Abstract:
:Unipolar depression and diabetes mellitus each account for a significant proportion of the global burden of disease. Epidemiological literature suggests a bi-directional relationship between these two common disorders, and evidence from the molecular sciences supports a role for inflammation in the pathogenesis and pathophysiology of each disorder individually. Recent advances in understanding the neurobiology of depression have implicated dysfunction of the hypothalamus-pituitary-adrenal axis, neurotrophins, and inflammatory mediators in the development of this disorder. Similarly, dysregulated facets of both the innate and adaptive immune system have been implicated in the onset of insulin resistance and type 2 diabetes. This review draws upon an emerging body of epidemiological and mechanistic evidence to support the hypothesis that shared inflammatory mechanisms may represent a key biological link in this co-morbidity. Given the shared mechanisms of this co-morbidity, these patients may be excellent candidates for novel immune targeted pharmacotherapy.
journal_name
Neurosci Biobehav Revjournal_title
Neuroscience and biobehavioral reviewsauthors
Stuart MJ,Baune BTdoi
10.1016/j.neubiorev.2011.10.001subject
Has Abstractpub_date
2012-01-01 00:00:00pages
658-76issue
1eissn
0149-7634issn
1873-7528pii
S0149-7634(11)00183-7journal_volume
36pub_type
杂志文章,评审abstract::Abnormalities in the simplest form of learning, habituation, have been reported in a variety of neuropsychiatric disorders as etiologically diverse as Autism Spectrum Disorder, Fragile X syndrome, Schizophrenia, Parkinson's Disease, Huntington's Disease, Attention Deficit Hyperactivity Disorder, Tourette's Syndrome, a...
journal_title:Neuroscience and biobehavioral reviews
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abstract::There is convincing evidence that schizophrenia is characterised by progressive brain volume changes during the course of the illness. In a large longitudinal study it was shown that different age-related trajectories of brain tissue loss are present in patients compared to healthy subjects, suggesting that brain matu...
journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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pub_type: 杂志文章,评审
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
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journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章
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journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
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