Abstract:
BACKGROUND:Application of collagen products to wounds has been shown to improve wound healing. Using a collagen-based hydrogel (cHG) capable of cellular support previously developed by our laboratory, we hypothesize that our hydrogel will increase the speed of wound healing by providing a 3-dimensional framework for cellular support, increasing angiogenesis and cell-proliferation at the wound bed. METHODS:Two, 10-mm excisional wounds were created over the dorsum of 12 male, genetically modified Zucker diabetic rats. Wounds were splinted open to limit healing by wound contracture. One wound was treated with an occlusive dressing (OD), whereas the adjacent wound was treated with an OD plus cHG. Occlusive dressings were changed every other day. Hydrogel was applied on day 2 and every 4 days after until complete wound closure. Rate of wound closure was monitored with digital photography every other day. Wounds were harvested at days 10 and 16 for histological and immunohistochemical analysis. RESULTS:Wound closure was significantly faster in cHG-treated wounds compared with OD-treated wounds. By day 10, cHG-treated wounds achieved 63% wound closure, compared with 55% wound closure in OD-treated wounds (P < 0.05). By day 16, cHG-treated wounds achieved 84% wound closure, compared with 68% wound closure in OD-treated wounds (P < 0.05).Histologically, wound depth was not different between the cHG and OD groups on days 10 and 16. However, wound length was significantly less in the cHG group compared with the OD group (P < 0.05) consistent with digital photographic analysis. Immunohistochemical analysis for RECA-1 demonstrated that blood vessel density in the wound bed was 2.3 times higher in the cHG group compared with the OD group (P = 0.01) on day 16. Cell proliferation was 3.8 times higher in the cHG group versus the OD group (P < 0.05) on day 10. CONCLUSIONS:Collagen-based hydrogel-treated wounds demonstrated significantly improved healing compared with control. The thermoresponsive feature of collagen hydrogel and its structural stability at body temperature demonstrate promising clinical potential as a vehicle for the delivery of therapeutic cells to the wound bed.
journal_name
Ann Plast Surgjournal_title
Annals of plastic surgeryauthors
Williams T,Sotelo Leon D,Kaizawa Y,Wang Z,Leyden J,Chang J,Fox PMdoi
10.1097/SAP.0000000000002380subject
Has Abstractpub_date
2020-09-01 00:00:00pages
290-294issue
3eissn
0148-7043issn
1536-3708journal_volume
85pub_type
杂志文章abstract::To determine the possible beneficial effect of postoperative splint immobilization after open carpal tunnel release, we performed a prospective, randomized study comparing 2 weeks of postoperative wrist splinting versus a bulky dressing only. Forty patients with 43 carpal tunnel releases were evaluated. There were no ...
journal_title:Annals of plastic surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000637-199507000-00004
更新日期:1995-07-01 00:00:00
abstract::Anterolateral ankle pain can persist despite the best care of sprains or fractures. It is possible that this pain is related to stretch or traction injuries to the nerves that innervate the subtalar joint. If this were true, identification of these nerve branches by local anesthetic block would provide an indication t...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200111000-00005
更新日期:2001-11-01 00:00:00
abstract::An evaluation of 220 cases of frontocranial remodeling for craniosynostosis is reported. The follow-up period was 10 years for children, 7 years for infants. The principles of the craniofacial techniques described in 1974 [4] and 1978 [3] were not modified; only variations were added. The floating forehead [5] concept...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198501000-00009
更新日期:1985-01-01 00:00:00
abstract::Plastic surgeons with a practice that includes breast augmentation, breast reduction, and breast reconstruction should have a working knowledge of both genetic and environmental breast cancer risk factors and of risk stratification of these patients. Specific tests to determine genetic susceptibility to certain cancer...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200045050-00017
更新日期:2000-11-01 00:00:00
abstract::A review of the English medical literature over the last 20 years reporting on flexor profundus lacerations revealed only 55 reported cases of zone I flexor profundus lacerations in children. The standard repair technique in young children (5-10 years of age) has been either tendon reinsertion into bone (usually Bunne...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31820e0e19
更新日期:2012-01-01 00:00:00
abstract::Despite many advances in reconstructive techniques, the full-thickness scalp defect remains a difficult problem for the reconstructive surgeon. Patient and disease-specific factors occasionally make reconstruction with a dermal regeneration template (DRT) an attractive option when other methods are less advised. Altho...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e318243390b
更新日期:2012-05-01 00:00:00
abstract::Hair transplantation involves the transplantation of hair, beard, eyebrows, eyelashes, and pubic hair. Based on our experience, the aesthetic result of hair transplantation mainly relies on 4 indicators, including selection of the donor site, direction and angle of grafted hairs, density, and survival rate of implante...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000778
更新日期:2016-02-01 00:00:00
abstract::This study evaluated the outcomes of extensor indicis proprius (EIP) transfer based on varying degrees of thumb extension after EIP transfer and elongation of the EIP. A total of 24 cases with extensor pollicis longus (EPL) ruptures who underwent EIP to EPL transfer were analyzed prospectively. The EIP transfer was pe...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,随机对照试验
doi:10.1097/SAP.0000000000000593
更新日期:2015-12-01 00:00:00
abstract::This study evaluated the recipient and donor site complications associated with breast reconstruction using a deep inferior epigastric artery perforator flap (DIEAP) flap compared with a free TRAM flap. The charts of 108 patients who underwent breast reconstruction using these techniques were reviewed. There were 130 ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000201549.83738.42
更新日期:2006-04-01 00:00:00
abstract::This reconstructive microsurgery course will run yearly and was borne and popularized from its infant meeting the year before, primarily focused on perforator flaps. It is a 2-day course updating residents/registrars to attending physicians/consultants about the most topical advancements in microvascular reconstructiv...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000824
更新日期:2017-01-01 00:00:00
abstract::Since 1998, 42 hand transplants in 30 patients have been performed in countries such as France, United States, China, Austria, Malaysia, Italy, Belgium, Poland, Spain, and Germany. Now, with recent improvements in immunosuppression, the clinical applicability may expand and the ethical obstacles may soon be overcome, ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/SAP.0b013e31818d45e9
更新日期:2009-09-01 00:00:00
abstract::Glomus tumors develop from a thermoregulatory unit called the glomus body which is found in high density within the digits of both the hands and feet. To note, even though less frequently, these tumors can present in extradigital locations. Usually it presents as a small, 1-cm bluish nodule. Glomangioma (multiple glom...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000222729.59856.e1
更新日期:2006-10-01 00:00:00
abstract::The split-thickness skin graft (STSG) donor site dressing has been an inconclusive topic. Each of the Hydrofiber (Aquacel, ConvaTec A Bristol-Myers Squibb Company, Deeside, UK) and silver dressings have applied in many types of wound care with favorable outcomes. Our study compared the ionic silver-containing Hydrofib...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31818a65e9
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:Post-burn cicatricle contractures of neck pose a challenge for plastic and reconstructive surgeons. To improve functional and cosmetic results, and to minimize the donor-site morbidity, we use pre-expanded cervico-acromial fasciocutaneous flap based on the supraclavicular artery as a feasible choice for resur...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000245
更新日期:2014-09-01 00:00:00
abstract::Postbariatric patients undergoing abdominoplasties were retrospectively analyzed to correlate postoperative local complications with the 2 most commonly used techniques of raising the abdominal flap: diathermocoagulation versus scalpel. All patients undergoing body-contouring abdominoplasties were included. Excluded w...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e3181856d85
更新日期:2009-06-01 00:00:00
abstract::The etiology of keloid formation is diverse. They are characterized grossly as thick scar tissue that extends beyond the boundaries of the original wound. Histologically, keloids are composed of excessive collagen with an abnormally large number of partially or totally occluded microvessels. This occlusion of keloid m...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199905000-00009
更新日期:1999-05-01 00:00:00
abstract::Between 1980 and 1990, 35 patients underwent conservative parotidectomy combining a rhytidectomy incision and a superficial musculoaponeurotic system preservation technique to reduce the postoperative incidence of Frey's syndrome. All patients were evaluated by questionnaire for subjective symptoms of gustatory sweati...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199209000-00005
更新日期:1992-09-01 00:00:00
abstract::The purpose of our retrospective study was to evaluate the outcomes of scaphoid fracture nonunion treated with a pronator quadratus pedicled vascularized bone graft and a headless compression screw with regard to early wrist and thumb mobilization. From January 2008 to June 2011, 27 patients (20 men and 7 women; mean ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000025
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Several techniques for vaginal reconstruction after pelvic exenteration such as myocutaneous and myoperitoneal flaps are available. However, the use of a myofascial flap has not been previously described. Thus, the objective of this article is to present our experience of vaginal reconstruction with rectus a...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001578
更新日期:2018-11-01 00:00:00
abstract::One of the 2 patients introduced here had osteoradionecrosis, which has been difficult to reconstruct. The other had a massive adamantinoma that required replacement of the mandible from the midportion of the right ramus to the left angle with the iliac bone using the conventional method. The grafted iliac bone was se...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198105000-00003
更新日期:1981-05-01 00:00:00
abstract::Technically we can divide full-thickness thoracic reconstruction into 2 parts: providing a rigid support and ensuring well-vascularized coverage. Since 1986, the authors' center has had ample experience with bone banks and the use of cryopreserved bone grafts, which led them to consider the possibility of using these ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000099961.00590.9b
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Hematomas after tissue expander immediate breast reconstruction (TE-IBR) pose a significant challenge during the recovery period. In this study, we aim to evaluate whether hematoma formation leads to subsequent complications and how management can impact final reconstructive goals. METHODS:A single-institut...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002343
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Children with giant congenital nevomelanocytic nevi (CNN) are referred to our pediatric burn center for the surgical management of this disfiguring and potentially malignant skin disorder. Use of tissue expanders has contributed significantly in limiting donor site morbidity associated with treatment of gian...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e318095a784
更新日期:2008-03-01 00:00:00
abstract::A total of 97 cases of metastatic basal cell carcinoma have been reported in the literature, 22 of which were metastatic to bone. To date there has been no survival following bone metastasis. A case report of significant long-term survival--over three times the expected--is presented. The treatment described is perhap...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-197912000-00010
更新日期:1979-12-01 00:00:00
abstract:INTRODUCTION:A greater supply of tendinous tissue can be obtained through tissue engineering technology with increasing application of adult stem cells. It is well known that adipose-derived stem cells (ADSCs), found in abundance in adipose tissue, have the same differentiating capacity as mesenchymal stem cells yet ha...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e3182583e99
更新日期:2013-12-01 00:00:00
abstract::Complications of miniplates and screws used for maxillofacial fractures were analyzed, and complications were evaluated in relation to fracture site. Motor vehicle accidents were the cause of all fractures in this study. During the last 7 years (1994-2001), noncompressive titanium miniplates and screws were used for s...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200203000-00006
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:Despite the recent surge in rates of immediate breast reconstruction, there is a paucity of large multicenter studies to compare differences in morbidity after immediate versus delayed breast reconstruction. This study used the National Surgical Quality Improvement Program (NSQIP) to study the association be...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002590
更新日期:2020-11-17 00:00:00
abstract::This study assesses the incidence and outcome of skin-sparing mastectomy (SSM) flap complications after breast reconstruction. The authors performed a retrospective review of 37 consecutive patients undergoing SSM and immediate breast reconstruction, focusing on preoperative demographics, management of complications, ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000046784.70583.e1
更新日期:2003-03-01 00:00:00
abstract::Entrapment of the lateral femoral cutaneous (LFC) nerve as a source of anterolateral thigh dysesthesias has been recognized for 100 years. Despite this historic recognition, its diagnosis today is often delayed, and definitive treatment of refractory cases by surgical decompression rarely reported. This study describe...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
abstract::To investigate a 3-dimensional (3D) model of human brachial plexus including its topography of sensory and motor fascicles with the assistance of the computer technology, 2 brachial plexus were serially horizontally sliced. Each slice was stained by Karnovsky-Roots acetylcholinesterase histochemical method. The staine...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31822f677e
更新日期:2011-12-01 00:00:00