The histopathological changes in irradiated vs. nonradiated tissue-expanded skin in the porcine model.

Abstract:

:This study examined the histological changes following irradiation on nonexpanded and tissue-expanded pigskin. Six Yorkshire pigs received 4860 cGy radiation to one flank with the opposite side serving as the control. A histopathological comparison of tissue expansion in irradiated tissue to nonradiated tissue showed a reduction in the thickness of the dermal and subcutaneous layers, with less prominent rete ridges and a thicker stratum spinosum (p < 0.05). Nonexpanded irradiated tissue showed a reduction of thickness in the dermis and subcutaneous layer, less prominent rete ridges, and a thicker stratum spinosum layer (p < 0.05) when compared with nonradiated tissue. Tissue-expanded irradiated tissue showed no significant differences (p > 0.05) in any of these parameters when compared with nonexpanded irradiated tissue. This study demonstrates that radiation produced a significant change in porcine skin, but tissue expansion did not further alter the histological changes associated with irradiation.

journal_name

Ann Plast Surg

authors

Kao JT,Dagum AB,Mahoney JL,Gardiner GW,Beaton D

doi

10.1097/00000637-199709000-00011

subject

Has Abstract

pub_date

1997-09-01 00:00:00

pages

287-91

issue

3

eissn

0148-7043

issn

1536-3708

journal_volume

39

pub_type

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