Abstract：
:Diagnosis of primary and secondary brain tumours and other focal intracranial mass lesions based on imaging procedures alone is still a challenging problem. Proton magnetic resonance spectroscopy (1H-MRS) gives completely different information related to cell membrane proliferation, neuronal damage, energy metabolism and necrotic transformation of brain or tumour tissues. Our purpose was to evaluate the clinical utility of 1H-MRS added to MRI for the differentiation of intracranial neoplastic and non-neoplastic mass lesions. 176 mostly histologically verified lesions were studied with a constant clinically available single volume 1H-MRS protocol following routine MRI. 12 spectra (6.8%) were not of satisfactory diagnostic quality; 164 spectroscopic data sets were therefore available for definitive evaluation. Our study shows that spectroscopy added to MRI helps in tissue characterization of intracranial mass lesions, thereby leading to an improved diagnosis of focal brain disease. Non-neoplastic lesions such as cerebral infarctions and brain abscesses are marked by decreases in choline (Cho), creatine (Cr) and N-acetyl-aspartate (NAA), while tumours generally have elevated Cho and decreased levels of Cr and NAA. Gliomas exhibit significantly increased Cho and lipid formation with higher WHO tumour grading. Metastases have elevated Cho similar to anaplastic astrocytomas, but can be differentiated from high-grade gliomas by their higher lipid levels. Extra-axial tumours, i.e. meningiomas and neurinomas, are characterized by a nearly complete absence of the neuronal marker NAA. The additive information of 1H-MRS led to a 15.4%-higher number of correct diagnoses, to 6.2% fewer incorrect and 16% fewer equivocal diagnoses than with structural MRI data alone.
journal_name
Neuroradiologyjournal_title
Neuroradiologyauthors
Möller-Hartmann W,Herminghaus S,Krings T,Marquardt G,Lanfermann H,Pilatus U,Zanella FEdoi
10.1007/s00234-001-0760-0subject
Has Abstractpub_date
2002-05-01 00:00:00pages
371-81issue
5eissn
0028-3940issn
1432-1920journal_volume
44pub_type
杂志文章相关文献
NEURORADIOLOGY文献大全abstract：:We report MRI and proton MR spectroscopy (MRS) findings in a 12-month-old girl with Epstein-Barr virus encephalitis. CT and MRI showed focal lesions in the basal ganglia. MRS of the lesions showed decreased N-acetyl aspartate and elevation of some amino acids, indicating an infectious rather than ischemic etiology. Th...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s002340000299
更新日期：2000-08-01 00:00:00
abstract：:Intracranial pial and dural arteriovenous shunts may exist at different sites in the same patient. The etiology, natural history and treatment of these associated conditions have not been completely determined. We reviewed the records of 765 cases of pial arteriovenous malformation and 137 dural arteriovenous fistulae...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s002340100571
更新日期：2001-09-01 00:00:00
abstract：:Ultrasonography by the Doppler technique combined with B-mode echotomography are useful methods in the investigation of disease of the major arteries in the neck supplying the brain. The investigations are described together with the significance of major findings. ...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/BF00340850
更新日期：1985-01-01 00:00:00
abstract：:Immediate complete occlusion of complex cerebral aneurysms associated with perforating or major branch arteries may cause serious ischemic complications due to poor collateral supply. Flow reversal with concomitant proximal occlusion is an important therapeutic strategy in clinical practice and induces gradual thrombo...
journal_title：Neuroradiology
pub_type： 杂志文章,评审
doi：10.1007/s00234-010-0791-5
更新日期：2011-06-01 00:00:00
abstract：INTRODUCTION:Internal carotid artery dissection with tandem internal carotid and middle cerebral artery occlusion may be responsible for large cerebral infarction that carries a general poor prognosis. Recanalization of internal carotid artery (ICA) dissection by stent-assisted thrombolysis has been recently proposed. ...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s00234-009-0597-5
更新日期：2010-02-01 00:00:00
abstract：INTRODUCTION:Susceptibility-weighted imaging (SWI) with high- and ultra-high-field magnetic resonance is a very helpful tool for evaluating brain gliomas and intratumoral structures, including microvasculature. Here, we test whether objective quantification of intratumoral SWI patterns by applying fractal analysis can ...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s00234-012-1081-1
更新日期：2013-01-01 00:00:00
abstract：:In the article "Magnetic resonance imaging features of the superior cervical ganglion and expected changes after radiation therapy to the head and neck in a long-term follow-up", one of the author names, K Chokkappan, was spelled incorrectly. ...
journal_title：Neuroradiology
pub_type： 已发布勘误
doi：10.1007/s00234-020-02394-z
更新日期：2020-06-01 00:00:00
abstract：:Two exemplary cases of upper carotid occlusion and successful local intraarterial fibrinolytic therapy are described. To achieve a positive result one has to perform a balloon occlusion of the affected internal carotid artery while applying the fibrinolytic agent. Possible time limits of instigating therapy are discus...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/BF00339777
更新日期：1984-01-01 00:00:00
abstract：INTRODUCTION:Change in tumor size is a frequent endpoint in cancer clinical trials, but whether change in size should be measured using volume on two-dimensional (2D) or three-dimensional (3D) images is not certain. We compared volumetric measurements on post-contrast 2D and high-resolution 3D T1-weighted MR images (T1...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s00234-010-0789-z
更新日期：2011-08-01 00:00:00
abstract：PURPOSE:To assess the MRI modifications of the intervertebral disc (IVD) treated by chemiodiscolysis using T2 mapping sequences. METHODS:Thirty sciatica patients (17 males, 13 females, mean age 47.52 years) were enrolled for percutaneous CT-guided O2-O3 chemiodiscolysis treatment. As a control group, we enrolled 30 pa...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s00234-019-02308-8
更新日期：2020-01-01 00:00:00
abstract：:CT demonstrated posterior fossa epidural hematoma in three patients with head trauma in whom this diagnosis was not clinically apparent. No patient was in stupor or coma and no patient experienced a lucid interval. Only one patient had signs referable to the posterior fossa. Two patients had occipital skull fracture d...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:Using an EMI 5005 scanner with high resolution option, 75% of syrinxes were shown as low density cavities. Most spinal cord tumours caused isodense swellings, but 41% contained low density zones and cystic elements were demonstrated in 76% of these at surgery or by puncture of the spinal cord; a few (11%) of the isode...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/BF00347553
更新日期：1982-01-01 00:00:00
abstract：:23Na MRI changes from the acute to chronic phase were investigated in seven patients with cerebral infarcts. They showed no signal increase during the first 13 h after the stroke and revealed a definite signal increase thereafter. This reached a maximum 45-82 h after stroke and became slightly less marked in the subac...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/BF00602819
更新日期：1993-01-01 00:00:00
abstract：:A prospective study of 16 patients was performed to compare quantitatively a contiguous single slice 2DFT version with a 3DFT version of a short TR, variable flip angle, gradient echo (GRASS) pulse sequence. The 3DFT GRASS scans had higher signal-to-noise ratios (SNR) of cord and CSF compared to the single slice 2DFT ...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/BF00344345
更新日期：1989-01-01 00:00:00
abstract：:Despite progress in ultrasonographic techniques visualisation of the origin of the vertebral arteries, particularly the left, by duplex and colour Doppler imaging, still poses a problem in a significant number of patients. In anatomical and radiological studies we demonstrated an anomalous origin in 6%, the left verte...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/BF00602620
更新日期：1993-01-01 00:00:00
abstract：:We report on two patients with intracranial atherosclerosis of the carotid artery or vertebral artery treated with stent-assisted angioplasty. Both patients have severe intracranial atherosclerosis (>70%) with refractory symptoms despite optimal medical treatment. In both patients, a coronary balloon-expandable stent ...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s00234-002-0794-y
更新日期：2002-08-01 00:00:00
abstract：:We report a neonate in whom clinical and radiologic studies revealed features of both neurocutaneous melanosis and a Dandy-Walker malformation. We suggest that the association of these two conditions is perhaps not chance. ...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/BF00607285
更新日期：1996-07-01 00:00:00
abstract：:The high resolution CT scanning system introduced by EMI in 1978 has added a new dimension to computerised tomography in otology. The apparatus used for this study was an EMI CT 5005 body scanner adapted for head and neck scanning and incorporating a high resolution facility. The latter has proved most advantageous in...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/BF00327687
更新日期：1979-12-12 00:00:00
abstract：:We compared MRI studies of the sellar area and embryological and adult histological studies of the cavernous sinuses and pituitary fossa. MRI studies were performed in 50 normal subjects with coronal sections using a fast inversion-recovery sequence to demonstrate the dural walls of the cavernous sinus and pituitary f...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s002340050653
更新日期：1998-10-01 00:00:00
abstract：:We monitored 10 patients with unresected (9) or partially resected (1) supratentorial gliomas with 11C-tyrosine position emission tomography (TYR-PET) before and after radiotherapy. TYR-PET tumour volumes were measured using a threshold technique. In seven patients the tumour volume decreased after radiotherapy, altho...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s002340050548
更新日期：1998-02-01 00:00:00
abstract：PURPOSE:Coiling associated with placement of a self-expandable intracranial stent has improved the treatment of intracranial wide-necked aneurysms. Little is known, however, about the durability of this treatment. The purpose of this report is to present our experience with the LEO stent and to evaluate the complicatio...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s00234-017-1965-1
更新日期：2018-02-01 00:00:00
abstract：PURPOSE:Computed tomography (CT) for minor head injury exposes a large number of children to ionizing radiation, with an associated increased lifetime risk of malignancy. To study imaging practices for children with minor head injury and the level of awareness of radiologists of the current clinical decision rules for ...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s00234-019-02326-6
更新日期：2020-02-01 00:00:00
abstract：:We carried out spectroscopic imaging (MRSI) on nine consecutive patients with temporal lobe epilepsy being assessed for epilepsy surgery, and nine neurologically healthy, age-matched volunteers. A volume of interest (VOI) was angled along the temporal horns on axial and sagittal images, and symmetrically over the temp...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s002340100560
更新日期：2001-09-01 00:00:00
abstract：:An imaging technique capable of detecting ischaemic cerebral injury at an early stage could improve diagnosis in acute or transient cerebral ischaemia. We compared the ability of superparamagnetically contrast-enhanced MRI and conventional T2-weighted MRI to detect ischaemic injury early after unilateral occlusion of ...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/BF00599188
更新日期：1994-01-01 00:00:00
abstract：PURPOSE:To search for the risk factors closely related to cerebral cavernous malformation associated with developmental venous anomaly (CCM-DVA) lesions rupture, laying foundations for the development of reasonable individual treatment plans for patients. METHODS:In this retrospective study, we collected CCM-DVA patie...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s00234-019-02274-1
更新日期：2020-01-01 00:00:00
abstract：INTRODUCTION:Metaplastic ossification is a rare event in nasal polyps. The purpose of this study was to review the computed tomography (CT) and magnetic resonance (MR) imaging findings of nasal polyps with metaplastic ossification. METHODS:CT (n=5) and MR (n=3) images of five patients (four men and one woman; mean age...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s00234-010-0758-6
更新日期：2010-12-01 00:00:00
abstract：:Mastoid effusion is a poorly understood complication after craniotomy. The incidence and severity of postoperative mastoid effusion were retrospectively examined on postoperative magnetic resonance (MR) images to assess any association with craniotomy procedures, time course, and neuro-otological complications. We eva...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s00234-003-0963-7
更新日期：2003-07-01 00:00:00
abstract：:We report long-term (average 30 months) clinical and radiological follow-up of 16 consecutive patients with uni- or bilateral proximal vertebral artery stenosis who underwent percutaneous transluminal angioplasty (PTA), without stenting, between 1995 and 1998. Assessment was performed by an independent neurologist. Al...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s00234-002-0895-7
更新日期：2004-01-01 00:00:00
abstract：INTRODUCTION:This study aims to evaluate the existence of anatomic abnormalities in the skull base that could contribute to the origin of primary spontaneous cerebrospinal fluid leaks (PSL). METHODS:Twenty PSL patients were compared with 20 healthy individuals. The following features were measured through an analysis ...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s00234-011-0901-z
更新日期：2012-05-01 00:00:00
abstract：:We report a case of glossopharyngeal neuralgia with vascular compression. High-resolution MRI at 3 tesla demonstrated the posterior inferior cerebellar artery to be closely related to the rootlets of the left glossopharyngeal nerve in a patient who suffered attacks of burning sensation in the left side of the throat. ...
journal_title：Neuroradiology
pub_type： 杂志文章
doi：10.1007/s00234-003-1078-x
更新日期：2003-11-01 00:00:00
