Ideal versus corrected body weight for dosage of sugammadex in morbidly obese patients.

Abstract:

:To date, the dosing of sugammadex is based on real body weight without taking fat content into account. We compared the reversal of profound rocuronium-induced neuromuscular blockade in morbidly obese patients using doses of sugammadex based on four different weight corrections. One hundred morbidly obese patients, scheduled for laparoscopic bariatric surgery under propofol-sufentanil anaesthesia, were randomly assigned four groups: ideal body weight; ideal body weight + 20%; ideal body weight + 40%; and real body weight. Patients received sugammadex 2 mg.kg(-1), when adductor pollicis monitoring showed two responses. The primary endpoint was full decurarisation. Secondary endpoints were the ability to get into bed independently on arrival to the post-anaesthetic care unit and clinical signs of residual paralysis. There was no residual paralysis in any patient. Morbidly obese patients can safely be decurarised from rocuronium-induced neuromuscular blockade T1-T2 with sugammadex dosed at 2 mg.kg(-1) ideal body weight + 40% (p < 0.0001).

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Van Lancker P,Dillemans B,Bogaert T,Mulier JP,De Kock M,Haspeslagh M

doi

10.1111/j.1365-2044.2011.06782.x

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

721-5

issue

8

eissn

0003-2409

issn

1365-2044

journal_volume

66

pub_type

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