Activin A in perinatal brain injury.


:Activin A is a multifunctional growth and differentiation factor belonging to the transforming growth factor β (TGF-β) family. Growing evidence indicates its role as a neurotrophic factor and regulator of synaptic transmission as well as its functional importance in several types of cerebral injury. We recently described age-dependent expression of activin A and its regulation at the mRNA and protein level under different conditions of global hypoxia in the neonatal mouse brain. This review discusses the current knowledge of the function and regulation of activin A from human studies as well as from experimental models of brain injury focusing on acquired lesions of the developing rodent brain during the early stages of brain maturation.






Brackmann FA,Alzheimer C,Trollmann R




Has Abstract


2015-04-01 00:00:00












  • Melatonin: experience in its use for recording sleep EEG in children and review of the literature.

    abstract:BACKGROUND:Sleep is known to improve the yield of EEG recording in children but is often difficult to obtain. In order to evaluate the efficacy and to test the practicability of oral melatonin in obtaining sleep for EEG recording, we studied its use in 70 children. RESULTS:Sleep was obtained in 56 children (80%) with ...


    pub_type: 杂志文章


    authors: Eisermann M,Kaminska A,Berdougo B,Brunet ML

    更新日期:2010-08-01 00:00:00

  • Biotin-responsive basal ganglia disease: case report and review of the literature.

    abstract::Biotin-responsive basal ganglia disease is a rare entity of which 10 cases have been reported in the literature. We report a case of biotin-responsive basal ganglia disease with similarities and differences compared to the previously reported cases by Ozand et al. Our case presented much earlier, was milder and respon...


    pub_type: 杂志文章,评审


    authors: El-Hajj TI,Karam PE,Mikati MA

    更新日期:2008-10-01 00:00:00

  • Epileptic EEG discharges during burst suppression.

    abstract::Barbiturate anaesthesia is used in the treatment of status epilepticus and severe epilepsy of children. EEG is then used as a measure of the depth of anaesthesia, burst suppression being an easily identified EEG pattern. In this case report we describe epileptiform discharges during EEG suppression in two children und...


    pub_type: 杂志文章


    authors: Jäntti V,Eriksson K,Hartikainen K,Baer GA

    更新日期:1994-10-01 00:00:00

  • Early predictors of cerebral visual impairment in infants with cystic leukomalacia.

    abstract::A longitudinal prospective follow-up study looking at the correlation between haemorrhagic-ischaemic lesions on neonatal cranial ultrasound (US) and the development of cerebral visual impairment (CVI) in infancy resulted in the detection of nine infants with severe visual impairment, which was not due to opthalmologic...


    pub_type: 杂志文章


    authors: Eken P,de Vries LS,van Nieuwenhuizen O,Schalij-Delfos NE,Reits D,Spekreijse H

    更新日期:1996-02-01 00:00:00

  • Mega-corpus callosum, polymicrogyria, and psychomotor retardation: confirmation of a syndromic entity.

    abstract::A mega-corpus callosum (CC) is not a common manifestation of neurological disease. Previous reports of patients with a constellation of findings including megalencephaly, perisylvian polymicrogyria, distinct facies, psychomotor retardation and mega-corpus callosum were designated as having megalencephaly, mega-corpus ...


    pub_type: 杂志文章


    authors: Pierson TM,Zimmerman RA,Tennekoon GI,Bönnemann CG

    更新日期:2008-04-01 00:00:00

  • Pediatric multiple sclerosis with primary progressive course--report of a retrospective cohort study in Iran.

    abstract::The aims of this study were to suggest the rate of primary progressive (PP) subtype of pediatric onset multiple sclerosis (MS) in Isfahan, Iran, and describe its clinical and paraclinical features. The data of patients were retrieved from Isfahan MS Society (IMSS) database from April 2003 to August 2011. Among 3,843 M...


    pub_type: 杂志文章


    authors: Etemadifar M,Afzali P,Tabrizi N,Hosseini SA

    更新日期:2013-06-01 00:00:00

  • Neuro-imaging of cerebral visual disturbances in children.

    abstract::The present study comprises the neuroradiological examination (computertomography++, magnetic resonance imaging) of 26 children--9 of them were premature, 16 were full-term and in one patient, no details of the pregnancy were known--all suffering from: a) visual disturbance, not caused by ocular disease or afflictions...


    pub_type: 杂志文章


    authors: van Nieuwenhuizen O,Willemse J

    更新日期:1988-02-01 00:00:00

  • Late infantile Krabbe leukodystrophy: MRI and evoked potentials in a Japanese girl.

    abstract::A Japanese girl showed deterioration in development from the age of 13 months. At the age of 16 months, there were mild spastic diplegia, increase in cerebrospinal fluid protein to 61.5 mg/dl and deficient galactosylceramidase I. Magnetic resonance imaging (MRI) demonstrated a high signal intensity with increased T2 i...


    pub_type: 杂志文章


    authors: Kurokawa T,Chen YJ,Nagata M,Hasuo K,Kobayashi T,Kitaguchi T

    更新日期:1987-08-01 00:00:00

  • Primary degeneration of the granular layer of the cerebellum. A study of 14 patients and review of the literature.

    abstract::Primary degeneration of the granular layer of the cerebellum is an autosomal recessive disorder exhibiting characteristic clinical features: hypotonia, strabismus, delayed motor development, nonprogressive ataxia, delayed language development with dysarthria and mental retardation. We studied fourteen children, seven ...


    pub_type: 杂志文章,评审


    authors: Pascual-Castroviejo I,Gutierrez M,Morales C,Gonzalez-Mediero I,Martínez-Bermejo A,Pascual-Pascual SI

    更新日期:1994-08-01 00:00:00

  • Perfusion abnormalities in hemimegalencephaly.

    abstract:INTRODUCTION:Cerebrovascular changes are rarely discussed in patients with hemimegalencephaly. These alterations have previously been associated with epileptical activity. CASE:We report the case of a 36-week gestation neonate presenting with total right hemimegalencephaly, as demonstrated by a magnetic resonance imag...


    pub_type: 杂志文章


    authors: Wintermark P,Roulet-Perez E,Maeder-Ingvar M,Moessinger AC,Gudinchet F,Meuli R

    更新日期:2009-04-01 00:00:00

  • The Clinical Picture of a Bilateral Perisylvian Syndrome as the Initial Symptom of Mega-Corpus-Callosum Syndrome due to a MAST1-Gene Mutation.

    abstract::Congenital bilateral perisylvian syndrome (CBPS) is a rare neurological disorder associated with typical clinical and imaging features such as bilateral symmetrical polymicrogyria, either exclusively or mainly affecting the perisylvian region of the brain. We present a girl with the typical clinical picture of a CBPS ...


    pub_type: 杂志文章


    authors: Hecher L,Johannsen J,Bierhals T,Buhk JH,Hempel M,Denecke J

    更新日期:2020-12-01 00:00:00

  • Hydrocephalus in infancy and childhood: diagnosis and indication for operation.

    abstract::Improvement of the prognosis for children suffering from hydrocephalus requires prompt diagnosis and reliable indication of surgical treatment. Today, intrauterine hydrocephalus is detectable within the first three months of pregnancy; in infancy, before the cranial sutures have fused, pathological growth of the head ...


    pub_type: 杂志文章


    authors: Gaab MR,Koos WT

    更新日期:1984-10-01 00:00:00

  • Mononeuritis multiplex in a child with cutaneous polyarteritis.

    abstract::A 14-year-old boy presented with a febrile illness associated with arthritis. Shortly later he developed mononeuritis multiplex. After certain typical skin lesions had developed after two months, the diagnosis cutaneous polyarteritis could be made. The diagnostic features of this benign disease, which may involve peri...


    pub_type: 杂志文章


    authors: Draaisma JM,Fiselier TJ,Mullaart RA

    更新日期:1992-02-01 00:00:00

  • The steroid treatment of hereditary motor and sensory neuropathy.

    abstract::A placebo or methylprednisolone (45-60 mg/M2) was administered in a crossover study as a single morning dose on alternate days to fourteen patients who had a familial progressive polyneuropathy that either began or was maximum in the distribution of the peroneal nerves. Neither the patients nor the examining physician...


    pub_type: 临床试验,杂志文章


    authors: Prensky AL,Dodson WE

    更新日期:1984-10-01 00:00:00

  • Melatonin increases following convulsive seizures may be related to its anticonvulsant properties at physiological concentrations.

    abstract::Melatonin ( N-acetyl-5-methoxytryptamine, aMT) is an indoleamine produced by several organs and tissues including the pineal gland. Melatonin (aMT) modulates the activity of the brain, mainly acting on both GABA and glutamate receptors. Previous studies have shown the participation of melatonin in the control of convu...


    pub_type: 杂志文章


    authors: Molina-Carballo A,Muñoz-Hoyos A,Sánchez-Forte M,Uberos-Fernández J,Moreno-Madrid F,Acuña-Castroviejo D

    更新日期:2007-06-01 00:00:00

  • The possible adjuvant role of bordetella pertussis and pertussis vaccine in causing severe encephalopathic illness: a presentation of three case histories.

    abstract::The clinical and some laboratory details of three children who had severe neurological sequelae after either infection with Bordetella pertussis or immunisation with diphtheria, tetanus and pertussis vaccine and oral polio vaccine are reported. Each of these patients had had a recent or concurrent viral illness. The s...


    pub_type: 杂志文章


    authors: Cavanagh NP,Brett EM,Marshall WC,Wilson J

    更新日期:1981-11-01 00:00:00

  • Scheie syndrome presenting as myopathy.

    abstract::We investigated two brothers with Scheie syndrome whose only complaint was exercise intolerance. In the quadriceps muscle biopsy of both patients, between the normal muscle fibres an increased number of markedly swollen periodic acid-Schiff-positive fibroblasts were seen. Ultrastructurally, these cells showed an accum...


    pub_type: 杂志文章


    authors: Verrips A,van Engelen BG,ter Laak H,Wesseling P,de Jong J,Gabreëls FJ

    更新日期:2001-04-01 00:00:00

  • Outcome in children with space-occupying posterior fossa arachnoid cysts.

    abstract::While prognostic information for Dandy-Walker syndrome and non-progressive cerebellar ataxia/cerebellar hypoplasia is available, surprisingly scant literature reports are found for space-occupying posterior fossa arachnoid cysts (PFAC). We describe the outcome of patients with symptomatic PFAC shunted as infants. Only...


    pub_type: 杂志文章


    authors: Boltshauser E,Martin F,Altermatt S

    更新日期:2002-06-01 00:00:00

  • Diffusion-Weighted Imaging of Periventricular Leukomalacia in Very Young Children: Assessment of Peritrigonal Stripe of Restricted Diffusion.

    abstract::Purpose In periventricular leukomalacia (PVL), apparent diffusion coefficient (ADC) reduction, normally shown as dark stripe in the peritrigonal (PT) white matter, may be incomplete. We assessed the PT dark stripe to differentiate between PVL patients and control subjects. Patients and Methods We reviewed the magnetic...


    pub_type: 杂志文章


    authors: Lu PS,Toh CH,Yeh CH,Wang HS,Lin KL,Wong AM

    更新日期:2017-04-01 00:00:00

  • Pitfalls in the diagnosis of multiple sulfatase deficiency.

    abstract::Multiple sulfatase deficiency (MSD, OMIM 272200) is an autosomal recessive leukodystrophy associated with the deficiency of several, in total seven, sulfatases. The disorder is clinically and biochemically variable. The clinical picture combines features of mucopolysaccharidosis and metachromatic leukodystrophy (MLD, ...


    pub_type: 杂志文章


    authors: Mancini GM,van Diggelen OP,Huijmans JG,Stroink H,de Coo RF

    更新日期:2001-02-01 00:00:00

  • The effect of ACTH on plastic synapses in the developing mouse brain.

    abstract::We studied the effect of ACTH on plastic synapses in the hippocampal gyrus of the developing mouse brain. Examination of ethanolic phosphotungustic acid stained synaptic junctions revealed no obvious differences between the ACTH-treated brains and controls qualitatively and quantitatively. Therefore, ACTH may not adve...


    pub_type: 杂志文章


    authors: Tateno A,Koya N,Aoki T,Nasu F

    更新日期:1987-11-01 00:00:00

  • Cardiac dysautonomia and serotonin plasma levels in Rett syndrome.

    abstract:BACKGROUND:In Rett syndrome the autonomic nervous system is abnormal at various levels, from the central to the peripheral nervous system. A role for serotoninergic dysfunction has been suggested. OBJECTIVES:The aim of our study was to evaluate the relation between cardiac dysautonomia (expressed by means of heart rat...


    pub_type: 杂志文章


    authors: Guideri F,Acampa M,Blardi P,de Lalla A,Zappella M,Hayek Y

    更新日期:2004-02-01 00:00:00

  • Multiple Causes of Pediatric Early Onset Chorea-Clinical and Genetic Approach.

    abstract:OBJECTIVE:This article elucidates a clinical and genetic approach to pediatric early-onset chorea in patients with normal neuroimaging. METHODS:We retrospectively studied patients with onset hyperkinetic movement disorders. Only children with onset of chorea in the first 3 years of life were included, those with an ab...


    pub_type: 杂志文章


    authors: Blumkin L,Lerman-Sagie T,Westenberger A,Ben-Pazi H,Zerem A,Yosovich K,Lev D

    更新日期:2018-08-01 00:00:00

  • Comparison of different tractography algorithms and validation by intraoperative stimulation in a child with a brain tumor.

    abstract:BACKGROUND:Advanced modalities such as functional magnetic resonance imaging (MRI) and diffusion MR tractography offer in vivo information about brain networks and are therefore increasingly used for neurosurgical planning in children also. AIM:This study aims to study the application of routine and advanced tractogra...


    pub_type: 杂志文章


    authors: Küpper H,Groeschel S,Alber M,Klose U,Schuhmann MU,Wilke M

    更新日期:2015-02-01 00:00:00

  • Positive rolandic sharp waves in preterm infants with periventricular leukomalacia: their relation to background electroencephalographic abnormalities.

    abstract::The aim of this study was to clarify the significance of positive rolandic sharp waves (PRS) in preterm infants with periventricular leukomalacia (PVL) and their relation to background electroencephalographic (EEG) abnormalities. We retrospectively evaluated EEG findings of 93 preterm infants; 31 infants in the PVL gr...


    pub_type: 杂志文章


    authors: Okumura A,Hayakawa F,Kato T,Kuno K,Watanabe K

    更新日期:1999-12-01 00:00:00

  • Ventricular Catheter Systems with Subcutaneous Reservoirs (Ommaya Reservoirs) in Pediatric Patients with Brain Tumors: Infections and Other Complications.

    abstract:OBJECTIVE:This study aims to describe complications related to ventricular catheter systems with subcutaneous reservoirs (VCSR) (such as Ommaya reservoirs) in pediatric patients with brain tumors. METHODS:Retrospective analysis of consecutive patients with a total of 31 VCSR treated at the Children's University Hospit...


    pub_type: 杂志文章


    authors: Gerber NU,Müller A,Bellut D,Bozinov O,Berger C,Grotzer MA

    更新日期:2015-12-01 00:00:00

  • Patterns of cerebral glucose metabolism using 18FDG and positron tomography in the neurologic investigation of the full term newborn infant.

    abstract::18F fluorodeoxyglucose (18FDG) and positron tomography (PT) were used in 20 full term babies with seizures or hypotonia to describe regional cerebral glucose metabolism. Among babies with seizures, birth asphyxia was the most common cause. PT was performed at age 6-17 days. One hour before PT, 18FDG (50-100 microCi/kg...


    pub_type: 杂志文章


    authors: Thorp PS,Levin SD,Garnett ES,Nahmias C,Firnau G,Toi A,Upton AR,Nobbs PT,Sinclair JC

    更新日期:1988-08-01 00:00:00

  • Ischemic stroke due to fibromuscular dysplasia.

    abstract::Fibromuscular dysplasia is a segmental, nonatheromatous angiopathy. A 13-year-old patient is reported with stroke. Left-sided carotid angiogram revealed typical findings of fibromuscular dysplasia in the left carotid artery. ...


    pub_type: 杂志文章


    authors: Emparanza JI,Aldamiz-Echevarria L,Perez-Yarza E,Hernandez J,Peña B,Gaztañaga R

    更新日期:1989-08-01 00:00:00

  • Neurophysiological and anatomical correlations in neonatal nonketotic hyperglycinemia.

    abstract::Electroencephalographic (EEG) and brainstem auditory evoked response (BAER) findings have not been previously described and correlated with the pathological findings in an autopsied case of neonatal nonketotic hyperglycinemia (NKH). A 38 week gestation male infant presented within two hours of age with stimulus-evoked...


    pub_type: 杂志文章


    authors: Scher MS,Bergman I,Ahdab-Barmada M,Fria T

    更新日期:1986-08-01 00:00:00

  • Neonatal Seizures-Are We there Yet?

    abstract::Neonatal seizures are the most prevalent and distinctive sign of neurologic dysfunction in early life and pose an immense challenge for clinicians. Improvements in neonatal care have increased the survival rate of extremely premature infants, considerably changing the spectrum of underlying etiologies, and instigating...


    pub_type: 杂志文章,评审


    authors: Ramantani G,Schmitt B,Plecko B,Pressler RM,Wohlrab G,Klebermass-Schrehof K,Hagmann C,Pisani F,Boylan GB

    更新日期:2019-10-01 00:00:00