Abstract:
:We studied the changes in brain water diffusion in childhood as seen on diffusion-weighted MRI in 30 children from 1 day of life to 17 years to provide a data base and to investigate the correlation of diffusion changes with known patterns of white matter maturation. The apparent diffusion coefficient (ADC) and apparent anisotropy (AA) were calculated in numerous regions of the brain to include major white matter tracts and gray matter. ADC and AA values were directly related to the structural maturity and compactness of the white matter tracts and changed with aging in a way that predated early myelination markers such as signal change on T1- or T2-weighted images. Diffusion of water is sensitive to structural changes in the brain such as white matter maturation and may be useful in investigating white matter disorders.
journal_name
Neuroradiologyjournal_title
Neuroradiologyauthors
Morriss MC,Zimmerman RA,Bilaniuk LT,Hunter JV,Haselgrove JCdoi
10.1007/s002340050869subject
Has Abstractpub_date
1999-12-01 00:00:00pages
929-34issue
12eissn
0028-3940issn
1432-1920journal_volume
41pub_type
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