Abstract:
:Anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARe) was originally described as a paraneoplastic disease with more than 50% cases involving a tumor. However, tumor incidence in anti-NMDARe in children is much lower. Herpes simplex virus-induced anti-NMDARe has been well-described; however, findings on Japanese encephalitis virus (JEV)-induced anti-NMDARe are scarce. Here, we describe a 7-year-old boy who presented with fever and headache that progressed to seizures and disturbance of consciousness. Brain magnetic resonance imaging (MRI) revealed abnormalities in the bilateral globus pallidus. The diagnosis of JE was made based on a positive JE antibody test results in serum and cerebrospinal fluid. Antiviral and symptomatic therapies led to rapid recovery. Four weeks after the onset of JE, the patient presented with emotional and behavioral disturbances, sleep difficulty, and extrapyramidal symptoms. MRI showed symmetrical lesions in the bilateral thalami and basal ganglia which were expanded than those on the original scan. Antibodies against NMDAR were detected and immunotherapy led to significant recovery. This case and our literature review suggest that JEV may be a clinically important cause of anti-NMDARe in children. Patients with JE-induced anti-NMDARe present with symptoms similar to those of patients with primary anti-NMDARe. Most patients with JE-induced anti-NMDARe showed a good response to first-line immunotherapies.
journal_name
Neuropediatricsjournal_title
Neuropediatricsauthors
Tian M,Li J,Lei W,Shu Xdoi
10.1055/s-0038-1675607subject
Has Abstractpub_date
2019-04-01 00:00:00pages
111-115issue
2eissn
0174-304Xissn
1439-1899journal_volume
50pub_type
杂志文章,评审相关文献
NEUROPEDIATRICS文献大全abstract::Rett syndrome is a neurological disorder associated with cortical atrophy, stereotyped hand movements, dementia, and extrapyramidal dysfunction. Endogenous levels of dopamine and its metabolites are decreased throughout the neocortex and basal ganglia and the number of dopamine type 2 receptors are decreased in the pu...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2007-979741
更新日期:1995-04-01 00:00:00
abstract::Clinical, biochemical and morphological findings in a 16-month-old infant girl with pseudo-neonatal adrenoleukodystrophy are reported. The parents were first cousins and the baby was born at term, small for gestational age. The neonatal period was characterized by convulsions resistant to treatment, generalized, sever...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1071495
更新日期:1990-11-01 00:00:00
abstract::Hemimegalencephaly, which previously has been associated with a poor clinical course characterized by intractable seizures and severe encephalopathy, was found without these conditions in two children with neurofibromatosis. These children showed relatively similar and favourable prognostic features: no presence of se...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1071490
更新日期:1990-11-01 00:00:00
abstract:AIM: Tonic tics (TTs) are a part of a clinical picture of Gilles de la Tourette syndrome (GTS) and manifest themselves as sustained and isometric contraction of a muscle group devoid of the movement effect or accompanied by only slight visible motion. The aim of this study was to evaluate the prevalence and phenomenolo...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-0040-1722689
更新日期:2021-01-14 00:00:00
abstract:PURPOSE:We aim to correlate size and shape of corpus callosum with severity of motor and cognitive impairments in children with periventricular leukomalacia (PVL). METHODS:Children with PVL were stratified based on the severity of their motor and cognitive impairments. An age-matched control group was established. The...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2003-43259
更新日期:2003-06-01 00:00:00
abstract::The effects of malnutrition on conduction in peripheral and central somatosensory pathways in humans, as measured by short-latency somatosensory evoked potentials (SEPs) have not been previously reported. A group of 28 children with kwashiorkor were compared to a control group of 35 children, aged 6-36 months. The mal...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1071265
更新日期:1989-02-01 00:00:00
abstract::A previously healthy one-year-old boy, the youngest child of unrelated parents, presented with a four-week history of episodes of myoclonus triggered only by tactile stimulation to his head. There had been no loss of developmental skills. The electroencephalogram (EEG) revealed generalised polyspike wave activity both...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2003-41275
更新日期:2003-06-01 00:00:00
abstract::Alpers-Huttenlocher syndrome (AHS) is a very rare autosomal recessive disorder. AHS is caused by homozygous or compound heterozygous mutations in the nuclear gene encoding mitochondrial DNA polymerase gamma (POLG, chromosome 15q25). Most patients become symptomatic before the age of 2 years. We report 3 patients who w...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-0031-1287812
更新日期:2011-10-01 00:00:00
abstract::Autosomal recessive Charcot-Marie-Tooth syndrome (AR-CMT) is often characterised by an infantile disease onset and a severe phenotype. Mutations in the ganglioside-induced differentiation-associated protein 1 (GDAP1) gene are thought to be a common cause of AR-CMT. Mutations in the periaxin (PRX) gene are rare. They a...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1077085
更新日期:2008-02-01 00:00:00
abstract::Headaches in children and adolescents remain a very common problem with migraine being the most common headache disorder to present to medical attention. The approach to the treatment of migraine in children has consisted of treatment with acute and preventive medications, combined with lifestyle modification and beha...
journal_title:Neuropediatrics
pub_type: 杂志文章,评审
doi:10.1055/s-0039-1695785
更新日期:2019-12-01 00:00:00
abstract::A newborn female born at term was admitted at 28 hours for seizures and generalized hypotonia. Cerebral ultrasound showed a right temporal echogenic lesion confirmed on MRI and thought to be secondary to thrombosis of the vein of Labbé. The EEG showed epileptic discharges over the right temporal region. Extensive thro...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2007-991149
更新日期:2007-08-01 00:00:00
abstract::A special form of partial occipital epilepsy clinically resembling migraine and possibly related to the benign focal epilepsies of childhood has recently attracted attention (Gastaut 1982) but its existence is still debated. To approach this problem, in a group of 195 children with idiopathic partial or generalized ep...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1052355
更新日期:1984-08-01 00:00:00
abstract::Functional MRI techniques were used to map the position of visual cortex in an awake and a sedated child with congenital anomalies of the posterior hemispheres. In one subject with cortical heterotopia, an activated cortex was found distinct from the structurally abnormal area detected on conventional MRI. In a sedate...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2000-15291
更新日期:2000-02-01 00:00:00
abstract::Micro syndrome is a rare condition in which congenital cataracts, microphthalmia, and facial dysmorphism are associated with severe neurological disorders, namely: microcephaly and psychomotor retardation. We report on polymicrogyria and motor neuropathy in a patient with Micro syndrome. These findings provide new ins...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2000-7463
更新日期:2000-08-01 00:00:00
abstract::Forty-four patients aged from one month to 16 years suffering from arterial stroke were carefully studied for any hereditary and acquired risk factors for stroke. No physiologic anticoagulant deficiency or antiphospholipid syndrome was found. Two patients had mitochondrial disease (MELAS). Six patients had migraineous...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1073026
更新日期:1994-10-01 00:00:00
abstract::The response of kidney and bone to parathyroid extract (PTE) was investigated in 8 epileptic children on long-term treatment with primidone in combination with phenytoin or other anticonvulsant drugs. The results indicate a dissociation between normal and cyclic AMP excretion and disturbed renal handling of phosphate ...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1059588
更新日期:1982-02-01 00:00:00
abstract::Chorea Huntington (CH) is a dominantly inherited, neurodegenerative disease usually with adult onset. The course of CH is characterized by movement disturbances, psychiatric symptoms and it may lead to dementia. Typically death occurs after 10 to 20 years of CH duration. Invariably, the underlying mutation concerns an...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2002-32367
更新日期:2002-04-01 00:00:00
abstract::Alexander disease (AD) is a leukodystrophy caused by heterozygous mutations in the gene encoding the glial fibrillary acidic protein (GFAP). Currently, de novo heterozygous missense mutations in the GFAP gene are identified in over 95% of patients with AD. However, patients with biopsy-proven AD have been reported in ...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-0037-1608921
更新日期:2018-04-01 00:00:00
abstract::Lacosamide (LCM) due to no known drug interaction and the absence of metabolic enzyme induction is a good candidate for an add-on medication, especially in combination with lamotrigine, levetiracetam (LEV), oxcarbazepine, topiramate, and valproic acid (VPA). Here we report for the first time, to our knowledge, that LC...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-0037-1600112
更新日期:2017-06-01 00:00:00
abstract::Activin A is a multifunctional growth and differentiation factor belonging to the transforming growth factor β (TGF-β) family. Growing evidence indicates its role as a neurotrophic factor and regulator of synaptic transmission as well as its functional importance in several types of cerebral injury. We recently descri...
journal_title:Neuropediatrics
pub_type: 杂志文章,评审
doi:10.1055/s-0035-1547345
更新日期:2015-04-01 00:00:00
abstract::Leukodystrophies were defined in the 1980s as progressive genetic disorders primarily affecting myelin of the central nervous system. At that time, a limited number of such disorders and no associated gene defects were known. The majority of the leukodystrophy patients remained without a specific diagnosis. In the fol...
journal_title:Neuropediatrics
pub_type: 历史文章,杂志文章,评审
doi:10.1055/s-0036-1588020
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Advanced modalities such as functional magnetic resonance imaging (MRI) and diffusion MR tractography offer in vivo information about brain networks and are therefore increasingly used for neurosurgical planning in children also. AIM:This study aims to study the application of routine and advanced tractogra...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-0034-1395346
更新日期:2015-02-01 00:00:00
abstract::Infant botulism is caused by intestinal colonization by Clostridium botulinum, C. barati or C. butyricum. Infant botulism has only rarely been reported outside the USA. A 3-month-old boy developed constipation, lethargy, feeding difficulties and descending, severe, symmetric weakness. He was breastfed but had also bee...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2007-973716
更新日期:1997-10-01 00:00:00
abstract::Muscular dystrophies are a heterogeneous group of inherited diseases. The natural history of these disorders along with their management have changed mainly due to a better understanding of their pathophysiology, the evolution of standards of care, and new treatment options. Dystrophinopathies include both Duchenne's ...
journal_title:Neuropediatrics
pub_type: 杂志文章,评审
doi:10.1055/s-0037-1601860
更新日期:2017-08-01 00:00:00
abstract::Seizures are the most common neurological emergency in the neonates, and this age group has the highest incidence of seizures compared with any other period of life. The author provides a narrative review of recent advances in the genetics of neonatal epilepsies, new neonatal seizure classification system, diagnostics...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-0040-1721702
更新日期:2020-12-08 00:00:00
abstract::Twenty Japanese children with Moyamoya disease were investigated by examining the multimodality evoked potentials (BAEPs, FVEPs and SSEPs). BAEPs were abnormally prolonged wave I-III and wave III-V in each one (10%). FVEPs were abnormal in 6 (30%), included prolonged latencies, reduced amplitudes and poor waveform in ...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1071259
更新日期:1989-02-01 00:00:00
abstract::We report a 7-year-old boy with serologic evidence of active Epstein-Barr virus (EBV) infection who developed transient unilateral hypoglossal nerve palsy, with complete recovery within 21 days. This is, to our knowledge, the youngest reported patient with isolated hypoglossal nerve palsy in the context of EBV infecti...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2007-973534
更新日期:1998-02-01 00:00:00
abstract::Narcolepsy type 1 (NT1) is a rare central disorder of hypersomnolence characterized by excessive daytime sleepiness, cataplexy, sleep paralysis, hallucinations, and fragmented nocturnal sleep usually arising in adolescence or young adulthood. Recently, the childhood NT1 diagnoses have increased for improved disease aw...
journal_title:Neuropediatrics
pub_type: 杂志文章,评审
doi:10.1055/s-0035-1550152
更新日期:2015-06-01 00:00:00
abstract::Sleep polygraphic recording was carried out on 52 normal full-term babies. 16 infants were recorded at 2 - 7 days of age, 14 at 2 to 5 weeks, 13 at 6 to 9 weeks and 9 at 10 - 13 weeks. Central apneas of 2 sec and over were analysed in Active Sleep (AS), Quiet Sleep (QS) and Transitional Sleep (TS). Apnea Index (AI, pe...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1059630
更新日期:1982-05-01 00:00:00
abstract::We here report a 13-year-old Marfan patient who suffered from severe, medication-resistant, intermittent headache, which was provoked when getting into an upright position and immediately relieved by lying down or after intravenous rehydration. The postural benefit and the sudden relief after intravenous hydration sug...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-0029-1243164
更新日期:2009-08-01 00:00:00