Abstract：
:Reductionist attempts to dissect complex mechanisms into simpler elements are necessary, but not sufficient for understanding how biological properties like reward emerge out of neuronal activity. Recent studies on intracranial self-administration of neurochemicals (drugs) found that rats learn to self-administer various drugs into the mesolimbic dopamine structures-the posterior ventral tegmental area, medial shell nucleus accumbens and medial olfactory tubercle. In addition, studies found roles of non-dopaminergic mechanisms of the supramammillary, rostromedial tegmental and midbrain raphe nuclei in reward. To explain intracranial self-administration and related effects of various drug manipulations, I outlined a neurobiological theory claiming that there is an intrinsic central process that coordinates various selective functions (including perceptual, visceral, and reinforcement processes) into a global function of approach. Further, this coordinating process for approach arises from interactions between brain structures including those structures mentioned above and their closely linked regions: the medial prefrontal cortex, septal area, ventral pallidum, bed nucleus of stria terminalis, preoptic area, lateral hypothalamic areas, lateral habenula, periaqueductal gray, laterodorsal tegmental nucleus and parabrachical area.
journal_name
Neurosci Biobehav Revjournal_title
Neuroscience and biobehavioral reviewsauthors
Ikemoto Sdoi
10.1016/j.neubiorev.2010.02.001subject
Has Abstractpub_date
2010-11-01 00:00:00pages
129-50issue
2eissn
0149-7634issn
1873-7528pii
S0149-7634(10)00025-4journal_volume
35pub_type
杂志文章,评审abstract：:Dementia is a major cause of disability amongst the elderly and represents a serious global health issue. Current treatments for dementia are limited; at best they provide inadequate symptomatic relief. In contrast, there are a plethora of approaches that provide symptomatic relief for abnormalities of movement includ...
journal_title：Neuroscience and biobehavioral reviews
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journal_title：Neuroscience and biobehavioral reviews
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journal_title：Neuroscience and biobehavioral reviews
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pub_type： 杂志文章,评审
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journal_title：Neuroscience and biobehavioral reviews
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journal_title：Neuroscience and biobehavioral reviews
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journal_title：Neuroscience and biobehavioral reviews
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journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
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abstract：:Among the most useful models for depressive disorders are those, which involve a stress induced change in behaviour. Learned helplessness is one such model and is induced through exposure to uncontrollable and unpredictable aversive events. Learned helplessness as induced in rats using foot shock is well characterized...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
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更新日期：2005-01-01 00:00:00
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journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2010.01.014
更新日期：2010-06-01 00:00:00
