Abstract：
:The effect of diethylstilbestrol (DES) on urethan-induced mouse lung tumorigenesis was assessed by a single intraperitoneal injecting of urethan (50 mg/kg) or/and multi intramuscular injecting of DES (5 or 50 mg/kg). All mice were sacrificed 18 weeks after administration, and the lung tumors were examined histopathologically. DES did not produce an elevated lung tumor response when administered alone, but it produced a statistically significant enhancement of incidence of tumors, average number of tumors, incidence of cancers and constituent ratio of malignant tumors when given in conjunction with urethan. The results indicated that DES may be a promoter in lung tumor formation.
journal_name
Chemospherejournal_title
Chemosphereauthors
Jiang YG,Chen JK,Wu ZLdoi
10.1016/s0045-6535(99)00410-5subject
Has Abstractpub_date
2000-07-01 00:00:00pages
187-90issue
1-2eissn
0045-6535issn
1879-1298pii
S0045-6535(99)00410-5journal_volume
41pub_type
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