A randomized trial comparing radiofrequency ablation and surgical resection for HCC conforming to the Milan criteria.

Abstract:

OBJECTIVE:To compare the long-term outcomes of surgical resection and radiofrequency ablation for the treatment of small hepatocellular carcinoma (HCC). SUMMARY BACKGROUND DATA:Radiofrequency ablation (RFA) is a promising, emerging therapy for small HCC. Whether it is as effective as surgical resection (RES) for long-term outcomes is still indefinite. METHODS:Two hundred thirty HCC patients who met the Milan criteria and were suitable to be treated by either RES or RFA entered into a randomized controlled trial. The patients were regularly followed up after treatment for 5 years (except for those who died). The primary end point was overall survival; the secondary end points were recurrence-free survival, overall recurrence, and early-stage recurrence. RESULTS:The 1-, 2-, 3-, 4- and 5-year overall survival rates for the RFA group and the RES group were 86.96%, 76.52%, 69.57%, 66.09%, 54.78% and 98.26%, 96.52%, 92.17%, 82.60%, 75.65%, respectively. The corresponding recurrence-free survival rates for the 2 groups were 81.74%, 59.13%, 46.08%, 33.91%, 28.69% and 85.22%, 73.92%, 60.87%, 54.78%, 51.30%, respectively. Overall survival and recurrence-free survival were significantly lower in the RFA group than in the RES group (P = 0.001 and P = 0.017). The 1-, 2-, 3-, 4-, and 5-year overall recurrence rates were 16.52%, 38.26%, 49.57%, 59.13%, and 63.48% for the RFA group and 12.17%, 22.60%, 33.91%, 39.13%, and 41.74% for the RES group. The overall recurrence was higher in the RFA group than in the RES group (P = 0.024). CONCLUSIONS:Surgical resection may provide better survival and lower recurrence rates than RFA for patients with HCC to the Milan criteria.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Huang J,Yan L,Cheng Z,Wu H,Du L,Wang J,Xu Y,Zeng Y

doi

10.1097/SLA.0b013e3181efc656

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

903-12

issue

6

eissn

0003-4932

issn

1528-1140

pii

00000658-201012000-00003

journal_volume

252

pub_type

杂志文章,随机对照试验
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    doi:10.1097/SLA.0b013e3181c1cfc9

    authors: Brouquet A,Cudennec T,Benoist S,Moulias S,Beauchet A,Penna C,Teillet L,Nordlinger B

    更新日期:2010-04-01 00:00:00

  • Tumor progression while on chemotherapy: a contraindication to liver resection for multiple colorectal metastases?

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    doi:10.1097/01.sla.0000145964.08365.01

    authors: Adam R,Pascal G,Castaing D,Azoulay D,Delvart V,Paule B,Levi F,Bismuth H

    更新日期:2004-12-01 00:00:00

  • Prevention of biliary lesions that may occur during radiofrequency ablation of the liver: study on the pig.

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    doi:10.1097/01.sla.0000193831.39362.07

    authors: Marchal F,Elias D,Rauch P,Zarnegar R,Leroux A,Stines J,Verhaeghe JL,Guillemin F,Carteaux JP,Villemot JP

    更新日期:2006-01-01 00:00:00

  • Improving the AJCC/TNM staging for adenocarcinomas of the appendix: the prognostic impact of histological grade.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e318269d680

    authors: Overman MJ,Fournier K,Hu CY,Eng C,Taggart M,Royal R,Mansfield P,Chang GJ

    更新日期:2013-06-01 00:00:00

  • Impact of hospital volume on recurrence and survival after surgery for gastric cancer.

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    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

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    authors: Enzinger PC,Benedetti JK,Meyerhardt JA,McCoy S,Hundahl SA,Macdonald JS,Fuchs CS

    更新日期:2007-03-01 00:00:00

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    doi:10.1097/00000658-200003000-00010

    authors: Kornmann M,Ishiwata T,Kleeff J,Beger HG,Korc M

    更新日期:2000-03-01 00:00:00

  • Brochial stump closure techniques following pneumonectomy: A serial comparative study.

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    doi:10.1097/00000658-197608000-00012

    authors: Scott RN,Faraci RP,Hough A,Chretien PB

    更新日期:1976-08-01 00:00:00

  • Perioperative granulocyte colony-stimulating factor does not prevent severe infections in patients undergoing esophagectomy for esophageal cancer: a randomized placebo-controlled clinical trial.

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    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/01.sla.0000129705.00210.24

    authors: Schaefer H,Engert A,Grass G,Mansmann G,Wassmer G,Hubel K,Loehlein D,Ulrich BC,Lippert H,Knoefel WT,Hoelscher AH

    更新日期:2004-07-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197801000-00011

    authors: Wise L,Stein T

    更新日期:1978-01-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200211000-00014

    authors: Pascual JL,Ferri LE,Seely AJ,Campisi G,Chaudhury P,Giannias B,Evans DC,Razek T,Michel RP,Christou NV

    更新日期:2002-11-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181f5b538

    authors: Bucher BT,Guth RM,Saito JM,Najaf T,Warner BW

    更新日期:2010-10-01 00:00:00

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    authors: Johnson WC,Gerzof SG,Robbins AH,Nabseth DC

    更新日期:1981-10-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/01.sla.0000086545.45918.ee

    authors: Law S,Kwong DL,Kwok KF,Wong KH,Chu KM,Sham JS,Wong J

    更新日期:2003-09-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/01.sla.0000164077.77912.98

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    更新日期:2005-06-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/SLA.0b013e318295fef8

    authors: Lee L,Li C,Landry T,Latimer E,Carli F,Fried GM,Feldman LS

    更新日期:2014-04-01 00:00:00

  • Influence of pentobarbital and chloralose on metabolic and hemodynamic changes in liver ischemia.

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    pub_type: 杂志文章

    doi:10.1097/00000658-199007000-00004

    authors: Nordström G,Winsö O,Biber B,Hasselgren PO

    更新日期:1990-07-01 00:00:00

  • Survival in Locally Advanced Pancreatic Cancer After Neoadjuvant Therapy and Surgical Resection.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

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  • Autologous blood in the treatment of intraoperative hemorrhage.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197703000-00013

    authors: Bonfils-Roberts EA,Stutman L,Nealon TF Jr

    更新日期:1977-03-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198001000-00014

    authors: Quatromoni JC,Rosoff L Sr,Halls JM,Yellin AE

    更新日期:1980-01-01 00:00:00

  • Influence of total parenteral nutrition on tissue lipoprotein lipase activity during chronic and acute illness.

    abstract::This study examines the influence of total parenteral nutrition (TPN) compared with 5% dextrose (D5) infusion on skeletal muscle and adipose tissue lipoprotein lipase (LPL) activity in nutritionally depleted, injured and infected patients. The plasma concentrations of glucose, free fatty acid (FFA), triglyceride and i...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198112000-00003

    authors: Robin AP,Greenwood MR,Askanazi J,Elwyn DH,Kinney JM

    更新日期:1981-12-01 00:00:00

  • Glucose turnover and recycling in colorectal carcinoma.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198311000-00007

    authors: Kokal WA,McCulloch A,Wright PD,Johnston ID

    更新日期:1983-11-01 00:00:00

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    pub_type: 共识发展会议,杂志文章

    doi:10.1097/SLA.0000000000001701

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    pub_type: 杂志文章

    doi:10.1097/00000658-200212000-00004

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    更新日期:2002-12-01 00:00:00

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    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0b013e3180caa415

    authors: Diamond IR,Fecteau A,Millis JM,Losanoff JE,Ng V,Anand R,Song C,SPLIT Research Group.

    更新日期:2007-08-01 00:00:00

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    pub_type: 杂志文章

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    authors: Lugaresi M,Mattioli B,Daddi N,Bassi F,Pilotti V,Ferruzzi L,Mattioli S

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    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181e4846e

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    更新日期:2010-07-01 00:00:00

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    doi:10.1097/00000658-197807000-00012

    authors: Lobe TE,Martin EW Jr,Cooperman M,Vasko J,Evans WE

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    更新日期:2015-02-01 00:00:00

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    authors: Laurent A,Sauvanet A,Farges O,Watrin T,Rivkine E,Belghiti J

    更新日期:2008-07-01 00:00:00