Abstract:
PURPOSE:The term clinical functional magnetic resonance imaging (fMRI) describes an examination with direct clinical impact on the patient. Interpretation of clinical fMRI especially in children, however, is often difficult due to suboptimal data quality. The current gold standard is standardized visual evaluation. To evaluate such data in an automated and objective way, we developed an approach to identify successful sessions. METHODS:Average activation inside a predefined, task-specific region of interest (ROI) is compared with average activation in the rest of the brain, and their ratio (classification factor [Fc]) is determined for different statistical thresholds (T). The approach was tested and validated using 239 clinical pediatric fMRI sessions (sensorimotor, perceptive /productive language). Performance was assessed in terms of sensitivity, specificity, and positive likelihood ratio. RESULTS:Best performance was found for Fc ≥ 2 and T ≥ 2.5, achieving a sensitivity of 0.87 and specificity of 0.94. Comparing the different domains, sensitivity was lowest for language production tasks, mainly due to atypical activation foci. CONCLUSION:We demonstrate that an objective, automated framework for the classification of clinical pediatric fMRI sessions may provide important additional information, supporting visual evaluation, especially from sensorimotor and language perception domains. In the current form, atypical or strong network activation is not easily captured.
journal_name
Neuropediatricsjournal_title
Neuropediatricsauthors
Zsoter A,Staudt M,Wilke Mdoi
10.1055/s-0032-1324731subject
Has Abstractpub_date
2012-10-01 00:00:00pages
249-57issue
5eissn
0174-304Xissn
1439-1899journal_volume
43pub_type
杂志文章相关文献
NEUROPEDIATRICS文献大全abstract:OBJECTIVES:The present study investigates the effect of topical injections of botulinum toxin A into the cephalic salivary glands of children with chronic hypersalivation due to neurodegenerative diseases. METHODS:Five children with hypersalivation due to severe neurological diseases received, under ultrasound guidanc...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2002-37084
更新日期:2002-12-01 00:00:00
abstract::A newborn with multiple congenital contractures (MCC) or arthrogryposis multiplex congenita and a leukodystrophy is described. The clinical features and neurophysiological studies suggested a disorder primarily involving the central white matter. The diagnosis of connatal Pelizaeus-Merzbacher disease was made post mor...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1052451
更新日期:1988-11-01 00:00:00
abstract::Birth asphyxia is a major concern in neonatal care. Epileptic seizures are associated with subsequent neurodevelopmental deficits. Eighty-five percent of these seizures remain subclinical and therefore an on-line monitoring device is needed. In an earlier study we showed that the synchronization likelihood was able to...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2004-830367
更新日期:2004-12-01 00:00:00
abstract:: ...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-0038-1675237
更新日期:2019-02-01 00:00:00
abstract::Seven epileptic patients with permanent ataxic dysfunction following DPH treatment are described. The ataxia correlates with cerebellar atrophy, though the extents of clinical and structural lesions are not necessarily proportional. Cerebellar atrophy is demonstrated by CT scans, the vermal region seems to be predomin...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1052345
更新日期:1984-05-01 00:00:00
abstract::A previously healthy one-year-old boy, the youngest child of unrelated parents, presented with a four-week history of episodes of myoclonus triggered only by tactile stimulation to his head. There had been no loss of developmental skills. The electroencephalogram (EEG) revealed generalised polyspike wave activity both...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2003-41275
更新日期:2003-06-01 00:00:00
abstract::Hashimoto's encephalopathy (HE) is an acute or subacute relapsing disorder usually affecting euthyroid patients with evidence of autoimmune thyroiditis. The neurological manifestations are non-specific, with subacute cognitive impairment, movement disorders, generalized seizures, focal neurological symptoms such as st...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2005-865712
更新日期:2005-06-01 00:00:00
abstract::A case of a child presenting with congenital abnormalities at birth is reported. The early development remained severely retarded and acquired skills minimally. The head circumference centile decreased. Magnetic resonance imaging showed progressive neuronal atrophy and secondary delay in myelination. Dihydropyrimidine...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2007-973681
更新日期:1997-04-01 00:00:00
abstract::Careful clinical delineation and advances in analytical methods have opened new possibilities for the detection of inherited neurometabolic disorders, some of which require specific CSF analyses for diagnosis. Although patients suffering from these disorders have recognizable phenotypes, there are strong indications t...
journal_title:Neuropediatrics
pub_type: 杂志文章,评审
doi:10.1055/s-2007-973538
更新日期:1998-04-01 00:00:00
abstract::Congenital or acquired disorders of hemostasis can cause thrombotic events in adults as well as in children. Recently, acute neurologic complications such as hemiparesis or transitory ischemic attacks (TIA) have been reported in patients with different disorders of hemostasis. In addition, the interaction between anio...
journal_title:Neuropediatrics
pub_type: 杂志文章,评审
doi:10.1055/s-2008-1071573
更新日期:1994-02-01 00:00:00
abstract::We here report a 13-year-old Marfan patient who suffered from severe, medication-resistant, intermittent headache, which was provoked when getting into an upright position and immediately relieved by lying down or after intravenous rehydration. The postural benefit and the sudden relief after intravenous hydration sug...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-0029-1243164
更新日期:2009-08-01 00:00:00
abstract::We report on 12 children with neuronal ceroid lipofuscinosis (NCL) diagnosed between 1974-1995 in the West of Scotland. Diagnosis was made on the basis of clinical, electrophysiological, radiological and pathological examination including electron microscopy (EM) in all cases. Incidence was calculated on the basis of ...
journal_title:Neuropediatrics
pub_type: 杂志文章,评审
doi:10.1055/s-2007-973690
更新日期:1997-06-01 00:00:00
abstract::Forty-four patients aged from one month to 16 years suffering from arterial stroke were carefully studied for any hereditary and acquired risk factors for stroke. No physiologic anticoagulant deficiency or antiphospholipid syndrome was found. Two patients had mitochondrial disease (MELAS). Six patients had migraineous...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1073026
更新日期:1994-10-01 00:00:00
abstract::Two sibs with an encephalopathy, including intracerebral calcification and a white matter disease, are reported. In the younger sister, the cerebrospinal fluid showed chronic pleocytosis and clinically she strictly fits to the diagnosis of Aicardi-Goutières syndrome. Both sisters were affected by a spastic tetraplegia...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2007-973455
更新日期:1999-02-01 00:00:00
abstract::Aim For children with medical complexity, interdisciplinary treatment approaches are required to address the various aspects defined within the biopsychosocial model. Methods The present study identifies dimensions of the biopsychosocial model to generate a standardized visualized severity score for chronic neurologic...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-0036-1584195
更新日期:2016-08-01 00:00:00
abstract::A number of frequently prescribed gastrointestinal drugs can cause movement disorders in children, as well as in adults. In our centre for paediatric neurology, we saw a 3-year-old girl with abnormal movements mostly of the legs with an inner restlessness (akathisia) while using cisapride. Another patient, a 17-year-o...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2006-923981
更新日期:2006-04-01 00:00:00
abstract::Micro syndrome is a rare condition in which congenital cataracts, microphthalmia, and facial dysmorphism are associated with severe neurological disorders, namely: microcephaly and psychomotor retardation. We report on polymicrogyria and motor neuropathy in a patient with Micro syndrome. These findings provide new ins...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2000-7463
更新日期:2000-08-01 00:00:00
abstract::The diagnosis of mitochondrial respiratory chain deficiency is usually made by analysis of mitochondrial respiratory chain activity in muscle biopsy. We describe 4 patients in whom the diagnosis was based on mitochondrial respiratory chain deficiency in liver alone. In 3 patients, liver complex IV activity was deficie...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2005-865866
更新日期:2005-08-01 00:00:00
abstract::We report antiphospholipid antibody positivity in three of a consecutive series of 23 children presenting partial epileptic seizures. There was no clinical or serological evidence of systemic lupus erythematosus or other connective-tissue disease. Neither computed tomography nor magnetic resonance imaging revealed isc...
journal_title:Neuropediatrics
pub_type: 临床试验,杂志文章
doi:10.1055/s-2007-973570
更新日期:1998-10-01 00:00:00
abstract::Although Joubert syndrome (JS) was first reported in 1969 by Joubert et al (21), the long-term outcome is not yet documented. We report 19 children (4 pairs of siblings) from a single institution diagnosed with JS. Nine children were last seen between ages 10 and 18 years, seven between ages 1 and 4 years. Three child...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2007-973701
更新日期:1997-08-01 00:00:00
abstract::In order to examine if specific findings from CT correlate with specific clinical or neurological findings, 30 children, 5 to 16 years old, born at term, affected by congenital hemiparesis without intellectual impairment, were submitted to neurofunctional and psychological assessment and examined by CT. 28 of the 30 c...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1052456
更新日期:1987-05-01 00:00:00
abstract::A forme fruste Rett variant female with partially preserved speech remnants is described. She was first seen by the author at an age of 4 years. She then presented with an unspecific syndrome of moderate mental retardation. At follow-up when aged 32 she had successively through the years developed a number of Rett cha...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2007-979730
更新日期:1995-04-01 00:00:00
abstract::24 healthy full-term newborns underwent polygraphic recordings of EEG, EMG, EOG, ECG, abdominal and thoracic respiration during day-time-sleep. Transient EEG patterns (rhythmic alpha and beta activity, spikes/sharp waves and frontal sharp transients) were visually evaluated and quantified. Rhythmic alpha activity is n...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1059609
更新日期:1982-08-01 00:00:00
abstract::Stimulant-associated growth deficits in children with attention deficit hyperactivity disorder (ADHD) have long been a concern. We chose 146 school age children diagnosed with ADHD being treated with methylphenidate (MPH) and 29 drug-free ADHD children, and followed them up for 2-4 years. We recorded the changes in he...
journal_title:Neuropediatrics
pub_type: 临床试验,杂志文章
doi:10.1055/s-0030-1261893
更新日期:2010-08-01 00:00:00
abstract::Fucosidosis, a progressive neurodegenerative disease, evident in early childhood, is associated with progressive loss of mental and motor function and increasing spasticity and hyperreflexia. We report a Canadian male, with clinical features similar to previously reported fucosidosis patients, however, since age 5 he ...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2007-979784
更新日期:1995-12-01 00:00:00
abstract::Narcolepsy type 1 (NT1) is a rare central disorder of hypersomnolence characterized by excessive daytime sleepiness, cataplexy, sleep paralysis, hallucinations, and fragmented nocturnal sleep usually arising in adolescence or young adulthood. Recently, the childhood NT1 diagnoses have increased for improved disease aw...
journal_title:Neuropediatrics
pub_type: 杂志文章,评审
doi:10.1055/s-0035-1550152
更新日期:2015-06-01 00:00:00
abstract::The fatty acid pattern of serum lecithin was studied in 31 children with hereditary motor and sensory neuropathies (HMSN) of types specified in the classification of Dyck et al. (1975). In 30 children no relevant changes were revealed. The remaining patient had changes which were reversible and were considered to be i...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1059635
更新日期:1981-02-01 00:00:00
abstract::The definition and the clinical picture of arthrogryposis multiplex congenita (AMC) are discussed and the associated anomalies, deformities and syndromes are listed. It is stressed that isolated congenital contractures in (progressive) neuromuscular disorders may be manifestations of AMC, dependent on the moment of th...
journal_title:Neuropediatrics
pub_type: 杂志文章,评审
doi:10.1055/s-2008-1059546
更新日期:1983-02-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the spectrum of muscle involvement on MRI in patients with autosomal dominant Emery-Dreifuss muscular dystrophy (EDMD2) due to mutations in the lamin A/C gene and to compare it to the pattern found in other conditions with similar phenotype. PATIENTS AND METHODS:Nine pat...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2002-23593
更新日期:2002-02-01 00:00:00
abstract::This report describes a patient with Gaucher disease type II who developed severe rhabdomyolysis. We treated him successfully and measured various cytokine and chemokine levels sequentially to elucidate the pathophysiology of rhabdomyolysis. The serum levels of interleukin-6, -8, -10, granulocyte colony-stimulating fa...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-0030-1253425
更新日期:2010-02-01 00:00:00