当前位置： SCI文献检索 > ANNALS OF PLASTIC SURGERY期刊下所有文献 > High risk of rhabdomyolysis and acute kidney injury after traumatic limb compartment syndrome.

High risk of rhabdomyolysis and acute kidney injury after traumatic limb compartment syndrome.

Abstract：

PURPOSE:Rhabdomyolysis often occurs after traumatic compartment syndrome, and high morbidity and mortality have been reported with the acute kidney injury that develops subsequently. We focused on the risk factors for rhabdomyolysis and acute kidney injury in patients with traumatic compartment syndrome. We also analyzed the relation between renal function and rhabdomyolysis in these patients. MATERIALS AND METHODS:A retrospective chart review was conducted from January 2006 to March 2012. Inpatients with traumatic compartment syndrome were included. We evaluated patients' demographics, history of illicit drugs use or alcohol consumption, mechanism of injury, symptoms, serum creatine kinase levels, and kidney function. RESULTS:A total of 52 patients with a mean age of 40.9 years were included; 23 patients had rhabdomyolysis (44.2%), of which 9 patients developed acute kidney injury (39.1%). Significant predictive factors for rhabdomyolysis were history of illicit drugs or alcohol use (P=0.039; odds ratio, 5.91) and ischemic injury (P=0.005). We found a moderate correlation between serum creatine kinase levels and serum creatinine levels (R=0.57; P<0.0001). The correlation coefficient (R) between serum creatine kinase levels and the estimated creatinine clearance rate was -0.45. Rhabdomyolysis was a predisposing factor for acute kidney injury (P=0.011; odds ratio, 8.68). Four patients with rhabdomyolysis required a short period of renal replacement therapy. CONCLUSION:A high percentage of patients with traumatic compartment syndrome developed rhabdomyolysis (44.2%). Patients with rhabdomyolysis had a higher possibility of developing acute kidney injury (39.1%), and rhabdomyolysis was correlated to renal function. Early diagnosis, frequent monitoring, and aggressive treatment are suggested once compartment syndrome is suspected. The overall prognosis is good with early diagnosis and proper treatment.

journal_name

Ann Plast Surg

journal_title

Annals of plastic surgery

authors

Tsai WH,Huang ST,Liu WC,Chen LW,Yang KC,Hsu KC,Lin CT,Ho YY

doi

10.1097/SAP.0000000000000460

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

S158-61

eissn

0148-7043

issn

1536-3708

journal_volume

74 Suppl 2

pub_type

杂志文章

在线工具

High risk of rhabdomyolysis and acute kidney injury after traumatic limb compartment syndrome.