Early diagnosis of intestinal ischemia using urinary and plasma fatty acid binding proteins.

Abstract:

OBJECTIVE:This study aims at improving diagnosis of intestinal ischemia, by measuring plasma and urinary fatty acid binding protein (FABP) levels. METHODS:Fifty consecutive patients suspected of intestinal ischemia were included and blood and urine were sampled at time of suspicion. Plasma and urinary concentrations of intestinal FABP (I-FABP), liver FABP (L-FABP) and ileal bile acid binding protein (I-BABP) were measured using enzyme-linked immunosorbent assays. RESULTS:Twenty-two patients suspected of intestinal ischemia were diagnosed with intestinal ischemia, 24 patients were diagnosed with other diseases, and 4 patients were excluded from further analysis fulfilling exclusion criteria. Median plasma concentrations of I-FABP and L-FABP and urinary concentrations of all 3 markers were significantly higher in patients with proven intestinal ischemia than in patients suspected of intestinal ischemia with other final diagnoses (plasma I-FABP; 653 pg/mL vs. 109 pg/mL, P = 0.02, plasma L-FABP; 117 ng/mL vs. 25 ng/mL, P = 0.006, urine I-FABP; 3377 pg/mL vs. 115 pg/mL, P = 0.001, urine L-FABP; 1,199 ng/mL vs. 37 ng/mL, P =0.004, urine I-BABP; 48.6 ng/mL vs. 0.6 ng/mL, P = 0.002). Positive and negative likelihood ratios significantly increased positive posttest probability and decreased negative posttest probability on intestinal ischemia. In patients with intestinal ischemia a trend to higher plasma I-BABP levels was observed when the ileum was involved (18.4 ng/mL vs. 2.9 ng/mL, P = 0.05). CONCLUSION:Plasma and especially urinary I-FABP and L-FABP levels and urinary I-BABP levels can improve early diagnosis of intestinal ischemia. Furthermore, plasma I-BABP levels can help in localizing ileal ischemia.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Thuijls G,van Wijck K,Grootjans J,Derikx JP,van Bijnen AA,Heineman E,Dejong CH,Buurman WA,Poeze M

doi

10.1097/SLA.0b013e318207a767

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

303-8

issue

2

eissn

0003-4932

issn

1528-1140

pii

00000658-201102000-00015

journal_volume

253

pub_type

杂志文章
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    authors: Kaufman RP Jr,Anner H,Kobzik L,Valeri CR,Shepro D,Hechtman HB

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    authors: Malangoni MA,Cué JI,Fallat ME,Willing SJ,Richardson JD

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    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/00000658-199810000-00007

    authors: Pedrazzoli S,DiCarlo V,Dionigi R,Mosca F,Pederzoli P,Pasquali C,Klöppel G,Dhaene K,Michelassi F

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    authors: Lagarde MC,Bolton JS,Cohn I Jr

    更新日期:1978-06-01 00:00:00

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    pub_type: 杂志文章

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    doi:10.1097/SLA.0000000000003721

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    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001918

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    更新日期:2017-07-01 00:00:00

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    authors: Myllärniemi H,Saario I

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  • A rational approach to surgery of the chronic venous statis syndrome.

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    authors: Goss JA,Nakafusa Y,Flye MW

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    pub_type: 杂志文章

    doi:10.1097/00000658-197510000-00007

    authors: Bradley EL 3rd,Isaacs J,Hersh T,Davidson ED,Millikan W

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    authors: Whittemore AD,Kauffman JL,Kohler TR,Mannick JA

    更新日期:1983-06-01 00:00:00

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    更新日期:2002-10-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/00000658-199710000-00003

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    更新日期:1997-10-01 00:00:00

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    abstract:OBJECTIVE:We examined management strategies, overall survival (OS), and progression-free survival (PFS) among patients with PMNSGCTs undergoing resection and multidisciplinary management at a high-volume institution. SUMMARY OF BACKGROUND DATA:Outcomes after resection of PMNSGCTs are not well-characterized, with limit...

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    pub_type: 杂志文章

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    authors: Perloff LJ,Rowlands DT,Barker CF

    更新日期:1977-08-01 00:00:00