The effect of hypermetabolism induced by burn trauma on the ethanol-oxidizing capacity of the liver.

abstract：OBJECTIVE:Trauma induces a complex immune response that requires a systems biology research approach. Here, we used a novel technology, mass cytometry by time-of-flight, to comprehensively characterize the multicellular response to trauma. DESIGN:Peripheral blood mononuclear cells samples were stained with a 38-marker...

journal_title：Critical care medicine

authors： Seshadri A,Brat GA,Yorkgitis BK,Keegan J,Dolan J,Salim A,Askari R,Lederer JA

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVES:To describe the most common serious adverse effects and organ toxicities associated with emerging therapies for cancer that may necessitate admission to the ICU. DATA SOURCES AND STUDY SELECTION:PubMed and Medline search of relevant articles in English on the management of adverse effects of immunotherapy f...

journal_title：Critical care medicine

authors： Gutierrez C,McEvoy C,Munshi L,Stephens RS,Detsky ME,Nates JL,Pastores SM

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Sepsis is associated with a marked depression of cellular immune function. The steroid hormone dehydroepiandrosterone (DHEA) is proposed to have immunoenhancing activities. We, therefore, investigated the effect of DHEA on the mortality rate and cellular immune functions in an experimental model of sepsis. D...

journal_title：Critical care medicine

authors： Oberbeck R,Dahlweid M,Koch R,van Griensven M,Emmendörfer A,Tscherne H,Pape HC

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVE:This survey was designed to study current practices in the monitoring and treatment of patients with severe head injury in the United States. DATA SOURCES:The collected data represent answers to telephone interviews of nurse managers, clinical specialists, and staff nurses specializing in neurotrauma care at...

journal_title：Critical care medicine

authors： Ghajar J,Hariri RJ,Narayan RK,Iacono LA,Firlik K,Patterson RH

更新日期：1995-03-01 00:00:00

abstract：OBJECTIVE:To describe the incidence of non-neurologic organ dysfunction and its association with outcome in patients with severe traumatic brain injury admitted to intensive care. DESIGN:Observational cohort study. SETTING:Foothills Medical Centre, which is the only neurosurgical service in southern Alberta (populati...

journal_title：Critical care medicine

authors： Zygun DA,Kortbeek JB,Fick GH,Laupland KB,Doig CJ

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:To determine whether blood lactate, base deficit, or oxygen-derived hemodynamic variables correlate with morbidity and mortality rates in a clinically-relevant LD50 model of penetrating trauma. DESIGN:Prospective, controlled study. SETTING:University research laboratory. SUBJECTS:Anesthetized, mechanically...

journal_title：Critical care medicine

authors： Moomey CB Jr,Melton SM,Croce MA,Fabian TC,Proctor KG

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:To assess the agreement between computed tomography and transcranial sonography in patients after decompressive craniectomy. DESIGN:Prospective study. SETTING:The medical intensive care unit of a university-affiliated teaching hospital. PATIENTS:Thirty head-injured patients consecutively admitted to the in...

journal_title：Critical care medicine

authors： Caricato A,Mignani V,Bocci MG,Pennisi MA,Sandroni C,Tersali A,Antonaci A,de Waure C,Antonelli M

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Septic shock represents the major cause of infection-associated mortality in the intensive care unit. The possibility that combination antibiotic therapy of bacterial septic shock improves outcome is controversial. Current guidelines do not recommend combination therapy except for the express purpose of broa...

journal_title：Critical care medicine

authors： Kumar A,Zarychanski R,Light B,Parrillo J,Maki D,Simon D,Laporta D,Lapinsky S,Ellis P,Mirzanejad Y,Martinka G,Keenan S,Wood G,Arabi Y,Feinstein D,Kumar A,Dodek P,Kravetsky L,Doucette S,Cooperative Antimicrobial Thera

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:Cortisol clearance is reduced in sepsis and may contribute to the development of impaired adrenocortical function that is thought to contribute to the pathophysiology of critical illness-related corticosteroid insufficiency. We sought to assess adrenocortical function using computer-assisted numerical modelin...

journal_title：Critical care medicine

authors： Dorin RI,Qualls CR,Torpy DJ,Schrader RM,Urban FK 3rd

更新日期：2015-03-01 00:00:00

abstract：:The relationship between oxygen uptake (Vo2) and delivery (Do2) was examined in 64 patients immediately after cardiopulmonary bypass. In 44 patients with lactate levels below 2.5 mmol/L, Vo2 decreased proportionally when Do2 decreased below 300 ml/min X m2. At a Do2 over this level, Vo2 plateaued at 105 +/- 13 (SD) ml...

journal_title：Critical care medicine

authors： Komatsu T,Shibutani K,Okamoto K,Kumar V,Kubal K,Sanchala V,Lees DE

更新日期：1987-03-01 00:00:00

abstract：OBJECTIVES:We sought to review findings from recent literature on the postresuscitation care of cardiac arrest patients using therapeutic hypothermia as part of nontrial treatment. DESIGN:Literature review. SETTING:Hospital-based environment. SUBJECTS:Patients initially resuscitated from cardiac arrest who underwent...

journal_title：Critical care medicine

authors： Sagalyn E,Band RA,Gaieski DF,Abella BS

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVES:To describe the effectiveness of a comprehensive, interdisciplinary sepsis treatment protocol with regard to both implementation and outcomes and to compare the mortality rates and therapies of patients with septic shock with similar historical controls. DESIGN:Prospective, interventional cohort study with ...

journal_title：Critical care medicine

authors： Shapiro NI,Howell MD,Talmor D,Lahey D,Ngo L,Buras J,Wolfe RE,Weiss JW,Lisbon A

更新日期：2006-04-01 00:00:00

abstract：:The hospital records of 7 patients with severe bronchopulmonary dysplasia (BPD) were reviewed. All patients were ventilator dependent for prolonged periods (mean duration intermittent mandatory ventilation (IMV) 14.3 +/- 3.5 months) but eventually were successfully weaned from mechanical ventilation and sent home. The...

journal_title：Critical care medicine

authors： Morray JP,Fox WW,Kettrick RG,Downes JJ

更新日期：1981-12-01 00:00:00

abstract：OBJECTIVES:To compare the plasma volume (PV) expanding effect of a fast infusion rate with that of a slow infusion rate of a fixed volume of 5% albumin, of the synthetic colloids, 6% hydroxyethyl starch 130/0.4 and 4% gelatin, and of 0.9% NaCl in a rat sepsis model and to compare the plasma-expanding effect among these...

journal_title：Critical care medicine

authors： Bark BP,Persson J,Grände PO

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:To examine the relationship between aminoglycoside disposition kinetics and hemodynamic response to sepsis, as well as vital support therapy, in critically ill patients with sepsis. DESIGN:Cross-sectional study of critically ill patients with sepsis undergoing physiologic and aminoglycoside pharmacokinetic m...

journal_title：Critical care medicine

authors： Lugo G,Castañeda-Hernández G

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:To describe blood conservation strategies for critically ill patients. DATA SOURCES:By using a predefined strategy, we searched the electronic databases of Medline, EMBASE, CINAHL, the Cochrane database of systematic reviews, Cochrane central register of controlled trials, ACP Journal Club, Database of abstr...

journal_title：Critical care medicine

authors： Fowler RA,Berenson M

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVES:Extracorporeal cardiopulmonary resuscitation has shown survival benefit in select patients with refractory cardiac arrest but there is insufficient data on the frequency of different types of brain injury. We aimed to systematically review the prevalence, predictors of and survival from neurologic complicati...

journal_title：Critical care medicine

authors： Migdady I,Rice C,Deshpande A,Hernandez AV,Price C,Whitman GJ,Geocadin RG,Cho SM

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:To determine the specific effect of peak volume history pressure on the inflation limb of the pressure-volume curve and peak pressure-volume curve pressure on the deflation limb of the pressure-volume curve. DESIGN:Prospective assessment of pressure-volume curves in saline, lung lavage injured sheep. SETTIN...

journal_title：Critical care medicine

authors： Nishida T,Suchodolski K,Schettino GP,Sedeek K,Takeuch M,Kacmarek RM

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVE:Sepsis and severe trauma result in endothelial activation and damage. The activated endothelium expresses adhesion receptors that control leukocyte trafficking. After activation, some adhesion molecules are also released into plasma as soluble forms. The present study was designed to compare the expression of...

journal_title：Critical care medicine

authors： Leone M,Boutière B,Camoin-Jau L,Albanèse J,Horschowsky N,Mège JL,Martin C,Dignat-George F

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVES:To determine whether delirium during ICU stay is associated with long-term mental health problems defined as symptoms of anxiety, depression, and posttraumatic stress disorder. DESIGN:Prospective cohort study. SETTING:Survey study, 1 year after discharge from a medical-surgical ICU in the Netherlands. PAT...

journal_title：Critical care medicine

authors： Wolters AE,Peelen LM,Welling MC,Kok L,de Lange DW,Cremer OL,van Dijk D,Slooter AJ,Veldhuijzen DS

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVES:To assess trends in the use of extracorporeal membrane oxygenation for poisoning in the United States. DESIGN:Retrospective cohort study. SETTING:The National Poison Data System, the databased owned and managed by the American Association of Poison Control Centers, the organization that supports and accred...

journal_title：Critical care medicine

authors： Cole JB,Olives TD,Ulici A,Litell JM,Bangh SA,Arens AM,Puskarich MA,Prekker ME

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:To evaluate if the up-regulation of vascular endothelial growth factor strengthens the protective effect of amniotic fluid stem cells in a renal ischemia-reperfusion injury model. DESIGN:Randomized animal study. SETTINGS:University research laboratory. SUBJECTS:A total of 40 males 12-week-old Wistar rats w...

journal_title：Critical care medicine

authors： Mori da Cunha MG,Zia S,Beckmann DV,Carlon MS,Arcolino FO,Albersen M,Pippi NL,Graça DL,Gysemans C,Carmeliet P,Levtchenko E,Deprest J,Toelen J

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:To define the impact of prehospital hypotension on the dynamic, systemic acute inflammatory response to blunt trauma. DESIGN:Retrospective study. SETTINGS:Tertiary care institution. PATIENTS:Twenty-two hypotensive blunt trauma patients matched with 28 normotensive blunt trauma patients. INTERVENTION:None....

journal_title：Critical care medicine

authors： Almahmoud K,Namas RA,Zaaqoq AM,Abdul-Malak O,Namas R,Zamora R,Sperry J,Billiar TR,Vodovotz Y

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:This study tested the hypothesis that interruption of the renin-angiotensin system with either an angiotensin-converting enzyme inhibitor or a mineralocorticoid receptor antagonist will decrease the prevalence of atrial fibrillation after cardiac surgery. DESIGN:Randomized double-blind placebo-controlled stu...

journal_title：Critical care medicine

authors： Pretorius M,Murray KT,Yu C,Byrne JG,Billings FT 4th,Petracek MR,Greelish JP,Hoff SJ,Ball SK,Mishra V,Body SC,Brown NJ

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND AND METHODS:The purpose of this study was twofold: the development of a chronic model of leukocyte-mediated pulmonary injury and the evaluation of the protective effects of methylprednisolone. Rabbits were inoculated ip with zymosan. Blood gases and circulating leukocytes were evaluated. Survivors were kille...

journal_title：Critical care medicine

authors： Chiara O,Giomarelli PP,Borrelli E,Casini A,Segala M,Grossi A

更新日期：1991-02-01 00:00:00

abstract：OBJECTIVE:To test the short-term physiologic effects (indexes of respiratory effort, ventilation, and gas exchange), leaks, patient-ventilator asynchrony, and comfort of four noninvasive ventilation (NIV) facial, oronasal, or oral interfaces with major differences in internal volume. DESIGN:Prospective, short-term, cr...

journal_title：Critical care medicine

authors： Fraticelli AT,Lellouche F,L'her E,Taillé S,Mancebo J,Brochard L

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:To determine the efficacy of supplemental 25% albumin in reducing morbidity and mortality rates in the surgical intensive care unit (ICU). DESIGN:Prospective, randomized, unblinded clinical study. SETTING:Surgical ICU in a community hospital. PATIENTS:Two hundred nineteen patients with admission circulatin...

journal_title：Critical care medicine

authors： Golub R,Sorrento JJ Jr,Cantu R Jr,Nierman DM,Moideen A,Stein HD

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND AND METHODS:Twelve adult male albino rabbits were assigned alternately to normotensive and hypotensive groups to assess the effect of hypovolemic shock on spontaneous correction of dilutional coagulopathy. All animals underwent dilutional exchange transfusion with 200 mL of rabbit RBCs and 5% human albumin. ...

journal_title：Critical care medicine

authors： Hewson JR,Prodger D,Roberts RS,Davis C,Fuller HD,Gregor P,Thomas EJ,Shragge BW,Russett J,Neame PB

更新日期：1991-02-01 00:00:00

abstract：OBJECTIVE:To compare the outcomes and the short- and long-term complications of percutaneous translaryngeal tracheostomy (TLT) and surgical tracheostomy (ST). DESIGN:Prospective, randomized clinical trial with 1-yr double-blind follow-up. SETTING:A general intensive care unit of a university hospital. PATIENTS:A tot...

journal_title：Critical care medicine

authors： Antonelli M,Michetti V,Di Palma A,Conti G,Pennisi MA,Arcangeli A,Montini L,Bocci MG,Bello G,Almadori G,Paludetti G,Proietti R

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:Rapid fluid loading is standard treatment for hypovolemia. Because volume expansion does not always improve hemodynamic status, predictive parameters of fluid responsiveness are needed. Passive leg raising is a reversible maneuver that mimics rapid volume expansion. Passive leg raising-induced changes in stro...

journal_title：Critical care medicine

authors： Préau S,Saulnier F,Dewavrin F,Durocher A,Chagnon JL

更新日期：2010-03-01 00:00:00