Abstract:
PURPOSE:We aim to correlate size and shape of corpus callosum with severity of motor and cognitive impairments in children with periventricular leukomalacia (PVL). METHODS:Children with PVL were stratified based on the severity of their motor and cognitive impairments. An age-matched control group was established. The corpus callosum was identified on mid-sagittal T (1)-weighted spin-echo (TR/TE: 550/15) MR images. The shape characteristics of the corpus callosum were measured with respect to a template via a shape transformation. The degree of callosal-shape transformation was quantified by a deformation function, which in turn was compared, using point-wise T-tests, for controls versus patients, diplegic versus quadriplegic patients, and patients with mild versus severe cognitive impairment. RESULTS:29 children with spastic cerebral palsy and PVL and 32 age-matched controls were identified. In the PVL group, the entire corpus callosum was significantly smaller than in the control group (p value = 0.001). Significant differences existed in the shape of the corpus callosum between patients with diplegic versus quadriplegic and between patients with severe versus mild cognitive impairment. CONCLUSION:Global and regional corpus callosal morphology can be quantified using deformation functions.
journal_name
Neuropediatricsjournal_title
Neuropediatricsauthors
Davatzikos C,Barzi A,Lawrie T,Hoon AH Jr,Melhem ERdoi
10.1055/s-2003-43259subject
Has Abstractpub_date
2003-06-01 00:00:00pages
247-52issue
5eissn
0174-304Xissn
1439-1899journal_volume
34pub_type
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