Abstract：
BACKGROUND:The purpose of this study was to define the redox sensitive cis-acting transcriptional mechanisms that regulate inducible nitric oxide synthase (iNOS) promoter function in the hepatocyte. METHODS:Clonal deletion constructs of the rat hepatocyte iNOS promoter (Genbank X95629; 1845 base pair)-reporter plasmid were transiently transfected into HepG2 cells treated with IL-1 beta and IL-1 beta + hydrogen peroxide. RESULTS:A segment of the promoter upstream from nucleotide -1126 was associated with redox-sensitive augmentation of promoter activity. Site-directed mutagenesis of 2 antioxidant response elements (AREs) was combined with transfection analysis to demonstrate that mutation of the ARE at nt-1347 ablated oxidant stress-mediated activation of the iNOS promoter. CONCLUSIONS:This ARE conveys the redox-sensitive response of the rat iNOS promoter. Hepatocyte iNOS expression is a novel and, as yet, poorly described antioxidant mechanism that is cytokine and redox sensitive and that plays a pleuripotent regulatory role in hepatocellular function in the face of sepsis and shock.
journal_name
Surgeryjournal_title
Surgeryauthors
Punzalan C,Cai C,Schroeder RA,Kuo PCsubject
Has Abstractpub_date
1999-08-01 00:00:00pages
450-5issue
2eissn
0039-6060issn
1532-7361pii
S0039-6060(99)70191-1journal_volume
126pub_type
杂志文章相关文献
SURGERY文献大全abstract：BACKGROUND:Antigen injected subcutaneously (SQ) results in a strong systemic immune response, whereas antigen infused orally or by the portal vein tends to induce tolerance. Nontransgenic C57BL/6J (H-2(b)), or B6, mice and transgenic 2C mice (that express a cytotoxic T cell receptor against major histocompatibility com...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2005.05.010
更新日期：2005-08-01 00:00:00
abstract：:Eighteen patients with arteriovenous malformations (AVM's) involving the extremities, pelvis, or head are reported and their treatment is discussed. Our experience has led us to the following conclusions: (1) careful selective angiography is mandatory to delineate the vascular anatomy, extent, and major afferent vesse...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：BACKGROUND:Publicly reported hospital scores are used by patients to make health care-related decisions; however, their relationship to clinical outcomes is unknown. METHODS:Through the use of the New York Statewide Planning and Research Cooperative System database, the association between two commonly used scores (He...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2018.12.006
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:Obese patients can develop a large lower abdominal panniculus (worsened by significant weight loss). Patients with advanced chronic kidney disease (CKD) affected by this obesity-related sequela are not infrequently declined for kidney transplantation because of the high risk for serious wound-healing complic...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2015.12.001
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:The aim of this prospective study was to elucidate the features, indications, and surgical treatment in patients affected by complications of Crohn's disease. METHODS:Between January 1985 and July 1996, 513 consecutive patients (248 male, 265 female; mean age, 38 years) were operated on for 542 occurrences ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(97)90071-4
更新日期：1997-10-01 00:00:00
abstract：BACKGROUND:Surgical wrapping (SW) of the pancreas causes islet neogenesis in rodents. Pancreatic duodenal hoemobox-1 (PDX-1) is one of the transcriptional factors needed by pancreatic stem cells to develop a mature pancreas. The purpose of this study was to determine whether islet neogenesis arises from ductal cells an...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(03)00394-5
更新日期：2004-03-01 00:00:00
abstract：:Five years ago a follow-up study of first rib resections disclosed a recurrence rate of over 15%. Many patients were reexplored supraclavicularly, and in every case the anterior scalene muslce was found to be reattached to the bed of the first rib. Scalenectomy invariably was successful, which led to this study of sca...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:In this study we describe the investigation and treatment of 14 patients with primary hepatocellular carcinoma. Patients were treated with intra-arterial infusion of iodized oil and doxorubicin hydrochloride. Five of these patients were alive after 1 year. Twelve patients showed a fall in alpha-fetoprotein, and in sev...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1991-06-01 00:00:00
abstract：:The effect of cimetidine and ranitidine (histamine type-2 receptor antagonists) on the production of interleukin-2 (IL-2) by mitogen-activated, normal murine spleen cells was studied in vitro. Cimetidine (10(-4) mol/L to 10(-6) mol/L) increased IL-2 production to a maximal 8.8 +/- 1.6 U (IL-2 activity), as compared wi...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1987-08-01 00:00:00
abstract：BACKGROUND:Postoperative pancreatic fistula represents the most important complication after distal pancreatectomy. The aim of this study was to evaluate the use of a preoperative endoscopic injection of botulinum toxin into the sphincter of Oddi to prevent postoperative pancreatic fistula (German Clinical Trials Regis...
journal_title：Surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.surg.2016.09.005
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND:Small bowel neuroendocrine tumors (SBNETs) present frequently with metastases, yet little is known about the molecular basis of this progression. This study sought to identify the serial differential expression of genes between normal small bowel, primary small bowel neuroendocrine tumors, and liver metastas...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2017.07.031
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:The quick parathyroid hormone assay (QPTH) reliably measures intact parathyroid hormone (iPTH) levels intraoperatively. The accuracy in predicting postoperative calcemia is related to blood sample timing and the criteria applied. To improve specificity or to decrease the cost of QPTH, several criteria have b...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2003.06.001
更新日期：2003-12-01 00:00:00
abstract：BACKGROUND:Serum concentrations of fatty acid binding protein 4, an adipose tissue fatty acid chaperone, have been correlated with insulin resistance and cardiovascular risk factors. The objective of this study were to assess relationships among Roux-en-Y gastric bypass, intensive lifestyle modification and medical man...
journal_title：Surgery
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.surg.2018.08.007
更新日期：2019-03-01 00:00:00
abstract：:To prevent aneurysm rupture, avoid pseudoaneurysm formation, and preserve intercostal arteries, a new procedure for repair of DeBakey type 3 dissecting aneurysm was developed. Since January 1977, 28 patients have undergone repair of type 3 dissecting aneurysm. Fifteen patients with type 3b underwent this new procedure...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:During a 30-month period 73 patients underwent operation for choledocholithiasis. Thirty-three of these patients (45%) had cholangitis preoperatively. When compared to patients with common duct stones who had no preoperative cholangitis, patients with cholangitis were older (P less than 0.001), more likely to present ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1983-09-01 00:00:00
abstract：BACKGROUND:The glial cell line-derived neurotrophic factor (GDNF) is a member of neurotrophic polypeptide family, which promotes survival and rescue of various neural cells in the central and peripheral nerve systems. We previously reported that GDNF promotes tumor cell invasion in pancreatic cancer cell lines. The pur...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2005.07.007
更新日期：2005-10-01 00:00:00
abstract：:A case of transient cerebral and retinal ischemia caused by giant cell arteritis is reported. Because of the distribution of the disease, the patient was treated with a subclavian to carotid reversed saphenous vein graft. The clinical features of giant cell arteritis affecting the branches of the aortic arch are revie...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1984-06-01 00:00:00
abstract：:Thyroglossal cysts are common developmental abnormalities of the thyroid gland. The malignant form of these cysts, however, is extremely rare, with fewer than 100 cases reported since 1915. Here we add 10 cases of malignant thyroglossal cysts, nine women and one man, encountered at M.D. Anderson Cancer Center, based o...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
abstract：:The recent surge in enthusiasm for laparoscopic surgery has created concern that abdominal insufflation with carbon dioxide produces a respiratory acidosis. This may be because of both transperitoneal gas absorption and impaired ventilation with increased dead space from elevated intraabdominal pressure. To examine th...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1993-05-01 00:00:00
abstract：BACKGROUND:Early survival after pancreaticoduodenectomy has improved, but its morbidity remains high. The purpose of this study is to determine how the intra-operative (OR) occurrence of major vascular complications affects the outcome of pancreaticoduodenectomy. METHODS:The medical records of 180 consecutive patients...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2002.127688
更新日期：2002-10-01 00:00:00
abstract：:This study was designed to show whether weight-losing cancer patients have an elevated glycerol turnover. Four groups of patients were examined: weight-losing cancer patients, weight-losing patients without cancer, cancer patients without weight loss, and weight-stable and well-nourished hospitalized control patients....
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1985-02-01 00:00:00
abstract：BACKGROUND:Lung contusion (LC) is a unique direct and focal insult that is considered a major risk factor for the initiation of acute lung injury and acute respiratory distress syndrome. We have shown recently that consumption of nitric oxide (due to excess superoxide) resulting in peroxynitrite formation leads to decr...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2013.05.023
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:The mortality rate for abdominal vena caval injuries remains high. We examined the experience of a level I trauma center to determine factors significant to the outcome in these injuries. METHODS:Forty-seven patients were identified in a retrospective review (1989 to 1999) of patients were identified with a...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2000.108054
更新日期：2000-10-01 00:00:00
abstract：:A quantitative directional Doppler system was used to determine blood flow in 8 mm. aortoaortic Dacron grafts in dogs. The Doppler was calibrated with frequency standards and the output was integrated for one minute intervals. With the probe held at an angle of 60 degrees to the flow axis, the average frequency of the...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1976-05-01 00:00:00
abstract：BACKGROUND:This study was performed to determine whether there is a significant association between abdominal aortic aneurysms (AAAs) and malignancy and to determine the impact of malignancy on late survival in patients with AAA. METHODS:We studied 126 men undergoing AAA repair and compared them with 99 men undergoing...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1998-02-01 00:00:00
abstract：BACKGROUND:Enthusiasm for neoadjuvant therapy is growing from the emerging consensus that pancreatic cancer is a systemic disease at the time of diagnosis. Those who remain in favor of upfront surgery often cite the lack of reported data to support alternative treatment sequencing. We therefore report the results of al...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2015.09.018
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Transplantation of pancreatic islets is an effective treatment for select patients with type 1 diabetes. Improved cellular therapy results may be realized by altering the gene expression profile of transplanted islets. Current viral and nonviral vectors used to introduce nucleic acids for gene regulation hol...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2010.05.013
更新日期：2010-08-01 00:00:00
abstract：:To clarify the physiopathologic mechanism leading to a marked increase in aromatic amino acids (AAA) in acute hepatic failure (AHF), we compared two experimental models of AHF. Ten pigs were submitted to one-stage hepatic devascularization (group A); in eight other pigs total hepatectomy was performed (group B). The a...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1981-09-01 00:00:00
abstract：BACKGROUND:In an attempt to prevent overly aggressive treatment of low-risk thyroid cancers, the American Thyroid Association changed guideline recommendations in late 2015 to state that either hemithyroidectomy or total thyroidectomy are acceptable operations for these patients. We hypothesized that surgeons would inc...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2019.03.002
更新日期：2019-09-01 00:00:00
abstract：:A clinical observation that patients with aortoiliac occlusive disease have a high aortic bifurcation serves as the stimulus for this study. A review of 100 consecutive abdominal aortograms revealed that patients with occlusive disease had an average bifurcation angle of 38 degrees and those with normal studies or ane...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1982-06-01 00:00:00
