Abstract:
:We have shown repeatedly that pre-treatment of neonatal rats with dexamethasone provides protection against hypoxic-ischemic brain damage. Although the mechanism of action is not certain, hypothermia, an alteration in cerebral perfusion or an induction of antioxidant enzymes does not readily explain this effect. A relative hyperglycemia is usually observed during hypoxia-ischemia in dexamethasone treated animals, and may provide partial protection, but does not account for the entire response. However, the protective effect is likely mediated by glucocorticoid receptors since alternate glucocorticoids such as methyl prednisolone and corticosterone are also effective. Furthermore, the effect can be inhibited by pre-treatment with a glucocorticoid antagonist RU38486. The neuroprotection also appears to be related to alterations in cerebral metabolism. Glucose utilization is reduced prior to hypoxia-ischemia in dexamethasone compared to vehicle treated animal and is better maintained during hypoxia-ischemia in dexamethasone treated animals. In addition, preliminary studies indicate that high energy phosphates in the brain are higher in dexamethasone animals. Thus, glucocorticoids may provide their protection against hypoxic-ischemic damage by decreasing basal metabolic energy requirements and/or increasing the availability or efficiency of use of energy substrates.
journal_name
Neurosci Biobehav Revjournal_title
Neuroscience and biobehavioral reviewsauthors
Tuor UIdoi
10.1016/s0149-7634(96)00007-3subject
Has Abstractpub_date
1997-03-01 00:00:00pages
175-9issue
2eissn
0149-7634issn
1873-7528pii
S0149-7634(96)00007-3journal_volume
21pub_type
杂志文章,评审abstract::The componential view of human emotion recognises that affective states comprise conscious, behavioural, physiological, neural and cognitive elements. Although many animals display bodily and behavioural changes consistent with the occurrence of affective states similar to those seen in humans, the question of whether...
journal_title:Neuroscience and biobehavioral reviews
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doi:10.1016/j.neubiorev.2019.11.014
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abstract::Handedness is a dynamic and complex aspect of human behavior. Changing it through practice, either willingly or obliged by some reason, requires a considerable amount of effort. Analyzing studies that presented handedness shifts may expand our comprehension of this phenomenon, since knowing how to change it might prov...
journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,meta分析,评审
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abstract::The main problem with sensory processing is the difficulty in relating sensory input to physiological responses and perception. This is especially problematic at higher levels of processing, where complex cues elicit highly specific responses. In olfaction, this relationship is particularly obfuscated by the difficult...
journal_title:Neuroscience and biobehavioral reviews
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abstract::Less than two decades after its inception, the burgeoning field of neuroaesthetics continues to grow in interest and momentum. Despite the biological and social importance of the human body and the attention people pay to its appearance in daily life, only recently has neuroaesthetic inquiry turned its attention to qu...
journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/j.neubiorev.2016.02.022
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
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更新日期:1998-03-01 00:00:00
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
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更新日期:1995-10-01 00:00:00
abstract::Environmental tobacco smoke, inhaled by active firsthand smokers and their entourage, is associated with morbidity and mortality. Many children are passively exposed to secondhand smoke worldwide. Infants and young children account for the largest global disease burden associated with prenatal and postnatal secondhand...
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abstract::Rapid instructed task learning (RITL) is one of the most remarkable human abilities, when considered from both computational and evolutionary perspectives. A key feature of RITL is that it enables new goals to be immediately pursued (and shared) following formation of task representations. Although RITL is a form of c...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
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更新日期:2017-10-01 00:00:00
abstract::Psychiatric disorders like mood disorders, schizophrenia, or drug addiction affect a sizeable proportion of the human population and severely compromise quality of life. Therefore, measures to prevent the manifestation, and treatments to ameliorate the symptoms, of these disorders are in high demand. Brain lipids dete...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
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abstract::Characterizing neuroanatomical markers of different stages of schizophrenia (SZ) to assess pathophysiological models of how the disorder develops is an important target for the clinical practice. We performed a meta-analysis of voxel-based morphometry studies of genetic and clinical high-risk subjects (g-/c-HR), recen...
journal_title:Neuroscience and biobehavioral reviews
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abstract::In a 1967 Physiological Reviews paper, Frank Beach put forth four propositions regarding forebrain and hormonal control of brainstem-spinal mechanisms of copulatory behavior. Simply stated, he proposed that: 1) the forebrain exerted an inhibitory control over species-typical copulatory reflexes through descending effe...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
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abstract::Post-stroke depression (PSD) is the most common mental health issue, afflicting around 33% of stroke survivors. PSD has a negative impact on the rehabilitation, recuperation of motor and cognitive deficits following stroke and significantly increases the chances of relapsing neurovascular events. It has been demonstra...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/j.neubiorev.2018.04.005
更新日期:2018-07-01 00:00:00
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journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
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更新日期:2020-12-28 00:00:00
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journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/s0149-7634(01)00005-7
更新日期:2001-03-01 00:00:00