Abstract:
:The etiology of keloid formation is diverse. They are characterized grossly as thick scar tissue that extends beyond the boundaries of the original wound. Histologically, keloids are composed of excessive collagen with an abnormally large number of partially or totally occluded microvessels. This occlusion of keloid microvessels has been hypothesized to contribute to a hypoxic microenvironment within these pathological scars. Vascular endothelial growth factor (VEGF), a potent endothelial cell mitogen, and proangiogenic cytokine have been implicated in normal and pathological wound healing. The purpose of this study was to evaluate the amount of VEGF protein production by fibroblast cell lines derived from keloids and normal human dermal skin in hypoxic compared with normoxic culture conditions. By enzyme-linked immunosorbent protein assay, VEGF was increased in both keloid and normal human dermal fibroblasts in hypoxia over normoxic controls. There was not, however, a significant difference between upregulation of VEGF protein when comparing the keloid and normal fibroblast groups. As the result of the data, alternative hypotheses for hypoxia-induced keloid formation were explored: (1) downstream modulation or signal transduction of VEGF, (2) VEGF production from cells other than fibroblasts, (3) the importance of matrix accumulation stimulated by hypoxia, or (4) increased migration of cells (other than fibroblasts) specific to keloid biology. These hypotheses may help explain the possible role of hypoxia in the pathogenesis of keloid formation. Future studies involving in situ hybridization or immunohistochemical analysis may offer greater insight into the mechanisms underlying keloid formation. Ultimately, our therapeutic goal is the utilization of biomolecular approaches for the suppression of keloid formation.
journal_name
Ann Plast Surgjournal_title
Annals of plastic surgeryauthors
Steinbrech DS,Mehrara BJ,Chau D,Rowe NM,Chin G,Lee T,Saadeh PB,Gittes GK,Longaker MTdoi
10.1097/00000637-199905000-00009subject
Has Abstractpub_date
1999-05-01 00:00:00pages
514-9; discussion 519-20issue
5eissn
0148-7043issn
1536-3708journal_volume
42pub_type
杂志文章abstract::Xeroderma pigmentosum is a relatively rare systemic disease transmitted through an incomplete sex-linked recessive gene. It is characterized by malignant skin degeneration. One of the most effective treatment choices for the malignant changes is full-face resurfacing with skin grafts. Grafts harvested from areas that ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract::The present study describes the techniques available for single-stage sarcoma resection, soft-tissue reconstruction, and radiotherapy for limb preservation in patients who are unable to undergo primary wound closure after a complete soft-tissue resection of their primary sarcoma. From 1989 to 1994, 19 patients (age ra...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199711000-00003
更新日期:1997-11-01 00:00:00
abstract::An extension of the "crane" principle is presented for use in compound frontal defects, and several case histories are described. The procedure would obviously not be possible if a foreign material had been used for the osseous defects, since take of the skin graft depends on circulation through the autogenous bone gr...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198410000-00008
更新日期:1984-10-01 00:00:00
abstract:BACKGROUND:Patients with craniofacial anomalies can have hard and soft tissue deficiencies. In some cases, distraction osteogenesis can restore the bony deficiencies, but the soft tissue contour defect remains problematic. For these patients, the union of distraction osteogenesis and microvascular free flaps (MVFF) can...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000263453.42788.67
更新日期:2007-07-01 00:00:00
abstract:PURPOSE:Little is known about professional burnout among plastic surgeons. Our purpose is to describe its prevalence among a large national sample of plastic surgeons and identify contributing factors. METHODS:A mailed, self-administered survey was sent to 708 plastic surgeons who were randomly sampled from the Americ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000056
更新日期:2014-03-01 00:00:00
abstract::We present an original technique of transposition of the fifth ray by intracarpal osteotomy. After a review of various techniques and their disadvantages, the principles of the procedure are described. It includes a resection of the whole fourth ray and translocation of the fifth ray following a wedge-shaped osteotomy...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198609000-00009
更新日期:1986-09-01 00:00:00
abstract::Lip augmentation is a well tolerated procedure that can lead to a more youthful appearance. Autologous tissue offers the safest and most long lasting results. Recently, a new source of autologous tissue, breast implant capsule, was described in the performance of permanent lip augmentation. Long term data in thirteen ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199803000-00012
更新日期:1998-03-01 00:00:00
abstract::In 8 male white Yorkshire pigs weighing approximately 42 kg each, 12 buttock neurovascular island skin flaps were dissected. Baseline recordings were made of blood flow and O2 consumption in the flap. Two series of experiments were carried out. In control animals (5), the flap was dissected and the "cold" aluminum pla...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198607000-00014
更新日期:1986-07-01 00:00:00
abstract::A patient who sustained frontal sinus fracture and who earlier had undergone an osteoplastic fat obliteration procedure is described. The literature is reviewed and recommendations are made for management of this and other cases of frontal sinus fractures with posterior table involvement. ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/00000637-198608000-00012
更新日期:1986-08-01 00:00:00
abstract::Apert syndrome is characterized by craniosynostosis, central nervous system anomalies, midface hypoplasia, and syndactyly. Current research has focused on genetic and neurologic correlates. Cognitive assessment has been primarily limited to global intellectual evaluations, which can fail to detect the diverse cognitiv...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000149387.95212.df
更新日期:2005-04-01 00:00:00
abstract::Many surgical procedures to improve mandibular contour have been introduced in East Asia. Despite consensus regarding mandible contouring surgery, surgery which includes angle ostectomy and lateral cortex excision, some patients require only mandibular angle ostectomy. The intraoral approach is a widely used method, b...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000216
更新日期:2016-01-01 00:00:00
abstract::The reverse sural artery flap is frequently used for reconstruction of the distal third of the leg, ankle, and heel. The major disadvantage of the flap is compression of the pedicle within the subcutaneous tunnel and venous congestion. Others have cited a decrease in this problem by harvesting a midline cuff of gastro...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Reduction gonioplasty is very popular in East Asia. However, there has been little quantitative criteria for mandibular angle classification or aesthetics. The aim of this study was to investigate the quantitative differences of mandibular angle types and determine the morphologic features of mandibular angl...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001463
更新日期:2018-07-01 00:00:00
abstract::Locoregional recurrent and distant metastases from squamous cell carcinomas, despite multimodality therapy, remain troublesome clinical realities. Discrepancies in success rates of various surgery and radiation treatment regimens dealing with these problems are confusing to the clinician attempting to recommend the mo...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199508000-00010
更新日期:1995-08-01 00:00:00
abstract::Local infection is a rare complication after aesthetic rhinoplasty. In the past serious complications and 1 death have been reported. We present 5 cases of local infection after primary and secondary procedures. Infection seems to have more to do with technical details during an operation, such as the external lateral...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198610000-00007
更新日期:1986-10-01 00:00:00
abstract:BACKGROUND:Whether postoperative care in the intensive care unit (ICU) is a necessity for patients undergoing head and neck free flap reconstruction remains debatable. In August 2012, our institute initiated a policy to care for these patients in the ICU, opposed to the previous policy of care in the ward. Thus, we use...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001301
更新日期:2018-02-01 00:00:00
abstract::Multiple symmetric lipomatosis (MSL) is a rare disease of unknown etiology, characterized by the presence of multiple, symmetrical, noncapsulated lipomas, mostly in the neck and upper trunk. To date, there is no effective medical treatment of MSL. Surgical treatment is based on 2 options, namely, lipectomy and/or lipo...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31827f5295
更新日期:2014-11-01 00:00:00
abstract::Activator protein 1 (AP-1) is thought to play an important role in the expression of genes expressed in response to ischemia-reperfusion injury. In this report, the activation of AP-1 in rat skeletal muscle during reperfusion after a 4-hour ischemic period was studied. AP-1 activation displayed a biphasic pattern, sho...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200212000-00016
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND:According to the American Society of Plastic Surgeons (2007), the number of cosmetic procedures has increased to over 10 million in 2006, representing a 48% increase from 2000. This increase in cosmetic surgery prevalence is paralleled by a surge in reality cosmetic surgery television programming. METHODS:T...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31817e2cb8
更新日期:2009-01-01 00:00:00
abstract::Transverse rectus abdominis musculocutaneous (TRAM) breast reconstruction in patients with advanced breast cancer is controversial. Management of these patients is often complex and consists of surgical extirpation, postoperative radiation, chemotherapy, and in some cases bone marrow transplantation. Few studies have ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.SAP.0000069075.27321.BC
更新日期:2003-06-01 00:00:00
abstract::During the past 10 years, there have been extensive developments in both "island" muscle and musculocutaneous flaps and in "free" microvascular transfers. Competition still exists between these two schools of surgical methodology, even though both methods are known to be complementary and have comparable success rates...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/00000637-198710000-00012
更新日期:1987-10-01 00:00:00
abstract::A 28-year-old woman underwent bilateral subcutaneous mastectomy and immediate reconstruction with silicone gel-filled prostheses. Three months after surgery, she developed an acute pressure sore on one side, owing to prolonged pressure of the insensitive breast against a hard surface. This complication is presented, t...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198502000-00014
更新日期:1985-02-01 00:00:00
abstract::The last 30 years has seen a shift in surgical treatment of breast diseases to less invasive, more conservative treatment options. The mammotome equipment was originally introduced as a diagnostic tool, but advances in technology have extended its role to therapeutic procedures. The mammotome device (8-gauge) is inser...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000095441.40759.1f
更新日期:2004-02-01 00:00:00
abstract::The Parkland formula is currently the most widely used protocol to guide fluid resuscitation of acute burns and has been adapted for pediatric use. We describe 3 novel graphic devices (a nomogram, slide rule, and disc calculator) based on this formula, which have significant advantages over existing graphic and electr...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e3182586d4e
更新日期:2012-09-01 00:00:00
abstract::Beckwith-Wiedemann syndrome (BWS) is a complex overgrowth disorder usually recognized at birth. Children diagnosed with BWS, particularly those with hemihypertrophy, experience an increased risk of developing benign and malignant tumors. This case report presents a 12-year-old girl with BWS and hemihypertrophy who rap...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/sap.0b013e3181b025f6
更新日期:2010-06-01 00:00:00
abstract::Five patients with avulsed scalps were treated with replantation between 1992 and 1998. All patients were women age 20 to 36 years. The percentage of the avulsed scalp ranged from 50% to 100% of the whole scalp. The vessels chosen for anastomosis were the superficial temporal artery, occipital artery, and superficial ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200044040-00002
更新日期:2000-04-01 00:00:00
abstract::Tissue engineering is an interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function. This field has enjoyed tremendous growth in the past 10 years fuelled by its potential role in regenerating ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/SAP.0b013e3181788ec9
更新日期:2009-01-01 00:00:00
abstract::Many techniques for cleft lip repair have been reported, but these techniques do not consider the contour lines of the upper lip and, in fact, destroy them. The upper lip has complicated contour lines including the vermilion free margin, vermilion border, upper lip horizontal groove (upper lip groove), philtrum (dimpl...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199109000-00008
更新日期:1991-09-01 00:00:00
abstract::This study has demonstrated that microcrystalline collagen is useful for controlling hemorrhage from an area where microvascular anastomoses are being performed, and that microcrystalline collagen does not adversely affect patency rates of microvascular repairs even when applied directly to the anastomosis itself. ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198212000-00004
更新日期:1982-12-01 00:00:00
abstract:OBJECTIVE:Forward-looking infrared (FLIR) thermography technology uses a handheld camera that measures skin infrared emissivity, captures photographs, and can be analyzed through specialized software. Forward-looking infrared images can be used to analyze and correlate burn wound temperature with burn depth, burn progr...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001363
更新日期:2018-04-01 00:00:00