Abstract:
:Capsular contracture is one of the most common complications resulting from implants placed during mammoplasty and rhinoplasty, and there is no definitive solution or a method for preventing it. Recent reports suggest that botulinum toxin A (BoTA) is effective at reducing keloid scars clinically. Peri-implant capsules are histologically similar to keloid scars and hypertrophic scars. Therefore, we hypothesized that BoTA may reduce peri-implant capsule formation.To test our hypothesis, we divided 24 male Sprague-Dawley rats into an experiment group and a control group. We created two 15 × 15-mm subpanniculus pockets in each rat. Botulinum toxin A (0.5 mL; 5 U) was injected into the carnosa layer of the experimental group's pockets and 0.5 mL normal saline was similarly injected in the control group. Hemispherical silicone implants, 15 mm in diameter, were inserted into the pockets. After 6 weeks, the peri-implant capsule was excised and examined by histologic evaluation, immunohistochemical stain, scanning electron microscope, and real-time polymerase chain reaction.Capsular thickness, number of inflammatory cells, number of vessels, and transforming growth factor β1 expression were reduced in the experimental group compared to the control group (P < 0.01). The experimental group's collagen pattern was loose and well organized. The total myofibroblast content was lower in the experimental group than in the control group; however, this difference was not statistically significant (P = 0.32). Additionally, the experimental group had a smaller fibrosis index than the control group (P < 0.05).Our results suggest that BoTA may provide an alternative treatment for reducing capsule formation and preventing contracture, and further studies may reveal the mechanism of action.
journal_name
Ann Plast Surgjournal_title
Annals of plastic surgeryauthors
Kim YS,Hong JW,Yoon JH,Hwang YS,Roh TS,Rah DKdoi
10.1097/SAP.0b013e318295de95subject
Has Abstractpub_date
2015-04-01 00:00:00pages
488-95issue
4eissn
0148-7043issn
1536-3708journal_volume
74pub_type
杂志文章abstract:BACKGROUND:Whether postoperative care in the intensive care unit (ICU) is a necessity for patients undergoing head and neck free flap reconstruction remains debatable. In August 2012, our institute initiated a policy to care for these patients in the ICU, opposed to the previous policy of care in the ward. Thus, we use...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001301
更新日期:2018-02-01 00:00:00
abstract::Internal and external diameters of sections of radial and ulnar arteries obtained from fresh cadavers were measured. Statistical analysis of the results obtained shows significant correlation (p less than 0.05). The wide range of values obtained suggests that, despite this degree of correlation, the internal diameter ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198709000-00006
更新日期:1987-09-01 00:00:00
abstract::Incomplete unilateral cleft lips show a wide range of deformities, ranging from microform to near-complete clefts. Because there are different amounts and qualities of tissue present on the cleft and non-cleft sides, surgical approaches should make distinctions based on the remnant tissue. A new procedure using an upp...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e318295dceb
更新日期:2015-03-01 00:00:00
abstract::There is still controversy about the correlation of thrombocytosis and thrombosis complication. Using a rodent splenectomy-induced thrombocytosis model and a thrombogenic endothelial damage model (inverted suture resulting in an intraluminal thrombogenic adventitia of divided femoral artery), the authors investigated ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200301000-00010
更新日期:2003-01-01 00:00:00
abstract::Soft-tissue defects in the area of the periolecranon may be a source of concern to the reconstructive surgeon who aims for durable protection with a minimum of drawbacks. Lamberty and Cormack described the antecubital fasciocutaneous flap both as a local transposition and as a free flap. The island version of this fla...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199809000-00005
更新日期:1998-09-01 00:00:00
abstract::Peripheral nerve gap injuries continue to present a clinical challenge to today's surgeons. One method of surgical repair, implantation of acellular allografts, has been developed with the aim of bridging the gap with a cadaveric graft after removal of its cellular components, thereby accelerating axonal regeneration ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001464
更新日期:2018-08-01 00:00:00
abstract::Patients with factitious physical disorders can present with a myriad of signs and symptoms. Common presentations include persistent wounds and abscesses that are often treated by plastic surgeons. Because these individuals are surreptitiously trying to maintain their illness, rather than recover, adverse outcomes are...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e318049cc41
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Ideal acellular dermal matrices (ADM) for breast reconstruction exhibit native extracellular matrix (ECM) structure to allow rapid biointegration and appropriate mechanical properties for desired clinical outcomes. In a novel in vivo model of irradiated breast reconstruction, we describe the cellular and vas...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002277
更新日期:2020-06-01 00:00:00
abstract::The gastrocnemius muscle flap has gained wide acceptance as a reconstructive technique for management of wounds of the knee and proximal tibia. The use of the muscle as a pedicle flap to the distal and middle femur has not been well quantified, and the proximal rotation arc has been underestimated. We report the use o...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199504000-00014
更新日期:1995-04-01 00:00:00
abstract:BACKGROUND:In male-to-female genital sex reassignment surgery, the clitoris, its prepuce, and the labia minora remain among the most difficult structures to construct. We describe the authors' clitoroplasty and vulvoplasty technique. METHODS:All patients who underwent male-to-female sex reassignment surgery at a singl...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001532
更新日期:2018-10-01 00:00:00
abstract::Double-breasted closure of the skin is achieved by deepithelialization of 1 edge of a wound and advancement of the opposite edge over this deepithelialized area. Such closure may prevent contamination or exposure of the implant in cases where immediate breast reconstruction with prosthetic material is obtained after s...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000174362.35948.65
更新日期:2005-09-01 00:00:00
abstract::The use of external devices for cranial suspension or immobilization may facilitate the transfer of skin grafts or flaps needed for scalp coverage. Skull tongs are readily available in any trauma center. Following composite tissue transfer to the skull, skull tongs can prevent compromise of the microanastomoses or the...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198901000-00015
更新日期:1989-01-01 00:00:00
abstract::Many techniques for cleft lip repair have been reported, but these techniques do not consider the contour lines of the upper lip and, in fact, destroy them. The upper lip has complicated contour lines including the vermilion free margin, vermilion border, upper lip horizontal groove (upper lip groove), philtrum (dimpl...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199109000-00008
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:Management of the nipple-areola complex is an important issue in primary breast reconstruction. When nipple-sparing mastectomy is not suitable, alternatives are immediate nipple-areola complex replantation and delayed reconstruction. The aim of this study was to examine whether patients benefit more from nip...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000883
更新日期:2017-04-01 00:00:00
abstract::Plastic surgeons have traditionally perceived male patients as more psychologically disturbed than female patients. This study employed a matched sample design to explore the psychosocial experiences of 50 male and 50 female elective cosmetic surgery and cosmetic dentistry patients. It also aimed to compare male and f...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e3181a72f50
更新日期:2010-06-01 00:00:00
abstract::The growth of vascularized onlay bone (autogenous) transfers on the skulls of 27 newborn New Zealand white rabbits was studied. Freeze-dried bone weight in control newborns and control adults (group 1) was compared with that in experimental adult animals (group 2). In the experimental group, the bone was transferred o...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198706000-00008
更新日期:1987-06-01 00:00:00
abstract::Superiorly based pharyngeal flaps (PFs) are commonly used for the treatment of velopharyngeal insufficiency (VPI) in patients with cleft palate. However, failure may occur with recurrence of hypernasality and surgical revision may be necessary. Hemisphincter pharyngoplasty using either unilateral or bilateral posterio...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e3181c71063
更新日期:2010-08-01 00:00:00
abstract::Medical photography of body contouring patients often requires complete nudity, placing patients in a vulnerable situation. We investigated patient perspectives on full body photography in an effort to better protect the patients and enhance comfort with the photography process. Sixty-five massive weight loss patients...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31824f2227
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Patients with hormone receptor-positive breast tumors receive hormonal therapy with either selective estrogen receptor modulators (SERMs) (eg, tamoxifen) or aromatase inhibitors (AIs) (eg, anastrozole) for 5 to 10 years. Patients are using these therapies frequently during breast reconstruction. Literature i...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002394
更新日期:2020-10-01 00:00:00
abstract::Individuals with gender dysphoria often seek medical interventions, such as hormone treatment and surgery, to live as their identified gender. Cross-sex hormone therapy typically consists of various estrogen formulations which confer varying risks of venous thromboembolism (VTE). Currently, there is no standard practi...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002300
更新日期:2021-01-01 00:00:00
abstract::The nasal reconstruction in 8 patients and cheek reconstruction in 1 using a free flap from the deltoid region has been successfully undertaken in our department since August 1987. The flap has a direct cutaneous artery--the acromial artery--as its vascular axis. The experiences and a brief anatomical review of the do...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198907000-00003
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:Currently no brief and objective screening protocol exists to assist surgeons and dentists in the identification of patients who are likely to report unsatisfactory outcomes after cosmetic surgery interventions. The aims of this study were to (1) investigate the relationship between postoperative dissatisfac...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e3181d50e54
更新日期:2011-01-01 00:00:00
abstract::Pitanguy conducted a series of anatomic studies on the dermocartilaginous ligament of the nose. However, information on its structure is as yet insufficient. In addition, some of the histologic findings described by Pitanguy are controversial. The present study was undertaken to clarify the anatomy of the dermocartila...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e318031c1b7
更新日期:2007-10-01 00:00:00
abstract::A 16-year-old male with fibrous dysplasia, in which rapidly increasing proptosis of the left eye was induced by a mucocele behind the globe, is reported. The mucocele was removed and the expanded bone was completely recontoured back to normal dimensions with the aid of an acrylic skull replica fabricated preoperativel...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199802000-00015
更新日期:1998-02-01 00:00:00
abstract::Severe, work-related hand injuries are often accompanied by a significant number of psychological symptoms that are frequently associated with posttraumatic stress disorders. These symptoms occur in the following four domains of psychological functioning: cognitive, affective, physiological, and behavioral. This study...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199212000-00010
更新日期:1992-12-01 00:00:00
abstract::A new genioplasty technique has been described and performed on 16 patients since 1995. The technique has been developed to avoid some undesired results of the current osseous genioplasty techniques and to achieve a more natural appearance in advancement genioplasty. According to the authors' technique, a rectangular ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:
更新日期:1999-08-01 00:00:00
abstract::Isolated dorsoradial capsule injuries of the thumb metacarpophalangeal joint are different from those associated with collateral ligament disruption. Early suspicion of this rare injury is important because, if overlooked, ulnarward subluxation of extensor pollicis longus tendon can develop. Functionally, active thumb...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001202
更新日期:2018-02-01 00:00:00
abstract::Since 1998, 42 hand transplants in 30 patients have been performed in countries such as France, United States, China, Austria, Malaysia, Italy, Belgium, Poland, Spain, and Germany. Now, with recent improvements in immunosuppression, the clinical applicability may expand and the ethical obstacles may soon be overcome, ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/SAP.0b013e31818d45e9
更新日期:2009-09-01 00:00:00
abstract::The development of the external oblique rectus musculofascial turnover flap has recently received a great deal of attention. With this method, the upper part of the external oblique muscle is lifted off the lower thoracic wall along with a segment of the rectus muscle, pedicled in the sixth intercostal space and subse...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199101000-00015
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Placement of suction drainage in submuscular pockets is routinely performed in breast reconstruction. Days of drain permanence (DDP) are associated with hospital stay and related health care costs. The aims of this study are to retrospectively compare data related to DDP and total drainage volume between hig...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001246
更新日期:2018-04-01 00:00:00