Abstract:
:This randomised, placebo-controlled study assessed the effects of midazolam premedication on children's postoperative cognition and physical morbidity. In all, 179 children aged 5-10 years were randomly assigned to receive buccal midazolam (0.2 mg x kg(-1)) or placebo before sevoflurane-nitrous oxide anaesthesia for multiple dental extractions. They performed tests of choice reaction time, attention, psychomotor co-ordination and memory pre-operatively (baseline), before discharge and at 48 h. The reaction time of both groups was significantly slower before discharge compared to baseline, with the midazolam group being significantly slower than placebo. Psychomotor co-ordination was also significantly impaired postoperatively after midazolam. Performance on both tests had recovered to baseline by 48 h. Midazolam was also associated with significant anterograde amnesia, both postoperatively and at 48 h, for information presented in the interval between premedication and surgery. The results show significant short-term impairment of children's cognitive function and amnesia enduring for 48 h after low-dose midazolam premedication.
journal_name
Anaesthesiajournal_title
Anaesthesiaauthors
Millar K,Asbury AJ,Bowman AW,Hosey MT,Martin K,Musiello T,Welbury RRdoi
10.1111/j.1365-2044.2007.05148.xsubject
Has Abstractpub_date
2007-09-01 00:00:00pages
923-30issue
9eissn
0003-2409issn
1365-2044pii
ANA5148journal_volume
62pub_type
杂志文章,随机对照试验相关文献
ANAESTHESIA文献大全abstract::Eighteen patients with advanced cystic fibrosis complicated by pneumothorax required either pleurectomy or abrasion pleurodesis. Anaesthesia with nitrous oxide and oxygen was combined with controlled ventilation to both lungs, usually through a double lumen endobronchial tube. Spontaneous ventilation was restored at t...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1984.tb06473.x
更新日期:1984-07-01 00:00:00
abstract::Anxiety before induction of anaesthesia was studied in 100 patients who were allocated randomly to one of two groups. Patients in one group were anaesthetised in an anaesthetic room and those in the other group were anaesthetised inside the operating theatre. Both subjective and objective induces of anxiety were used ...
journal_title:Anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1365-2044.1989.tb13586.x
更新日期:1989-08-01 00:00:00
abstract::The elderly have the ethical and legal equivalence of younger adults, yet are treated differently by society. Numerous recent reports have exposed poor inpatient care resulting in part from institutional ageism, which has moral and legal implications for healthcare providers. Morally, there is an argument for positive...
journal_title:Anaesthesia
pub_type: 杂志文章,评审
doi:10.1111/anae.12519
更新日期:2014-01-01 00:00:00
abstract::The use of a low-power nerve stimulator to aid nerve location during the performance of sciatic nerve block was compared with a conventional anatomically based technique. The success rate, both in terms of the production of an effective block and the duration of postoperative analgesia, was significantly higher in the...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1987.tb03043.x
更新日期:1987-03-01 00:00:00
abstract::We report two patients with difficult airways who underwent tracheal intubation using the new fibreoptic intubating Laryngeal Mask Airway CTrach. The imaging technology of the LMA-CTrach was decisive in the management of these two patients. The first patient had lingual tonsillar hyperplasia, and an omega-shaped retro...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.2006.04660.x
更新日期:2006-06-01 00:00:00
abstract::Acute risk change has been described as the difference in calculated mortality risk between the pre-operative and postoperative periods of cardiac surgery. We aimed to assess whether this was associated with long-term survival after cardiac surgery. We retrospectively analysed 22,570 cardiac surgical patients, with mi...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/anae.13967
更新日期:2017-12-01 00:00:00
abstract::Pain relief after surgery is frequently inadequate. In the last few years much research has been devoted to improving the situation. Unfortunately, very little work has been undertaken to explore the patients' contribution to pain management. The beliefs and attitudes held by patients when they enter the hospital envi...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1996.tb13647.x
更新日期:1996-03-01 00:00:00
abstract::The large lateral hole of the Sprotte needle is claimed to aid cerebrospinal fluid efflux during the performance of spinal anaesthesia. Using theoretical calculations and practical measurement we have shown that reducing the area of the lateral hole to that of the cross sectional area of the needle does not affect the...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1992.tb02277.x
更新日期:1992-06-01 00:00:00
abstract::The incidence of pneumothorax in the neonatal period is reviewed. Most infants who developed a pneumothorax were undergoing intermittent positive pressure ventilation. The most common underlying pathology associated with pneumothorax was idiopathic respiratory distress syndrome. This was the only condition in which a ...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1983.tb12024.x
更新日期:1983-10-01 00:00:00
abstract::The effects of cardiopulmonary bypass and hypothermia were studied on the plasma concentration and metabolism of a continuous infusion of etomidate in six patients. Continuous etomidate infusions (20 micrograms/kg/minute) with analgesic cover may be a suitable anaesthetic for cardiac surgery. This rate of infusion pro...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1983.tb15183.x
更新日期:1983-07-01 00:00:00
abstract::We report 13 cases of presumed rocuronium-induced anaphylaxis in which sugammadex was administered with the intention of reversing the immunological reaction. Of these 13 cases, eight (62%) were later confirmed to be type-1 hypersensitivity reactions to rocuronium, three (23%) were triggered by an antibiotic and two (...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/anae.13178
更新日期:2015-11-01 00:00:00
abstract::We have compared the performance of the Baxter disposable with the Graseby electronic patient-controlled analgesia system in 30 patients following major gynaecological surgery. Patients were allocated randomly to receive analgesia via the Baxter or Graseby device for postoperative pain relief. There were no significan...
journal_title:Anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1365-2044.1992.tb02020.x
更新日期:1992-02-01 00:00:00
abstract::I report the case of a 57-year-old patient admitted to the intensive care unit with severe community-acquired pneumonia, complicated by prolonged mechanical ventilation of the lungs and intractable cardiac failure. He underwent percutaneous coronary angioplasty of the right coronary artery, but this did not improve hi...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.2011.06982.x
更新日期:2012-04-01 00:00:00
abstract::A predicted difficult airway is sometimes considered a contra-indication to rapid sequence induction of general anaesthesia, even in an urgent case such as a category-1 caesarean section for fetal distress. However, formally assessing the risk is difficult because of the rarity and urgency of such cases. We have used ...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/anae.13729
更新日期:2017-02-01 00:00:00
abstract::There is an ongoing debate as to whether propofol exhibits pro- or anticonvulsant effects, and whether it should be used in patients with epilepsy. We prospectively assessed the occurrence of seizure-like phenomena and the effects of intravenous propofol on the electroencephalogram (EEG) in 25 children with epilepsy (...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.2006.04782.x
更新日期:2006-11-01 00:00:00
abstract::The circulatory depressant action of papaveretum was demonstrated when the drug was injected accidentally into the radial artery during neuroanaesthesia in the upright (sitting) position. The signs of air embolism were mimicked. The condition reponded promptly to a vasopressor given intravenously. There were no harmfu...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1979.tb06328.x
更新日期:1979-05-01 00:00:00
abstract::A 5-year-old girl with Noonan's syndrome and a hypertrophic cardiomyopathy presented for myelography and subsequently, laminectomy. The anaesthetic management of the patient is described and the potential problems of the facial, cardiovascular and skeletal abnormalities associated with the condition are discussed. ...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1992.tb02010.x
更新日期:1992-02-01 00:00:00
abstract::The possibility exists that agents used in anaesthesia may have adverse teratogenic effects on staff, patients, and developing fetuses. It has been shown that a range of neurotropic drugs, when injected into pregnant mice on the 9th day of gestation, produce a characteristic group of central nervous system malformatio...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1992.tb02267.x
更新日期:1992-06-01 00:00:00
abstract::New anaesthetic agents are continually being developed in an effort to prepare the ideal agent. Isoflurane is the first choice of many anaesthetists, although it clearly falls short of the ideal on a number of counts. The need and place for any new agent depends on comparing the properties of a theoretically ideal age...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1995.tb06181.x
更新日期:1995-10-01 00:00:00
abstract::The ability of a number of drugs to abolish the emergence delirium and unpleasant dreams which follow anaesthesia induced with 2 mg/kg ketamine was studied. These included three benzodiazepines, droperidol and 'neurolept' combinations and four commonly-used premedicants. When given intravenously 10 min before inductio...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1978.tb12412.x
更新日期:1978-04-01 00:00:00
abstract::A long-forgotten chloroform inhaler, probably the first accurately calibrated, temperature compensatable, plenum vaporizer, is described. Its place in the dosimetric movement at the beginning of the 20th century is considered, together with a brief account of the life of its designer. ...
journal_title:Anaesthesia
pub_type: 传,历史文章,杂志文章
doi:10.1111/j.1365-2044.1988.tb05667.x
更新日期:1988-11-01 00:00:00
abstract::Twenty-eight patients who had a history of severe postoperative vomiting were divided into two groups. The first group received various anaesthetic drugs and the second group received a pethidine promethazine premedication and thiopentone, alcuronium, fentanyl and droperidol. There was a significant reduction in posto...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1984.tb07244.x
更新日期:1984-03-01 00:00:00
abstract::A postal questionnaire on blood ordering practices and blood availability was sent to 89 randomly selected maternity units within the United Kingdom. The replies demonstrated a wide variation in crossmatching practices. Of those units that replied, 56% crossmatch for elective and 64% for emergency Caesarean section, 5...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1993.tb07483.x
更新日期:1993-11-01 00:00:00
abstract::Neurotoxicity manifesting as convulsions is a recognised complication of the administration of local anaesthetic drugs as part of a regional anaesthetic technique. We describe a case of self-limiting convulsions following the institution of an axillary brachial plexus block with levobupivacaine. Although the occurrenc...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1046/j.1365-2044.2002.02860.x
更新日期:2002-12-01 00:00:00
abstract::We describe the administration of anaesthesia to a patient with Angelman syndrome, which is characterised by an abnormality of chromosome 15, where a subunit of the GABA receptor is coded. This has far-reaching anaesthetic implications as many drugs used in anaesthesia are thought to act via GABA receptors. Our patien...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.2008.05439.x
更新日期:2008-06-01 00:00:00
abstract::Electrophysiological monitoring of selected neural pathways of the brain, brainstem, spinal cord and peripheral nervous system has become mandatory in some surgery of the nervous system where preventable neural injury can occur. Evoked potentials are relatively simple methods of testing the integrity of various aspect...
journal_title:Anaesthesia
pub_type: 杂志文章,评审
doi:10.1046/j.1365-2044.2000.01120.x
更新日期:2000-03-01 00:00:00
abstract::A simple modification to an existing adult ventilator has been designed to permit mechanical ventilation of neonates and small children with the Ayre's T-piece circuit. The Nuffield Anaesthesia Ventilator Series 200 has been modified by replacing the piston in the patient valve with a fixed leak. This arrangement avoi...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1981.tb08595.x
更新日期:1981-01-01 00:00:00
abstract::In order to find out how the response to operative trauma is influenced by chronic alcohol consumption, 53 patients (28 alcoholics and 25 non-alcoholics) were investigated. The chronic alcoholic was defined as a person having a regular, daily alcohol consumption of over 70 g pure alcohol for at least 3 years. The mean...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1982.tb01810.x
更新日期:1982-08-01 00:00:00
abstract::Implantable cardioverter defibrillator implantation is performed under general anaesthesia. This report describes awareness or recall in two of 33 patients scheduled for implantation. After induction, anaesthesia was maintained using continuous infusions of propofol and atracurium and intermittent boluses of alfentani...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1995.tb06107.x
更新日期:1995-08-01 00:00:00
abstract::High-dose aprotinin for reduction of intra- and postoperative blood loss was associated with profound hypotension and flushing in a 3.5-year-old child who underwent cardiac surgery. Treatment with noradrenaline and intravenous fluid was required. Cardiovascular stability was restored after 10 minutes. ...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1990.tb14571.x
更新日期:1990-10-01 00:00:00