Influence of pentobarbital and chloralose on metabolic and hemodynamic changes in liver ischemia.

Abstract:

:Hemodynamic and metabolic consequences of a 90-minute period of liver ischemia followed by 120 minutes of reperfusion were studied in rats that were awake during most of the experiment and in rats anesthetized with either pentobarbital (40 mg/kg body weight) or chloralose (30 mg/kg X hour) during the complete length of the experiment. Ischemia was induced by occluding the blood vessels to the left and median liver lobes with a small vascular clamp, which was removed after 90 minutes. Protein synthesis rate was determined by measuring incorporation rate of 14C-leucine into protein in incubated liver slices. At the end of the ischemic period, adenosine triphosphate levels in liver tissue and protein synthesis rate were reduced by 80% to 90%, with no significant differences among groups. During reperfusion, energy levels and protein synthesis rate remained depressed in the anesthetized animals, but improved, although not to normal values, in the awake rats. Hepatic tissue water increased during ischemia, probably reflecting hepatocellular membrane injury. The increase in hepatic tissue water was more pronounced in the chloralose group than in the other groups of rats. During reperfusion hepatic tissue water remained increased in the anesthetized rats but was normalized in the awake group. Mean arterial blood pressure was stable during ischemia and reperfusion in the pentobarbital anesthetized rats, while a progressive decrease in blood pressure during the experiment was noted in the chloralose group. The results suggest that hemodynamic and metabolic responses to liver ischemia and reperfusion can be influenced by anesthetics. Chloralose may be less suitable than pentobarbital for anesthesia when liver ischemia is inflicted.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Nordström G,Winsö O,Biber B,Hasselgren PO

doi

10.1097/00000658-199007000-00004

subject

Has Abstract

pub_date

1990-07-01 00:00:00

pages

23-9

issue

1

eissn

0003-4932

issn

1528-1140

journal_volume

212

pub_type

杂志文章
  • Preoperative systemic chemoimmunotherapy and sequential resection for unresectable hepatocellular carcinoma.

    abstract:OBJECTIVE:To examine the surgical and pathologic findings of 15 patients who had initially unresectable hepatocellular carcinoma (HCC) and received preoperative systemic chemoimmunotherapy and sequential resection. SUMMARY BACKGROUND DATA:More than 80% of patients with HCC present for treatment at an unresectable stag...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200102000-00013

    authors: Lau WY,Leung TW,Lai BS,Liew CT,Ho SK,Yu SC,Tang AM

    更新日期:2001-02-01 00:00:00

  • The treatment of venous leg ulcers: a new therapeutic use of iloprost.

    abstract:BACKGROUND:We conducted a study using an intravenous (i.v.) infusion of iloprost in the treatment of venous ulcers to verify whether the association of i.v. iloprost + local therapy + elastic compression has a favorable effect when compared with traditional treatment with local therapy and elastic compression. STUDY D...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0b013e3180caa44c

    authors: Ferrara F,Meli F,Raimondi F,Amato C,Bonura F,Mulè G,Novo G,Novo S S

    更新日期:2007-11-01 00:00:00

  • Aneurysm of sinus of Valsalva with coronary atherosclerosis: successful surgical correction.

    abstract::A case of acquired aneurysm of the sinus of Valsalva, associated with severe coronary atherosclerosis and successfully treated surgically, is reported. The unusual features of the case are the presenting symptom (angina pectoris) and the cause of the aneurysm (severe coronary atherosclerosis). ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197903000-00008

    authors: Debakey ME,Lawrie GM

    更新日期:1979-03-01 00:00:00

  • Implications of Tumor Characteristics and Treatment Modality on Local Recurrence and Functional Outcomes in Children with Chest Wall Sarcoma: A Pediatric Surgical Oncology Research Collaborative Study.

    abstract:OBJECTIVE:To determine the impact of tumor characteristics and treatment approach on (1) local recurrence, (2) scoliosis development and (3) patient-reported quality of life in children with sarcoma of the chest wall. SUMMARY BACKGROUND DATA:Children with chest wall sarcoma require multimodal therapy including chemoth...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004579

    authors: Harris CJ,Helenowski I,Murphy AJ,Mansfield SA,LaQuaglia MP,Heaton TE,Cavalli M,Murphy JT,Newman E,Overmen RE,Kartal TT,Cooke-Barber J,Donaher A,Malek MM,Kalsi R,Kim ES,Zobel MJ,Goodhue CJ,Naik-Mathuria BJ,Jefferson

    更新日期:2020-11-04 00:00:00

  • Glutathione protects the rat liver against reperfusion injury after prolonged warm ischemia.

    abstract:OBJECTIVE:To evaluate the potential of postischemic intravenous infusion of the endogenous antioxidant glutathione (GSH) to protect the liver from reperfusion injury following prolonged warm ischemia. BACKGROUND DATA:The release of reactive oxygen species (ROS) by activated Kupffer cells (KC) and leukocytes causes rep...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000110321.64275.95

    authors: Schauer RJ,Gerbes AL,Vonier D,Meissner H,Michl P,Leiderer R,Schildberg FW,Messmer K,Bilzer M

    更新日期:2004-02-01 00:00:00

  • Twenty-three-year follow-up of separated ischiopagus tetrapus conjoined twins.

    abstract::This paper presents a 23-year follow-up of the separation of ischiopagus tetrapus conjoined twins reported in Annals of Surgery in December 1966. One twin died of septicemia at age 2 years after bilateral pelvic osteotomies for the treatment of her marked pelvic diastasis. The surviving twin has done reasonably well, ...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/00000658-198911000-00017

    authors: Hoyle RM,Thomas CG Jr

    更新日期:1989-11-01 00:00:00

  • Expression of the neurotensin gene in fetal human liver and fibrolamellar carcinoma.

    abstract:OBJECTIVE:This study determined whether the neurotensin gene (NT/N) is expressed in the normal adult liver and focal nodular hyperplasia (FNH) and confirmed NT/N expression in fibrolamellar carcinoma; whether NT/N or the neurotensin receptor is expressed in the fetal liver; and whether hepatic resection leads to expres...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199410000-00007

    authors: Ehrenfried JA,Zhou Z,Thompson JC,Evers BM

    更新日期:1994-10-01 00:00:00

  • Preventing Parastomal Hernia Using a Modified Sugarbaker Technique With Composite Mesh During Laparoscopic Abdominoperineal Resection: A Randomized Controlled Trial.

    abstract:OBJECTIVE:The aim of this study was to assess the reduction in the incidence of parastomal hernia (PH) after placement of prophylactic synthetic mesh using a modified Sugarbaker technique when a permanent end-colostomy is needed. SUMMARY OF BACKGROUND DATA:Prevention of PH formation is crucial given the high prevalenc...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/SLA.0000000000001684

    authors: López-Cano M,Serra-Aracil X,Mora L,Sánchez-García JL,Jiménez-Gómez LM,Martí M,Vallribera F,Fraccalvieri D,Serracant A,Kreisler E,Biondo S,Espín E,Navarro-Soto S,Armengol-Carrasco M

    更新日期:2016-12-01 00:00:00

  • Axillary lymph node status, but not tumor size, predicts locoregional recurrence and overall survival after mastectomy for breast cancer.

    abstract:OBJECTIVE:To assess the significance of axillary lymph node status and tumor size for predicting locoregional recurrence (LRR) and overall survival after mastectomy for breast cancer and to discuss the utility of postmastectomy radiation therapy. SUMMARY BACKGROUND DATA:Patients with locally advanced breast cancer req...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.SLA.0000065289.06765.71

    authors: Beenken SW,Urist MM,Zhang Y,Desmond R,Krontiras H,Medina H,Bland KI

    更新日期:2003-05-01 00:00:00

  • A new type of sliding hiatus hernia.

    abstract::A series of patients showing a previously unrecognized type of sliding hiatus hernia is presented and analyzed. This type of hernia is characterized by reflux of the mucous membrane of the Hiss angle into the lumen of the esophagus. The occurrence of mucosal prolapse is a secondary phase of gastroesophageal reflux. Th...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198508000-00004

    authors: Myllärniemi H,Saario I

    更新日期:1985-08-01 00:00:00

  • Patterns of failure in patients with resected stage I and II non-small-cell carcinoma of the lung. The Ludwig Lung Cancer Study Group.

    abstract::The pattern of failure was studied in 1012 patients with resected Stage I or II non-small-cell carcinoma of the lung. Initial intrathoracic failure (41%) was more common than initial extrathoracic failure (34%) even though a complete resection was the intent in all patients. The most frequent sites of initial failure ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198701000-00012

    authors:

    更新日期:1987-01-01 00:00:00

  • Results of omental flap transposition for deep sternal wound infection after cardiovascular surgery.

    abstract:OBJECTIVE:Our experience with omental flap transposition in the treatment of deep sternal wound infections is reviewed here with an emphasis on efficacy, risk factors for in-hospital mortality rates, and long-term results. SUMMARY BACKGROUND DATA:Even with improvements in muscle and omental flap transposition, the tim...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199803000-00019

    authors: Yasuura K,Okamoto H,Morita S,Ogawa Y,Sawazaki M,Seki A,Masumoto H,Matsuura A,Maseki T,Torii S

    更新日期:1998-03-01 00:00:00

  • An evaluation of information transfer through the continuum of surgical care: a feasibility study.

    abstract:OBJECTIVE:To evaluate information transfer and communication (ITC) across the surgical care pathway with the use of Information Transfer and Communication Assessment Tool for Surgery (ITCAS). BACKGROUND:Communication failures are the leading cause of surgical errors and adverse events. It is vital to assess the ITC ac...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181e986df

    authors: Nagpal K,Vats A,Ahmed K,Vincent C,Moorthy K

    更新日期:2010-08-01 00:00:00

  • Surgical adverse outcomes in patients with schizophrenia: a population-based study.

    abstract:OBJECTIVE:To validate the global features of postoperative adverse outcomes for surgical patients with schizophrenia. BACKGROUND:Patients with schizophrenia were known to have a higher risk of complications during hospitalization. Quality of care has become the key factor in reducing their potential mortality afterwar...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0b013e31827b9b25

    authors: Liao CC,Shen WW,Chang CC,Chang H,Chen TL

    更新日期:2013-03-01 00:00:00

  • Genetic variants in DNA repair predicts the survival of patients with esophageal cancer.

    abstract:OBJECTIVE:To investigate the association of the genetic variants in excision repair cross-complementation group 2 (ERCC2) R156R and ERCC4 rs3136038 with survival duration for patients with esophageal cancer. BACKGROUND:ERCC2 and ERCC4 are important molecules participating nucleotide excision repair system. The clinica...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e318216f374

    authors: Lee JM,Yang PW,Yang SY,Chuang TH,Tung EC,Chen JS,Huang PM,Lee YC

    更新日期:2011-05-01 00:00:00

  • Gastrointestinal hemorrhage from adhesion-related mesenteric varices.

    abstract::As a result of this retrospective analysis of hemorrhage from a porta-systemic venous shunt occurring within the small intestine, we believe that the early diagnosis of the syndrome is strongly suggested by the presence of varices in unusual locations demonstrated by the venous phase of mesenteric arteriography. In al...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197601000-00005

    authors: Moncure AC,Waltman AC,Vandersalm TJ,Linton RR,Levine FH,Abbott WM

    更新日期:1976-01-01 00:00:00

  • Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients.

    abstract:OBJECTIVE:To determine the effectiveness of early, routine antioxidant supplementation using alpha-tocopherol and ascorbic acid in reducing the rate of pulmonary morbidity and organ dysfunction in critically ill surgical patients. SUMMARY BACKGROUND DATA:Oxidative stress has been associated with the development of the...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-200212000-00014

    authors: Nathens AB,Neff MJ,Jurkovich GJ,Klotz P,Farver K,Ruzinski JT,Radella F,Garcia I,Maier RV

    更新日期:2002-12-01 00:00:00

  • Staging laparotomy in Hodgkin's disease.

    abstract::Staging laparotomy (multiple liver and lymph node biopsies and splenectomy) was performed at the North Carolina Baptist Hospital in 123 patients with Hodgkin's disease. There were no deaths. Wound, pulmonary, intra-abdominal or urinary tract complications developed in 17 patients. Of those complications, one case each...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198005000-00008

    authors: Sterchi JM,Myers RT

    更新日期:1980-05-01 00:00:00

  • Mild hypothermia provides significant protection against ischemia/reperfusion injury in livers of obese and lean rats.

    abstract:OBJECTIVE:To evaluate the effect of anesthesia induced mild systemic hypothermia on hepatic injury in lean and obese rats during warm ischemia. SUMMARY BACKGROUND DATA:Hepatic warm ischemia during surgery remains a significant problem, particularly in organs with presumed baseline dysfunction. METHODS:The left and me...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000154259.73060.f1

    authors: Choi S,Noh J,Hirose R,Ferell L,Bedolli M,Roberts JP,Niemann CU

    更新日期:2005-03-01 00:00:00

  • Subtotal versus total gastrectomy for gastric cancer: five-year survival rates in a multicenter randomized Italian trial. Italian Gastrointestinal Tumor Study Group.

    abstract:OBJECTIVE:To evaluate the impact of subtotal (SG) versus total (TG) gastrectomy on the oncologic outcome of patients with cancer of the distal stomach from 28 Italian institutions. SUMMARY BACKGROUND DATA:There is controversy over whether SG and TG have a different impact on the 5-year survival probability of patients...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/00000658-199908000-00006

    authors: Bozzetti F,Marubini E,Bonfanti G,Miceli R,Piano C,Gennari L

    更新日期:1999-08-01 00:00:00

  • Institutional and individual learning curves for focused abdominal ultrasound for trauma: cumulative sum analysis.

    abstract:OBJECTIVE:To evaluate both institutional and individual learning curves with focused abdominal ultrasound for trauma (FAST) by analyzing the incidence of diagnostic inaccuracies as a function of examiner experience for a group of trauma surgeons performing the study in the setting of an urban level I trauma center. SU...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200005000-00009

    authors: McCarter FD,Luchette FA,Molloy M,Hurst JM,Davis K Jr,Johannigman JA,Frame SB,Fischer JE

    更新日期:2000-05-01 00:00:00

  • Pulsatile reperfusion after cardiac arrest improves neurologic outcome.

    abstract::Cardiopulmonary bypass (CPB) using nonpulsatile flow (NPF) is advocated for refractory cardiac arrest. This study examined cerebral outcome after resuscitation with pulsatile flow (PF) versus NPF. Dogs arrested for 12.5 minute were reperfused with NPF (n = 11) using roller pump CPB or PF (n = 11) using mechanical bive...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199110000-00012

    authors: Anstadt MP,Stonnington MJ,Tedder M,Crain BJ,Brothers MF,Hilleren DJ,Rahija RJ,Menius JA Jr,Lowe JE

    更新日期:1991-10-01 00:00:00

  • Addition of glutamine to total parenteral nutrition after elective abdominal surgery spares free glutamine in muscle, counteracts the fall in muscle protein synthesis, and improves nitrogen balance.

    abstract::Twenty-two patients undergoing elective abdominal surgery were given total parenteral nutrition (TPN) after the operation. The TPN contained either a conventional amino acid solution supplemented with glutamine or a conventional amino acid solution without supplementation. To study amino acid and protein metabolism, m...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198904000-00011

    authors: Hammarqvist F,Wernerman J,Ali R,von der Decken A,Vinnars E

    更新日期:1989-04-01 00:00:00

  • Long-term results of intraoperative electron beam irradiation (IOERT) for patients with unresectable pancreatic cancer.

    abstract:SUMMARY BACKGROUND DATA:To analyze the effects of a treatment program of intraoperative electron beam radiation therapy (IOERT) and external beam radiation therapy and chemotherapy on the outcome of patients with unresectable or locally advanced pancreatic cancer. METHODS:From 1978 to 2001, 150 patients with unresecta...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000152016.40331.bb

    authors: Willett CG,Del Castillo CF,Shih HA,Goldberg S,Biggs P,Clark JW,Lauwers G,Ryan DP,Zhu AX,Warshaw AL

    更新日期:2005-02-01 00:00:00

  • Prevention of Postsurgical Lymphedema by 9-cis Retinoic Acid.

    abstract:OBJECTIVE:To determine the effect of 9-cis retinoic acid (9-cis RA) on postsurgical lymphedema. BACKGROUND:9-cis RA promotes lymphangiogenesis in vitro and in vivo and has promise as a therapeutic agent to limit the development of postsurgical lymphedema. METHODS:Lymphedema was induced in the right hind limb after a ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001525

    authors: Bramos A,Perrault D,Yang S,Jung E,Hong YK,Wong AK

    更新日期:2016-08-01 00:00:00

  • Comparative Effectiveness and Risks of Bowel Preparation Before Elective Colorectal Surgery.

    abstract:OBJECTIVE:The objective of this study was to determine the relationship between bowel preparation and surgical site infections (SSIs), and also other postoperative complications, after elective colorectal surgery. BACKGROUND:SSI is a major source of postoperative morbidity/costs after colorectal surgery. The value of ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002159

    authors: Koller SE,Bauer KW,Egleston BL,Smith R,Philp MM,Ross HM,Esnaola NF

    更新日期:2018-04-01 00:00:00

  • Variation and Impact of Multiple Complications on Failure to Rescue After Inpatient Surgery.

    abstract:OBJECTIVE:To examine the extent to which multiple, sequential complications impacts variation in institutional postoperative mortality rates. BACKGROUND:Failure to rescue (FTR) has been proposed as an underlying factor in hospital variation in surgical mortality. However, little is currently known about hospital varia...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001917

    authors: Massarweh NN,Anaya DA,Kougias P,Bakaeen FG,Awad SS,Berger DH

    更新日期:2017-07-01 00:00:00

  • Oxygen as an isolated variable influences resistance to infection.

    abstract::The relative importance of oxygen in relation to resistance to infection was assessed in 24 mongrel dogs. Rectus abdominis musculocutaneous (MC) and corresponding cutaneous random pattern (RP) flaps based at the level of the xiphoid were elevated, replaced, and sutured. Immediately after the surgical procedure, 0.1 ml...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198812000-00018

    authors: Jönsson K,Hunt TK,Mathes SJ

    更新日期:1988-12-01 00:00:00

  • The impact of Clostridium difficile on a surgical service: a prospective study of 374 patients.

    abstract:OBJECTIVE:To evaluate the epidemiology of Clostridium difficile colitis (CDC) in a subset of patients admitted specifically to a surgical service. SUMMARY BACKGROUND DATA:CDC is an increasingly prevalent nosocomial infection that can prolong hospitalization and adversely affect patient outcome. Although this disease h...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199802000-00021

    authors: Kent KC,Rubin MS,Wroblewski L,Hanff PA,Silen W

    更新日期:1998-02-01 00:00:00

  • Treatment of intra-abdominal and abdominal wall desmoid tumors with drugs that affect the metabolism of cyclic 3',5'-adenosine monophosphate.

    abstract::A female patient with Gardner's syndrome was treated with delta1-testololactone (200 mg daily) because of growth of a large desmoid tumor in the pelvis and lower abdomen and a tumor in a scar from a previous laparotomy. There was also pain and swelling of the left leg. An immediate effect of the drug therapy was compl...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197503000-00009

    authors: Waddell WR

    更新日期:1975-03-01 00:00:00