Abstract：
:Carbon monoxide (CO) rebreathing procedures are used to assess hemoglobin mass (Hbmass) but recent evidence suggests that CO is a signaling molecule that may alter physiological functions. We examined the effects of 10 days of intermittent, low-dose CO inhalation on Hbmass, aerobic performance predictors, and peak-power exercise tolerance. 18 recreationally-active men were randomized to either CO or placebo inhalation groups in a single-blind, pre-post parallel-groups trial. Primary outcomes were assessed before and after an intervention period during which subjects inhaled a bolus of 1.2 ml kg(-1) CO or placebo (room air) for 30 s, once per day on 10 days over a 12-day period. Cycling tests were performed >16 h following CO inhalation to exclude acute effects of CO exposure. CO inhalation elevated carboxyhemoglobin by 4.4±0.4% (mean±SD) following each exposure. Compared to placebo, chronic CO inhalation did not significantly alter Hbmass (p=0.99), peak oxygen uptake (p=0.59), peak power output (p=0.10), submaximal oxygen uptake (p=0.91), submaximal RER (p=0.22), lactate threshold (p=0.65), or peak-power exercise tolerance (p=0.60). In conclusion, our data support the ability to perform repeated measurements of Hbmass using CO rebreathing over a 12-day period without altering physiological responses.
journal_name
Int J Sports Medjournal_title
International journal of sports medicineauthors
Ryan BJ,Goodrich JA,Schmidt W,Kane LA,Byrnes WCdoi
10.1055/s-0042-108197subject
Has Abstractpub_date
2016-10-01 00:00:00pages
884-9issue
11eissn
0172-4622issn
1439-3964journal_volume
37pub_type
杂志文章,随机对照试验abstract：:The purpose of the present study was to ascertain whether increase in step frequency at a given velocity during running reduces the lower extremity loading variables, which is associated with tibial stress fracture in runner. We hypothesized that the lower extremity loading variables at a given speed would be minimize...
journal_title：International journal of sports medicine
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journal_title：International journal of sports medicine
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journal_title：International journal of sports medicine
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journal_title：International journal of sports medicine
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journal_title：International journal of sports medicine
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journal_title：International journal of sports medicine
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journal_title：International journal of sports medicine
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journal_title：International journal of sports medicine
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journal_title：International journal of sports medicine
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journal_title：International journal of sports medicine
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pub_type： 杂志文章,随机对照试验
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