The management of metformin overdose.

Abstract:

:Only two cases of deliberate self-poisoning with metformin have been described in the literature. We report the management of three cases, all of which presented with severe lactic acidosis. Two cases had a fatal outcome. The options for treatment and previous cases reported in the literature are reviewed. Recommendations for the management of metformin overdose include early recognition, intensive support of the cardiovascular system, the correction of metabolic acidosis and the maintenance of body temperature. The use of venovenous haemofiltration against a non-lactate containing fluid may improve outcome when sodium bicarbonate alone fails to reverse severe systemic acidosis.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Teale KF,Devine A,Stewart H,Harper NJ

doi

10.1046/j.1365-2044.1998.436-az0549.x

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

698-701

issue

7

eissn

0003-2409

issn

1365-2044

journal_volume

53

pub_type

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