Abstract:
:Activin A is a multifunctional growth and differentiation factor belonging to the transforming growth factor β (TGF-β) family. Growing evidence indicates its role as a neurotrophic factor and regulator of synaptic transmission as well as its functional importance in several types of cerebral injury. We recently described age-dependent expression of activin A and its regulation at the mRNA and protein level under different conditions of global hypoxia in the neonatal mouse brain. This review discusses the current knowledge of the function and regulation of activin A from human studies as well as from experimental models of brain injury focusing on acquired lesions of the developing rodent brain during the early stages of brain maturation.
journal_name
Neuropediatricsjournal_title
Neuropediatricsauthors
Brackmann FA,Alzheimer C,Trollmann Rdoi
10.1055/s-0035-1547345subject
Has Abstractpub_date
2015-04-01 00:00:00pages
82-7issue
2eissn
0174-304Xissn
1439-1899journal_volume
46pub_type
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