Abstract:
:There is convincing evidence that schizophrenia is characterised by progressive brain volume changes during the course of the illness. In a large longitudinal study it was shown that different age-related trajectories of brain tissue loss are present in patients compared to healthy subjects, suggesting that brain maturation that occurs in the third and fourth decade of life is abnormal in schizophrenia. However, studies show that medication intake and cannabis use are important confounding factors when interpreting brain volume (change) abnormalities. Indeed, continues use of cannabis, but not cigarette smoking, is associated to a more pronounced loss of grey matter in the anterior cingulated and the prefrontal cortex. Atypical antipsychotics have been found to be related to smaller decreases in tissue loss. Moreover, independent of antipsychotic medication intake, the brain volume abnormalities appear associated to the outcome of the illness.
journal_name
Neurosci Biobehav Revjournal_title
Neuroscience and biobehavioral reviewsauthors
Van Haren NE,Cahn W,Hulshoff Pol HE,Kahn RSdoi
10.1016/j.neubiorev.2012.09.006subject
Has Abstractpub_date
2013-12-01 00:00:00pages
2418-23issue
10 Pt 1eissn
0149-7634issn
1873-7528pii
S0149-7634(12)00153-4journal_volume
37pub_type
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