Abstract：
PURPOSE:Determinants of early loss of ischemic tissue (core) or its prolonged survival (penumbra) in acute ischemic stroke (AIS) are poorly understood. We aimed to identify radiological associations of core and penumbra volumes on CT perfusion (CTP) in a large cohort of AIS. METHODS:In the ASTRAL registry (2003-2016), we identified consecutive AIS patients with proximal middle cerebral artery (MCA) occlusion. We calculated core and penumbra volumes using established thresholds and the mismatch ratio (MR). We graded collaterals into three categories on CT-angiography. We used clot burden score (CBS) to quantify the clot length. We related CTP volumes to radiological variables in multivariate regression analyses, adjusted for time from stroke onset to first imaging. RESULTS:The median age of the 415 included patients was 69 years (IQR = 21) and 49% were female. Median admission NIHSS was 16 (11) and median delay to imaging 2.2 h (1.9). Lower core volumes were associated with higher ASPECTS (hazard ratio = 1.08), absence of hyperdense MCA sign (HR = 0.70), higher CBS (i.e., smaller clot, HR = 1.10), and better collaterals (HR = 1.95). Higher penumbra volumes were related to lower CBS (i.e., longer clot, HR = 1.08) and proximal intracranial occlusion (HR = 1.47), but not to collaterals. Higher MR was found in absence of hyperdense MCA sign (HR = 1.28), absence of distal intracranial occlusion (HR = 1.39), and with better collaterals (HR = 0.52). CONCLUSIONS:In AIS, better collaterals were associated with lower core volumes, but not with higher penumbra volumes. This suggests a major role of collaterals in early tissue loss and their limited significance as marker of salvageable tissue.
journal_name
Neuroradiologyjournal_title
Neuroradiologyauthors
Nannoni S,Cereda CW,Sirimarco G,Lambrou D,Strambo D,Eskandari A,Dunet V,Wintermark M,Michel Pdoi
10.1007/s00234-019-02224-xsubject
Has Abstractpub_date
2019-09-01 00:00:00pages
971-978issue
9eissn
0028-3940issn
1432-1920pii
10.1007/s00234-019-02224-xjournal_volume
61pub_type
杂志文章相关文献
NEURORADIOLOGY文献大全abstract：PURPOSE:Seatbelts and airbags are the most important devices protecting drivers from cervical spine injury (CSI) following motor vehicle collisions (MVCs). However, there have been few reports on the radiographic characteristics of CSI sustained by restrained, airbag-deployed drivers. METHODS:A single-center, retrospe...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s00234-018-2114-1
更新日期：2018-12-01 00:00:00
abstract：:It is possible to underestimate the grade of nonenhancing cerebral tumours on conventional contrast-enhanced MRI or CT. Differentiation of high- and low-grade gliomas by measurement of the brain-blood partition coefficient lambda (T lambda) with Xe-enhanced CT (XeCT) has been reported. We assessed the practical applic...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s002340050481
更新日期：1997-09-01 00:00:00
abstract：:Cerebral sparganosis is a rare parasitic CNS disease, producing chronic active granulomatous inflammation. We retrospectively reviewed the clinical data, CT scans and histopathologic specimens in 34 patients with cerebral sparganosis. The majority of the patients (89%) were rural inhabitants; 75% had a history of inge...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/BF00588423
更新日期：1992-01-01 00:00:00
abstract：INTRODUCTION:We present a previously unreported complication following the treatment of a patient with two small, wide-necked, posterior communicating artery aneurysms. METHODS:Endovascular embolization of one aneurysm was performed using a stent-assisted technique. Follow-up angiography 5 months later revealed that a...
journal_title：Neuroradiology
pub_type： 杂志文章,评审
doi：10.1007/s00234-005-0044-1
更新日期：2006-05-01 00:00:00
abstract：:We present a case of plasma cell granuloma involving the dura mater with infiltration of the adjacent brain parenchyma. The radiological and pathological features of this entity are described. ...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/BF02278129
更新日期：1996-05-01 00:00:00
abstract：:Duplication of the vertebral artery is rare. We report two cases in which it was an incidental finding. In the first, duplication of the right vertebral artery was demonstrated by magnetic resonance angiography (MRA) and conventional angiography. The second patient had duplication of the right vertebral artery demonst...
journal_title：Neuroradiology
pub_type： 杂志文章,评审
doi：10.1007/s002340000515
更新日期：2001-06-01 00:00:00
abstract：:Computed tomographic analysis of lesions of the corpus callosum in 13 patients with "inner cerebral trauma" showed significant congruence of linear translation of acceleration and the topographic distribution of such lesions. This congruence permits computed tomography to be used to reconstruct the course of linear tr...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/BF00588158
更新日期：1992-01-01 00:00:00
abstract：:A case of rare intraspinal sparganosis treated by surgical excision is described. In this 59-year-old male with paraparesis and voiding problem, an intradural mass was noted on myelogram. Magnetic resonance (MR) and computed tomographic appearance of spinal and associated cerebral lesion are illustrated and possible r...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/BF00596346
更新日期：1992-01-01 00:00:00
abstract：:Diastematomyelia is an uncommon congenital anomaly of the spine. Four unusual variations of diastematomyelia are presented. These include (1) double diastematomyelia, (2) adult presentation, (3) diastermatomyelia without a septum and unusual termination of two halves of the spinal cord, and (4) recurrence of a fibrous...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/BF00395213
更新日期：1978-01-01 00:00:00
abstract：:A patient presented with the clinical features of a brain stem infarct. MRI confirmed changes of infarction but also revealed an unusual lesion in the left cerebellopontine angle cistern. The evolution of this lesion on MRI, together with angiographic changes, indicated a dissecting aneurysm of the left anterior infer...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s002340000324
更新日期：2000-07-01 00:00:00
abstract：:After cervical myelography by direct puncture at C 1/2 level, 120 patients were randomly allocated to one of two groups, in one the patients were allowed to be fully ambulant and in the other the regimen was bed rest for 24 h. Questionnaires recording the frequency and severity of side effects were completed at interv...
journal_title：Neuroradiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00333297
更新日期：1983-01-01 00:00:00
abstract：:We present the case of a 56-year-old man who complained of numbness in his cheek, and was shown to have a very large partly thrombosed aneurysm of the ipsilateral petrous carotid artery. The radiological findings and differential diagnosis are discussed. Aneurysm of the petrous carotid should be included in the differ...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/BF00343872
更新日期：1989-01-01 00:00:00
abstract：:We describe the evolution of parenchymal cerebral cysticerci on MRI, to assess signs of early cyst degeneration. We studied 15 lesions in four treated and one untreated patient. MRI was performed before therapy and repeated in the 1st month after each course of anticysticercus drugs, every 4 months during the 1st year...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s002340050358
更新日期：1997-01-01 00:00:00
abstract：INTRODUCTION:Toxoplasmosis and lymphoma are common lesions of the central nervous system in patients with AIDS. It is often difficult to distinguish between these lesions both clinically and radiographically. Previous research has demonstrated restricted diffusion within cerebral lymphomas and bacterial abscesses. Howe...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s00234-006-0123-y
更新日期：2006-10-01 00:00:00
abstract：:A technique utilizing dilute water-soluble intrathecal contrast medium is described which allows a full columnar upright examination thereby facilitating sensitive simultaneous myelographic evaluation of the lumbar region and thoracolumbar junction. ...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/BF00348917
更新日期：1987-01-01 00:00:00
abstract：:A rare arterial anastomosis between the right and left internal carotid arteries at the base at the skull, with aplasia of the cervical part of the left internal carotid artery is reported. The case is unusual because, in addition to the vascular anomaly of the carotid artery, there is an aneurysm of the anterior comm...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/BF00336685
更新日期：1980-12-01 00:00:00
abstract：:A patient with an amyloid tumor of the orbit was studied by computed tomographic scanning. The tumor density was 10 delta units unenhanced and 72 units enhanced. ...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/BF00346872
更新日期：1979-09-26 00:00:00
abstract：PURPOSE:Imaging is crucial for management of patients with possible cerebral venous thrombosis (CVT). To evaluate the cost-effectiveness of different noninvasive imaging strategies in patients with possible CVT. METHODS:A decision model based on Markov simulations estimated lifetime costs and quality-adjusted life yea...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s00234-019-02252-7
更新日期：2019-10-01 00:00:00
abstract：:The density of metrizamide injected accidentally into the spinal cord during cervical CT myelography was measured with CT scanning and compared with a series of dilutions of metrizamide scanned with a special phantom. The test suggests that the metrizamide is diluted rapidly in the spinal canal, and in an accidental i...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/BF00342522
更新日期：1985-01-01 00:00:00
abstract：:We report the cranial CT and MRI findings in three children with Lyme disease (neuroborreliosis). The neuroimaging findings in children have been rarely reported. We found cranial MRI far superior to cranial CT. Ring-enhancing lesions have been described in acute disseminating encephalomyelitis and multiple sclerosis ...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/BF00593726
更新日期：1995-10-01 00:00:00
abstract：PURPOSE:For safe deep brain stimulation (DBS) planning, an accurate visualization and localization of vessels is mandatory. Contrast enhanced (ce) MRI depicts both arteries and veins. Computed tomography angiography (CTA) detects arteries with high geometric accuracy. We routinely combine both modalities for DBS planni...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s00234-018-2079-0
更新日期：2018-11-01 00:00:00
abstract：:There is still a controversy regarding the best regional brain atrophy measurements in multiple sclerosis (MS) studies. The aim of this study was to establish whether, in a cross-sectional study, the normalized measurements of regional brain atrophy correlate better with the MRI-defined regional brain lesions than the...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s00234-003-1101-2
更新日期：2003-11-01 00:00:00
abstract：:Accurate interpretation of orbital imaging in the presence of either orbital implants requires a sound knowledge of both the surgical approach used and the imaging characteristics of the implanted devices themselves. In this article, the radiological appearance of the various devices used in ophthalmology, and their r...
journal_title：Neuroradiology
pub_type： 杂志文章,评审
doi：10.1007/s00234-014-1403-6
更新日期：2014-11-01 00:00:00
abstract：INTRODUCTION:The decision on thrombolytics administration is usually based on a generalized, rigid time-based rule rather than an individualized evaluation of the "tissue at risk of infarction" which is the target of the recanalization therapies. The goals of our article are to assess whether there is tissue at risk of...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s00234-013-1164-7
更新日期：2013-07-01 00:00:00
abstract：:Diagnosis of primary and secondary brain tumours and other focal intracranial mass lesions based on imaging procedures alone is still a challenging problem. Proton magnetic resonance spectroscopy (1H-MRS) gives completely different information related to cell membrane proliferation, neuronal damage, energy metabolism ...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s00234-001-0760-0
更新日期：2002-05-01 00:00:00
abstract：:We report an asymptomatic 15-year-old boy with X-linked adrenoleukodystrophy and his symptomatic 38-year-old mother. MRI revealed similar, subtle high-signal lesions in the periventricular white matter of the parieto-occipital regions, without involvement of the corpus callosum, more pronounced in the mother. ...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s002340100575
更新日期：2001-11-01 00:00:00
abstract：:We report a case of extensive craniocervical bone pneumatisation presenting after minor trauma. The patient had neurological signs and initial radiographs showed multiple lucencies in the skull base and the atlas vertebra. CT established the true nature of this rare condition. ...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/BF00596581
更新日期：1996-05-01 00:00:00
abstract：PURPOSE:Complex neurovascular lesions in children require precise anatomic understanding for treatment planning. Although 3DRA is commonly employed for volumetric reformation in neurointerventional procedures, the ability to reconstruct this data into CT-like images (3DRA-CT) is not widely utilized. This study demonstr...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s00234-017-1818-y
更新日期：2017-06-01 00:00:00
abstract：:Serial MRI findings are described in two patients with Reye's syndrome, demonstrating diffuse cortical and white matter changes. In the acute stage, T2-weighted images showed subtle but definite laminar high signal and contrast-enhanced T1-weighted images laminar enhancement, along the entire cerebral cortex bilateral...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/BF00596545
更新日期：1996-04-01 00:00:00
abstract：INTRODUCTION:Rarely in the anterior circulation, an anastomosis of the carotid and anterior cerebral arteries occurs when an anomalous branch arises from the ophthalmic segment of the internal carotid artery and anastomoses with the A1-A2 junction of the anterior communicating artery. Right-side predominance is known. ...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s00234-011-0847-1
更新日期：2012-01-01 00:00:00
