: Cohler LF,Saba TM,Lewis EP

    更新日期:1985-08-01 00:00:00

  • Fibrin sealant versus mechanical stapling for mesh fixation during endoscopic extraperitoneal inguinal hernioplasty: a randomized prospective trial.

    abstract:OBJECTIVE:To compare the clinical outcome of simultaneous bilateral endoscopic totally extraperitoneal inguinal hernioplasty (TEP) using fibrin sealant (FS) and mechanical stapling for prosthetic mesh fixation. SUMMARY BACKGROUND DATA:Similar efficacy of FS and mechanical stapling for mesh fixation has been demonstrat...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.sla.0000186440.02977.de

    authors: Lau H

    更新日期:2005-11-01 00:00:00

  • System Factors Affecting Patient Safety in the OR: An Analysis of Safety Threats and Resiliency.

    abstract:OBJECTIVE:The objective of this study is to determine the characteristics and frequency of intraoperative safety threats and resilience supports using a human factors measurement tool. BACKGROUND:Human factors analysis can provide insight into how system elements contribute to intraoperative adverse events. Empiric ev...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003616

    authors: Adams-McGavin RC,Jung JJ,van Dalen ASHM,Grantcharov TP,Schijven MP

    更新日期:2019-10-04 00:00:00

  • Platelet-rich fibrin versus albumin in surgical wound repair: a randomized trial with paired design.

    abstract:OBJECTIVE:To study the effects of autologous platelet-rich fibrin (PRF) versus human albumin on incisional wound breaking strength and subcutaneous collagen deposition in patients undergoing laparoscopic cholecystectomy in a randomized trial. SUMMARY BACKGROUND DATA:Platelet peptidic growth factors may stimulate colla...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0b013e3181d3548c

    authors: Danielsen PL,Agren MS,Jorgensen LN

    更新日期:2010-05-01 00:00:00

  • Sensitivity of the canine pancreatic intraductal pressure to subclinical reduction in cholinesterase acitivity.

    abstract::As a continuation of work from this laboratory on anticholinesterase induced pancreatitis, a study of the relationship between reduced serum cholinesterase activity and changes in pancreatic intraductal pressure was undertaken. Pharmakokinetic studies in three dogs revealed rapid reduction in serum cholinesterase acti...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197907000-00002

    authors: Dressel TD,Goodale RL Jr,Hunninghake DB,Borner JW

    更新日期:1979-07-01 00:00:00

  • Marfan's syndrome. Broad spectral surgical treatment cardiovascular manifestations.

    abstract::Most patients with Marfan's syndrome have cardiovascular manifestations and complications of these abnormalities lead to death in 50% of patients by the age of 32. This report is concerned with the performance of 79 operations to control these problems in 41 patients during a 16-year period. There were 3 early deaths ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198310000-00009

    authors: Crawford ES

    更新日期:1983-10-01 00:00:00

  • Quality of life after treatment for pancreatitis.

    abstract:OBJECTIVE:The authors evaluated the morbidity, mortality, and quality of life after pancreatic debridement for necrosis and compared these values to those for quality of life after elective medical and surgical management for chronic pancreatitis. SUMMARY BACKGROUND DATA:Quality of life after pancreatic debridement fo...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199606000-00005

    authors: Broome AH,Eisen GM,Harland RC,Collins BH,Meyers WC,Pappas TN

    更新日期:1996-06-01 00:00:00

  • Laparoscopic resection for rectal cancers: lessons learned from 579 cases.

    abstract:OBJECTIVE:The aim of this study is to evaluate the short-term outcomes and long-term survival of laparoscopic rectal cancer resection at a single institution with 579 cases over a 15-year period. SUMMARY BACKGROUND DATA:The use of laparoscopic resection for colon cancer has been shown to be safe with comparable oncolo...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31818e418a

    authors: Ng KH,Ng DC,Cheung HY,Wong JC,Yau KK,Chung CC,Li MK

    更新日期:2009-01-01 00:00:00

  • Brush border transport of glutamine and other substrates during sepsis and endotoxemia.

    abstract::The effects of severe infection on luminal transport of amino acids and glucose by the small intestine were investigated. Studies were done in endotoxin-treated rats and in septic patients who underwent resection of otherwise normal small bowel. In rats the kinetics of the brush border glutamine transporter and the gl...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199105000-00004

    authors: Salloum RM,Copeland EM,Souba WW

    更新日期:1991-05-01 00:00:00

  • Successful long-term limb salvage using cephalic vein bypass grafts.

    abstract::Successful long-term limb salvage using cephalic vein bypass grafts was attained in 70 limbs of 67 patients over the past 11 years. The saphenous vein was absent in 76% and inadequate in 24% of the cases. Revascularization for limb salvage was carried out in 83%. Ninety per cent of the grafts were extended to the infr...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198412000-00019

    authors: Harris RW,Andros G,Dulawa LB,Oblath RW,Salles-Cunha SX,Apyan R

    更新日期:1984-12-01 00:00:00

  • Comparison of Patient Outcomes of Surgeons Who Are US Versus International Medical Graduates.

    abstract:OBJECTIVE:The aim of this study was to compare patient outcomes between International Medical Graduate (IMG) versus US medical graduate (USMG) surgeons. SUMMARY BACKGROUND DATA:One in 7 surgeons practicing in the US graduated from a foreign medical school. However, it remains unknown whether patient outcomes differ be...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003736

    authors: Tsugawa Y,Dimick JB,Jena AB,Maggard-Gibbons M,Blumenthal DM,Gross N,Jha AK

    更新日期:2019-12-10 00:00:00

  • Chest Wall Resection for Recurrent Breast Cancer in the Modern Era: A Systematic Review and Meta-analysis.

    abstract:OBJECTIVE:To review the literature on chest wall resection for recurrent breast cancer and evaluate overall survival (OS) and quality-of-life (QOL) outcomes. BACKGROUND:Full-thickness chest wall resection for recurrent breast cancer is controversial, as historically these recurrences have been thought of as a harbinge...

    journal_title:Annals of surgery

    pub_type: 杂志文章,meta分析

    doi:10.1097/SLA.0000000000002310

    authors: Wakeam E,Acuna SA,Keshavjee S

    更新日期:2018-04-01 00:00:00

  • Smartphone-Based Assessment of Preoperative Decision Conflict and Postoperative Physical Activity Among Patients Undergoing Cancer Surgery: A Prospective Cohort Study.

    abstract:OBJECTIVE:To determine the prevalence of clinically significant decision conflict (CSDC) among patients undergoing cancer surgery and associations with postoperative physical activity, as measured through smartphone accelerometer data. BACKGROUND:Patients with cancer face challenging treatment decisions, which may lea...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004487

    authors: Panda N,Solsky I,Cauley CE,Lipsitz S,Desai EV,Huang EJ,Benjamin EM,Lubitz CC,Onnela JP,Haynes AB

    更新日期:2020-09-15 00:00:00

  • Intestinal Oxygenation and Survival After Surgery for Necrotizing Enterocolitis: An Observational Cohort Study.

    abstract:OBJECTIVE:To assess whether regional intestinal oxygen saturation (rintSO2) and regional cerebral oxygen saturation (rcSO2) measurements aid in estimating survival of preterm infants after surgery for NEC. SUMMARY OF BACKGROUND DATA:Predicting survival after surgery for NEC is difficult yet of the utmost importance fo...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003913

    authors: Kuik SJ,van der Heide M,Bruggink JLM,Bos AF,Verhagen AAE,Kooi EMW,Hulscher JBF

    更新日期:2020-04-20 00:00:00

  • Computed tomography in the diagnosis of intra-abdominal abscesses.

    abstract::The diagnosis of intra-abdominal abscess by radiographic means often relies on combining the results of several different imaging modalities. Computed tomography (CT) has been shown to be a safe, accurate and rapid diagnostic method of diagnosing these abscesses. Five patients with a variety of intra-abdominal abscess...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197901000-00006

    authors: Daffner RH,Halber MD,Morgan CL,Trought WS,Thompson WM,Rice RP

    更新日期:1979-01-01 00:00:00

  • Management of external gastrointestinal fistulas.

    abstract::We analyzed the course of 186 patients with external gastrointestinal fistulas treated at the University of California Medical Center, San Francisco from 1968 to 1977. There were 82 patients in the earlier group (1968-1971) and 104 patients in the later group (1972-1977). The groups differed in that 35% of patients in...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197810000-00003

    authors: Reber HA,Roberts C,Way LW,Dunphy JE

    更新日期:1978-10-01 00:00:00

  • Impaired myocardial function and oxygen utilization due to protamine sulfate in an isolated rabbit heart preparation.

    abstract::The myocardial effects of protamine, with and without heparin, were documented in this investigation. Isolated rabbit hearts (n = 30) were retrograde perfused with Krebs-Ringers bicarbonate solution aerated with 95% O2/5% CO2 through the aortic root (37 C, 80 mmHg). Developed left ventricular blood pressure, heart rat...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199010000-00001

    authors: Wakefield TW,Bies LE,Wrobleski SK,Bolling SF,Stanley JC,Kirsh MM

    更新日期:1990-10-01 00:00:00

  • The use of closed suction drainage after lumpectomy and axillary node dissection for breast cancer. A prospective randomized trial.

    abstract::Closed suction drainage has been used to prevent seroma formation after lumpectomy and axillary node dissection for breast cancer. To study the efficacy of closed suction drains, the authors conducted a prospective randomized study from 1987 to 1990 of 227 axillary dissections. One hundred eight were randomized to a d...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-199202000-00009

    authors: Somers RG,Jablon LK,Kaplan MJ,Sandler GL,Rosenblatt NK

    更新日期:1992-02-01 00:00:00

  • Computerized nuclear morphometry: a new morphologic assessment for advanced gastric adenocarcinoma.

    abstract:OBJECTIVE:To evaluate the correlation between the morphologic nuclear features and clinicopathologic parameters in patients with advanced gastric cancer. SUMMARY BACKGROUND DATA:Nuclear profiles have been reported as useful prognostic predictors in various cancers. Data from computerized morphometries are objective an...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199901000-00007

    authors: Ikeguchi M,Oka S,Saito H,Kondo A,Tsujitani S,Maeta M,Kaibara N

    更新日期:1999-01-01 00:00:00

  • Postoperative Morbidity After Radical Resection of Primary Retroperitoneal Sarcoma: A Report From the Transatlantic RPS Working Group.

    abstract:OBJECTIVE:To investigate the safety of radical resection for retroperitoneal sarcoma (RPS). BACKGROUND:The surgical management of RPS frequently involves complex multivisceral resection. Improved oncologic outcomes have been demonstrated with this approach compared to marginal excision, but the safety of radical resec...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000002250

    authors: MacNeill AJ,Gronchi A,Miceli R,Bonvalot S,Swallow CJ,Hohenberger P,Van Coevorden F,Rutkowski P,Callegaro D,Hayes AJ,Honoré C,Fairweather M,Cannell A,Jakob J,Haas RL,Szacht M,Fiore M,Casali PG,Pollock RE,Barretta F,

    更新日期:2018-05-01 00:00:00

  • Surgical management of pheochromocytoma with the use of metyrosine.

    abstract::Despite recommended preoperative preparation with alpha-adrenergic blockers, severe hemodynamic instability may occur during operations to resect pheochromocytoma. We combined the alpha-blocker phenoxybenzamine with the tyrosine hydroxylase inhibitor metyrosine in an attempt to better manage the hypertension of patien...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000658-199011000-00010

    authors: Perry RR,Keiser HR,Norton JA,Wall RT,Robertson CN,Travis W,Pass HI,Walther MM,Linehan WM

    更新日期:1990-11-01 00:00:00