Administration of a GABAB agonist baclofen before running to exhaustion in the rat: effects on performance and on some indicators of fatigue.

Abstract:

:The present study was designed to examine the effects of administration of a GABAergic agonist (Baclofen) on run-time to exhaustion in trained and untrained rats, and on some indicators of fatigue. Run-time to exhaustion on a treadmill set at a speed of 25 m.min-1 was significantly increased in both untrained (p < 0.01) and trained rats (p < 0.005) administered with baclofen one hour before the exercise. The animals who had run the longest time displayed the lowest concentrations of liver and muscle glycogen, and a decrease in plasma glucose concentrations (p < 0.05). The results of this investigation suggest that fatigue during prolonged exercise can be influenced by pharmacological administration of a GABAergic agonist. Indicators of fatigue such as glycemia, liver and muscular glycogen are not the limiting factors of performance and central mechanisms play a key role at exhaustion.

journal_name

Int J Sports Med

authors

Abdelmalki A,Merino D,Bonneau D,Bigard AX,Guezennec CY

doi

10.1055/s-2007-972598

subject

Has Abstract

pub_date

1997-02-01 00:00:00

pages

75-8

issue

2

eissn

0172-4622

issn

1439-3964

journal_volume

18

pub_type

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