Biostatistical basis of elective node dissection for malignant melanoma.

Abstract:

:During the years 1954 through 1964, 259 individuals with primary malignant melanoma had an elective node dissection. Microscopic metastases were found in 15% of these patients. The presence of only a microscopic focus of involvement gave a 10-year cure rate of 67%; metastasis larger than a microscopic focus in a single node, 50%; and more than one node, 15%. One hundred forty-five individuals were treated by wide excision alone with 18% subsequently requiring a therapeutic lymphadenectomy with a ten-year cure of only 6%. A prospective study was then initiated which was concerned with efficacy of selection of patients for elective node dissection. Clark's level of invasion was determined for 258 patients treated since January 1972. The depth of invasion of the primary lesion was found to correlate directly with the absence of lymph node metastases, extent of nodal involvement, and rate of recurrence. It is concluded that the concept of elective node dissection is valid.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Fortner JG,Woodruff J,Schottenfeld D,Maclean B

doi

10.1097/00000658-197707000-00014

subject

Has Abstract

pub_date

1977-07-01 00:00:00

pages

101-3

issue

1

eissn

0003-4932

issn

1528-1140

journal_volume

186

pub_type

杂志文章
  • Prolonged continuous or intermittent vascular inflow occlusion during hemihepatectomy in pigs.

    abstract:OBJECTIVE:To assess ischemia and reperfusion (I/R) injury in a hemihepatectomy model in pigs after prolonged continuous or intermittent vascular inflow occlusion in the liver. SUMMARY BACKGROUND DATA:Massive intraoperative blood loss during liver resections can be prevented by temporary vascular inflow occlusion, cons...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199903000-00011

    authors: van Wagensveld BA,van Gulik TM,Gelderblom HC,Scheepers JJ,Bosma A,Endert E,Gouma DJ

    更新日期:1999-03-01 00:00:00

  • Prevention of biliary lesions that may occur during radiofrequency ablation of the liver: study on the pig.

    abstract:OBJECTIVE:To prevent bile duct injury by using a cold 5% glucose isotonic solution cooling in the bile ducts when radiofrequency (RF) is performed in a porcine model. SUMMARY BACKGROUND DATA:Complications that may arise during liver RF ablation include biliary stenosis and abscesses. METHODS:The RITA 1500 generator w...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000193831.39362.07

    authors: Marchal F,Elias D,Rauch P,Zarnegar R,Leroux A,Stines J,Verhaeghe JL,Guillemin F,Carteaux JP,Villemot JP

    更新日期:2006-01-01 00:00:00

  • The Importance of Registries in the Postmarketing Surveillance of Surgical Meshes.

    abstract:OBJECTIVE:To assess the role of registries in the postmarketing surveillance of surgical meshes. BACKGROUND:To date, surgical meshes are classified as group II medical devices. Class II devices do not require premarket clearance by clinical studies. Ethicon initiated a voluntary market withdrawal of Physiomesh for lap...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000002326

    authors: Köckerling F,Simon T,Hukauf M,Hellinger A,Fortelny R,Reinpold W,Bittner R

    更新日期:2018-12-01 00:00:00

  • Gastrin release by ethanol in man and in dogs.

    abstract::In man, oral or intravenous administration of ethanol caused a small but definite increase in peripheral serum gastrin concentration (measured by radioimmunoassay). In dogs, perfusion of the antrum with 10% ethanol caused an immediate increase in gastrin levels in the antral venous outflow. Acidification of the perfus...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197406000-00015

    authors: Becker HD,Reeder DD,Thompson JC

    更新日期:1974-06-01 00:00:00

  • The Global Incidence of Appendicitis: A Systematic Review of Population-based Studies.

    abstract:OBJECTIVE:We compared the incidence of appendicitis or appendectomy across the world and evaluated temporal trends. SUMMARY BACKGROUND DATA:Population-based studies reported the incidence of appendicitis. METHODS:We searched MEDLINE and EMBASE databases for population-based studies reporting the incidence of appendic...

    journal_title:Annals of surgery

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/SLA.0000000000002188

    authors: Ferris M,Quan S,Kaplan BS,Molodecky N,Ball CG,Chernoff GW,Bhala N,Ghosh S,Dixon E,Ng S,Kaplan GG

    更新日期:2017-08-01 00:00:00

  • Pedal vasomotor tone following aortofemoral reconstructions: a randomized study of concomitant lumbar sympathectomy.

    abstract::A prospective randomized trial was undertaken to evaluate effects of lumbar sympathectomy as an adjunct to reconstructive surgery of the lower limb. The objective of this study was to assess the early postoperative effect of these procedures on pedal vasomotor tone. A pedal arterial resistance index (PARI) at rest was...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-197602000-00009

    authors: Shanik GD,Ford J,Hayes AC,Baker WH,Barnes RW

    更新日期:1976-02-01 00:00:00

  • Utility of Adjuvant Chemotherapy After Neoadjuvant Chemoradiation and Esophagectomy for Esophageal Cancer.

    abstract:OBJECTIVE:To determine whether adjuvant chemotherapy (AC) after neoadjuvant chemoradiation and esophagectomy is associated with improved overall survival for patients with locally advanced esophageal cancer, and to evaluate how pathologic disease response to neoadjuvant treatment impacts this effect. BACKGROUND:Neoadj...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001954

    authors: Burt BM,Groth SS,Sada YH,Farjah F,Cornwell L,Sugarbaker DJ,Massarweh NN

    更新日期:2017-08-01 00:00:00

  • Vein cuff interposition prevents juxta-anastomotic neointimal hyperplasia.

    abstract::This study sought to minimize juxta-anastomotic neointimal hyperplasia (JNIH) following the use of polytetrafluorethylene (PTFE) conduits. PTFE anastomoses to canine carotid arteries (noncuff grafts) were compared with grafts with vein cuffs interposed proximally and distally between the graft and native artery. This ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198806000-00011

    authors: Suggs WD,Henriques HF,DePalma RG

    更新日期:1988-06-01 00:00:00

  • Repeat hepatic surgery for colorectal cancer metastasis to the liver.

    abstract:OBJECTIVE:The authors addressed whether a repeat hepatic operation is warranted in patients with recurrent isolated hepatic metastases. Are the results as good after second operation as after first hepatic operation? SUMMARY BACKGROUND DATA:Five-year survival after initial hepatic operation for colorectal metastases i...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199606000-00015

    authors: Pinson CW,Wright JK,Chapman WC,Garrard CL,Blair TK,Sawyers JL

    更新日期:1996-06-01 00:00:00

  • Hepatic resection but not radiofrequency ablation results in tumor growth and increased growth factor expression.

    abstract:OBJECTIVE:The purpose of this study was to examine the effects of radiofrequency ablation (RFA) on tumor growth and growth factor expression in a murine model. BACKGROUND:Surgical excision remains the only potentially curative therapy for hepatic malignancies. Tumor growth in the remaining liver may be accelerated aft...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000261319.51744.59

    authors: Meredith K,Haemmerich D,Qi C,Mahvi D

    更新日期:2007-05-01 00:00:00

  • Wnt pathway activation predicts increased risk of tumor recurrence in patients with stage I nonsmall cell lung cancer.

    abstract:OBJECTIVE:To determine the incidence of Wnt pathway activation in patients with stage I NSCLC and its influence on lung cancer recurrence. BACKGROUND:Despite resection, the 5-year recurrence with localized stage I nonsmall cell lung cancer (NSCLC) is 18.4%-24%. Aberrant Wnt signaling activation plays an important role...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31826d81fd

    authors: Shapiro M,Akiri G,Chin C,Wisnivesky JP,Beasley MB,Weiser TS,Swanson SJ,Aaronson SA

    更新日期:2013-03-01 00:00:00

  • Human umbilical veins and autogenous veins as canine arterial bypass grafts.

    abstract::Glutaraldehyde treated human umbilical veins (Dardik Biograft) were used to bypass short segments of the femoral artery in 15 dogs and were compared to autogenous jugular veins placed in the contralateral femoral artery of each animal. All 15 autogenous jugular veins remained patent for the four month period of observ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197808000-00005

    authors: Oblath RW,Buckley FO Jr,Donnelly WA,Green RM,Deweese JA

    更新日期:1978-08-01 00:00:00

  • Should perioperative supplemental oxygen be routinely recommended for surgery patients? A Bayesian meta-analysis.

    abstract:OBJECTIVE:The purpose of this study is to use updated data and Bayesian methods to evaluate the effectiveness of hyperoxia to reduce surgical site infections (SSIs) and/or mortality in both colorectal and all surgery patients. Because few trials assessed potential harms of hyperoxia, hazards were not included. BACKGRO...

    journal_title:Annals of surgery

    pub_type: 杂志文章,meta分析

    doi:10.1097/SLA.0b013e31826cc8da

    authors: Kao LS,Millas SG,Pedroza C,Tyson JE,Lally KP

    更新日期:2012-12-01 00:00:00

  • Laparoscopic cholecystectomy versus mini-laparotomy cholecystectomy: a prospective, randomized, single-blind study.

    abstract:OBJECTIVE:To analyze outcomes after open small-incision surgery (minilaparotomy) and laparoscopic surgery for gallstone disease in general surgical practice. METHODS:This study was a randomized, single-blind, multicenter trial comparing laparoscopic cholecystectomy (LC) to minilaparotomy cholecystectomy (MC). Both ele...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/00000658-200112000-00005

    authors: Ros A,Gustafsson L,Krook H,Nordgren CE,Thorell A,Wallin G,Nilsson E

    更新日期:2001-12-01 00:00:00

  • Surgical management of papillary and follicular carcinoma of the thyroid.

    abstract::The clinical outcome in 155 patients with papillary or follicular carcinoma of the thyroid gland operated on over a 25-year period demonstrated no difference in survival rates or incidence of recurrent tumor between those treated by total thyroidectomy and those undergoing less than total thyroidectomy. However, the c...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198012000-00001

    authors: Farrar WB,Cooperman M,James AG

    更新日期:1980-12-01 00:00:00

  • The role of neurotensin in human gallbladder motility.

    abstract::Gallbladder contraction in response to a fatty meal is thought to be caused by release of cholecystokinin (CCK). We have previously demonstrated a close correlation between circulating concentrations of CCK and contraction of the gallbladder in normal humans and in gallstone patients. Recent studies in animals, howeve...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198506000-00002

    authors: Walker JP,Khalil T,Wiener I,Fagan CJ,Townsend CM Jr,Greeley GH Jr,Thompson JC

    更新日期:1985-06-01 00:00:00

  • In-hospital Surgical Delay Does Not Increase the Risk for Perforated Appendicitis in Children: A Single-center Retrospective Cohort Study.

    abstract:OBJECTIVE:To investigate the correlation between in-hospital surgical delay before appendectomy for suspected appendicitis and the finding of perforated appendicitis in children. METHODS:All children undergoing acute appendectomy for suspected acute appendicitis at Karolinska University Hospital, Stockholm, Sweden fro...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001694

    authors: Almström M,Svensson JF,Patkova B,Svenningsson A,Wester T

    更新日期:2017-03-01 00:00:00

  • Interleukin-6 in the injured patient. Marker of injury or mediator of inflammation?

    abstract:OBJECTIVE:The effects of interleukin (IL)-6 in the injured patient are examined in an attempt to clarify the potential pathophysiologic role of IL-6 in the response to injury. SUMMARY BACKGROUND DATA:Interleukin-6 is an integral cytokine mediator of the acute phase response to injury and infection. However, prolonged ...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/00000658-199611000-00009

    authors: Biffl WL,Moore EE,Moore FA,Peterson VM

    更新日期:1996-11-01 00:00:00

  • Specialty networking in pediatric surgery: a paradigm for the future of academic surgery.

    abstract:OBJECTIVE:To review retrospectively a 4-year experience with pediatric surgical networking at a major academic medical center in the Midwest. BACKGROUND:The growth of managed care in the United States during the past decade has had a major impact on the practice of medicine in general, but especially on academic medic...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199909000-00006

    authors: Coran AG,Blackman PM,Sikina C,Harmon CM,Lelli JL Jr,Geiger JD,Hirschl RB,Teitelbaum DH,Polley TZ Jr,Golladay ES,Austin E,Adelman SH

    更新日期:1999-09-01 00:00:00

  • Morbidity and mortality after pelvic exenteration for colorectal adenocarcinoma.

    abstract::A retrospective analysis was made of the complications from pelvic exenterations performed over the past 30 years for colorectal adenocarcinoma at the Roswell Park Cancer Institute. Seventy-five patients underwent exenteration, 51 for primary disease (PD) and 24 for recurrent disease (RD). Both total and posterior exe...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199201000-00009

    authors: Hafner GH,Herrera L,Petrelli NJ

    更新日期:1992-01-01 00:00:00

  • Impact of Weekday of Esophagectomy on Short-term and Long-term Oncological Outcomes: A Nationwide Population-based Cohort Study in the Netherlands.

    abstract:OBJECTIVE:The aim of this study was to determine whether weekday of esophagectomy impacts 30-day mortality, and short- and long-term oncologic outcomes in esophageal cancer. SUMMARY OF BACKGROUND DATA:Recent literature suggests a relationship between the weekday of esophagectomy and overall survival. This finding coul...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001909

    authors: Visser E,van Rossum PSN,Verhoeven RHA,Ruurda JP,van Hillegersberg R

    更新日期:2017-07-01 00:00:00

  • Prevalence and Risk Factors for Bariatric Surgery Readmissions: Findings From 130,007 Admissions in the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program.

    abstract:OBJECTIVE:To evaluate readmissions following laparoscopic adjustable gastric banding (LAGB), laparoscopic sleeve gastrectomy (LSG), and laparoscopic Roux-en-Y gastric bypass (LRYGB). BACKGROUND:Few studies have evaluated national readmission rates for primary bariatric surgery with national, bariatric-specific data. ...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000002079

    authors: Berger ER,Huffman KM,Fraker T,Petrick AT,Brethauer SA,Hall BL,Ko CY,Morton JM

    更新日期:2018-01-01 00:00:00

  • Defining the "Tipping Point" to Success as a Surgeon-Scientist: An Analysis of Applicants and Awardees of the American College of Surgeons Jacobson Promising Investigator Award.

    abstract:BACKGROUND:Since 2005, the American College of Surgeons has administered the Jacobson Promising Investigator Award (JPIA), which recognizes surgeon-scientists at the "tipping point" of their research careers. OBJECTIVE:We retrospectively reviewed JPIA applicants to identify factors associated with selection for the aw...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004142

    authors: Emamaullee J,Lian T,Moroz S,Zuckerbraun B,Matthews J,Gosain A

    更新日期:2020-07-07 00:00:00

  • Choice of abdominal operative incision in the obese patient: a study using blood gas measurements.

    abstract::Although many factors may influence the choice of the operative incision, physiologic safety in terms of the degree of postoperative hypoxemia should be considered. No data currently exist to delineate in markedly obese patients the effect of the operative incision on the extent or duration of this hypoxemia. Fifty-f...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000658-197506000-00012

    authors: Vaughan RW,Wise L

    更新日期:1975-06-01 00:00:00

  • Effect of a prior portasystemic shunt on subsequent liver transplantation.

    abstract::Fifteen patients who had a prior portasystemic shunt underwent orthotopic liver transplantation. Shunt types were portacaval in six patients, H-graft mesocaval in six, distal splenorenal in two, and proximal splenorenal in one. Mean blood loss and hospital stay were highest in the portacaval group. Retransplants (two ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198901000-00008

    authors: Brems JJ,Hiatt JR,Klein AS,Millis JM,Colonna JO,Quinones-Baldrich WJ,Ramming KP,Busuttil RW

    更新日期:1989-01-01 00:00:00

  • Incidence and consequence of an hepatic artery injury in patients with postcholecystectomy bile duct strictures.

    abstract:OBJECTIVE:To compare the clinical presentation and results of treatment of postcholecystectomy bile duct injuries in patients with and without arterial injuries. SUMMARY BACKGROUND DATA:Incidence and impact of arterial injuries in patients with a postcholecystectomy biliary injury are unknown, although they are claime...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000074983.39297.c5

    authors: Alves A,Farges O,Nicolet J,Watrin T,Sauvanet A,Belghiti J

    更新日期:2003-07-01 00:00:00

  • Long-term survival after pancreatoduodenectomy for pancreatic adenocarcinoma: is cure possible?

    abstract:OBJECTIVE:To determine long-term survival after pancreatoduodenectomy for pancreatic ductal adenocarcinoma and to identify clinical factors associated with long-term survival. SUMMARY BACKGROUND DATA:The prognosis for long-term survival even after potentially curative resection for pancreatic adenocarcinoma is thought...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181613142

    authors: Schnelldorfer T,Ware AL,Sarr MG,Smyrk TC,Zhang L,Qin R,Gullerud RE,Donohue JH,Nagorney DM,Farnell MB

    更新日期:2008-03-01 00:00:00

  • Accelerated partial breast irradiation after conservative surgery for breast cancer.

    abstract:OBJECTIVE:To critically review the theoretical and actual risks and benefits of accelerated partial breast irradiation (APBI) after breast-conserving surgery. SUMMARY BACKGROUND DATA:Because of rapid evolution of radiation therapy techniques related to brachytherapy and three-dimensional conformal radiation therapy, A...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/01.sla.0000114219.71899.13

    authors: Kuerer HM,Julian TB,Strom EA,Lyerly HK,Giuliano AE,Mamounas EP,Vicini FA

    更新日期:2004-03-01 00:00:00

  • Open Versus Fenestrated Endovascular Repair of Complex Abdominal Aortic Aneurysms.

    abstract:OBJECTIVE:To compare outcomes of fenestrated (FEVAR) and open repairs of complex abdominal aortic aneurysms (cAAA). BACKGROUND:FEVAR has emerged as an alternative to open surgery for treating cAAA, but direct comparisons are limited. METHODS:We studied all repairs of intact or symptomatic cAAA in the Vascular Quality...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000003094

    authors: O'Donnell TFX,Boitano LT,Deery SE,Schermerhorn ML,Schanzer A,Beck AW,Green RM,Takayama H,Patel VI

    更新日期:2020-05-01 00:00:00

  • Proposed Modification of the 8th Edition of the AJCC Staging System for Pancreatic Ductal Adenocarcinoma.

    abstract:OBJECTIVE:The aim of this study was to improve the 8th edition (8th) of the American Joint Committee on Cancer (AJCC) staging system for pancreatic ductal adenocarcinoma (PDAC). BACKGROUND:The new 8th AJCC staging system for PDAC was released in October, 2016, and will be applied in clinical practice in 2018. METHODS...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002668

    authors: Shi S,Hua J,Liang C,Meng Q,Liang D,Xu J,Ni Q,Yu X

    更新日期:2019-05-01 00:00:00