Abstract:
:To date, the dosing of sugammadex is based on real body weight without taking fat content into account. We compared the reversal of profound rocuronium-induced neuromuscular blockade in morbidly obese patients using doses of sugammadex based on four different weight corrections. One hundred morbidly obese patients, scheduled for laparoscopic bariatric surgery under propofol-sufentanil anaesthesia, were randomly assigned four groups: ideal body weight; ideal body weight + 20%; ideal body weight + 40%; and real body weight. Patients received sugammadex 2 mg.kg(-1), when adductor pollicis monitoring showed two responses. The primary endpoint was full decurarisation. Secondary endpoints were the ability to get into bed independently on arrival to the post-anaesthetic care unit and clinical signs of residual paralysis. There was no residual paralysis in any patient. Morbidly obese patients can safely be decurarised from rocuronium-induced neuromuscular blockade T1-T2 with sugammadex dosed at 2 mg.kg(-1) ideal body weight + 40% (p < 0.0001).
journal_name
Anaesthesiajournal_title
Anaesthesiaauthors
Van Lancker P,Dillemans B,Bogaert T,Mulier JP,De Kock M,Haspeslagh Mdoi
10.1111/j.1365-2044.2011.06782.xsubject
Has Abstractpub_date
2011-08-01 00:00:00pages
721-5issue
8eissn
0003-2409issn
1365-2044journal_volume
66pub_type
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