Abstract:
INTRODUCTION:Change in tumor size is a frequent endpoint in cancer clinical trials, but whether change in size should be measured using volume on two-dimensional (2D) or three-dimensional (3D) images is not certain. We compared volumetric measurements on post-contrast 2D and high-resolution 3D T1-weighted MR images (T1WI) in evaluating tumor response in glioblastoma multiforme (GBM). METHODS:Tumor volume measurements were performed on 86 MRI studies from 37 adult patients with GBM on post-contrast 5 mm 2D T1WI and isotropic high-resolution T1WI. The means of the two volumes were compared and their association was analyzed. RESULTS:There is no significant difference between volumes measured on 2D and 3D in 86 scans (Z = 0.63, p = 0.53), and a high correlation was revealed between them (r = 0.95, 95% CI: 0.93-0.97, p < 0.001). When the percentage changes were categorized into traditional tumor response criteria (complete response/partial response/stable disease/progressive disease), the kappa coefficient between the volume on 2D and volume on 3D was 0.80 (95% CI: 0.57-1.03, p < 0.05) with an overall agreement of 84%. CONCLUSIONS:Volume on post-contrast 2D T1WI appears comparable to volume on 3D T1WI and should be a practical alternative to volume on 3D in evaluating tumor response.
journal_name
Neuroradiologyjournal_title
Neuroradiologyauthors
Wang MY,Cheng JL,Han YH,Li YL,Dou SW,Yan FS,Shi DPdoi
10.1007/s00234-010-0789-zsubject
Has Abstractpub_date
2011-08-01 00:00:00pages
565-9issue
8eissn
0028-3940issn
1432-1920journal_volume
53pub_type
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