Abstract:
:The carboxyl terminal of the predicted amino acid sequence of the Batten disease CLN3 gene protein is CQLS. This motif is expected to be a site for farnesylation at the cysteine residue. In order to determine whether this is indeed farnesylated we have carried out the in-vitro prenylation of tetrapeptides CVLS, CAIL and CQLS using a farnesyl transferase preparation from bovine brain. The data shows that the CQLS is a good acceptor of a farnesyl group similar to CVLS while it is a poor acceptor of a geranylgeranyl group unlike CAIL, which is a good acceptor of a geranylgeranyl group. This suggests that the CLN3 gene product may be a farnesylated protein.
journal_name
Neuropediatricsjournal_title
Neuropediatricsauthors
Pullarkat RK,Morris GNdoi
10.1055/s-2007-973665subject
Has Abstractpub_date
1997-02-01 00:00:00pages
42-4issue
1eissn
0174-304Xissn
1439-1899journal_volume
28pub_type
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