Abstract:
:Nimodipine is widely used in patients with aneurysmal subarachnoid haemorrhage for the prevention and treatment of delayed ischaemic neurological deficits. Intravenous nimodipine has significant vasodilatory properties and may compromise the achievement of haemodynamic targets in patients who receive hypertensive hypervolaemic haemodilution therapy. We have studied 22 patients who received postoperative therapy with intravenous nimodipine and show that in a substantial minority (29%) hypotension was not reversed by simple volume loading or low doses of inotropes. Formal haemodynamic assessment in these patients showed widely varying haemodynamic variables, with differences in the need for inotropic and vasopressor therapy. We conclude that optimal haemodynamic management in this subgroup of patients will require the use of pulmonary artery catheterisation.
journal_name
Anaesthesiajournal_title
Anaesthesiaauthors
Radhakrishnan D,Menon DKdoi
10.1111/j.1365-2044.1997.112-az0105.xsubject
Has Abstractpub_date
1997-05-01 00:00:00pages
489-91issue
5eissn
0003-2409issn
1365-2044journal_volume
52pub_type
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