Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) gene.

abstract：:Daily nocturnal (N) and diurnal (D) surges of PRL are characteristic of a pseudopregnancy (psp) induced by cervical stimulation (CS). These semicircadian surges persist for 13-14 days, after which time they cease, and psp ends. The purpose of this study was to describe the involvement of the ovarian steroids in the ma...

journal_title：Endocrinology

authors： Gorospe WC,Freeman ME

更新日期：1981-04-01 00:00:00

abstract：:Adiposity is regulated in a sexually divergent manner. This is partly due to sex steroids, but the differential effects of androgens in males and females are unclear. We investigated effects of testosterone on energy balance in castrated male (n = 6) and female sheep (n = 4), which received 3 × 200 mg testosterone imp...

journal_title：Endocrinology

authors： Clarke SD,Clarke IJ,Rao A,Cowley MA,Henry BA

更新日期：2012-01-01 00:00:00

abstract：:Thyroid hormone (T(3)) regulates growth, development, and differentiation. These activities are mediated by the nuclear thyroid hormone receptors (TRs), which belong to the steroid/TR superfamily of ligand-dependent transcription factors. The effect of T(3) treatment on target gene regulation was investigated in a TRa...

journal_title：Endocrinology

authors： Shih CH,Chen SL,Yen CC,Huang YH,Chen CD,Lee YS,Lin KH

更新日期：2004-06-01 00:00:00

abstract：:Cholesterol pellets inserted directly into mammary glands of 4- and 10-week-old mice resulted in lactogens, such as human growth hormone and prolactin, and epidermal growth factor. The effects of cholesterol the binding of lactogens and epidermal growth factor to the livers of these same animals was unaffected. Pellet...

journal_title：Endocrinology

authors： Vonderhaar BK

更新日期：1993-07-01 00:00:00

abstract：:The activity of the Na+/H+ exchanger was studied by measuring the effects of intracellular pH (pHi) and extracellular Na+ [(Na+)o] on pHi recovery and 22Na uptake in rat adipocytes. The resting pHi was acidified from 7.30 +/- 0.02 to 6.99 +/- 0.01 with nigericin in the absence of (Na+)o. pHi recovery induced by 30 mM ...

journal_title：Endocrinology

authors： Arsenis G

更新日期：1995-07-01 00:00:00

abstract：:For insight into transcriptional mechanisms mediating physiological responses to GH, data mining was performed on a profile of GH-regulated genes induced or inhibited at different times in highly responsive 3T3-F442A adipocytes. Gene set enrichment analysis indicated that GH-regulated genes are enriched in pathways in...

journal_title：Endocrinology

authors： Chen Y,Lin G,Huo JS,Barney D,Wang Z,Livshiz T,States DJ,Qin ZS,Schwartz J

更新日期：2009-08-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I), a prevalent growth factor secreted by bone cells, has important effects on bone remodeling. Hormones are known to regulate the synthesis of skeletal IGF-I, but there is limited information about the actions of growth factors on IGF-I synthesis. We tested the effects of basic fibro...

journal_title：Endocrinology

authors： Canalis E,Pash J,Gabbitas B,Rydziel S,Varghese S

更新日期：1993-07-01 00:00:00

abstract：:Progestins have been implicated in breast cancer development, yet a role for progesterone (Pg) in ductal morphogenesis (DM) has not been established. To determine whether Pg could cause DM, we compared relative effects of Pg, estradiol (E2) and IGF-I on anatomical and molecular biological parameters of IGF-I-related D...

journal_title：Endocrinology

authors： Ruan W,Monaco ME,Kleinberg DL

更新日期：2005-03-01 00:00:00

abstract：:Open pig thyroid follicles in which the apical surface of the follicle cells is in direct contact with the incubation medium were used to study the effect of stimulated exocytosis and stimulated H2O2 generation on the iodination of protein in the incubation medium. In previous studies on this system of follicles we ha...

journal_title：Endocrinology

authors： Björkman U,Ekholm R

更新日期：1988-02-01 00:00:00

abstract：:The assembly of the developmentally arrested primordial follicle and the subsequent transition of the primordial follicle to the primary follicle are critical processes in normal ovarian physiology that remain to be elucidated. Ovarian follicles do not proliferate and the primordial follicles present in the neonate re...

journal_title：Endocrinology

authors： Kezele P,Skinner MK

更新日期：2003-08-01 00:00:00

abstract：:Lipoprotein lipase (LPL) is a key regulator of triglyceride clearance. Its coordinated regulation during feeding and fasting is critical for maintaining lipid homeostasis and energy supply. Angiopoietin-like (Angptl)3 and Angptl4 are secreted proteins that have been demonstrated to regulate triglyceride metabolism by ...

journal_title：Endocrinology

authors： Köster A,Chao YB,Mosior M,Ford A,Gonzalez-DeWhitt PA,Hale JE,Li D,Qiu Y,Fraser CC,Yang DD,Heuer JG,Jaskunas SR,Eacho P

更新日期：2005-11-01 00:00:00

abstract：:The signals that regulate cardiac myocyte maturation in the neonatal heart are not completely understood. In our study we examined the effects of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] on primary cultures of ventricular myocytes isolated from neonatal rat hearts. Our data show that 1,25-(OH)2D3 inhibited an increase ...

journal_title：Endocrinology

authors： O'Connell TD,Giacherio DA,Jarvis AK,Simpson RU

更新日期：1995-02-01 00:00:00

abstract：:Cell proliferation, terminal differentiation, and angiogenesis occur during cycles of follicular and luteal development. In other paradigms, mac25, a potent tumor inhibitor is strongly induced in senescent epithelial cells, whereas CTGF stimulates angiogenesis and wound healing. Using in situ hybridization and immunoh...

journal_title：Endocrinology

authors： Wandji SA,Gadsby JE,Barber JA,Hammond JM

更新日期：2000-07-01 00:00:00

abstract：:The effects of dopamine on PRL secretion and lysosomal enzyme activity in anterior pituitary tissue from rats selected during various stages of the estrous cycle were examined under in vitro conditions. During the estrous cycle, there was a marked variation in the capacity of dopamine to stimulate the activity of the ...

journal_title：Endocrinology

authors： Nansel DD,Gudelsky GA,Reymond MJ,Porter JC

更新日期：1981-03-01 00:00:00

abstract：:We investigated, in five cell strains per experiment, whether several cytokines known or believed to have effects on bone resorption were produced by nearly homogeneous strains of cultured normal human osteoblast-like (hOB) cells that display virtually the complete phenotype of the mature osteoblast. In unstimulated h...

journal_title：Endocrinology

authors： Chaudhary LR,Spelsberg TC,Riggs BL

更新日期：1992-05-01 00:00:00

abstract：:Plasma concentrations of IGF-1 decrease markedly during starvation secondary to a reduction in somatotropic receptors in the liver. We investigated whether IGF-1 administration during starvation in mice inhibits the catabolic state normally observed. Plasma concentrations of IGF-1 in starved mice receiving IGF-1 thera...

journal_title：Endocrinology

authors： O'Sullivan U,Gluckman PD,Breier BH,Woodall S,Siddiqui RA,McCutcheon SN

更新日期：1989-11-01 00:00:00

abstract：:Reproductive fitness in females is susceptible to obesogenic diets. Energy balance and reproduction are tightly regulated, in part, by hypothalamic neurons in the arcuate nucleus (ARC), and high-fat diet (HFD) can steadily increase estradiol levels in rodents. Estradiol regulates the reproductive axis via negative fee...

journal_title：Endocrinology

authors： Negrón AL,Radovick S

更新日期：2020-10-01 00:00:00

abstract：:Kisspeptin regulates reproductive events, including puberty and ovulation, primarily via GnRH neurons. Prolonged treatment of prepubertal striped bass females with kisspeptin (Kiss) 1 or Kiss2 peptides failed to enhance puberty but suggested a gnrh-independent pituitary control pathway. Kiss2 inhibited, but Kiss1 stim...

journal_title：Endocrinology

authors： Zmora N,Stubblefield J,Golan M,Servili A,Levavi-Sivan B,Zohar Y

更新日期：2014-05-01 00:00:00

abstract：:Transforming growth factor-alpha (TGF alpha) is a growth regulatory polypeptide factor that is expressed by several prostatic tumor cell lines. In this investigation, we examined whether TGF alpha is expressed during morphogenesis of the rat prostate gland. We first examined whether the prostate gland expressed TGF al...

journal_title：Endocrinology

authors： Taylor TB,Ramsdell JS

更新日期：1993-09-01 00:00:00

abstract：:Hypophysectomized rats bearing three transplanted pituitaries under the kidney capsule responded to synthetic lysine vasopressin or pitressin with a significant elevation of plasma corticosterone, whereas hypophysectomized rats with no grafts did not. This response was completely abolished by pretreatment of animals w...

journal_title：Endocrinology

authors： Yasuda N,Greer MA,Greer SE,Panton P

更新日期：1978-09-01 00:00:00

abstract：:Glucocorticoid hormones act in the nucleus of the cell to alter expression of specific genes and change cell metabolism. In liver, these hormones have been reported to increase mitochondrial respiratory activity, which is regulated by both nuclear and mitochondrial gene products. We examined the effects of the synthet...

journal_title：Endocrinology

authors： Van Itallie CM

更新日期：1992-02-01 00:00:00

abstract：:The mechanism by which the proto-oncogene, c-fos, is up-regulated in response to PGE2 in the mouse osteoblastic (MC3T3-E1) cell line was investigated using RT-PCR. c-fos messenger RNA up-regulation by dmPGE2 is rapid, starting 10 min post stimulation, and transient. The specific protein kinase A (PKA) inhibitor, H89, ...

journal_title：Endocrinology

authors： Fitzgerald J,Dietz TJ,Hughes-Fulford M

更新日期：2000-01-01 00:00:00

abstract：:Type 2 deiodinase (D2), which is highly expressed in brown adipose tissue (BAT), is an enzyme that amplifies thyroid hormone signaling in individual cells. Mice with inactivation of the D2 pathway (D2KO) exhibit dramatically impaired thermogenesis in BAT, leading to hypothermia during cold exposure and a greater susce...

journal_title：Endocrinology

authors： Hall JA,Ribich S,Christoffolete MA,Simovic G,Correa-Medina M,Patti ME,Bianco AC

更新日期：2010-09-01 00:00:00

abstract：:Neurotensin (NT) and Neuromedin N (NN) are two biologically active peptides present in one copy each in the C-terminal region of a 169-residue precursor. Four basic Lys-Arg doublets occur within the precursor and represent putative processing sites. We investigated the effects of dexamethasone on the biosynthesis and ...

journal_title：Endocrinology

authors： de Nadai F,Rovere C,Bidard JN,Laur J,Martinez J,Cuber JC,Kitabgi P

更新日期：1993-04-01 00:00:00

abstract：:GnRH peptides in the hypothalami of marsupials (tammar wallaby, short-nosed bandicoot, and eastern quoll) and a monotreme (echidna) were investigated by reverse phase HPLC and RIA with region-specific antisera. In the wallaby hypothalamic extract, a single form of GnRH was present, which eluted in the same position as...

journal_title：Endocrinology

authors： King JA,Mehl AE,Tyndale-Biscoe CH,Hinds L,Millar RP

更新日期：1989-11-01 00:00:00

abstract：:Androgen-sensitive prostate cancer cells turn androgen resistant through complex mechanisms that involve dysregulation of apoptosis. We investigated the role of antiapoptotic Bcl-xL in the progression of prostate cancer as well as the interactions of Bcl-xL with proapoptotic Bax and Bak in androgen-dependent and -inde...

journal_title：Endocrinology

authors： Castilla C,Congregado B,Chinchón D,Torrubia FJ,Japón MA,Sáez C

更新日期：2006-10-01 00:00:00

abstract：:Prolactin (PRL) is tonically inhibited by dopamine (DA) released from neurons in the arcuate and periventricular nuclei. Kisspeptin plays a pivotal role in LH regulation. In rodents, kisspeptin neurons are found mostly in the anteroventral periventricular and arcuate nuclei, but the physiology of arcuate kisspeptin ne...

journal_title：Endocrinology

authors： Szawka RE,Ribeiro AB,Leite CM,Helena CV,Franci CR,Anderson GM,Hoffman GE,Anselmo-Franci JA

更新日期：2010-07-01 00:00:00

abstract：:The response of fat tissue to GH or insulin-like growth factor I (IGF-I) differs between humans with hypopituitarism and those with exogenous obesity; the effects of combined GH and IGF-I administration have not been compared in these two situations. In GH-deficient dwarf rats (who have a primary GH deficiency), the e...

journal_title：Endocrinology

authors： Dubuis JM,Deal C,Tsagaroulis P,Clark RG,Van Vliet G

更新日期：1996-07-01 00:00:00

abstract：:We have previously demonstrated that the gonadotropin-mediated inhibition of apoptosis in ovarian granulosa cells is linked to changes in the expression of several cell death-related genes, including members of the bcl-2 gene family (bcl-2, bax, and bcl-x). Recently, the product of the p53 tumor suppressor gene, a pro...

journal_title：Endocrinology

authors： Tilly KI,Banerjee S,Banerjee PP,Tilly JL

更新日期：1995-04-01 00:00:00

abstract：:In preovulatory ovarian follicles, the oocyte is maintained in meiotic prophase arrest by natriuretic peptide precursor C (NPPC) and its receptor natriuretic peptide receptor 2 (NPR2). LH treatment results in the decrease of NPR2 guanylyl cyclase activity that promotes resumption of meiosis. We investigated the regula...

journal_title：Endocrinology

authors： Wang Y,Kong N,Li N,Hao X,Wei K,Xiang X,Xia G,Zhang M

更新日期：2013-09-01 00:00:00