Blood transfusions and prognosis in colorectal cancer: long-term results of a randomized controlled trial.

Abstract:

OBJECTIVE:Perioperative blood transfusions may adversely affect survival in patients with colorectal malignancy, although definite proof of a causal relationship has never been reported. BACKGROUND:We report the long-term outcomes of a randomized controlled trial performed between 1986 and 1991 to compare the effects of allogeneic blood transfusions and an autologous blood transfusion program in colorectal cancer patients. METHODS:All 475 randomized patients operated upon for colorectal cancer were tracked via a national computerized record-linkage system to investigate survival and cause of death. Kaplan-Meier survival curves were constructed and multivariate Cox regression analysis was performed to study 20 years' overall survival. Colorectal cancer-specific survival was analyzed over the 10-year time period after surgery. RESULTS:The overall survival percentage at 20 years after surgery was worse in the autologous group (21%) compared to the allogeneic group (28%) (P = 0.041; log-rank test). Cox regression, allowing for tumor stage, age, and sex, resulted in a hazard ratio (autologous vs allogeneic group) for overall mortality of 1.24 (95% confidence interval 1.00-1.54; P = 0.051). Colorectal cancer-specific survival at 10 years for the whole study group was 48% and 60% for the autologous and allogeneic group, respectively (P = 0.020; log-rank test). The adjusted hazard ratio was 1.39 (95 confidence interval 1.05-1.83; P = 0.045). CONCLUSIONS:At long-term follow-up colorectal cancer patients did not benefit from autologous transfusion compared with standard allogeneic transfusion. On the contrary, the overall and colorectal cancer-specific survival rates were worse in the patients in the autologous transfusion group.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Harlaar JJ,Gosselink MP,Hop WC,Lange JF,Busch OR,Jeekel H

doi

10.1097/SLA.0b013e318271cedf

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

681-6; discussion 686-7

issue

5

eissn

0003-4932

issn

1528-1140

pii

00000658-201211000-00003

journal_volume

256

pub_type

杂志文章,多中心研究,随机对照试验
  • Tailoring the management of nonparasitic liver cysts.

    abstract:OBJECTIVE:To determine the optimal management of symptomatic non-parasitic liver cysts. SUMMARY BACKGROUND DATA:Management options for symptomatic nonparasitic liver cysts lack substantiation through comparative studies with respect to safety and long-term effectiveness. METHODS:A retrospective review of the surgical...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199808000-00004

    authors: Martin IJ,McKinley AJ,Currie EJ,Holmes P,Garden OJ

    更新日期:1998-08-01 00:00:00

  • Academic Advancement in Global Surgery: Appointment, Promotion, and Tenure: Recommendations From the American Surgical Association Working Group on Global Surgery.

    abstract::: There is growing interest in global surgery among US academic surgical departments. As academic global surgery is a relatively new field, departments may have minimal experience in evaluation of faculty contributions and how they integrate into the existing academic paradigm for promotion and tenure. The American Su...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003480

    authors: Wren SM,Balch CM,Doherty GM,Finlayson SR,Kauffman GL,Kibbe MR,Haider AH,Minter RM,Mock C,Muguti GI,Numann PJ,Olutoye OO,Roy N,Weigel RJ

    更新日期:2020-02-01 00:00:00

  • Combined preoperative mechanical bowel preparation with oral antibiotics significantly reduces surgical site infection, anastomotic leak, and ileus after colorectal surgery.

    abstract:OBJECTIVES:To clarify whether bowel preparation use or its individual components [mechanical bowel preparation (MBP)/oral antibiotics] impact specific outcomes after colorectal surgery. METHODS:National Surgical Quality Improvement Program-targeted colectomy data initiated in 2012 capture information on the use/type o...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001416

    authors: Kiran RP,Murray AC,Chiuzan C,Estrada D,Forde K

    更新日期:2015-09-01 00:00:00

  • Role of Serum Carcinoma Embryonic Antigen (CEA) Level in Localized Pancreatic Adenocarcinoma: CEA Level Before Operation is a Significant Prognostic Indicator in Patients With Locally Advanced Pancreatic Cancer Treated With Neoadjuvant Therapy Followed by

    abstract:OBJECTIVE:The aim of the study was to identify the prognostic factors before neoadjuvant chemoradiotherapy (NCRT) in the patients with localized PDAC. Furthermore, to identify the post-surgical survival predictors of patients with LAPC. SUMMARY OF BACKGROUND DATA:Surgical resection may occupy an important position in ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004148

    authors: Kato H,Kishiwada M,Hayasaki A,Chipaila J,Maeda K,Noguchi D,Gyoten K,Fujii T,Iizawa Y,Tanemura A,Murata Y,Kuriyama N,Usui M,Sakurai H,Isaji S,Mizuno S

    更新日期:2020-07-24 00:00:00

  • The effects of metoclopramide on postoperative ileus. A randomized double-blind study.

    abstract::Metoclopramide or placebo was administered postoperatively in a randomized, double-blind fashion to 115 patients undergoing laparotomy. The effect of metoclopramide on postoperative adynamic ileus (PAI) was evaluated. The patients were stratified into two groups: Group A--those with laparotomy without a gastrointestin...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-197907000-00006

    authors: Davidson ED,Hersh T,Brinner RA,Barnett SM,Boyle LP

    更新日期:1979-07-01 00:00:00

  • Clinical significance of the mesorectal extension of rectal cancer: a Japanese multi-institutional study.

    abstract:OBJECTIVE:The aim of this study was to emphasize the importance of a subclassification in the TNM staging system of rectal cancer. BACKGROUND:The clinical significance of the mesorectal extension of rectal cancer is unclear. PATIENTS AND METHODS:Data from 463 consecutive patients with stage IIa disease (T3N0) undergo...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0b013e3182119331

    authors: Shirouzu K,Akagi Y,Fujita S,Ueno H,Takii Y,Komori K,Ito M,Sugihara K,Japanese Society for Cancer of the Colon and Rectum (JSCCR) on Clinical Significance of the Mesorectal Extension of Rectal Cancer.

    更新日期:2011-04-01 00:00:00

  • Demography of penetrating cardiac trauma.

    abstract::All cases of penetrating cardiac trauma in 1985 and 1986 in Jefferson County, Alabama, where patients dying of penetrating trauma received autopsies, were retrospectively reviewed. All hospitals in the county plus the single coroner's office provided the records of the 72 patients comprising this study. Incidents occu...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198906000-00004

    authors: Naughton MJ,Brissie RM,Bessey PQ,McEachern MM,Donald JM Jr,Laws HL

    更新日期:1989-06-01 00:00:00

  • Biliary reconstruction in right lobe living-donor liver transplantation: Comparison of different techniques in 321 recipients.

    abstract:OBJECTIVE:To assess the incidence of biliary complications after right lobe living-donor liver transplantation (LDLT) in patients undergoing duct-to-duct choledochocholedochostomy or Roux-en-Y choledochojejunostomy reconstruction. SUMMARY BACKGROUND DATA:Biliary tract complications remain one of the most serious morbi...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000206419.65678.2e

    authors: Kasahara M,Egawa H,Takada Y,Oike F,Sakamoto S,Kiuchi T,Yazumi S,Shibata T,Tanaka K

    更新日期:2006-04-01 00:00:00

  • Effect of optimization of hemodynamics on fibrinolytic activity and antithrombotic efficacy of external pneumatic calf compression.

    abstract::External pneumatic calf compression is effective but imperfect for antithrombotic prophylaxis in surgical patients. In preliminary studies, sequential filling of multisegmented leggings with graded pressure decreasing from ankle to knee increased venous flow velocity and wall shear stress, decreased residual venous vo...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-198711000-00014

    authors: Salzman EW,McManama GP,Shapiro AH,Robertson LK,Donovan AS,Blume HW,Sweeney J,Kamm RD,Johnson MC,Black PM

    更新日期:1987-11-01 00:00:00

  • Elective colon and rectal surgery without nasogastric decompression. A prospective, randomized trial.

    abstract::Nasogastric (NG) decompression after colorectal surgery is practiced commonly. Our aim was to determine whether routine NG decompression benefitted patients undergoing this type of surgery. Five hundred thirty-five patients were randomized prospectively to either NG decompression or no decompression. Stratification wa...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-198906000-00003

    authors: Wolff BG,Pembeton JH,van Heerden JA,Beart RW Jr,Nivatvongs S,Devine RM,Dozois RR,Ilstrup DM

    更新日期:1989-06-01 00:00:00

  • Recurrent carotid artery stenosis following endarterectomy.

    abstract::Spectral analysis was used to examine 257 carotid arteries in 227 patients who had undergone carotid endarterectomy at 1, 3, 6, and 12 months after surgery and annually thereafter. Routine intraoperative completion angiography ensured that the operations were technically satisfactory. Postoperative restenoses were ide...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198407000-00013

    authors: Thomas M,Otis SM,Rush M,Zyroff J,Dilley RB,Bernstein EF

    更新日期:1984-07-01 00:00:00

  • Five hundred intestinal and multivisceral transplantations at a single center: major advances with new challenges.

    abstract:OBJECTIVE:To assess the evolution of visceral transplantation in the milieu of surgical technical modifications, new immunosuppressive protocols, and other management strategies. SUMMARY BACKGROUND DATA:With the clinical feasibility of intestinal and multivisceral transplantation in 1990, multifaceted innovative tacti...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181b67725

    authors: Abu-Elmagd KM,Costa G,Bond GJ,Soltys K,Sindhi R,Wu T,Koritsky DA,Schuster B,Martin L,Cruz RJ,Murase N,Zeevi A,Irish W,Ayyash MO,Matarese L,Humar A,Mazariegos G

    更新日期:2009-10-01 00:00:00

  • Bariatric Surgery in Medicare Patients: Examining Safety and Healthcare Utilization in the Disabled and Elderly.

    abstract:OBJECTIVE:To compare safety and healthcare utilization after sleeve gastrectomy versus Roux-en-Y gastric bypass in a national Medicare cohort. SUMMARY BACKGROUND DATA:Though bariatric surgery is increasing among Medicare beneficiaries, no long-term, national studies examining comparative effectiveness between procedur...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004526

    authors: Chao GF,Chhabra KR,Yang J,Thumma JR,Arterburn DE,Ryan AM,Telem DA,Dimick JB

    更新日期:2020-11-17 00:00:00

  • Improving Benchmarks for Global Surgery: Nationwide Enumeration of Operations Performed in Ghana.

    abstract:OBJECTIVE:To evaluate the operation rate in Ghana and characterize it by types of procedures and hospital level. BACKGROUND:The Lancet Commission on Global Surgery recommended an annual rate of 5000 operations/100,000 people as a benchmark at which low- and middle-income countries could achieve most of the population-...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002457

    authors: Gyedu A,Stewart B,Gaskill C,Boakye G,Appiah-Denkyira E,Donkor P,Maier R,Quansah R,Mock C

    更新日期:2018-08-01 00:00:00

  • Systemic cytokine response after laparoscopic-assisted resection of rectosigmoid carcinoma: A prospective randomized trial.

    abstract:OBJECTIVE:To compare the systemic cytokine response in patients after laparoscopic-assisted resection with those after open resection of rectosigmoid carcinoma. SUMMARY BACKGROUND DATA:Laparoscopic resection of colorectal carcinoma is technically feasible, but objective evidence of its benefit is scarce. Systemic cyto...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-200004000-00008

    authors: Leung KL,Lai PB,Ho RL,Meng WC,Yiu RY,Lee JF,Lau WY

    更新日期:2000-04-01 00:00:00

  • Sciatic and Femoral Nerve Resection During Extended Radical Surgery for Advanced Pelvic Tumours: Long-term Survival, Functional, and Quality-of-life Outcomes.

    abstract:OBJECTIVE:To report survival, functional, and quality-of-life (QoL) outcomes after extended radical resection for advanced pelvic tumors with en bloc sciatic or femoral nerve resection. BACKGROUND:Advanced pelvic tumors involving the sciatic or femoral nerve have traditionally been considered inoperable. Small studies...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003390

    authors: Brown KGM,Solomon MJ,Lau YC,Steffens D,Austin KKS,Lee PJ

    更新日期:2019-06-07 00:00:00

  • Long-term results of brachial thrombectomy following cardiac catheterization.

    abstract::The late results of brachial thrombectomy following cardiac catheterization were evaluated in 20 patients. All patients had a radial pulse present and no symptoms or signs of ischemia of the hand at the time of discharge from the hospital. Late evaluation of these 20 patients revealed 8 in whom the long-term results w...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197604000-00019

    authors: Nicholas GG,DeMuth WE Jr

    更新日期:1976-04-01 00:00:00

  • Laparoscopic liver resection for malignant liver tumors: preliminary results of a multicenter European study.

    abstract:OBJECTIVE:To assess the feasibility, safety, and outcome of laparoscopic liver resection for malignant liver tumors. SUMMARY BACKGROUND DATA:The precise role of laparoscopy in resection of liver malignancies (hepatocellular carcinoma [HCC] and liver metastases) remains controversial despite an increasing number of pub...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/00000658-200207000-00014

    authors: Gigot JF,Glineur D,Santiago Azagra J,Goergen M,Ceuterick M,Morino M,Etienne J,Marescaux J,Mutter D,van Krunckelsven L,Descottes B,Valleix D,Lachachi F,Bertrand C,Mansvelt B,Hubens G,Saey JP,Schockmel R,Hepatobiliary a

    更新日期:2002-07-01 00:00:00

  • A decade's experience with quality improvement in cardiac surgery using the Veterans Affairs and Society of Thoracic Surgeons national databases.

    abstract:OBJECTIVE:To review the Department of Veteran Affairs (VA) and the Society of Thoracic Surgeons (STS) national databases over the past 10 years to evaluate their relative similarities and differences, to appraise their use as quality improvement tools, and to assess their potential to facilitate improvements in quality...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200110000-00006

    authors: Grover FL,Shroyer AL,Hammermeister K,Edwards FH,Ferguson TB Jr,Dziuban SW Jr,Cleveland JC Jr,Clark RE,McDonald G

    更新日期:2001-10-01 00:00:00

  • Significantly increased pregnancy rates after laparoscopic restorative proctocolectomy: a cross-sectional study.

    abstract:OBJECTIVE:To assess the impact of a laparoscopic approach on female fecundity in ileoanal pouch surgery. BACKGROUND:Restorative proctocolectomy with ileal pouch anal anastomosis (IPAA) is associated with tubal factor infertility in female patients. Different studies showed less adhesion formation after laparoscopic co...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/SLA.0b013e318250caa9

    authors: Bartels SA,DʼHoore A,Cuesta MA,Bensdorp AJ,Lucas C,Bemelman WA

    更新日期:2012-12-01 00:00:00

  • A prospective evaluation of the ligation of the intersphincteric tract procedure for complex anal fistula in patients with Crohn's disease.

    abstract:OBJECTIVE:To evaluate 2- and 12-month outcomes after ligation of the intersphincteric fistula tract (LIFT) in Crohn's disease (CD). BACKGROUND:Surgical approaches to perianal fistulas in CD are frequently ineffective and hampered by concerns over adequate wound healing and sphincter injury. The efficacy of LIFT in CD ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000479

    authors: Gingold DS,Murrell ZA,Fleshner PR

    更新日期:2014-12-01 00:00:00

  • Surgical strategies in esophageal carcinoma with emphasis on radical lymphadenectomy.

    abstract::From 1975 through 1988, 257 patients with carcinoma of the thoracic esophagus have been treated in our department. Operability was 90% (232/257); overall resectability, 77% (198/257), and for the operated group, 85% (198/232). Hospital mortality rate was 9.6% but decreased to 3% over the period 1986 to 1988. There wer...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199211000-00010

    authors: Lerut T,De Leyn P,Coosemans W,Van Raemdonck D,Scheys I,LeSaffre E

    更新日期:1992-11-01 00:00:00

  • Pylorus Resection Does Not Reduce Delayed Gastric Emptying After Partial Pancreatoduodenectomy: A Blinded Randomized Controlled Trial (PROPP Study, DRKS00004191).

    abstract:OBJECTIVES:The aim of this study was to investigate the effect of pylorus resection on postoperative delayed gastric emptying (DGE) after partial pancreatoduodenectomy (PD). BACKGROUND:PD is the standard treatment for tumors of the pancreatic head. Preservation of the pylorus has been widely accepted as standard proce...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0000000000002480

    authors: Hackert T,Probst P,Knebel P,Doerr-Harim C,Bruckner T,Klaiber U,Werner J,Schneider L,Michalski CW,Strobel O,Ulrich A,Diener MK,Büchler MW

    更新日期:2018-06-01 00:00:00

  • Epidural electrical stimulation in severe limb ischemia. Pain relief, increased blood flow, and a possible limb-saving effect.

    abstract::Peripheral vascular disease of the extremities causes ischemic pain and, at times, skin ulcerations and gangrene. It has been suggested that epidural spinal electrical stimulation (ESES) could improve peripheral circulation. Since 1978 we have used ESES in 34 patients with severe limb ischemia; all had resting pain an...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198507000-00017

    authors: Augustinsson LE,Carlsson CA,Holm J,Jivegård L

    更新日期:1985-07-01 00:00:00

  • Prospective randomized trial of two wound management strategies for dirty abdominal wounds.

    abstract:OBJECTIVE:To determine the optimal method of wound closure for dirty abdominal wounds. SUMMARY BACKGROUND DATA:The rate of wound infection for dirty abdominal wounds is approximately 40%, but the optimal method of wound closure remains controversial. Three randomized studies comparing delayed primary closure (DPC) wit...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-200103000-00016

    authors: Cohn SM,Giannotti G,Ong AW,Varela JE,Shatz DV,McKenney MG,Sleeman D,Ginzburg E,Augenstein JS,Byers PM,Sands LR,Hellinger MD,Namias N

    更新日期:2001-03-01 00:00:00

  • Preoperative and long-term cardiac risk assessment. Predictive value of 23 clinical descriptors, 7 multivariate scoring systems, and quantitative dipyridamole imaging in 360 patients.

    abstract::A total of 360 patients underwent preoperative cardiac risk assessment using 23 clinical parameters, seven multivariate clinical scoring systems, and quantitative dipyridamole-thallium imaging to predict postoperative and long-term myocardial infarction and cardiac death after noncardiac surgery. There were 30 postope...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199208000-00010

    authors: Lette J,Waters D,Bernier H,Champagne P,Lassonde J,Picard M,Cerino M,Nattel S,Boucher Y,Heyen F

    更新日期:1992-08-01 00:00:00

  • Predicting risk for serious complications with bariatric surgery: results from the Michigan Bariatric Surgery Collaborative.

    abstract:OBJECTIVES:To develop a risk prediction model for serious complications after bariatric surgery. BACKGROUND:Despite evidence for improved safety with bariatric surgery, serious complications remain a concern for patients, providers and payers. There is little population-level data on which risk factors can be used to ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e318230058c

    authors: Finks JF,Kole KL,Yenumula PR,English WJ,Krause KR,Carlin AM,Genaw JA,Banerjee M,Birkmeyer JD,Birkmeyer NJ,Michigan Bariatric Surgery Collaborative, from the Center for Healthcare Outcomes and Policy.

    更新日期:2011-10-01 00:00:00

  • Reduction of Postoperative Wound Infections by Antiseptica (RECIPE)?: A Randomized Controlled Trial.

    abstract:OBJECTIVE:To evaluate whether intraoperative subcutaneous wound irrigation with 0.04% polyhexanide can reduce surgical site infection (SSI) in elective laparotomies compared to saline. BACKGROUND:SSI is a common complication after gastrointestinal surgery. To date, there is a lack of evidence whether subcutaneous woun...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0000000000003645

    authors: Strobel RM,Leonhardt M,Krochmann A,Neumann K,Speichinger F,Hartmann L,Lee LD,Beyer K,Daum S,Kreis ME,Lauscher JC

    更新日期:2020-07-01 00:00:00

  • A prospective study of thymectomy and serum acetylcholine receptor antibodies in myasthenia gravis.

    abstract::Forty-seven consecutively presenting myasthenia gravis (MG) patients with generalized weakness were treated according to a standardized prospective protocol. All patients underwent a sternal splitting "total" thymectomy. Medical status before surgery was optimized by plasmapheresis without immunosuppression. Medicatio...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198208000-00001

    authors: Olanow CW,Wechsler AS,Roses AD

    更新日期:1982-08-01 00:00:00

  • Treatment trends in early-stage invasive lobular carcinoma: a report from the National Cancer Data Base.

    abstract:OBJECTIVE:To examine treatment trends in invasive lobular carcinoma (ILC) over the last 15 years and, in particular, to compare rates of recurrence and disease-free survival associated with breast conservation therapy compared with mastectomy. SUMMARY BACKGROUND DATA:The biologic characteristics of ILC make it difficu...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000171306.74366.22

    authors: Singletary SE,Patel-Parekh L,Bland KI

    更新日期:2005-08-01 00:00:00