Abstract:
:Only two cases of deliberate self-poisoning with metformin have been described in the literature. We report the management of three cases, all of which presented with severe lactic acidosis. Two cases had a fatal outcome. The options for treatment and previous cases reported in the literature are reviewed. Recommendations for the management of metformin overdose include early recognition, intensive support of the cardiovascular system, the correction of metabolic acidosis and the maintenance of body temperature. The use of venovenous haemofiltration against a non-lactate containing fluid may improve outcome when sodium bicarbonate alone fails to reverse severe systemic acidosis.
journal_name
Anaesthesiajournal_title
Anaesthesiaauthors
Teale KF,Devine A,Stewart H,Harper NJdoi
10.1046/j.1365-2044.1998.436-az0549.xsubject
Has Abstractpub_date
1998-07-01 00:00:00pages
698-701issue
7eissn
0003-2409issn
1365-2044journal_volume
53pub_type
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